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WO2003029419A3 - Polypeptide de domaine de liaison au ligand grp94 isole et acide nucleique codant pour celui-ci, forme cristalline de ce polypeptide et technique de recherche utilisant ce polypeptide - Google Patents

Polypeptide de domaine de liaison au ligand grp94 isole et acide nucleique codant pour celui-ci, forme cristalline de ce polypeptide et technique de recherche utilisant ce polypeptide Download PDF

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Publication number
WO2003029419A3
WO2003029419A3 PCT/US2002/031207 US0231207W WO03029419A3 WO 2003029419 A3 WO2003029419 A3 WO 2003029419A3 US 0231207 W US0231207 W US 0231207W WO 03029419 A3 WO03029419 A3 WO 03029419A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
binding domain
crystalline
dimensional structure
grp94 binding
Prior art date
Application number
PCT/US2002/031207
Other languages
English (en)
Other versions
WO2003029419A2 (fr
Inventor
Daniel T Gewirth
Christopher V Nicchitta
Original Assignee
Univ Duke
Daniel T Gewirth
Christopher V Nicchitta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke, Daniel T Gewirth, Christopher V Nicchitta filed Critical Univ Duke
Priority to CA002460396A priority Critical patent/CA2460396A1/fr
Priority to AU2002327804A priority patent/AU2002327804B2/en
Priority to JP2003532637A priority patent/JP2005512519A/ja
Priority to EP02763818A priority patent/EP1551957A4/fr
Publication of WO2003029419A2 publication Critical patent/WO2003029419A2/fr
Publication of WO2003029419A3 publication Critical patent/WO2003029419A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un polypeptide de domaine de liaison au ligand grp94 isolé, une structure cristalline en trois dimensions de ce polypeptide et des techniques d'utilisation de ce polypeptide destinées à concevoir des modulateurs de protéines Hsp90.
PCT/US2002/031207 2001-10-01 2002-09-30 Polypeptide de domaine de liaison au ligand grp94 isole et acide nucleique codant pour celui-ci, forme cristalline de ce polypeptide et technique de recherche utilisant ce polypeptide WO2003029419A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002460396A CA2460396A1 (fr) 2001-10-01 2002-09-30 Polypeptide de domaine de liaison au ligand grp94 isole et acide nucleique codant pour celui-ci, forme cristalline de ce polypeptide et technique de recherche utilisant ce polypeptide
AU2002327804A AU2002327804B2 (en) 2001-10-01 2002-09-30 Three dimensional structure of crystalline GRP94 binding domain, and its methods of use
JP2003532637A JP2005512519A (ja) 2001-10-01 2002-09-30 単離ｇｒｐ９４リガンド結合ドメインポリペプチドおよびそれをコードする核酸、その結晶、およびそれを用いるスクリーニング方法
EP02763818A EP1551957A4 (fr) 2001-10-01 2002-09-30 Polypeptide de domaine de liaison au ligand grp94 isole et acide nucleique codant pour celui-ci, forme cristalline de ce polypeptide et technique de recherche utilisant ce polypeptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32629101P 2001-10-01 2001-10-01
US60/326,291 2001-10-01

Publications (2)

Publication Number Publication Date
WO2003029419A2 WO2003029419A2 (fr) 2003-04-10
WO2003029419A3 true WO2003029419A3 (fr) 2005-05-19

Family

ID=23271602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/031207 WO2003029419A2 (fr) 2001-10-01 2002-09-30 Polypeptide de domaine de liaison au ligand grp94 isole et acide nucleique codant pour celui-ci, forme cristalline de ce polypeptide et technique de recherche utilisant ce polypeptide

Country Status (6)

Country Link
US (2) US7691969B2 (fr)
EP (1) EP1551957A4 (fr)
JP (2) JP2005512519A (fr)
AU (1) AU2002327804B2 (fr)
CA (1) CA2460396A1 (fr)
WO (1) WO2003029419A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235649B2 (en) * 2000-03-24 2007-06-26 Duke University Isolated GRP94 ligand binding domain polypeptide and nucleic acid encoding same, and screening methods employing same
US7691969B2 (en) * 2001-10-01 2010-04-06 Duke University Isolated GRP94 ligand binding domain polypeptide and nucleic acid encoding same, crystalline form of same, and screening methods employing same
CA2476556A1 (fr) * 2002-02-13 2003-08-21 Duke University Modulation de reponse immunitaire par des polypeptides de reponse a un stress se liant a des non peptides
GB0328627D0 (en) * 2003-12-10 2004-01-14 Inst Of Cancer Res The Interaction between Hsp90 and p50 cdc37
WO2009113074A1 (fr) * 2008-03-13 2009-09-17 Compugen Ltd. Nouveaux peptides dérivés de gp96

