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WO2003017784A1 - Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation - Google Patents

Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation Download PDF

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Publication number
WO2003017784A1
WO2003017784A1 PCT/IN2001/000151 IN0100151W WO03017784A1 WO 2003017784 A1 WO2003017784 A1 WO 2003017784A1 IN 0100151 W IN0100151 W IN 0100151W WO 03017784 A1 WO03017784 A1 WO 03017784A1
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WIPO (PCT)
Prior art keywords
ranging
powder
plants
herbs
seed
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PCT/IN2001/000151
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English (en)
Inventor
Palpu Pushpangadan
Dhan Prakash
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Council Of Scientific And Industrial Research
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Application filed by Council Of Scientific And Industrial Research filed Critical Council Of Scientific And Industrial Research
Priority to CNB018236812A priority Critical patent/CN100521969C/zh
Priority to EP01963364A priority patent/EP1420657A1/fr
Priority to JP2003522317A priority patent/JP2005500074A/ja
Priority to KR1020047003064A priority patent/KR100855376B1/ko
Priority to PCT/IN2001/000151 priority patent/WO2003017784A1/fr
Publication of WO2003017784A1 publication Critical patent/WO2003017784A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Definitions

  • the present invention relates to an herbal health protective and promotive nutraceutical formulations for females / expectant mothers.
  • Nutraceuticals are foods or bioactive ingredients in foods that protect or promote health whether delivered in raw agricultural commodities, processed foods, dietary supplements, extracts, beverages or other products and occurs at the intersection of food and pharmaceutical industries.
  • Nutraceuticals have potential to be used as food supplement, preventive medicine and the growing evidence points in the direction that certain foods fight and or prevent against diseases.
  • the food may be nutraceutical i.e. a food or parts of food that provide medical health benefits including the prevention and or treatment of diseases.
  • Functional foods provide specific benefits, and medical foods developed for use under medical supervision to treat or manage particular disease or nutritional deficiency stage.
  • Nutraceutical and functional- foods are a hybrid of both the traditionally defined food and drug arenas.
  • the word Nutraceuticals combines 'nutrition' and 'pharmaceuticals' to mean that food can be used as preventive drugs or food supplements.
  • the entire concept is based on the disease preventing phytonutrients present in foodstuffs of the diet in combating diseases.
  • the major phytonutrients identified to have nutraceutical properties include terpenes, phytosterols, phenols and theols.
  • Carotenoids found in green leafy vegetables like amaranth, Chenopodium (goose foot), mustard, 'Methi', spinach and cabbage etc are precursor of vitamin A. They have preventive action against many eye diseases, cancer and also acts as antioxidant. Limonoids also acts as antioxidants by protecting lung tissues from oxygen free radicals. Antioxidants have been associated with reduced risk of cardiovascular diseases and several types of cancer. They are known to act to defuse the volatile toxic molecules of free oxygen radicals, a by-product of cell metabolism. These are also produced in the body on exposure to sunlight, X-rays, ozone, tobacco smoke, auto-exhaust and other environmental pollutants.
  • Carotenoids, tocopherols, ascorbates and polyphenols are strong natural antioxidants generally found in plants and foods. They enhance the body's detoxification activity and protect against certain type of cancers by eliminating ill health causing chemical from the body to prevent degenerative diseases.
  • Phytosterols competes with dietary cholesterol for uptake in intestine thereby blocking cholesterol absorption into the body and can also prevent the development of tumor in breast and prostate glands.
  • Phenols a large group of phytonutrients, with sub classes in flavonoids, biflavonoids, anthocyanines and isoflavonoids have profound importance in preventive medicine. Berries, grapes and eggplants are rich in phenolics and have protective action against oxidative damage of tissues and inflammation.
  • phytochemicals can enhance the efficacy of vitamin C, can also act against allergies, ulcers, tumors, platelet aggregation, controlling hypertension and can reduce the risk of estrogen induced cancer.
  • Anthocyanidines or flavonals have significant role in collagen protein synthesis and are important in sports medicine. Beans and other legumes are rich natural sources of protein with the necessary nutrients needed for a healthy body and many of them contain specific immune- boosting potential.
  • Theols are major sulfur containing phytonutrients and the nutraceutical foods rich in theols include garlic, onion, mustard, cabbage, turnip and chives. They are potent antimutagenic and anticarcinogenic agents and gives cardio vascular protection.
  • Cruciferous vegetables are rich source of glucosinolates, which activate liver detoxification enzymes and can reduce tumor. They can also block the activity of toxins produced by bacteria and viruses thereby building immunity against diseases. Indoles found in citrus and gooseberries are effective against carcinogenic chemicals in the intestine.
  • the herbs like alfalfa, Ginko biloba, Ginseng, St John's wort etc are considered to be good for brain development.
  • Malnutrition is a major problem in the developing and third world countries resulting several diseases and low IQ in children.
  • a child's capacity to learn is directly related to food intake and good nutrition (Child Nutrition Advisory Council, USA).
  • the development of brain mainly depends on the health of pregnant and lactating mother finally on the quality of mother's diet.
  • the food also plays significant role in the general health of infants, growing children, diabetics, heart, nerves and aged.
  • the right foods do have the power to heal, keeping good health of body functions, ageing, rejuvenating, immuno-modulating and prevention against diseases, just as the wrong foods can cause sickness, rapid ageing and premature death.
  • the environmental and dietary factors i.e. poor nutrition habits are one of the co-factors for different diseases.
  • To combat malnutrition and growing demand of nutraceuticals need tailoring practices through value addition to optimize the concentration and bioavailability of the desired food
  • soybean (Glycine max), kidney-bean (Phaseolus vulgaris), chick-pea (Cicer arietinum), black-gra /'Urd' (Phaseolus mungo), green-gram/'Mung' (Phaseolus radiatus), winged bean (Psophocarpus tetragonolobus), 'Kewanch' (Mucuna pruriens), wheat (Triticum aestivum) barley (Hordeum vulgare), amaranth (Amaranthus hypochondriacus), goose foot/quinoa (Chenopodium quinoa) and buckwheat (Fagopyrum esculantus) have been described.
  • nutraceuticals and ingredients for functional foods are prepared by co- spray drying using fructans, fructooligosaccharides instead of maltodextrins as a drying agent and ingredients such as flavonoids, anthocyanins, resveratrol.
  • the main emphasis has been limited to phenolic phytochemicals and products are in the form of a gel or cream, showing fat like texture which can only be used as spreader. Reference is made to patents (Patent No.
  • nutraceuticals comprising a blend of N-[N-(3,3- dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester (neotame) with another sweetener has been mentioned.
  • the compounds used are synthetic and have limited importance only as sweetener or flavor modifier in nutraceuticals.
  • Neotame is a synthetic variation of aspartame and poses potential major health problems like incidents of grand mal seizures, brain tumors and environmental hazards. Reference is made to patents (Patent No.
  • nutracuticals with branded name as Dieter's Formula, Digestive Formula, Mega Man, Stress formula, vegetative Laxative, Memory helper with Ginko biloba, Revitalizer with Ginseng, Dieter's helper etc are available in international market (Internet).
  • Boost Horlics, Bounrvita, Cerelac, Protinex, Body Pro, Mega Mass, Muscle Builder, 90 Plus Protein and Soyatein etc are available.
  • Boost Horlics
  • Bounrvita Cerelac
  • Protinex Body Pro
  • Mega Mass Muscle Builder
  • 90 Plus Protein and Soyatein etc are available.
  • natural ingredients majority of the products also contain some synthetic amino acids, vitamins and other ingredients. Most of them are without any natural herbs/medicinal plants and recommended as food supplement for nutrition.
  • the present invention provides a process for the preparation of nutraceuticals with specific combination of edible legumes, cereals, pseudocereals for natural nutrients and herbs/medicinal plants with significant medicinal values to provide optimum balanced nutrition and general health protective, preventive and promotive benefits.
  • any process for nutraceutical preparation does not exist comprising a combination of legumes, cereals, pseudocereals fortified with herbs/ medicinal plants used in the present investigation.
  • nutraceuticals comprising a proper combination of natural edible seeds, herbs and medicinal plants has not yet been prepared to provide adequate nutrition and health protective benefits.
  • the main object of the present invention relates to the custom made tailored nutraceutical functional food composition(s), in a proper combination of natural edible seeds, herbs/ medicinal plants to provide optimum nutrition, health protective, preventive and promotive benefits for general health care of the females, pregnant and lactating mothers and to ward off malnutrition.
  • Another object of the present invention is to provide an herbal health protective nutraceutical formulation, which obviates the drawbacks as detailed above.
  • Yet another object of the present invention is to provide nutraceutical formulation for optimum nutrition, general health promotive and well being of the females to ameliorate the general health at prenatal and post natal stages and to ward off malnutrition.
  • the present invention relates to the custom made tailored nutraceutical functional food composition(s), in a proper combination of natural edible seeds, herbs/ medicinal plants to provide optimum nutrition, health protective, preventive and promotive benefits for general health care of the women, pregnant and lactating mothers and to ward off malnutrition.
  • the present invention provides a herbal health protective, promotive neutraceutical formulation for women/expectant human mothers, said formulation comprising seeds/seed products selected from the group consisting of legumes, cereals and pseudocereals ranging from 80-90% and an extract ranging between 10-20%.
  • the present invention provides a composition used as a herbal health protective, promotive neutraceutical formulation for females/expectant mothers, said composition comprising the said formulation consisting of seed powder mixture herbs/medicinal plant extract, and the composition further comprising sugar/jaggary , milk powder, Piper longum fruits, Myristica fragrans fruit powder, Elettaria cardamomum seed powder and coca powder.
  • the present invention also provide a process for the preparation of custom made herbal health protective, promotive nutraceutical formulations which may be used as food supplements to ameliorate the general health of females with optimum nutrients so as to ensure the optimal growth and development of the child both at prenatal and post natal stages.
  • the process comprises the seeds, from selected genera of Glycine, Phaseolus, Cicer, Psophocarpus, Mucuna, Triticum, Hordeum, Amaranthus, Chenopodium and Fagopyrum, may be roasted by keeping in microwave oven (BPL-Sanyo, model BMO 800 TS, frequency 2450 Mhz) ranging from 2 to 15 minutes separately, the microwave roasted seeds, 12 in number, may be powdered separately to pass through a sieve ranging from 50 to 400- mesh, the seed powders may be mixed ranging from 0 to 75% to get the base products, in a mixer grinder ranging from 5 to 55 minutes and may be called as base product, the roots, fruits, bark, whole plant of natural authentic herbs/medicinal plants from the genera of Centella, Withania, Pueraria, Asparagus, Chlorophytum, Boerhaavia, Sida, Saraca, Piper, Elettaria and Myristica may be collected from different natural sources in India and may be cut into small pieces 2
  • the combination of the present nutraceuticals is not a mere admixture of the ingredients used resulting in aggregation of their properties but a mixture having synergistically enhanced properties useful as food supplement for health protective, preventive and promotive benefits of the females, pregnant and lactating mothers including pre and post natal stages.
  • the said formulation comprising seeds/ seed products selected from the group consisting of legumes, cereals and pseudocereals ranging from 80-90% by wt; 10 - 20 % by wt of extract obtained from essential herbs/ medicinal plants of the genera Centella, Chlorophytum, Boerhaavia and Sida, and optional herbs / medicinal plants selected from the Withania somnifera, Pueraria tuberosa, Asparagus racemosus and Saraca indica.
  • the seeds/ seed products are selected from dried seeds, roasted seeds and powdered seeds.
  • the legumes used are essentially selected from the group comprising Glycine max, Cicer arietinum, Phaseolus mungo, Phaseolus vulgaris and
  • Phaseolus radiatus and optionally selected from the group comprising Psophocarpus tetragonolobus and Mucuna pruriens.
  • the total amount of legumes used in the formulation is ranging from 55 - 60 % by wt.
  • the cereals used are selected from Triticum aestivum, Hordeum vulgare or mixtures thereof.
  • pseudocereals used are selected from
  • the total amount of cereals used is in the range between 15-25 % by wt.
  • the total amount of pseudocereal used is in the range between 20 - 30 % by wt.
  • the said herbs/medicinal plant parts used is selected from roots, fruits, bark and whole plants.
  • the total amount of herbs/medicinal plants used is X, wherein X is ranging between 10 - 20 % by wt of the formulation.
  • Yet another embodiment of the invention relates to the amounts of the essential herbs/medicinal plants namely Centella asiatica, Chlorophytum tuberosum, Boerhaavia diffusa and Sida cordifolia are used in the ranges between 10-40 % by wt of X, 2-20% by wt of X, 5-30 % by wt of X and 10-20 % by wt of X respectively.
  • the amounts of the essential herbs/medicinal plants namely Centella asiatica, Chlorophytum tuberosum, Boerhaavia diffusa and Sida cordifolia are used in the ranges between 16-32 % by wt of X, 4-16% by wt of X , 5-24 % by wt of X and 12-16 % by wt of X respectively.
  • the amount of the optional herbs/medicinal plants namely Withania somnifera, Pueraria tuberosa, Asparagus racemosus and Saraca indica are used in the ranges between 0-16 % by wt of X, 0-24 % by wt of X and 0-16 % by wt of X and 0- 12 % by wt of X respecti vel y .
  • the said herbal formulation optionally contains acceptable amount of further additives selected from Piper, Elettaria and Myristica.
  • One more embodiment of the invention relates to a herbal health protective, promotive and nutraceutical composition for females and expectant mothers, wherein the said formulation comprising of seed powder mixture ranging from 44 to 52 %, herbs/medicinal plant extract ranging from 5 to 13 %, sugar/jaggary ranging form 20 to 35 %, milk powder ranging from 0 to 20%, Piper longum fruit powder ranging from 0.5 to 5.0%, Myristica fragrans fruit powder ranging from 0 to 5.0%, Elettaria cardamomum seed powder ranging from 0 to 4.0%, coca powder ranging from 0 tolO %.
  • the seed powder mixture contain legumes in the range between 23-31%, cereals in the range between 6- 17% and psuedocereals in the range between 10- 13%.
  • the end-product is suitable for use in the form of powder, granules, biscuits, tablets, capsules or any other suitable forms.
  • One more embodiment of the invention relates to a process for the preparation of herbal health protective, promotive nutraceutical compositions useful as food supplements to ameliorate the general health of females/ expectant mothers with optimum nutrients so as to ensure the optimal growth and development of the child both at pre-natal and post-natal stages, said process comprising: a.
  • seeds/seed products from the group consisting of legumes, cereals and pseudocerels wherein, the legumes consisting plants of genera Glycine, Cicer, Phaseolus, Psophocarpus, Mucuna, P.vulgaris, and P. radiatus, cereals consisting plants of genera Triticum and Hordeum, and, pseudocereals consisting plants of genera Amaranthus Chenopodium and Fagopyrum, b. roasting the seeds/seed products for 2 to 15 minutes under microwave conditions having frequency 1500-2500 Mhz, c. powdering the roasted seeds to a mesh size of 50 - 400 and mixing the same to obtain a base product, d. obtaining extract of herbs/medicinal plants from one or more plants of genera
  • the roasted seed powders are mixed in various proportions ranging up to 80% and the plant parts used are selected from roots, fruits, bark and whole plant of herbs/medicinal plants ranging up to 20% are selected for use in the nutraceutical products.
  • the herbs/medicinal plants are cut into small pieces ranging from 2 to 10 cm, dried under shade at the temperature ranging from 25 to 45°C and crushed to coarse powder ranging from 10 to 20 mesh size before extraction and the crushed and powdered herbs/medicinal plants are mixed up to 50% of the total mixture.
  • the powdered herbs/medicinal plants mixture is extracted with aqueous alcohol in the range of 10 to 90% v/v thrice for 12 to 48 hours, at temperature ranging from 25 to 45°C.
  • the alcohol is selected from methanol, ethanol, propanol and butanol.
  • the said solvent from combined extracts is removed under reduced pressure ranging from 20 to 100 PSI at temperature ranging from 35 to 65°C and the viscous residue thus obtained is called as plants extract, the plants extract is suspended in water in the ratio ranging from 20 to 70% by stirring for 10 to 50 minutes and is mixed with roasted seed powder mixture in the ratio ranging up to 20%.
  • the mixture of plants extract and roasted seed powders are mixed thoroughly in a mixer grinder for a period of ranging from 5 to 50 minutes and the mixture is dried for a period of ranging from 12 to 48 hours at temperature ranging from 30 to 50°C.
  • the dried plants extract and seed powders mixture is again mixed thoroughly in a mixer grinder for a period of ranging from 5 to 50 minutes and the powder thus obtained is used to prepare final nutraceuticals.
  • the amount of optional additives used namely sugar/jaggary or mixture thereof, milk powder, Viper longum, Myristica fragrants, Elettaria cardamomun and coca powder are in the ranges between 23-50 % by wt, 0-30 % by wt, 0.5 -
  • the optional additives present are in the ranges between sugar/jaggary 20 - 35 % by wt, milk powder 0-20 % by wt, Piper longum 0.5 -5 % by wt, Myristica fragrants 0-3 % by wt, Elettaria cardamomun 0-4 % by wt and coca powder 0-
  • the dried, powdered, mixture of plants extract, roasted seed powders, sugar/jaggary, milk powder, coca powder, Elettaria cardamomum powder, Piper longum fruit powder and Myristica fragrans (Jaiphal) fruit powder mixture is mixed thoroughly in a mixer grinder for a period of ranging from 5 to 50 minutes to get the final nutraceuticals.
  • nutraceutical formulations as herein described for the composition, methodology, preparation of base materials and value addition by plants extract to get the end products, may be used as health protective, promotive, food supplements to ameliorate the general health of females with optimum nutrients so as to ensure the optimal growth and development of the child both at prenatal and post natal stages.
  • the novelty of present invention is the specific combination of legumes, cereals, pseudocereals fortified with herbs/ medicinal plants and the process for the preparation of nutraceuticals.
  • the nutraceuticals are with optimum nutrition, non toxic, natural herbal plant products, easy to digest, have protective, preventive and health promotive properties for the best health and vigour of the females, pregnant and lactating mothers so as to ensure the optimal growth and development of the child both at prenatal and post natal stages.
  • the present invention provides a process for the preparation of custom-made herbal health protective nutraceuticals.
  • the present invention provides formulation for the combination of edible legumes, cereals, pseudocereals with promising potential for the development of well balanced nutritional base material.
  • the present invention provides value added products with synergistic health promotive, protective and preventive effects of natural herbs/medicinal plants to get specifically designed nutraceuticals for well balanced natural nutrients, to get optimum nutrition for general health protective benefits to the females, pregnant and lactating mothers and to ward off malnutrition.
  • nutraceutical formulation To prepare nutraceutical formulation the seeds of Glycine max, Cicer arietinum, Phaseolus mungo, Triticum aestivum, Hordeum vulgare, Amaranthus hypochondriacus and Fagopyrum esculantus were roasted by keeping in microwave oven for 3 minutes separately. The microwave roasted seeds, were powdered separately to pass through a 100-mesh sieve. The seed powders and herbs/medicinal plants extract were mixed as given in example 1.
  • the microwave roasted seed powders of Glycine max 30g, Cicer arietinum 15g, Phaseolus mungo lOg, Triticum aestivum lOg, Hordeum vulgare lOg, Amaranthus hypochondriacus 15g and Fagopyrum esculantus lOg were mixed for 20 minutes in a mixer grinder.
  • the roots, fruits, bark, whole plant of natural authentic herbs/medicinal plants collected from different natural sources in India were cut into small pieces of about 3 cm, dried under shade at 25°C, crushed and powdered to 10- mesh.
  • the 10 g of plants extract was suspended in 20 ml water and mixed with mixer grinder for a period of 30 minutes, the suspension of plants extract was mixed with the 90 g mixture of roasted seed powders and mixed thoroughly for a period of 30 minutes.
  • the plants extract and seed powders mixture was dried for 42 hours at 40° C, the dried plants extract and seed powders mixture was again mixed thoroughly in a mixer grinder for 25 minutes. The powder thus obtained was used to prepare final nutraceuticals.
  • the 53. Og dried plants extract and seed powders mixture was mixed with 35.
  • the combination of the present nutraceuticals is a mixture having synergistic health protective and promotive properties useful as food supplement for females.
  • nutraceutical formulation To prepare nutraceutical formulation the seeds of Glycine max, Phaseolus vulgaris, Phaseolus radiatus, Psophocarpus tetragonolobus, Triticum aestivum, Amaranthus hypochondriacus and Chenopodium quinoa were roasted by keeping in microwave oven for 7 minutes separately. The microwave roasted seeds, were powdered separately to pass through a 200- mesh sieve. The seed powders and herbs/medicinal plants extract were mixed as given in example 2.
  • Example 2 The microwave roasted seed powders of Glycine max 15g, Phaseolus vulgaris 15g, Phaseolus radiatus 20g, Psophocarpus tetragonolobus 5g, Triticum aestivum 15g, Amaranthus hypochondriacus 25g and Chenopodium quinoa 5g were mixed for 30 minutes in a mixer grinder.
  • the roots, whole plant, bark, fruits of natural authentic herbs/medicinal plants collected from different natural sources in India were cut into small pieces of about 3 cm, dried under shade at 30°C, crushed and powdered to 10- mesh.
  • the 12 g of plants extract was suspended in 30 ml water and mixed with mixer grinder for a period of 30 minutes, the suspension of plants extract was mixed with the 88 g mixture of roasted seed powders and mixed thoroughly for a period of 35 minutes.
  • the plants extract and seed powders mixture was dried for 36 hours at 45°C, the dried plants extract and seed powder mixtures were again mixed thoroughly in a mixer grinder 35 minutes. The powder thus obtained was used to prepare final nutraceuticals.
  • the 50g dried plants extract and seed powders mixture was mixed with 20g jaggary, 20g milk powder, 3.0g Piper longum (Pippali) fruit powder and 3.0g Myristica fragrans (Jaiphal) fruit powder, 4.0g Elettaria cardamomum (Elaichi) powder and the total mixture was mixed thoroughly in a mixer grinder for 30 minutes to get the final nutraceuticals.
  • the combination of the legumes, cereals, pseudocereals and herbs/medicinal plants in the present investigation is a mixture having synergistic properties useful as food supplement for females, pregnant and lactating mothers for pre and post natal health protective and promotive benefits.
  • nutraceutical formulation To prepare nutraceutical formulation the seeds of Glycine max, Phaseolus radiatus, Mucuna pruriens, Hordeum vulgare, Amaranthus hypochondriacus and Fagopyrum esculantus were roasted by keeping in microwave oven for 10 minutes separately. The microwave roasted seeds were powdered separately to pass through a 300-mesh sieve. The seed powders and herbs/medicinal plants were mixed as given in example 3.
  • the microwave roasted seed powders of Glycine max 40g, Phaseolus radiatus lOg, Mucuna pruriens lOg, Hordeum vulgare 20g, Amaranthus hypochondriacus 15g, and Fagopyrum esculantus 5g were mixed for 25 minutes in a mixer grinder.
  • the roots, fruits, whole plant of natural authentic herbs/medicinal plants collected from different natural sources in India were cut into small pieces of about 6 cm, dried under shade at 40°C, crushed and powdered to 20- mesh.
  • the dried powder of Centella asiatica (Brahmi) whole plant lOOg, Pueraria tuberosa (Vidhari) roots 150g, Chlorophytum tuberosum (Safed musli) roots 50g, Boerhaavia diffusa (Punarnava) roots 150g, Sida cordifolia (Bala) roots lOOg and Asparagus racemosus (Satawari) roots 75g were mixed and extracted with 1.5 lit aqueous alcohol 70% v/v thrice for 36 hours, at 55°C, the solvent from combined extractives was removed under reduced pressure at 50 psi, temperature of 50°C and the viscous residue thus obtained was called as the plants extract.
  • the 15 g of plants extract was suspended in 50 ml water and mixed with mixer grinder for a period of 35 minutes, the suspension of plants extract was mixed with the 85 g mixture of roasted seed powders and mixed thoroughly for a period of 40 minutes.
  • the plants extract and seed powders mixture was dried for 28 hours at 50° C, the dried plants extract and seed powders mixture was again mixed thoroughly in a mixer grinder 45 minutes.
  • the powder thus obtained was used to prepare final nutraceuticals.
  • the 60 g dried plants extract and seed powders mixture was mixed with 30g pale sugar powder powder, 6.0g coca powder and 4.0g Piper longum (Pippali) fruit powder. The total mixture was mixed thoroughly in a mixer grinder for 50 minutes to get the final nutraceuticals.
  • the combination of the legumes, cereals, pseudocereals and herbs/medicinal plants in the present investigation is a mixture having synergistic properties useful as food supplement for health protective and promotive benefits of the females.
  • Phaseolus mungo lOg, Phaseolus radiatus 15g, Hordeum vulgare 25g, Amaranthus hypochondriacus lOg and Fagopyrum esculantus 10 g were mixed for 35 minutes in a mixer grinder.
  • the whole plant, roots of natural authentic herbs/medicinal plants collected from different natural sources in India were cut into small pieces of about 7 cm, dried under shade at 40°C, crushed and powdered to 10- mesh.
  • the 20 g of plants extract was suspended in 60 ml water and mixed with mixer grinder for a period of 45 minutes, the suspension of plants extract was mixed with the 80 g mixture of roasted seed powders and mixed thoroughly for a period of 45 minutes.
  • the plants extract and seed powders mixture was dried for 48 hours at 50° C, the dried plants extract and seed powders mixture was again mixed thoroughly in a mixer grinder for 35 minutes.
  • the powder thus obtained was used to prepare final nutraceuticals.
  • the 65.0g dried herbs extract and seed powder mixture was mixed with 20g jaggary, 5.0g Piper longum (Pippali) fruit powder and lO.Og coca powder and the total mixture was mixed thoroughly in a grinder mixture for 40 minutes to get the final nutraceuticals.
  • the combination of the present nutraceuticals have synergistic health protective and promotive properties useful as food supplement for females, pregnant and lactating mothers.
  • Table 1 The amount (% composition) of seed powders (legumes, cereals & pseudocereals) in the base products.
  • Table 2 The amount (%) of different herbs/medicinal plants in the total used for extraction with alcohol.
  • Table 3 The percent composition & ratio of the seed powders and Herbs/Plants extract 10-20 g (10, 12, 15 and 20 g) of the extract was mixed with 80-90g of the base products (90, 88, 85 and 80 g mixture of the seed powders in examples 1, 2, 3 and 4 respectively).
  • Table 5 Record of Clinical Trial & Feed Back from Volunteers after consuming the Herbal Health Protective and Promotive Nutraceuticals for Females / Expectant mothers
  • Age group 20 - 50 years
  • Product 1-9 Base (Seed powders mixture) + Extract of single plant or different combinations of herbs/medicinal plants Nutrition Composition of Commercially Available Samples: 1. BOURNVITA:
  • Protein V g 40 Helps to build muscle tissues
  • Vitamin B 6 0.76 mg
  • Vitamin B I2 0.76 mg
  • Vitamin K 3 0.13 mg; Iron-gluconate 17 mg; Niacinamide 15 mg; Pantothenate 1.0 mg; Folic acid 50 Meg ; Biotin 10 mg
  • Fatless milk solid Fatless milk solid, wheat flour, sucrose, edible vegetable oil, vitamins & minerals.
  • