+

WO2003031828A1 - Microvalve ajustable et procede de reglage et d'actionnement de cette derniere - Google Patents

Microvalve ajustable et procede de reglage et d'actionnement de cette derniere Download PDF

Info

Publication number
WO2003031828A1
WO2003031828A1 PCT/IB2002/003999 IB0203999W WO03031828A1 WO 2003031828 A1 WO2003031828 A1 WO 2003031828A1 IB 0203999 W IB0203999 W IB 0203999W WO 03031828 A1 WO03031828 A1 WO 03031828A1
Authority
WO
WIPO (PCT)
Prior art keywords
actuating members
micro valve
array
actuating
temperature
Prior art date
Application number
PCT/IB2002/003999
Other languages
English (en)
Inventor
Alec Ginggen
Original Assignee
Medos S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP20010123923 external-priority patent/EP1273808B1/fr
Application filed by Medos S.A. filed Critical Medos S.A.
Priority to BRPI0213130-7A priority Critical patent/BR0213130B1/pt
Priority to JP2003534774A priority patent/JP2005504939A/ja
Priority to CA2462968A priority patent/CA2462968C/fr
Priority to AU2002341249A priority patent/AU2002341249B2/en
Publication of WO2003031828A1 publication Critical patent/WO2003031828A1/fr

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0011—Gate valves or sliding valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K2099/0069—Bistable microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0086—Medical applications
    • F16K2099/0088—Implanted devices
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0094—Micropumps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/6416—With heating or cooling of the system