Citations (1)

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Publication number Priority date Publication date Assignee Title
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JPH09504513A (ja) 1993-08-12 1997-05-06 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 臓器および組織用リンス液
US5997873A (en) 1994-01-13 1999-12-07 Mount Sinai School Of Medicine Of The City University Of New York Method of preparation of heat shock protein 70-peptide complexes
US5750119A (en) 1994-01-13 1998-05-12 Mount Sinai School Of Medicine Of The City University Of New York Immunotherapeutic stress protein-peptide complexes against cancer
US5961979A (en) 1994-03-16 1999-10-05 Mount Sinai School Of Medicine Of The City University Of New York Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens
US6106866A (en) 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
WO1997010000A1 (fr) 1995-09-13 1997-03-20 Fordham University Procedes therapeutique et profilactique utilisant des proteines du choque thermique
US5837251A (en) 1995-09-13 1998-11-17 Fordham University Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases
US5985270A (en) 1995-09-13 1999-11-16 Fordham University Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes
US6066716A (en) 1996-09-20 2000-05-23 University Of New Mexico Purified heat shock protein complexes
US5747332A (en) 1996-09-20 1998-05-05 University Of New Mexico Methods for purifying and synthesizing heat shock protein complexes
US6017540A (en) 1997-02-07 2000-01-25 Fordham University Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes
US5830464A (en) 1997-02-07 1998-11-03 Fordham University Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy
US5834228A (en) 1997-02-13 1998-11-10 Merck & Co., Inc. Method for identifying inhibitors for apopain based upon the crystal structure of the apopain: Ac-DEVD-CHO complex
US5872011A (en) 1997-06-13 1999-02-16 The Rockefeller University Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof
US6180084B1 (en) 1998-08-25 2001-01-30 The Burnham Institute NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same
US6007821A (en) 1997-10-16 1999-12-28 Fordham University Method and compositions for the treatment of autoimmune disease using heat shock proteins
CA2308299A1 (fr) 1997-10-31 1999-05-14 Sloan-Kettering Institute For Cancer Research Peptides conjugues se liant aux proteines du stress
JP2001525347A (ja) 1997-12-05 2001-12-11 ザ ユニバーシティ オブ ニュー メキシコ 熱ショックペプチド錯体の精製方法
AU2337499A (en) 1998-01-23 1999-08-09 National Jewish Medical And Research Center Method for treating inflammatory diseases using heat shock proteins
EP2295065B1 (fr) 1998-02-20 2013-10-09 The University of Miami Complexe de peptide antigènes à protéines de choc thermique modifiées
AU6291799A (en) 1998-10-06 2000-04-26 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The Use of calreticulin and calreticulin fragments to inhibit endothelial cell growth and angiogenesis, and suppress tumor growth
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AU2001247759A1 (en) 2000-03-24 2001-10-08 Duke University Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto
US7235649B2 (en) 2000-03-24 2007-06-26 Duke University Isolated GRP94 ligand binding domain polypeptide and nucleic acid encoding same, and screening methods employing same
CN1501928A (zh) 2000-11-02 2004-06-02 斯隆-凯特林癌症研究所 结合hsp90的小分子组合物
US7691969B2 (en) 2001-10-01 2010-04-06 Duke University Isolated GRP94 ligand binding domain polypeptide and nucleic acid encoding same, crystalline form of same, and screening methods employing same
CA2476556A1 (fr) 2002-02-13 2003-08-21 Duke University Modulation de reponse immunitaire par des polypeptides de reponse a un stress se liant a des non peptides

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130105A (en) * 1990-10-23 1992-07-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Protein crystal growth tray assembly

Non-Patent Citations (9)

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Title
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Also Published As

Publication number Publication date
JP2005512519A (ja) 2005-05-12
EP1551957A4 (fr) 2007-01-24
US7991601B2 (en) 2011-08-02
JP2010110324A (ja) 2010-05-20
US7691969B2 (en) 2010-04-06
CA2460396A1 (fr) 2003-04-10
AU2002327804B2 (en) 2008-09-11
WO2003029419A2 (fr) 2003-04-10
US20030215874A1 (en) 2003-11-20
US20100255608A1 (en) 2010-10-07
EP1551957A2 (fr) 2005-07-13

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