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WO2003028698A3 - Procede et dispositif de production de granules comprenant au moins un principe actif pharmaceutique - Google Patents

Procede et dispositif de production de granules comprenant au moins un principe actif pharmaceutique Download PDF

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Publication number
WO2003028698A3
WO2003028698A3 PCT/EP2002/010743 EP0210743W WO03028698A3 WO 2003028698 A3 WO2003028698 A3 WO 2003028698A3 EP 0210743 W EP0210743 W EP 0210743W WO 03028698 A3 WO03028698 A3 WO 03028698A3
Authority
WO
WIPO (PCT)
Prior art keywords
active substance
pharmaceutical active
producing granulates
granulated material
granulates
Prior art date
Application number
PCT/EP2002/010743
Other languages
German (de)
English (en)
Other versions
WO2003028698A2 (fr
Inventor
Klaus-Juergen Steffens
Rudolf Schroeder
Original Assignee
Klaus-Juergen Steffens
Rudolf Schroeder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klaus-Juergen Steffens, Rudolf Schroeder filed Critical Klaus-Juergen Steffens
Priority to AU2002342755A priority Critical patent/AU2002342755A1/en
Priority to EP02779415A priority patent/EP1429735A2/fr
Publication of WO2003028698A2 publication Critical patent/WO2003028698A2/fr
Publication of WO2003028698A3 publication Critical patent/WO2003028698A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un procédé de production de granules comprenant au moins un principe actif pharmaceutique. Selon ledit procédé, la poudre à mettre sous forme de granules est introduite dans une extrudeuse, réduite à l'état de masse de granulation par adjonction d'un liquide de granulation, ladite masse étant compactée grâce à l'application de forces de cisaillement. Un gaz ou un mélange gazeux peut éventuellement être introduit dans la masse de granulation compactée, afin de conférer de la porosité à la masse de granulation.
PCT/EP2002/010743 2001-09-26 2002-09-25 Procede et dispositif de production de granules comprenant au moins un principe actif pharmaceutique WO2003028698A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002342755A AU2002342755A1 (en) 2001-09-26 2002-09-25 Method and device for producing granulates that comprise at least one pharmaceutical active substance
EP02779415A EP1429735A2 (fr) 2001-09-26 2002-09-25 Procede et dispositif de production de granules comprenant au moins un principe actif pharmaceutique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10147414.8 2001-09-26
DE10147414 2001-09-26

Publications (2)

Publication Number Publication Date
WO2003028698A2 WO2003028698A2 (fr) 2003-04-10
WO2003028698A3 true WO2003028698A3 (fr) 2003-10-23

Family

ID=7700318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/010743 WO2003028698A2 (fr) 2001-09-26 2002-09-25 Procede et dispositif de production de granules comprenant au moins un principe actif pharmaceutique

Country Status (3)

Country Link
EP (1) EP1429735A2 (fr)
AU (1) AU2002342755A1 (fr)
WO (1) WO2003028698A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8834925B2 (en) 2006-08-25 2014-09-16 Purdue Pharma L.P. Tamper resistant dosage forms
US9161917B2 (en) 2008-05-09 2015-10-20 Grünenthal GmbH Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
US9913814B2 (en) 2014-05-12 2018-03-13 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
US11844865B2 (en) 2004-07-01 2023-12-19 Grünenthal GmbH Abuse-proofed oral dosage form

