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WO2003018793A1 - Novel gene having guanine nucleotide exchange factor-like sequence - Google Patents

Novel gene having guanine nucleotide exchange factor-like sequence Download PDF

Info

Publication number
WO2003018793A1
WO2003018793A1 PCT/JP2002/008408 JP0208408W WO03018793A1 WO 2003018793 A1 WO2003018793 A1 WO 2003018793A1 JP 0208408 W JP0208408 W JP 0208408W WO 03018793 A1 WO03018793 A1 WO 03018793A1
Authority
WO
WIPO (PCT)
Prior art keywords
sequence
guanine nucleotide
nucleotide exchange
exchange factor
same
Prior art date
Application number
PCT/JP2002/008408
Other languages
French (fr)
Japanese (ja)
Inventor
Shuichiro Inagaki
Yoshihiro Kawamura
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Priority to JP2003523642A priority Critical patent/JP4219808B2/en
Publication of WO2003018793A1 publication Critical patent/WO2003018793A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A novel polypeptide having a human and mouse guanine nucleotide exchange factor-like (SecL-1) sequence and a gene encoding the same; a recombinant polypeptide using the DNA sequence encoding the above polypeptide and a process for producing the same; an antibody specifically recognizing it and a process for producing the same; a cell proliferation inhibitor, an apoptosis inducing agent and a remedy for liver diseases containing it; a method of screening a compound which specifically controlls the above protein with the use of it, etc.
PCT/JP2002/008408 2001-08-23 2002-08-21 Novel gene having guanine nucleotide exchange factor-like sequence WO2003018793A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003523642A JP4219808B2 (en) 2001-08-23 2002-08-21 A novel gene with a guanine nucleotide exchange factor-like sequence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001253344 2001-08-23
JP2001-253344 2001-08-23

Publications (1)

Publication Number Publication Date
WO2003018793A1 true WO2003018793A1 (en) 2003-03-06

Family

ID=19081693

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008408 WO2003018793A1 (en) 2001-08-23 2002-08-21 Novel gene having guanine nucleotide exchange factor-like sequence

Country Status (2)

Country Link
JP (1) JP4219808B2 (en)
WO (1) WO2003018793A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018126A1 (en) * 1997-10-07 1999-04-15 Ono Pharmaceutical Co., Ltd. POLYPEPTIDE, cDNA ENCODING THE POLYPEPTIDE, AND USE OF THE BOTH
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001029221A2 (en) * 1999-10-20 2001-04-26 Zymogenetics, Inc. Proteins and polynucleotides encoding them
WO2001032676A1 (en) * 1999-10-29 2001-05-10 Human Genome Sciences, Inc. 25 human secreted proteins
WO2001053453A2 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel bone marrow nucleic acids and polypeptides
WO2001059063A2 (en) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018126A1 (en) * 1997-10-07 1999-04-15 Ono Pharmaceutical Co., Ltd. POLYPEPTIDE, cDNA ENCODING THE POLYPEPTIDE, AND USE OF THE BOTH
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001029221A2 (en) * 1999-10-20 2001-04-26 Zymogenetics, Inc. Proteins and polynucleotides encoding them
WO2001032676A1 (en) * 1999-10-29 2001-05-10 Human Genome Sciences, Inc. 25 human secreted proteins
WO2001053453A2 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel bone marrow nucleic acids and polypeptides
WO2001059063A2 (en) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ACHSTETTER T. ET AL.: "SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast golgi apparatus", J. BIOL. CHEM., vol. 263, no. 24, 1988, pages 11711 - 11717, XP002040610 *
AKIRA TOGAWA ET AL.: "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors", J. BIOL. CHEM., vol. 274, no. 18, 1999, pages 12308 - 12315, XP002966803 *
MORINAGA N. ET AL.: "Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor", PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 12926 - 12931, XP002966802 *

Also Published As

Publication number Publication date
JPWO2003018793A1 (en) 2004-12-09
JP4219808B2 (en) 2009-02-04

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