+

WO2003017972A8 - Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers) - Google Patents

Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers)

Info

Publication number
WO2003017972A8
WO2003017972A8 PCT/IL2002/000699 IL0200699W WO03017972A8 WO 2003017972 A8 WO2003017972 A8 WO 2003017972A8 IL 0200699 W IL0200699 W IL 0200699W WO 03017972 A8 WO03017972 A8 WO 03017972A8
Authority
WO
WIPO (PCT)
Prior art keywords
peo
thermal gelation
reverse thermal
polymeric systems
component polymeric
Prior art date
Application number
PCT/IL2002/000699
Other languages
French (fr)
Other versions
WO2003017972A3 (en
WO2003017972A2 (en
Inventor
Daniel Cohn
Alejandro Sosnik
Original Assignee
Yissum Res Dev Co
Daniel Cohn
Alejandro Sosnik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL15128802A external-priority patent/IL151288A0/en
Application filed by Yissum Res Dev Co, Daniel Cohn, Alejandro Sosnik filed Critical Yissum Res Dev Co
Priority to AU2002321818A priority Critical patent/AU2002321818A1/en
Publication of WO2003017972A2 publication Critical patent/WO2003017972A2/en
Publication of WO2003017972A3 publication Critical patent/WO2003017972A3/en
Publication of WO2003017972A8 publication Critical patent/WO2003017972A8/en
Priority to US10/789,431 priority patent/US20050008609A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention provides a multi-component environmentally responsive polymeric system (e.g block copolymer comprising PEO and PPO), comprising at least two environmentally responsive polymeric components capable of undergoing a transition that results in a sharp increase in viscosity in response to a change in temperature at a predetermined body site, wherein said at least two components display different reverse thermal gelation behavior.
PCT/IL2002/000699 2001-08-27 2002-08-22 Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers) WO2003017972A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002321818A AU2002321818A1 (en) 2001-08-27 2002-08-22 Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers)
US10/789,431 US20050008609A1 (en) 2001-08-27 2004-02-27 Multi-component reverse thermo-sensitive polymeric systems

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31464001P 2001-08-27 2001-08-27
US60/314,640 2001-08-27
IL15128802A IL151288A0 (en) 2001-08-27 2002-08-15 Multi-component reverse thermo-sensitive polymeric systems
IL151288 2002-08-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/789,431 Continuation US20050008609A1 (en) 2001-08-27 2004-02-27 Multi-component reverse thermo-sensitive polymeric systems

Publications (3)

Publication Number Publication Date
WO2003017972A2 WO2003017972A2 (en) 2003-03-06
WO2003017972A3 WO2003017972A3 (en) 2003-10-02
WO2003017972A8 true WO2003017972A8 (en) 2003-11-20

Family

ID=26324061

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000699 WO2003017972A2 (en) 2001-08-27 2002-08-22 Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers)

Country Status (2)

Country Link
AU (1) AU2002321818A1 (en)
WO (1) WO2003017972A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1023720C2 (en) * 2003-06-23 2004-12-28 Univ Eindhoven Tech Method for changing the transport properties of a material, method for releasing a drug from an implant, as well as implant with drug.
US8217219B2 (en) 2003-12-29 2012-07-10 Kimberly-Clark Worldwide, Inc. Anatomically conforming vaginal insert
AU2009259492A1 (en) * 2008-06-18 2009-12-23 F. Hoffmann-La Roche Ag Aryl ketone as MRI
EP2453940A2 (en) 2009-07-13 2012-05-23 Yissum Research Development Company of The Hebrew University of Jerusalem Intraluminal polymeric devices for the treatment of aneurysms
DE102012223416A1 (en) * 2012-12-17 2014-07-03 Polymaterials Ag Chain extended poloxamers, thermoreversible hydrogels formed therefrom with biological materials, and medical applications thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0180334B1 (en) * 1995-09-21 1999-03-20 김윤 Drug messenger using el-2l-2 micelle and method for sealing drug to it
US6287588B1 (en) * 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
US6998137B2 (en) * 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
US7018645B1 (en) * 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties

Also Published As

Publication number Publication date
WO2003017972A3 (en) 2003-10-02
AU2002321818A1 (en) 2003-03-10
WO2003017972A2 (en) 2003-03-06

Similar Documents

Publication Publication Date Title
ATE513886T1 (en) HYDRAULIC FRACTURE FLUID CONTAINING BLOCK COPOLYMERS WITH HYDROPHILIC AND HYDROPHOBIC BLOCKS
EP1431363A3 (en) Hot melt adhesive based on acrylic block copolymers
CA2528075A1 (en) Low temperature liquid polythioether polymers
ATE373682T1 (en) EMBOLIC COMPOSITIONS
WO2001086249A3 (en) Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
WO2007111808A3 (en) Medical devices having biodegradable polymeric regions
WO2007136574A3 (en) Medical devices having polymeric regions based on vinyl ether block copolymers
ATE456643T1 (en) HOT MELT ADHESIVE
CA2435735A1 (en) Triggered response compositions
AU2003286533A1 (en) Block copolymer melt-processable compositions, methods of their preparation, and articles therefrom
MY137823A (en) Adhesives with improved die-cutting performance
WO2005059860A3 (en) Zwitterionic polymers comprising betaine-type units and use of zwitterionic polymers in drilling fluids
MXPA02012114A (en) Microsystem process networks.
WO2001091814A3 (en) Polyubiquitin based hydrogel and uses thereof
DE50207876D1 (en) POLYMERIC COMPOSITION, CONTAINING AT LEAST ONE MEDIUM-MOLECULAR REACTIVE POLYISOBUTENE
EP1223030A3 (en) Fuel hose of low fuel permeability
WO2000060023A3 (en) Quaternary nitrogen containing amphoteric water soluble polymers and their use in drilling fluids
SG125077A1 (en) Copolymer, polymer composition and polymer light-emitting device
WO2003078947A3 (en) Method for control of temperature-sensitivity of polymers in solution
WO2003017972A8 (en) Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers)
BR0110067A (en) Polymeric composition for pipes
MXPA03004828A (en) Liquid dispersion polymer compositions, their preparation and their use.
EP1418222A3 (en) Freeze tolerant friction control compositions
WO2007136700A3 (en) Method of purifying block copolymers
ATE527001T1 (en) HIGHLY BRANCHED THERMOPLASTIC ELASTIC BLOCK COPOLYMERS AND PRODUCTS BASED THEREOF

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 10/2003 UNDER (71) THE NAME SHOULD READ "YISSUM RESEARCH DEVELOPMENT COMPANY OF THEHEBREW UNIVERSITY OF JERUSALEM"

Free format text: IN PCT GAZETTE 10/2003 UNDER (71) THE NAME SHOULD READ "YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM"

WWE Wipo information: entry into national phase

Ref document number: 10789431

Country of ref document: US

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase in:

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载