Definitions

  • the present invention relates to a method of setting and/or actuating a multi-stable valve used in fluidic or in micro fluidic applications.
  • Another object of the invention is an adjustable multi stable valve for use in medical devices implanted in a human body.
  • the invention relates to a micro valve having at least two stable states at operating temperature.
  • An opening pressure and a resistance to fluid flow correspond to each state of the valve.
  • the valve may be actuated non- invasively, by telemetry for example, thanks to an external device, providing an adjustable opening pressure valve or alternatively a valve assembly with adjustable resistance to flow.
  • the valve object of the present invention has a wide range of applications in different fields (medical, hydraulics, micro-engineering, ).
  • a shunt system that derives the excess of liquid from the brain to the peritonea or to another cavity of the patient.
  • Some existing shunt systems comprise an adjustable valve that allows the surgeon to modify non-invasively the valve opening pressure after implantation.
  • These existing implantable valves for the treatment of hydrocephalic patients have successfully shown that the feature allowing the surgeon to adjust non-invasively the valve opening pressure after implantation is extremely useful. Nevertheless, there are some drawbacks associated with devices of this type that can be summarised as follows:
  • valve object of the present invention overcomes the problems exposed above by providing a micro valve having at least two stable states at operating temperature.
  • the valve according to the invention does not require energy at rest during normal operation and is insensitive to magnetic fields by design. Since the valve setting may be adjusted without mechanical movement of any parts, the valve is less sensitive to blockage due to an accumulation of bio substances.
  • the actuation concept is based on temperature changes above and below body temperature. Energy is only required to change the valve from one state to the other. Valves for the treatment of hydrocephalic patients, as well as valves for all kind of implantable pumps constitute major applications of that concept that may be extended to other fields.
  • a method for setting and actuating an implantable valve having the steps disclosed in claim 1 as well as a micro valve having the characteristics recited in claim 4 obviates the above mentioned drawbacks.
  • Figure 1 is a graph showing the typical temperature hysteresis of shape memory alloy (SMA).
  • Figure 2 is a graph showing the typical stress-strain characteristics of a shape memory alloy in each of its states.
  • Figure 3 is a schematic perspective top view of a first embodiment of a micro valve according to the invention.
  • Figure 4 is a bottom perspective view according to the first embodiment shown at figure 3.
  • Figure 5 is cross sectional view of the first embodiment of the valve shown at figure 3.
  • Figure 6 is a perspective top view of a second embodiment of a micro valve according to the invention.
  • Figure 7 is perspective bottom view of the second embodiment depicted in figure 6.
  • Figure 8 is schematic cross sectional view of the second embodiment depicted in figure 6.
  • Figure 9 is schematic perspective top view of a third embodiment of a micro valve according to the invention.
  • Figure 10 is a perspective bottom view of the third embodiment depicted in figure 9.
  • Figure 11 is a perspective top view of an implantable assembly incorporating a valve according to the invention, the top cover being exploded.
  • Figure 12 is a perspective view of the assembly depicted in figure 11 with the bottom cover exploded.
  • Figure 13 is a bottom perspective view of the assembly shown at figures 11 and 12.
  • Figure 14 is an exploded perspective view of an implantable pump embodying a valve according to the invention.
  • shape memory alloys hereafter called SMA material.
  • SMA material shape memory alloys
  • SMA material is characterised by reversible metallurgical phase transformations that are activated either by temperature change or by induced stress. Below a range of transition temperature, the material is in the martensitic state, whereas above that temperature range, the material is in the austenitic state.
  • the transformation occurs across a range of temperatures which are commonly named A s (start) and A f (finish) for the transformation from martensitic to austenitic state and M s (start) and M f (finish) for the transformation from austenitic to martensitic state as referenced in figure 1.
  • These transformations are reversible so that the material may be treated to assume different shapes in each of the two phases, and can reversibly switch between the two shapes when transformed from one state to the other. More commonly, the material is treated to only return to a shape upon transformation to the austenitic phase a biasing force, acting against the SMA material returns it to its alternate shape upon transformation to the martensitic phase.
  • the elastic modulus of the SMA material depends on its metallurgical state.
  • Figure 2 shows a typical stress-strain graph of a SMA material in both states. It appears clearly that the austenitic state has a higher elastic modulus than the martensitic state.
  • the stress-strain curve is roughly linear and the Young's modulus corresponds to the slope of the curve in the initial loading region. For materials tested at temperatures just above the A f temperature, if the material is further deformed beyond this initial loading region, it will experience a stress-induced martensitic transformation.