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
WO2005023215A2 (fr) * 2003-09-10 2005-03-17 Janssen Pharmaceutica N.V. Particules en forme de lamelles
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
MX2010008138A (es) 2008-01-25 2010-08-10 Gruenenthal Gmbh Forma de dosis farmaceutica.
PL2456427T3 (pl) 2009-07-22 2015-07-31 Gruenenthal Gmbh Wytłaczana na gorąco postać dawki o kontrolowanym uwalnianiu
RU2015138422A (ru) 2009-07-22 2018-12-25 Грюненталь Гмбх Стабильная при окислении, прочная на излом лекарственная форма
CA2808219C (fr) 2010-09-02 2019-05-14 Gruenenthal Gmbh Forme pharmaceutique inviolable comportant un sel inorganique
PL2611425T3 (pl) 2010-09-02 2014-09-30 Gruenenthal Gmbh Odporna na ingerencję postać dawki zawierająca polimer anionowy
HUE034710T2 (hu) 2011-07-29 2018-02-28 Gruenenthal Gmbh Visszaéléssel szemben ellenálló, azonnali hatóanyagfelszabadulást biztosító tabletta
RS56528B1 (sr) 2011-07-29 2018-02-28 Gruenenthal Gmbh Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu
EP2819656A1 (fr) 2012-02-28 2015-01-07 Grünenthal GmbH Forme pharmaceutique inviolable comprenant un composé pharmacologiquement actif et un polymère anionique
CN104394851B (zh) 2012-04-18 2017-12-01 格吕伦塔尔有限公司 抗篡改和抗剂量‑倾泻药物剂型
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
WO2014191396A1 (fr) 2013-05-29 2014-12-04 Grünenthal GmbH Forme dosifiée inviolable à profil de libération bimodale
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
WO2015078891A1 (fr) 2013-11-26 2015-06-04 Farmaceutici Formenti S.P.A. Préparation de composition pharmaceutique en poudre par cryo-broyage
AU2015266117A1 (en) 2014-05-26 2016-11-24 Grunenthal Gmbh Multiparticles safeguarded against ethanolic dose-dumping
JP2018517676A (ja) 2015-04-24 2018-07-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時放出および溶媒抽出に対する耐性を有する改変防止製剤
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
WO2017185040A1 (fr) 2016-04-22 2017-10-26 University Of Mississippi Granulation à sec à double vis pour la production de formulations solides
DE102016218135A1 (de) * 2016-09-21 2018-03-22 Robert Bosch Gmbh Produktionsmodul zum Herstellen fester Arzneiformen

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1629423A1 (de) * 1966-04-02 1971-01-14 Gruenzweig & Hartmann Verfahren zur Herstellung von Kunstharz-Schaumstoffen und Verwendung eines nach diesem Verfahren gefertigten Rohres
US3922339A (en) * 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
JPH07184550A (ja) * 1993-12-24 1995-07-25 Lotte Co Ltd 比重低減化チューインガムの製造方法
US5496865A (en) * 1993-12-08 1996-03-05 Brugg Kabel Ag Additive-charged porous carrier material

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19918325A1 (de) * 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1629423A1 (de) * 1966-04-02 1971-01-14 Gruenzweig & Hartmann Verfahren zur Herstellung von Kunstharz-Schaumstoffen und Verwendung eines nach diesem Verfahren gefertigten Rohres
US3922339A (en) * 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
US5496865A (en) * 1993-12-08 1996-03-05 Brugg Kabel Ag Additive-charged porous carrier material
JPH07184550A (ja) * 1993-12-24 1995-07-25 Lotte Co Ltd 比重低減化チューインガムの製造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 10 30 November 1995 (1995-11-30) *
SCHROEDER R ET AL: "A new system for continuous wet granulation", PHARMAZEUTISCHE INDUSTRIE 2002 GERMANY, vol. 64, no. 3, 2002, pages 283 - 288, XP009012069, ISSN: 0031-711X *
See also references of EP1429735A2 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844865B2 (en) 2004-07-01 2023-12-19 Grünenthal GmbH Abuse-proofed oral dosage form
US8834925B2 (en) 2006-08-25 2014-09-16 Purdue Pharma L.P. Tamper resistant dosage forms
US8846086B2 (en) 2006-08-25 2014-09-30 Purdue Pharma L.P. Tamper resistant dosage forms
US8894987B2 (en) 2006-08-25 2014-11-25 William H. McKenna Tamper resistant dosage forms
US8894988B2 (en) 2006-08-25 2014-11-25 Purdue Pharma L.P. Tamper resistant dosage forms
US8911719B2 (en) 2006-08-25 2014-12-16 Purdue Pharma Lp Tamper resistant dosage forms
US9084816B2 (en) 2006-08-25 2015-07-21 Purdue Pharma L.P. Tamper resistant dosage forms
US9095614B2 (en) 2006-08-25 2015-08-04 Purdue Pharma L.P. Tamper resistant dosage forms
US9095615B2 (en) 2006-08-25 2015-08-04 Purdue Pharma L.P. Tamper resistant dosage forms
US9101661B2 (en) 2006-08-25 2015-08-11 Purdue Pharma L.P. Tamper resistant dosage forms
US9161917B2 (en) 2008-05-09 2015-10-20 Grünenthal GmbH Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
US9913814B2 (en) 2014-05-12 2018-03-13 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol

Also Published As

Publication number Publication date
EP1429735A2 (fr) 2004-06-23
AU2002342755A1 (en) 2003-04-14
WO2003028698A2 (fr) 2003-04-10

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