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WO2003028673A1 - Preparation cosmetique - Google Patents

Preparation cosmetique Download PDF

Info

Publication number
WO2003028673A1
WO2003028673A1 PCT/JP2002/009269 JP0209269W WO03028673A1 WO 2003028673 A1 WO2003028673 A1 WO 2003028673A1 JP 0209269 W JP0209269 W JP 0209269W WO 03028673 A1 WO03028673 A1 WO 03028673A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
cedrol
oil
acid
cosmetic
Prior art date
Application number
PCT/JP2002/009269
Other languages
English (en)
Japanese (ja)
Inventor
Atsushi Suzumatsu
Hikaru Sumida
Toshio Uesaka
Kimihiko Hori
Mami Nonomura
Original Assignee
Kao Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corporation filed Critical Kao Corporation
Publication of WO2003028673A1 publication Critical patent/WO2003028673A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Definitions

  • the present invention relates to a cosmetic composition in which the transdermal absorbability of cedrol is improved and the antiallergic (IL4 production suppression) action is excellent.
  • the surface of the skin is covered with the stratum corneum, and has a structure that prevents the invasion of foreign substances from outside the body.
  • Sufficient transdermal absorbability can be obtained simply by incorporating the active ingredient into cosmetics. hard.
  • various percutaneous absorption enhancers for example, polar compounds such as dimethyl sulfoxide, N-methylpyrrolidone, and methyl sorbate have been proposed (Japanese Patent Application Laid-Open No. 61-331129).
  • these transdermal absorption enhancers are excellent in transdermal absorption, they are not sufficient in terms of irritation, stability, and feeling of use.
  • cedrol has an antiallergic action due to its excellent inhibitory action on IL4 production (Japanese Unexamined Patent Publication No. 2000-3099528).
  • IL4 production Japanese Unexamined Patent Publication No. 2000-3099528
  • transdermal absorption of cedrol into the stratum corneum was not sufficient.
  • An object of the present invention is to provide a cosmetic composition in which the transdermal absorbability of cedrol is improved, the effect of cedrol can be sufficiently exerted, and there is no irritation. Disclosure of the invention
  • the inventor of the present invention has found that, when an oil agent having a specific SP value range is used in combination with Cedokul, cedrol can be stably compounded, and at the same time, the antiallergic (IL4 production inhibitory) action of a cosmetic containing cedrol is further enhanced.
  • the present invention comprises the following components (A) and (B):
  • Cedrol of component (A) used in the cosmetic of the present invention is a kind of sesquiterpene alcohol, and has an optical isomer, but is generally a (d) isomer represented by the formula (1).
  • d isomer represented by the formula (1).
  • the (d) isomer is preferred, but the optical isomer (1) or the (d) isomer
  • Cedrol is generally known as a fragrance component contained in essential oils of plants such as Pinaceae, Cedars, Cypresses, Scorpiones, Prunus, etc. It can be obtained by purifying essential oils such as fern wood oil and hiba oil by distillation or the like, and can also be obtained by synthesis. As the cedrol used in the present invention, any of the above-mentioned essential oil products and synthetic products may be used, or a commercially available product may be used.
  • Cedrol of the component (A) is contained in the cosmetic of the present invention in an amount of 0.01 to 10% by weight, particularly 0.1 to 5% by weight. / 0 is preferable because an antiallergic effect can be effectively exerted.
  • the oil agent of the component (B) used in the cosmetic of the present invention has a total carbon number of 22 or more. 7 to 21 things.
  • the SP value is obtained by the method for obtaining the dissolution parameters described on pages 78 to 78 of “Solutions and Solubility, 3rd Edition” by Kozo Shinoda (Maruzen Co., Ltd., 1991).
  • the total carbon number of the oil agent of the component ( ⁇ ) is 22 or more, and particularly preferably 22 to 40, Further, the SP value at 25 ° C is preferably from 17 to 21, particularly preferably from 17.0 to 19.0.
  • Specific examples of the component (B) include d 1 - ⁇ -tocopherol (total carbon number 29: SP value (25 ° C) 19.4 (the same applies hereinafter)), glyceryl monoisostearate and glyceryl monomyristate (35: 18.4), diisostearyl malate (40:
  • glyceryl triisostearate (57: 17.2), diglyceryl triisostearate (60: 18.0), trimethylpropane triisostearate (65: 17.2), glyceryl trioctanoate (57:17) 7), glyceryl tricaprate (33: 17.8), polyoxyethylene pyrostearate isostearate (25) glyceryl ether (175: 205), polyoxyethylene pionate (2) myristyl ether (23) : 17.3), polyoxyethylene myristate (3) myristyl ether (34: 17.5), dioctyldodecyl lauroylglutamate (57: 17.5), cetyl ricinolate (34: 18.0), ricinolein Acid tetrahydrofurfuryl (28:
  • polyglyceryl disostearate (42: 17.0), polyglyceryl disostearate (42-192:
  • component (B) glyceryl monomyristate monoisostearate, diisostearyl malate, neopentyl alcohol dicaprate, propylene glycol dicaprate, propylene glycol dinonanoate, decyltetradecaate are particularly preferred.
  • Two or more types of oil agents of component (B) may be used in combination. Further, in the cosmetic of the present invention 0. 0 0 1-5 0 weight 0/0, especially 0. 0 1-2 0 weight 0/0 preferably contained. In the cosmetic of the present invention, disodium edetate, sodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, dalconic acid, etc. can be used to appropriately contain an oil agent other than the component (B).
  • the cosmetics of the present invention also contain components commonly used in external preparations for skin such as cosmetics, for example, humectants, antioxidants, ultraviolet absorbers, surfactants, thickeners, alcohols, and organic compounds. Acids, alkalis, powder components, coloring agents, aqueous components, water, fragrances, various skin nutrients, and the like can be appropriately contained as necessary.
  • the cosmetic of the present invention can be produced according to a usual method, for example, cream, 9 Can be used as cosmetics such as emulsions, lotions, packs, and jewels.
  • composition A cosmetic having the following composition was prepared by a conventional method, and its transdermal absorption and irritation were evaluated.
  • Composition Cedrol 0 1 (wt 0/0) oil (Table 1) 2
  • a patch test patch with a hole diameter of 16 mm was applied to the upper arm of panelists (10 persons), and 200 L of the sample was applied. After the application, the pansoil was peeled off for 6 hours, and then the applied portion was tape-striped 10 times with a cellophane tape, and the amount of cedrol in the stratum corneum adhered to the cellophane tape was measured.
  • the quantification of cedrol was measured by gas chromatography of an ethanol extract from 10 cellophane tapes.
  • the percutaneous absorption rate was determined by the following formula, and was determined according to the criteria.
  • Example 6 (Emulsion) Cedrol 0 Polyglyceryl diisostearate 25 Glyceryl monoisostearate 25 Glyceryl monomyristate 25 Polyoxyethylene (20) hydrogenated castor oil 2 Methyl polysiloxane (6 cs) 0 5 Cholesterol 0 2 Cholesteryl disostearate 0 1 Cetinoreanoconore 0 3 Stearyl alcohol 0 2 Glycerin 0 Carboxyvinyl polymer
  • Example 7 (Giel) Cedrol 0.1 Diisostearyl malate 4 Polyoxyethylene (40) hydrogenated castor oil 0.2
  • Example 1 1 (water-in-oil cream) Cedrol 0.5 0.5 glyceryl tricaprylate 1.5 kN. Dextrin noremitate 1 N-lauroyl mono-L-glutamic acid
  • Siloxane copolymer 1 Polyoxyethylene tristearyl phosphate (15) Hardened castor oil 1
  • the cosmetic composition of the present invention has improved percutaneous absorption of cedrol, has excellent antiallergic (IL 4 production inhibition) action, and has no irritation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une préparation cosmétique renfermant les ingrédients (A) et (B) : (A) est un cédrol et (B) est une huile comprenant au moins 22 carbones et possédant une valeur SP comprise entre 17 et 21. La préparation cosmétique présente une absorbabilité percutanée du cédrol améliorée, une excellente activité anti-allergique (inhibitrice de la production de IL4) et est non irritante.
PCT/JP2002/009269 2001-09-11 2002-09-11 Preparation cosmetique WO2003028673A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-274776 2001-09-11
JP2001274776 2001-09-11