  • the point on the stress-strain curve at which the stress-induced martensitic transformation begins can be called the M s 0 .
  • the elastic modulus In the martensitic state, the elastic modulus is lower than in the austenitic state, and the corresponding M s ⁇ (in this case, the stress required to rearrange the pre-existing martensitic phase) is also lower.
  • the invention makes use of the change in mechanical properties (mainly Young's modulus) of an array of actuators in SMA material when a transition between the two metallurgical states occurs.
  • the SMA material is preferably chosen within SMA materials having a working temperature corresponding to body temperature located between M s and A s . In that case, the material is stable in both states at rest. Heating the material above A f will transform it into austenite (higher modulus material). Cooling the material below M f will transform it into martensite (lower modulus material). While the effect is most pronounced with the temperature of use located between M s and A s , the effect can be observed to some extent at a number of temperatures in the broader range between M f and A f .
  • TiNi (Nitinol) is a good choice for the actuating members of a valve according to the invention as it is biocompatible. Further, TiNi can be manufactured such that body temperature is located between M s and A s .
  • Fine tuning the temperature cycle and the mechanical properties may be achieved by playing with the chemical composition and thermomechanical processing of the material.
  • the micro valve object of the invention comprises an array of actuators or actuating members made of a SMA material that interact either directly with the fluid path or with an elastic mean, the tension of which being modified by said array of SMA actuators.
  • the SMA material is selected to have two stable metallurgical states at the temperature of use, e.g., body temperature.
  • the metallurgical state can be changed either by cooling or by heating the SMA actuator.
  • One of the metallurgical states has a higher elastic modulus, whereas the other state has a lower elastic modulus.
  • the heating is obtained by circulating a current through or in the proximity of the SMA material (Joule effect).
  • the cooling is achieved thanks to a Peltier cell or an array of Peltier cells integrated in the base plate of the valve, in the vicinity of the SMA actuators.
  • the fluid path crosses a base plate 2 having an array of orifices 3, closed by the free extremity of a corresponding array of actuating members 1.
  • the base plate 2 is preferably made of a glass type material like Pyrex for example.
  • the geometry of the orifices 3 is identical across the array, which ensures that the resistance to fluid is the same for each single orifice 3.
  • the array of actuating members 1 comprises, in this embodiment, an elongated body from which extend perpendicularly elongated actuating members. Some other configurations are of course possible.
  • the actuating members 1 are made of SMA material, preferably TiNi, and their geometry is chosen so that each fluid path 3 can be considered as closed when the corresponding actuating member 1 is in the austenitic state and open in the martensitic state.
  • a Peltier cell 4 is integrated in the base plate 2, and allows, once energised, the cooling of the array of actuating members 1.
  • Each actuating member 1 may be heated individually by circulating an electrical current through the connectors 5 bounded to each of the actuating members 1.
  • the valve setting is modified in the following manner. First, the temperature of the array of SMA actuating members 1 is decreased to a temperature substantially lower than M s (preferably below M f ) by energising the Peltier cell 4. This transforms all or part of the actuating members 1 to the martensitic state (lower modulus). Then, at least one actuating member is selected within the array and the temperature of all actuating members 1 except the previously selected is increased to a temperature substantially higher than A s (preferably above A f ) This is achieved by circulating an electrical current through the connectors 5 connected to the actuating members 1. Once the higher temperature is reached, all or part of the actuating members 1 are in the austenitic state (higher modulus) except the selected actuating member which remains all or partially in the martensitic state thus determining the opening pressure of the valve.
  • the array of SMA actuators may be first heated to a temperature at which an austenitic transformation occurs and then at least one selected actuating member is cooled down to a temperature at which a martensitic transformation occurs.
  • an array of Peltier cells is provided. Each Peltier cell forming the array being located in the vicinity of an actuating member so as to enable the individual cooling of each actuating member.
  • each actuating member 1 forming the array can be adjusted for providing different opening pressure depending on which actuating member remains in the martensitic state.
  • Figures 6, 7 and 8 depict another embodiment of a valve with an adjustable opening pressure.
  • the base plate 2 has only one orifice 3 through which the fluid may flow.
  • a ball 6 is maintained in the seat of the orifice 3 thanks to an elastic element like a flexible flat spring 7 for example.
  • the spring 7 need not be made of a SMA material.
  • An array of SMA actuating members 1 is arranged perpendicularly to the spring 7 and the free end of each actuating member 1 interacts with the spring 7.
  • the length of the spring allowed to move freely is restricted.
