+

WO2003031408A3 - Tricyclic compounds useful for modulating lxr - Google Patents

Tricyclic compounds useful for modulating lxr Download PDF

Info

Publication number
WO2003031408A3
WO2003031408A3 PCT/US2002/028147 US0228147W WO03031408A3 WO 2003031408 A3 WO2003031408 A3 WO 2003031408A3 US 0228147 W US0228147 W US 0228147W WO 03031408 A3 WO03031408 A3 WO 03031408A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds useful
tricyclic compounds
modulating lxr
modulating
lxr
Prior art date
Application number
PCT/US2002/028147
Other languages
French (fr)
Other versions
WO2003031408A2 (en
Inventor
Thomas Patrick Burris
Guoqing Cao
George Joseph Cullinan
Patrick Irving Eacho
Jefferson Ray Mccowan
Kuo-Long Yu
Original Assignee
Lilly Co Eli
Thomas Patrick Burris
Guoqing Cao
George Joseph Cullinan
Patrick Irving Eacho
Jefferson Ray Mccowan
Kuo-Long Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Thomas Patrick Burris, Guoqing Cao, George Joseph Cullinan, Patrick Irving Eacho, Jefferson Ray Mccowan, Kuo-Long Yu filed Critical Lilly Co Eli
Priority to AU2002336433A priority Critical patent/AU2002336433A1/en
Publication of WO2003031408A2 publication Critical patent/WO2003031408A2/en
Publication of WO2003031408A3 publication Critical patent/WO2003031408A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compounds of formula (I) useful for treating artherosclerosis and its sequelae, useful for modulating LXR activity, their compositions and processes for their preparing are provided.
PCT/US2002/028147 2001-10-08 2002-09-30 Tricyclic compounds useful for modulating lxr WO2003031408A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002336433A AU2002336433A1 (en) 2001-10-08 2002-09-30 Tricyclic compounds useful for modulating lxr

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32764401P 2001-10-08 2001-10-08
US60/327,644 2001-10-08

Publications (2)

Publication Number Publication Date
WO2003031408A2 WO2003031408A2 (en) 2003-04-17
WO2003031408A3 true WO2003031408A3 (en) 2003-08-14

Family

ID=23277404

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/028147 WO2003031408A2 (en) 2001-10-08 2002-09-30 Tricyclic compounds useful for modulating lxr

Country Status (2)

Country Link
AU (1) AU2002336433A1 (en)
WO (1) WO2003031408A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576215B2 (en) 2003-12-12 2009-08-18 Wyeth Quinolines and pharmaceutical compositions thereof

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072046A2 (en) * 2003-02-12 2004-08-26 Carex S.A. Quinoline derivatives and their use for modulation of lxr activity
BRPI0518229A (en) 2004-10-27 2008-11-04 Daiichi Sankyo Co Ltd benzene compound having 2 or more substituents
CN102264228A (en) 2008-10-22 2011-11-30 默沙东公司 Novel cyclic benzimidazole derivatives useful for anti-diabetic agents
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2538784B1 (en) 2010-02-25 2015-09-09 Merck Sharp & Dohme Corp. Benzimidazole derivatives useful anti-diabetic agents
CN103517908A (en) 2010-09-07 2014-01-15 Seoul大学校产学协力财团 Sesterterpene compounds and use thereof
JP5728099B2 (en) 2011-02-25 2015-06-03 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Novel cyclic azabenzimidazole derivatives useful as antidiabetic agents
MX2015001500A (en) 2012-08-02 2015-04-08 Merck Sharp & Dohme Antidiabetic tricyclic compounds.
AU2014219020A1 (en) 2013-02-22 2015-07-23 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
AU2015204572B2 (en) 2014-01-10 2020-07-30 Inspirna, Inc. LXR agonists and uses thereof
EP3402477A4 (en) 2016-01-11 2019-08-21 The Rockefeller University METHODS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH SUPPRESSIVE CELLS DERIVED FROM MYELOID CELLS
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
WO2019104062A1 (en) 2017-11-21 2019-05-31 Rgenix, Inc. Polymorphs and uses thereof
CN111303017B (en) * 2019-08-28 2022-11-11 上海中医药大学 A class of compounds containing 9,10-dihydrophenanthrene skeleton and preparation method and use thereof
AU2020401286A1 (en) 2019-12-13 2022-06-23 Inspirna, Inc. Metal salts and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
WO1999066915A2 (en) * 1998-06-23 1999-12-29 Southern Illinois University At Carbondale Therapeutic applications of estrogenic carboxylic acids
WO2001041704A2 (en) * 1999-12-13 2001-06-14 Merck & Co., Inc. Method for the prevention and/or treatment of atherosclerosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
WO1999066915A2 (en) * 1998-06-23 1999-12-29 Southern Illinois University At Carbondale Therapeutic applications of estrogenic carboxylic acids
WO2001041704A2 (en) * 1999-12-13 2001-06-14 Merck & Co., Inc. Method for the prevention and/or treatment of atherosclerosis

