WO2003023045A1 - Sulfated polysaccharides, process for producing the same and substances having the same as the active ingredient - Google Patents
Sulfated polysaccharides, process for producing the same and substances having the same as the active ingredient Download PDFInfo
- Publication number
- WO2003023045A1 WO2003023045A1 PCT/JP2002/009094 JP0209094W WO03023045A1 WO 2003023045 A1 WO2003023045 A1 WO 2003023045A1 JP 0209094 W JP0209094 W JP 0209094W WO 03023045 A1 WO03023045 A1 WO 03023045A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- same
- substances
- active ingredient
- sulfated polysaccharides
- producing
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 5
- 229920001282 polysaccharide Polymers 0.000 title abstract 5
- 239000005017 polysaccharide Substances 0.000 title abstract 5
- 239000004480 active ingredient Substances 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 3
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical group OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 241000589774 Pseudomonas sp. Species 0.000 abstract 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract 1
- FJEKYHHLGZLYAT-FKUIBCNASA-N galp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(O)=O)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)[C@@H](C)O)C(C)C)C1=CNC=N1 FJEKYHHLGZLYAT-FKUIBCNASA-N 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
It is intended to provide novel sulfated polysaccharides, a process for producing the same, substances, in particular, antitumor agents having the same as the active ingredient, and a method of utilizing the physiological activities thereof. Sulfated polysaccharides preferably having a molecular weight of about 380,000, characterized by comprising a structural unit represented by the following formula (I): (I) wherein Galp represents a galactopyranose residue; and Glcp represents a glucopyranose residue; and pharmaceutically acceptable salts thereof; a process characterized in that the above sulfated polysaccharides are collected from the culture of a microorganism Pseudomonas sp. WAK-1; and substances, in particular, antitumor agents containing these polysaccharides as the active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003527109A JP4390259B2 (en) | 2001-09-06 | 2002-09-06 | Sulfuric acid polysaccharide, method for producing the same, and substance containing the same as an active ingredient |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001270284 | 2001-09-06 | ||
| JP2001-270284 | 2001-09-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003023045A1 true WO2003023045A1 (en) | 2003-03-20 |
Family
ID=19095953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2002/009094 WO2003023045A1 (en) | 2001-09-06 | 2002-09-06 | Sulfated polysaccharides, process for producing the same and substances having the same as the active ingredient |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP4390259B2 (en) |
| WO (1) | WO2003023045A1 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006016336A (en) * | 2004-07-01 | 2006-01-19 | Shiibaion:Kk | Macrophage-activating agent having il-12 production-inducing activity |
| JP2006062983A (en) * | 2004-08-24 | 2006-03-09 | Kyoto Sangyo Univ | Composition and antitumor agent containing the same |
| FR2975906A1 (en) * | 2011-06-06 | 2012-12-07 | Courtage Et De Diffusion Codif Internat Soc D | Composition, useful for regulating sebum secretion and reducing wrinkles and fine lines on the skin, comprises exopolysaccharide, which has sebum-regulating properties and is composed of a chain of galacturonic acid monomers |
| FR2981847A1 (en) * | 2011-10-28 | 2013-05-03 | Courtage Et De Diffusion Codif Internat Soc D | Cosmetic or pharmaceutical composition, useful for treating inflammation including erythema, edema, itching and pain, comprises an exopolysaccharide obtained from Cobetia marina strain |
| JP2013249275A (en) * | 2012-05-31 | 2013-12-12 | Picaso Cosmetic Laboratory Ltd | Whitening agent |
| CN116042286A (en) * | 2022-11-22 | 2023-05-02 | 中国林业科学研究院林产化学工业研究所 | Preparation method and application of glucosyl/amino acid composite carbon sphere |
| CN118027235A (en) * | 2024-02-03 | 2024-05-14 | 山东焦点福瑞达生物股份有限公司 | Preparation method of tremella aurantialba polysaccharide for cosmetics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002002189A2 (en) * | 2000-06-30 | 2002-01-10 | Polydex Pharmaceuticals Limited | Cellulose sulfate and other sulfated polysaccharides to prevent and treat papilloma virus infection and other infections |
| JP2002179579A (en) * | 2000-12-14 | 2002-06-26 | Koichi Okuya | Method for biologically utilizing apoptosis-inducing polysaccharides |
-
2002
- 2002-09-06 WO PCT/JP2002/009094 patent/WO2003023045A1/en active Application Filing
- 2002-09-06 JP JP2003527109A patent/JP4390259B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002002189A2 (en) * | 2000-06-30 | 2002-01-10 | Polydex Pharmaceuticals Limited | Cellulose sulfate and other sulfated polysaccharides to prevent and treat papilloma virus infection and other infections |
| JP2002179579A (en) * | 2000-12-14 | 2002-06-26 | Koichi Okuya | Method for biologically utilizing apoptosis-inducing polysaccharides |
Non-Patent Citations (2)
| Title |
|---|
| MATSUDA M. ET AL.: "Antiviral activities of marine pseudomonas polysaccharides and their oversulfated derivatives", MARINE BIOTECHNOLOGY, vol. 1, June 1999 (1999-06-01), pages 68 - 73, XP002957361 * |
| MATSUDA M. ET AL.: "Simultaneous production of muco- and sulfated polysaccharides by marine pseudomonas", NIPPON SUISAN GAKKAISHI, vol. 58, no. 9, September 1992 (1992-09-01), pages 1735 - 1741, XP002957362 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006016336A (en) * | 2004-07-01 | 2006-01-19 | Shiibaion:Kk | Macrophage-activating agent having il-12 production-inducing activity |
| JP2006062983A (en) * | 2004-08-24 | 2006-03-09 | Kyoto Sangyo Univ | Composition and antitumor agent containing the same |
| FR2975906A1 (en) * | 2011-06-06 | 2012-12-07 | Courtage Et De Diffusion Codif Internat Soc D | Composition, useful for regulating sebum secretion and reducing wrinkles and fine lines on the skin, comprises exopolysaccharide, which has sebum-regulating properties and is composed of a chain of galacturonic acid monomers |
| FR2975910A1 (en) * | 2011-06-06 | 2012-12-07 | Courtage Et De Diffusion Codif Internat Soc D | ANTI-WRINKLE COSMETIC COMPOSITION COMPRISING AN EXOPOLYSACCHARIDE FROM A MARINE BACTERIUM |
| FR2981847A1 (en) * | 2011-10-28 | 2013-05-03 | Courtage Et De Diffusion Codif Internat Soc D | Cosmetic or pharmaceutical composition, useful for treating inflammation including erythema, edema, itching and pain, comprises an exopolysaccharide obtained from Cobetia marina strain |
| JP2013249275A (en) * | 2012-05-31 | 2013-12-12 | Picaso Cosmetic Laboratory Ltd | Whitening agent |
| CN116042286A (en) * | 2022-11-22 | 2023-05-02 | 中国林业科学研究院林产化学工业研究所 | Preparation method and application of glucosyl/amino acid composite carbon sphere |
| CN116042286B (en) * | 2022-11-22 | 2023-08-11 | 中国林业科学研究院林产化学工业研究所 | Preparation method and application of glucosyl/amino acid composite carbon sphere |
| CN118027235A (en) * | 2024-02-03 | 2024-05-14 | 山东焦点福瑞达生物股份有限公司 | Preparation method of tremella aurantialba polysaccharide for cosmetics |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2003023045A1 (en) | 2004-12-24 |
| JP4390259B2 (en) | 2009-12-24 |
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