  • the force applied to the ball is determined by the tension of the spring 7 which varies with the metallurgical states of the actuating members 1.
  • a Peltier cell is integrated in the base plate 2 in the vicinity of the SMA array of actuating members 1. Upon activation, the Peltier cell cools the array and all the actuating members 1 change to martensitic state.
  • Each of the actuating members 1 may then be individually heated to a temperature at which an austenitic transformation occurs. This determines the length of activation of the spring 7 and therefore the opening pressure of the valve.
  • a third embodiment of a valve according to the invention provides a valve with an adjustable resistance to flow.
  • a circular base plate 9 comprises, on its periphery, an array of openings 10 through which a fluid may flow.
  • An array of actuating members 11 is arranged on the base plate 9 so that the free end of each actuating member 11 closes a corresponding opening 10 of the base plate.
  • the SMA actuating members 11 are preferably extending from the centre of the base plate 9 to the periphery of said plate.
  • all the actuating members 11 have the same geometry but the geometry of the orifices 10 may differ in order to provide a range of different resistances to flow.
  • a Peltier cell or an array of Peltier cells is integrated in the base plate 9, preferably in the centre of the base plate so as to enable cooling of the complete array of SMA actuating members 11.
  • the setting or the actuating of the valve is similar to what has been disclosed in reference to the first embodiment at figure 3 to 5.
  • FIG. 11 , 12 and 13 illustrate an implantable valve with adjustable opening pressure.
  • the implantable valve comprises a valve assembly 12 according to one of the first or second embodiment disclosed above.
  • a top cover 13 having a fluid outlet 14 is adapted to receive the valve assembly 12.
  • An antenna 17 as well as the necessary electronic components 18 to power and control the valve assembly by telemetry are integrated on the bottom of the base plate of the valve assembly 12.
  • a bottom cover 15 having a fluid inlet 16 and a leak tight compartment 19 for protecting the electronic components closes the structure.
  • the user may then power the assembly by telemetry and select non- invasively the opening pressure from outside the body by firstly cooling the SMA array of actuating members 11 and then selectively heating by Joule effect one or more actuating members 11.
  • the electronic components 18 integrate a feedback mechanism that can be used to confirm that the correct actuating member 11 or array of actuating members have been heated.
  • a valve according to the invention may also be used in an implantable drug delivery pump.
  • a few existing adjustable implantable pumps allow the user (patient and/or doctor) to select non-invasively a flow rate of chemicals to inject, thanks to an external programming unit.
  • the existing devices can be divided in two main categories: the active or passive pumping mechanisms.
  • a battery energises a pump that regulates the flow rate of chemicals.
  • a pressure reservoir "pushes" the chemicals out of the pump.
  • the later concept is very elegant since the pumping does not require energy. Nevertheless, the regulation of the fluid flow is ensured by a valve, the opening of which depends on the power delivered to the valve. Therefore, a battery is still required.
  • valve according to the invention when used in an implantable adjustable pump, the energy consumption problem is solved, since energy is only required to change the flow setting of the pump.
  • the implantable pump comprises a pressurised reservoir 20 that contains the drug substance to administrate.
  • a valve assembly 21 as described with reference to the third embodiment shown in figures 9 and 10 constitutes the adjustable flow resistance valve of the pump.
  • the bottom of the base plate of the valve assembly 21 incorporates electronic components and an antenna that are used to power and control the valve non invasively by telemetry.
  • a leak tight cover 22 protects the bottom face of the base plate and the electronics components, avoiding contact with the pressurised liquid contained in the reservoir 20.
  • a top cover 23 having a fluid outlet 24 closes the structure.
  • the user may select the resistance of the valve from outside with a dedicated reading unit and therefore regulates the outflow of chemicals contained in the pressurised reservoir.
  • valve has multi stable states, energy is only required to switch from one state to the other. No energy is needed to maintain a selected state.
  • Each state can either correspond to a selected opening pressure or to a flow resistance, depending on the application.
  • valve settings can be adjusted without a movement of any part. Only the elastic modulus of the material is modified and therefore the valve is less sensitive to blockage by clogs and other bio-substances.
  • the energy required is the energy needed to power a Peltier cell, and the energy for heating the actuating members. This energy can be provided to the implantable device by telemetry avoiding the use of batteries.
  • the choice of the SMA material is of importance. It must be chosen from the SMA materials that have two stable states at a temperature in the vicinity of the body temperature. Furthermore, the SMA material ideally should fulfill the following conditions. M s ⁇ T ⁇ A s where T is the temperature of the human body and an hysteresis ⁇ T, comprised between 10 and 40 degrees centigrade. TiNi (Nitinol) is a material that fulfills these requirements and which is also biocompatible.