Publications (1)

Publication Number Publication Date
WO2003028673A1 true WO2003028673A1 (fr) 2003-04-10

Family

ID=19099757

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009269 WO2003028673A1 (fr) 2001-09-11 2002-09-11 Preparation cosmetique

Country Status (1)

Country Link
WO (1) WO2003028673A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112870161A (zh) * 2021-02-02 2021-06-01 贵州大学 一种雪松醇纳米乳及其优化制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1036246A (ja) * 1996-07-24 1998-02-10 Pola Chem Ind Inc メラニン産生抑制剤及び皮膚外用剤
JPH10194920A (ja) * 1996-11-15 1998-07-28 Kao Corp 化粧料
EP0872228A1 (fr) * 1996-08-21 1998-10-21 Kao Corporation Procedes cosmetologiques
WO2001013881A1 (fr) * 1999-08-24 2001-03-01 Kao Corporation Produits cosmetiques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1036246A (ja) * 1996-07-24 1998-02-10 Pola Chem Ind Inc メラニン産生抑制剤及び皮膚外用剤
EP0872228A1 (fr) * 1996-08-21 1998-10-21 Kao Corporation Procedes cosmetologiques
JPH10194920A (ja) * 1996-11-15 1998-07-28 Kao Corp 化粧料
WO2001013881A1 (fr) * 1999-08-24 2001-03-01 Kao Corporation Produits cosmetiques

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112870161A (zh) * 2021-02-02 2021-06-01 贵州大学 一种雪松醇纳米乳及其优化制备方法
CN112870161B (zh) * 2021-02-02 2023-03-21 贵州大学 一种雪松醇纳米乳及其优化制备方法

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