+

WO2003035692A3 - Modified peptides and their uses - Google Patents

Modified peptides and their uses Download PDF

Info

Publication number
WO2003035692A3
WO2003035692A3 PCT/GB2002/004785 GB0204785W WO03035692A3 WO 2003035692 A3 WO2003035692 A3 WO 2003035692A3 GB 0204785 W GB0204785 W GB 0204785W WO 03035692 A3 WO03035692 A3 WO 03035692A3
Authority
WO
WIPO (PCT)
Prior art keywords
terminal domain
chain
pro
procollagen
modified peptides
Prior art date
Application number
PCT/GB2002/004785
Other languages
French (fr)
Other versions
WO2003035692A2 (en
Inventor
Karl Ernest Kadler
Neil John Bulleid
Original Assignee
Univ Manchester
Karl Ernest Kadler
Neil John Bulleid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0125372A external-priority patent/GB0125372D0/en
Priority claimed from GB0125369A external-priority patent/GB0125369D0/en
Application filed by Univ Manchester, Karl Ernest Kadler, Neil John Bulleid filed Critical Univ Manchester
Publication of WO2003035692A2 publication Critical patent/WO2003035692A2/en
Publication of WO2003035692A3 publication Critical patent/WO2003035692A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A modified pro-α chain comprising a triple helix forming domain linked to at least an N-terminal domain, the N-terminal domain containing a polypeptide from at least part of a proteoglycan core, such as decorin. The pro-α chain may form part of a procollagen molecule that has the N-terminal domain retained. The procollagen molecules may be incorporated into collagen polymers, matrices and gels and be used for such applications as wound healing, tissue replacement and cosmetic treatments.
PCT/GB2002/004785 2001-10-23 2002-10-23 Modified peptides and their uses WO2003035692A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0125369.9 2001-10-23
GB0125372A GB0125372D0 (en) 2001-10-23 2001-10-23 Modified peptides
GB0125372.3 2001-10-23
GB0125369A GB0125369D0 (en) 2001-10-23 2001-10-23 Wound healing

Publications (2)

Publication Number Publication Date
WO2003035692A2 WO2003035692A2 (en) 2003-05-01
WO2003035692A3 true WO2003035692A3 (en) 2003-10-30

Family

ID=26246686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/004785 WO2003035692A2 (en) 2001-10-23 2002-10-23 Modified peptides and their uses

Country Status (1)

Country Link
WO (1) WO2003035692A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0309064D0 (en) * 2003-04-22 2003-05-28 Univ Manchester Modified peptides and their uses

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0704532A2 (en) * 1994-06-10 1996-04-03 United States Surgical Corporation Recombinant chimeric proteins and methods of use thereof
US5986052A (en) * 1993-01-06 1999-11-16 The General Hospital Corporation Fusion polypeptide containing fragments of cartilage matrix protein and link protein
EP0985732A2 (en) * 1998-09-07 2000-03-15 Terumo Kabushiki Kaisha Trimeric chimera protein and collagen matrix containing chimera protein
EP0992586A2 (en) * 1998-10-09 2000-04-12 United States Surgical Corporation Extracellular matrix proteins with modified amino acid
WO2001034647A2 (en) * 1999-11-12 2001-05-17 Fibrogen, Inc. Animal collagens and gelatins

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986052A (en) * 1993-01-06 1999-11-16 The General Hospital Corporation Fusion polypeptide containing fragments of cartilage matrix protein and link protein
EP0704532A2 (en) * 1994-06-10 1996-04-03 United States Surgical Corporation Recombinant chimeric proteins and methods of use thereof
EP0985732A2 (en) * 1998-09-07 2000-03-15 Terumo Kabushiki Kaisha Trimeric chimera protein and collagen matrix containing chimera protein
EP0992586A2 (en) * 1998-10-09 2000-04-12 United States Surgical Corporation Extracellular matrix proteins with modified amino acid
WO2001034647A2 (en) * 1999-11-12 2001-05-17 Fibrogen, Inc. Animal collagens and gelatins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GRAHAM HK ET AL.: "Identification of Collagen Fibril Fusion during Vertebrate Tendon Morphogenesis. The Process Relies on Unipolar Fibrills and is Regulated by Collagen-proteoglycan Interaction", JOURNAL OF MOLECULAR BIOLOGY, vol. 295, no. 4, 28 January 2000 (2000-01-28), pages 891 - 902, XP001161220 *

Also Published As

Publication number Publication date
WO2003035692A2 (en) 2003-05-01

Similar Documents

Publication Publication Date Title
DE602004028455D1 (en) Crosslinked polysaccharide composition
ATE267249T1 (en) POLYPEPTIDES ISOLATED FROM THE EPIDERMIS AND USE THEREOF
Parry et al. Structural studies on lamin. Similarities and differences between lamin and intermediate-filament proteins
WO2001094381A3 (en) Novel compounds of the n-acylamino-amide family, compositions comprising same, and uses
DE60230873D1 (en) MEDICAMENT RELEASING MATRICES FOR THE PROMOTION OF WOUND HEALING
EP1652862A8 (en) Deproteinized natural rubber, its composition and use thereof
ATE386538T1 (en) COMBINED USE OF FACTOR VII POLYPEPTIDES AND FACTOR VIII POLYPEPTIDES
DE60113121T2 (en) Preparation of crosslinked hyaluronic acid and its hydrogel, products made therefrom and their use
ATE552864T1 (en) THERAPEUTICALLY ACTIVE WOUND DRESSINGS, THEIR PRODUCTION AND THEIR USE
WO1996017935A3 (en) Rantes peptide and fragments and compositions comprising it for treatment of inflammation
ATE285219T1 (en) RECOMBINANT HAIR TREATMENTS
ATE551048T1 (en) COSMETIC COMPOSITIONS CONTAINING PROTEIN HYDROLYSATES
AU3003199A (en) Tourmaline in cosmetic cleansing compositions
EP2392655A3 (en) Coagulation factor VII polypeptides
ES2156375T3 (en) COMPOSITION OF CONDITIONING SHAMPOO.
MXPA03010684A (en) Peptides and the use thereof in darkening the skin.
IL143516A (en) E3 ubiquitin ligase polypeptide, polynucleotide encoding the same and uses thereof
WO2003035692A3 (en) Modified peptides and their uses
WO2005024006A3 (en) Coagulation factor vii polypeptides
WO2004094472A3 (en) Collagen fibrils carrying bioactive heterologous domains and their use in e.g. wound healing
AU2002214102A1 (en) Use of the association of at least a carotenoid with provitamin a activity and at least a carotenoid without provitamin a activity for treating ageing symptoms
DE69120390D1 (en) Collagen-binding protein and its production
CA2529001A1 (en) Binding peptides: methods for their generation and use
ATE449107T1 (en) PEPTIDES AND NUCLEIC ACIDS OF THE CATHELICIDIN FAMILY OBTAINED FROM FISH AND THEIR USE
ATE242552T1 (en) POLARIZER AND METHOD FOR PRODUCING THE SAME

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载