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Computer Hardware Design (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Fluid Mechanics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Temperature-Responsive Valves (AREA)
  • Prostheses (AREA)
  • Micromachines (AREA)
  • Electrically Driven Valve-Operating Means (AREA)

Abstract

La présente invention concerne un procédé de réglage ou d'actionnement d'une microvalve destinée à des applications fluidiques, lequel procédé consiste à refroidir un réseau d'organes d'actionnement réalisés dans un matériau d'alliage à mémoire de forme (SMA) jusqu'à une température inférieure ou égale à la température à laquelle se produit une transformation de l'état austénitique à l'état martensitique de façon que la totalité du réseau d'organes d'actionnement en SMA se trouve entièrement ou partiellement à l'état martensitique, à choisir ensuite au moins l'un des organes d'actionnement correspondant à une pression d'ouverture ou à une résistance à l'écoulement prédéterminée, et à chauffer individuellement chacun des organes d'actionnement, à l'exception de celui qui a été choisi auparavant, jusqu'à une température supérieure ou égale à la température à laquelle se produit une transformation de l'état martensitique à l'état austénitique. L'invention se rapporte également à une microvalve comprenant un réseau d'organes d'actionnement réalisés dans un matériau d'alliage à mémoire de forme.
PCT/IB2002/003999 2001-10-06 2002-09-30 Microvalve ajustable et procede de reglage et d'actionnement de cette derniere WO2003031828A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BRPI0213130-7A BR0213130B1 (pt) 2001-10-06 2002-09-30 Método para regular uma microválvula ajustável, microválvula ajustável, arranjo de microválvula implantável e bomba implantável
JP2003534774A JP2005504939A (ja) 2001-10-06 2002-09-30 多安定型のマイクロバルブおよび可調整型のマイクロバルブを設定および作動する方法
CA2462968A CA2462968C (fr) 2001-10-06 2002-09-30 Microvalve ajustable et procede de reglage et d'actionnement de cette derniere
AU2002341249A AU2002341249B2 (en) 2001-10-06 2002-09-30 Method of setting and actuating a multi-stable micro valve and adjustable micro valve

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01123923.3 2001-10-06
EP20010123923 EP1273808B1 (fr) 2001-07-02 2001-10-06 Micro-soupape réglable et procédé de réglage et manoeuvre

Publications (1)

Publication Number Publication Date
WO2003031828A1 true WO2003031828A1 (fr) 2003-04-17

Family

ID=8178870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/003999 WO2003031828A1 (fr) 2001-10-06 2002-09-30 Microvalve ajustable et procede de reglage et d'actionnement de cette derniere

Country Status (6)