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIEN, SHLOMO ET AL: "Steric aspects of the intramolecular cyclization of 2-arylcyclohexylacetic acids. III", JOURNAL OF THE CHEMICAL SOCIETY [SECTION] C: ORGANIC (1967), (1), 115-19, XP009010266 *
CHINI, MARCO ET AL: "Effect of the 7-methyl substituent on the ring opening process of the diastereoisomeric benzylic epoxides derived from 1,2,3,9,10,10a-hexahydrophenanthrene. Differences and similarities between different 2-aryloxirane models", GAZZETTA CHIMICA ITALIANA (1990), 120(12), 733-9, XP009010270 *
CHINI, MARCO ET AL: "Synthesis and reactivity of benzylic epoxides derived from 1,2,3,9,10,10a-hexahydrophenanthrene. Search for a unified mechanism for the ring opening of 2-aryloxiranes", JOURNAL OF ORGANIC CHEMISTRY (1989), 54(16), 3930-6, XP002240152 *
DUTHALER, RUDOLF O. ET AL: "The relative stabilities of substituted cis- and trans-1,2,3,4,4a,9,10,10a-octahydrophenanthrenes, including configurational corrections in the Elad-Ginsburg morphine synthesis", HELVETICA CHIMICA ACTA (1986), 69(7), 1559-66, XP009010269 *
THOMPSON, HUGH W. ET AL: "Mechanism of the catalyzed Diels-Alder reaction", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1970), 92(10), 3218-20, XP002240150 *
THOMPSON, HUGH W. ET AL: "Stereochemical equilibrium in benzoctalones", JOURNAL OF ORGANIC CHEMISTRY (1988), 53(18), 4201-9, XP002008448 *
ZEE, SHENG HSU ET AL: "The reduction and nitration of 1-keto and 4-keto-1,2,3,4- tetrahydrophenanthrene", JOURNAL OF THE CHINESE CHEMICAL SOCIETY (TAIPEI, TAIWAN) (1987), 34(1), 25-32, XP009010265 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576215B2 (en) 2003-12-12 2009-08-18 Wyeth Quinolines and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
AU2002336433A1 (en) 2003-04-22
WO2003031408A2 (en) 2003-04-17

Similar Documents

Publication Publication Date Title
WO2003031408A3 (en) Tricyclic compounds useful for modulating lxr
WO2002048147A3 (en) Pyrazolopyridines
AU2002305143A1 (en) Pyrazolo'1,5-a!pyridine derivatives
DE602004021472D1 (en) Pyrimiidinverbindungen
DE60112330D1 (en) Pyrazolopyridinderivate
WO2003095455A3 (en) Substituted pyrazolopyrimidines
WO2001098236A3 (en) 7-phenyl-substituted tetracycline compounds
MXPA02012271A (en) Novel compounds possessing antibacterial, antifungal or antitumor activity.
WO2004080377A3 (en) Kcnq channel modulating compounds and their pharmaceutical use
YU5503A (en) Non-steroidal inflammation inhibitors
WO2004014893A3 (en) Antimicrobial aza-bicyclic derivates, their compositions and uses
UA74439C2 (en) Compounds of spiropyrazole
HK1096549A1 (en) Imidazopyridine-derivatives as inducible no-synthase inhibitors
WO2005021497A3 (en) Tethered dimers and trimers of 1,4-diphenylazetidn-2-ones
PL371127A1 (en) 6-aminomorphinane derivatives, method for the production and use thereof
WO2002101073A3 (en) Aryl-benzimidazole compounds having antiinfective activity
AU2003217712A1 (en) Pyrazolopyrimidine and pyrazolotriazine derivatives and pharmaceutical compositions containing them
WO2002010152A3 (en) Novel indole derivatives and their use as medicaments
WO2005060693A3 (en) 9-desoxoerythromycin compounds as prokinetic agents
WO2001079158A3 (en) Compounds for modulating cell proliferation
WO2004087652A3 (en) Imidazotriazine compounds
WO2005085236A3 (en) Caspase inhibitors and uses thereof
AU2002357740A1 (en) Pyrazolo-pyridine derivatives as antiherpes agents
WO2003035613A3 (en) Nitrogen heterocycle inhibitors of aspartyl protease
DE60201074D1 (en) Pyrazolopyridinderivate

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MK MN MW MX MZ NO NZ OM PH PT RO RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载