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WO2003033708A3 - Regulation of human serine/threonine protein kinase - Google Patents

Regulation of human serine/threonine protein kinase Download PDF

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Publication number
WO2003033708A3
WO2003033708A3 PCT/EP2002/011478 EP0211478W WO03033708A3 WO 2003033708 A3 WO2003033708 A3 WO 2003033708A3 EP 0211478 W EP0211478 W EP 0211478W WO 03033708 A3 WO03033708 A3 WO 03033708A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
threonine protein
human serine
regulation
reagents
Prior art date
Application number
PCT/EP2002/011478
Other languages
French (fr)
Other versions
WO2003033708A2 (en
Inventor
Rainer H Koehler
Original Assignee
Bayer Healthcare Ag
Rainer H Koehler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Rainer H Koehler filed Critical Bayer Healthcare Ag
Publication of WO2003033708A2 publication Critical patent/WO2003033708A2/en
Publication of WO2003033708A3 publication Critical patent/WO2003033708A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents that regulate human serine/threonine protein kinase and reagents which bind to human serine/threonine protein kinase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cancer, diabetes, CNS disorders or COPD.
PCT/EP2002/011478 2001-10-15 2002-10-14 Regulation of human serine/threonine protein kinase WO2003033708A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US32880401P 2001-10-15 2001-10-15
US60/328,804 2001-10-15
US35968802P 2002-02-27 2002-02-27
US60/359,688 2002-02-27
US39236502P 2002-07-01 2002-07-01
US60/392,365 2002-07-01

Publications (2)

Publication Number Publication Date
WO2003033708A2 WO2003033708A2 (en) 2003-04-24
WO2003033708A3 true WO2003033708A3 (en) 2004-01-29

Family

ID=27406629

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/011478 WO2003033708A2 (en) 2001-10-15 2002-10-14 Regulation of human serine/threonine protein kinase

Country Status (1)

Country Link
WO (1) WO2003033708A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099044A2 (en) 2001-06-05 2002-12-12 Exelixis, Inc. B3galts as modifiers of the p53 pathway and methods of use
US6492156B1 (en) * 2001-10-31 2002-12-10 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US20100311807A1 (en) * 2007-03-14 2010-12-09 Washington University Methods for identifying diabetes and obesity therapeutics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060062A2 (en) * 1999-04-01 2000-10-12 Astrazeneca Uk Limited Human signal transduction serine/threonine protein kinase
WO2002010402A2 (en) * 2000-07-28 2002-02-07 Chiron Corporation Isolation of drosophila and human polynucleotides encoding par-1 kinase, polypeptides encoded by the polynucleotides and methods utilizing the polynucleotides and polypeptides
WO2003038115A2 (en) * 2001-10-31 2003-05-08 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060062A2 (en) * 1999-04-01 2000-10-12 Astrazeneca Uk Limited Human signal transduction serine/threonine protein kinase
WO2002010402A2 (en) * 2000-07-28 2002-02-07 Chiron Corporation Isolation of drosophila and human polynucleotides encoding par-1 kinase, polypeptides encoded by the polynucleotides and methods utilizing the polynucleotides and polypeptides
WO2003038115A2 (en) * 2001-10-31 2003-05-08 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 25 April 1997 (1997-04-25), XP002242844, Database accession no. Z83869 *
DATABASE EMBL [online] 31 July 2001 (2001-07-31), XP002242843, Database accession no. AF387638 *
DREWES ET AL.: "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 89, 18 April 1997 (1997-04-18), pages 297 - 308, XP002105681 *
SUN T-G ET AL: "Par-1 is a dishevelled-associated kinase and a positive regulator of WNT signalling", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 3, no. 7, July 2001 (2001-07-01), pages 628 - 636, XP008004678 *

Also Published As

Publication number Publication date
WO2003033708A2 (en) 2003-04-24

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