Country Link
US (2) US6926246B2 (fr)
JP (1) JP2005504939A (fr)
AU (1) AU2002341249B2 (fr)
BR (1) BR0213130B1 (fr)
CA (1) CA2462968C (fr)
WO (1) WO2003031828A1 (fr)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7474180B2 (en) 2002-11-01 2009-01-06 Georgia Tech Research Corp. Single substrate electromagnetic actuator
FR2849258B1 (fr) * 2002-12-19 2006-12-22 Commissariat Energie Atomique Plaque a modification de surface
US7186247B2 (en) * 2003-04-04 2007-03-06 Medtronic, Inc. Apparatus and system for delivery of drug therapies
DE202004021949U1 (de) 2003-09-12 2013-05-27 Vessix Vascular, Inc. Auswählbare exzentrische Remodellierung und/oder Ablation von atherosklerotischem Material
US9125667B2 (en) 2004-09-10 2015-09-08 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US7927270B2 (en) 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US7699770B2 (en) 2005-02-24 2010-04-20 Ethicon Endo-Surgery, Inc. Device for non-invasive measurement of fluid pressure in an adjustable restriction device
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
WO2007021811A2 (fr) * 2005-08-11 2007-02-22 Eksigent Technologies, Llc Appareil et procede microfluidiques permettant de reguler la temperature et de reduire le bruit
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
ES2560006T3 (es) 2006-10-18 2016-02-17 Vessix Vascular, Inc. Inducción de efectos de temperatura deseables sobre tejido corporal
US8187163B2 (en) 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8499779B2 (en) 2008-01-16 2013-08-06 The United States Of America As Represented By The Administrator Of The National Aeronautics Space Administration Systems, methods and apparatus of a nitinol valve
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8221439B2 (en) 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8034065B2 (en) 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
US8187162B2 (en) 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
AU2009314133B2 (en) 2008-11-17 2015-12-10 Vessix Vascular, Inc. Selective accumulation of energy with or without knowledge of tissue topography
AU2011238925B2 (en) 2010-04-09 2016-06-16 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
WO2012100095A1 (fr) 2011-01-19 2012-07-26 Boston Scientific Scimed, Inc. Cathéter à grande électrode compatible avec un guide pour ablation de nerf rénal à lésion artérielle réduite
CN103813745B (zh) 2011-07-20 2016-06-29 波士顿科学西美德公司 用以可视化、对准和消融神经的经皮装置及方法
AU2012287189B2 (en) 2011-07-22 2016-10-06 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US9186210B2 (en) 2011-10-10 2015-11-17 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
WO2013055815A1 (fr) 2011-10-11 2013-04-18 Boston Scientific Scimed, Inc. Dispositif d'électrode hors paroi pour une modulation nerveuse
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US9079000B2 (en) 2011-10-18 2015-07-14 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US9162046B2 (en) 2011-10-18 2015-10-20 Boston Scientific Scimed, Inc. Deflectable medical devices
EP2775948B1 (fr) 2011-11-08 2018-04-04 Boston Scientific Scimed, Inc. Ablation ostiale du nerf rénal
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
US9037259B2 (en) 2011-12-23 2015-05-19 Vessix Vascular, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
CN104135958B (zh) 2011-12-28 2017-05-03 波士顿科学西美德公司 用有聚合物消融元件的新消融导管调变神经的装置和方法
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
CN104780859B (zh) 2012-09-17 2017-07-25 波士顿科学西美德公司 用于肾神经调节的自定位电极系统及方法
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
WO2014047411A1 (fr) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. Système de modulation des nerfs et blocage des nerfs par gradient thermique inoffensif
EP2906135A2 (fr) 2012-10-10 2015-08-19 Boston Scientific Scimed, Inc. Dispositifs et procédés de modulation de nerf rénal
WO2014124524A1 (fr) * 2013-02-15 2014-08-21 Canadian Space Agency Évaluation de fatigue destinée à un actionneur sma
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US9050436B2 (en) 2013-03-14 2015-06-09 DePuy Synthes Products, LLC Adjustable resistance, gravitationally activated, anti-syphon valve
WO2014149690A2 (fr) 2013-03-15 2014-09-25 Boston Scientific Scimed, Inc. Dispositifs médicaux et méthodes de traitement de l'hypertension à l'aide d'une compensation d'impédance
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
CN105473090B (zh) 2013-03-15 2019-05-03 波士顿科学国际有限公司 重建身体通道的组织或邻近身体通道的组织的方法及装置
JP2016523147A (ja) 2013-06-21 2016-08-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 同乗型電極支持体を備えた腎除神経バルーンカテーテル
JP2016524949A (ja) 2013-06-21 2016-08-22 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 回転可能シャフトを有する腎神経アブレーション用医療装置
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
US9833283B2 (en) 2013-07-01 2017-12-05 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US10413357B2 (en) 2013-07-11 2019-09-17 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
CN105377169B (zh) 2013-07-11 2019-04-19 波士顿科学国际有限公司 用于神经调制的装置和方法
WO2015010074A1 (fr) 2013-07-19 2015-01-22 Boston Scientific Scimed, Inc. Ballonnet de dénervation rénale à électrode bipolaire en spirale
US10342609B2 (en) 2013-07-22 2019-07-09 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP3024405A1 (fr) 2013-07-22 2016-06-01 Boston Scientific Scimed, Inc. Cathéter d'ablation de nerf rénal ayant un ballonnet de torsion
JP6159888B2 (ja) 2013-08-22 2017-07-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経変調バルーンへの接着性を向上させたフレキシブル回路
CN105555218B (zh) 2013-09-04 2019-01-15 波士顿科学国际有限公司 具有冲洗和冷却能力的射频(rf)球囊导管
EP3043733A1 (fr) 2013-09-13 2016-07-20 Boston Scientific Scimed, Inc. Ballonnet d'ablation à couche de revêtement déposée en phase vapeur
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
CN105592778B (zh) 2013-10-14 2019-07-23 波士顿科学医学有限公司 高分辨率心脏标测电极阵列导管
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
EP3057520A1 (fr) 2013-10-15 2016-08-24 Boston Scientific Scimed, Inc. Ballonnet de dispositif médical
CN105636538B (zh) 2013-10-18 2019-01-15 波士顿科学国际有限公司 具有柔性导线的球囊导管及其使用和制造的相关方法
WO2015061457A1 (fr) 2013-10-25 2015-04-30 Boston Scientific Scimed, Inc. Thermocouple intégré dans un circuit souple d'énervation
WO2015103617A1 (fr) 2014-01-06 2015-07-09 Boston Scientific Scimed, Inc. Ensemble circuit souple résistant aux déchirures
EP3102136B1 (fr) 2014-02-04 2018-06-27 Boston Scientific Scimed, Inc. Variante de placement de capteurs thermiques sur une électrode bipolaire
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
DE102016219342B4 (de) 2016-10-06 2025-03-13 Conti Temic Microelectronic Gmbh Pneumatisches Ventil
WO2019218072A1 (fr) * 2018-05-16 2019-11-21 Smarter Alloys Inc. Vanne en alliage à mémoire de forme et procédé pour sa fabrication
DE102018216876B4 (de) 2018-10-01 2022-10-27 Conti Temic Microelectronic Gmbh Pneumatisches Ventil
US11913563B2 (en) 2021-12-30 2024-02-27 Applied Materials, Inc. Temperature actuated valve and methods of use thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5619177A (en) * 1995-01-27 1997-04-08 Mjb Company Shape memory alloy microactuator having an electrostatic force and heating means
EP0778043A1 (fr) * 1995-12-04 1997-06-11 Pacesetter AB Fil de guidage comprenant un fil interne en alliage à memoire de forme
DE19645725C1 (de) * 1996-11-06 1997-12-11 Sican F & E Gmbh Sibet Implantierbares und steuerbares Ventil für medizinische Anwendungen
US5697951A (en) * 1996-04-25 1997-12-16 Medtronic, Inc. Implantable stimulation and drug infusion techniques
WO1999038551A1 (fr) * 1998-02-02 1999-08-05 Medtronic, Inc. Dispositif implantable servant a administrer un medicament par perfusion et possedant un clapet de surete
WO1999039118A1 (fr) * 1998-02-03 1999-08-05 The Board Of Trustees Operating Michigan State University Et Al. Systeme de regulation de fluides a film mince et procede de fabrication correspondant
US6149123A (en) * 1996-09-27 2000-11-21 Redwood Microsystems, Inc. Integrated electrically operable micro-valve

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60195386A (ja) * 1984-03-16 1985-10-03 Nec Corp 形状記憶アクチユエ−タ
JPH0878340A (ja) * 1994-09-06 1996-03-22 Olympus Optical Co Ltd 流速分布制御装置
US6133547A (en) * 1996-09-05 2000-10-17 Medtronic, Inc. Distributed activator for a two-dimensional shape memory alloy
JP4231918B2 (ja) * 1998-07-21 2009-03-04 国立大学法人東北大学 運動素子
JP2000110709A (ja) * 1998-10-01 2000-04-18 Seiko Epson Corp アクチュエータ及びこれを備えた駆動システム
US6354839B1 (en) * 1998-10-10 2002-03-12 Orbital Research, Inc. Refreshable braille display system
US6474795B1 (en) * 1999-12-21 2002-11-05 Eastman Kodak Company Continuous ink jet printer with micro-valve deflection mechanism and method of controlling same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5619177A (en) * 1995-01-27 1997-04-08 Mjb Company Shape memory alloy microactuator having an electrostatic force and heating means
EP0778043A1 (fr) * 1995-12-04 1997-06-11 Pacesetter AB Fil de guidage comprenant un fil interne en alliage à memoire de forme
US5697951A (en) * 1996-04-25 1997-12-16 Medtronic, Inc. Implantable stimulation and drug infusion techniques
US6149123A (en) * 1996-09-27 2000-11-21 Redwood Microsystems, Inc. Integrated electrically operable micro-valve
DE19645725C1 (de) * 1996-11-06 1997-12-11 Sican F & E Gmbh Sibet Implantierbares und steuerbares Ventil für medizinische Anwendungen
WO1999038551A1 (fr) * 1998-02-02 1999-08-05 Medtronic, Inc. Dispositif implantable servant a administrer un medicament par perfusion et possedant un clapet de surete
WO1999039118A1 (fr) * 1998-02-03 1999-08-05 The Board Of Trustees Operating Michigan State University Et Al. Systeme de regulation de fluides a film mince et procede de fabrication correspondant

