WO2003030884A3 - Use of solasonine for the treatment of skin tumors - Google Patents
Use of solasonine for the treatment of skin tumors Download PDFInfo
- Publication number
- WO2003030884A3 WO2003030884A3 PCT/EP2002/011317 EP0211317W WO03030884A3 WO 2003030884 A3 WO2003030884 A3 WO 2003030884A3 EP 0211317 W EP0211317 W EP 0211317W WO 03030884 A3 WO03030884 A3 WO 03030884A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- solasonine
- treatment
- skin tumors
- tumors
- en3β
- Prior art date
Links
- 206010029098 Neoplasm skin Diseases 0.000 title abstract 2
- 208000000453 Skin Neoplasms Diseases 0.000 title abstract 2
- KNLOWJPFLKGYGQ-UHFFFAOYSA-N Solasodine 3-O-??-L-rhamnopyranosyl (1‘Â∆2)-O-[??-D-glucopyranosyl (1‘Â∆4)]-??-D-glucopyranoside Natural products O1C2(NCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C(C1O)OC2C(C(O)C(O)C(C)O2)O)OC(CO)C1OC1OC(CO)C(O)C(O)C1O KNLOWJPFLKGYGQ-UHFFFAOYSA-N 0.000 title 1
- QCTMYNGDIBTNSK-UHFFFAOYSA-N Solasonin Natural products O1C2(NCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C1OC2C(C(O)C(O)C(C)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O QCTMYNGDIBTNSK-UHFFFAOYSA-N 0.000 title 1
- QCTMYNGDIBTNSK-QCNFCIKQSA-N Solasonine Natural products O([C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O2)[C@@H](O[C@@H]2CC=3[C@@](C)([C@@H]4[C@H]([C@H]5[C@@](C)([C@H]6[C@@H](C)[C@@]7(O[C@H]6C5)NC[C@H](C)CC7)CC4)CC=3)CC2)O[C@@H](CO)[C@@H]1O)[C@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 QCTMYNGDIBTNSK-QCNFCIKQSA-N 0.000 title 1
- RCTKRNCKOYYRIO-UHFFFAOYSA-N alpha-Solamarine Natural products O1C2(NCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C1O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O RCTKRNCKOYYRIO-UHFFFAOYSA-N 0.000 title 1
- QCTMYNGDIBTNSK-XEAAVONHSA-N α-Solamarine Chemical compound O([C@H]1[C@@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@]1(NC[C@H](C)CC1)O5)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QCTMYNGDIBTNSK-XEAAVONHSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to the use of the triglycoside (22R, 25R)-spiro-5-en3β-yl-α-L-rhamnopyranosyl-(1→2gal)-O-p-D-glucopyranosyl-(1→3gal)-β-D-galactopyranose for the preparation of pharmaceutical compositions for treating skin tumors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002350513A AU2002350513A1 (en) | 2001-10-09 | 2002-10-09 | Use of solasonine for the treatment of skin tumors |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01124675.8 | 2001-10-09 | ||
| EP01124675 | 2001-10-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003030884A2 WO2003030884A2 (en) | 2003-04-17 |
| WO2003030884A3 true WO2003030884A3 (en) | 2003-09-04 |
Family
ID=8178980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2002/011317 WO2003030884A2 (en) | 2001-10-09 | 2002-10-09 | Use of solasonine for the treatment of skin tumors |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2002350513A1 (en) |
| WO (1) | WO2003030884A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1644391A2 (en) * | 2003-07-08 | 2006-04-12 | GlycoMed Sciences Limited | Steroid modified solatrioses |
| TWI476012B (en) | 2011-05-12 | 2015-03-11 | G & E Herbal Biotechnology Co Ltd | Treatment and/or prevention of inflammation and cutaneous photodamage and photoprotection of the skin with a water soluble extract from plant of solanum genus |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0020029A1 (en) * | 1979-05-02 | 1980-12-10 | Aruba (Qld.) Pty. Ltd. | Pharmaceutical compositions comprising steroid alkaloids |
| WO1991010743A1 (en) * | 1990-01-18 | 1991-07-25 | Cura Nominees Pty Ltd | Glycoalkaloids |
| WO2000061153A1 (en) * | 1999-04-09 | 2000-10-19 | Cura Nominees Pty. Ltd. | Medicinal compositions and their method of preparation |
-
2002
- 2002-10-09 AU AU2002350513A patent/AU2002350513A1/en not_active Abandoned
- 2002-10-09 WO PCT/EP2002/011317 patent/WO2003030884A2/en not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0020029A1 (en) * | 1979-05-02 | 1980-12-10 | Aruba (Qld.) Pty. Ltd. | Pharmaceutical compositions comprising steroid alkaloids |
| WO1991010743A1 (en) * | 1990-01-18 | 1991-07-25 | Cura Nominees Pty Ltd | Glycoalkaloids |
| WO2000061153A1 (en) * | 1999-04-09 | 2000-10-19 | Cura Nominees Pty. Ltd. | Medicinal compositions and their method of preparation |
Non-Patent Citations (3)
| Title |
|---|
| CHAM B E ET AL: "TOPICAL TREATMENT OF MALIGNANT AND PREMALIGNANT SKIN LESIONS BY VERY LOW CONCENTRATIONS OF A STANDARD MIXTURE (BEC) OF SOLASODINE GLYCOSIDES", CANCER LETTERS, NEW YORK, NY, US, vol. 59, 1991, pages 183 - 192, XP001077064, ISSN: 0304-3835 * |
| CHAM B E: "SOLASODINE GLYCOSIDES AS ANTI-CANCER AGENTS: PRE-CLINICAL AND CLINICAL STUDIES", ASIA PACIFIC JOURNAL OF PHARMACOLOGY, SINGAPORE UNIVERSITY PRESS, SG, vol. 9, 1994, pages 113 - 118, XP002950616, ISSN: 0217-9687 * |
| CHEM B E ET AL: "GLYCOALKALOIDS FROM SOLANUM SODOMAEUM ARE EFFECTIVE IN THE TREATMENT OF SKIN CANCERS IN MAN", CANCER LETTERS, NEW YORK, NY, US, vol. 36, 1987, pages 111 - 118, XP002950615, ISSN: 0304-3835 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003030884A2 (en) | 2003-04-17 |
| AU2002350513A1 (en) | 2003-04-22 |
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