Also Published As

Publication number Publication date
US20050252553A1 (en) 2005-11-17
BR0213130B1 (pt) 2014-10-07
AU2002341249B2 (en) 2009-03-05
CA2462968A1 (fr) 2003-04-17
US20030155539A1 (en) 2003-08-21
JP2005504939A (ja) 2005-02-17
BR0213130A (pt) 2004-10-19
US6926246B2 (en) 2005-08-09
CA2462968C (fr) 2012-11-20

Similar Documents

Publication Publication Date Title
CA2462968C (fr) Microvalve ajustable et procede de reglage et d'actionnement de cette derniere
AU2002341249A1 (en) Method of setting and actuating a multi-stable micro valve and adjustable micro valve
JP5863238B2 (ja) 流体の流れを滴定するための動電アクチュエータ
EP3654894B1 (fr) Dérivations de glaucome à écoulement réglable
US5820589A (en) Implantable non-invasive rate-adjustable pump
US4556050A (en) Artificial sphincter including a shape memory member
EP1058565B1 (fr) Dispositif implantable servant a administrer un medicament par perfusion et possedant un clapet de surete
JP6002154B2 (ja) 水頭症シャント弁の調整
US20050273081A1 (en) Regulator
US20240173169A1 (en) Adjustable shunting systems and associated systems and methods
JPH074429B2 (ja) 定圧の埋め込み型ポンプリザーバ
WO2002070047A1 (fr) Pompe a perfusion a pression non constante
AU2002236842A1 (en) Non-constant pressure infusion pump
JP2010507750A (ja) ワックスマイクロアクチュエータ
EP2754935A1 (fr) Régulateur d'écoulement passif réglable
EP2307076B1 (fr) Pompe à soupape programmable compatible avec une imagerie par résonance magnétique
EP1273808B1 (fr) Micro-soupape réglable et procédé de réglage et manoeuvre
WO2024097743A2 (fr) Shunts réglables à commande de flux améliorée et systèmes et procédés associés
Bae et al. In vitro experiment of the pressure regulating valve for a glaucoma implant
US9259530B2 (en) Implantable infusion device
DE60118540T2 (de) Einstellbares Mikroventil und Verfahren zur Einstellung und Betätigung
Reynaerts et al. A SMA-actuated implantable system for delivery of liquid drugs
WO2004050536A2 (fr) Dispositif distributeur de fluide a element d'equilibrage thermique
JPH0984881A (ja) 体内埋込式薬剤投与装置

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MK MN MW MX MZ NO NZ OM PH PT RO RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2003534774

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2462968

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002341249

Country of ref document: AU

122 Ep: pct application non-entry in european phase
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载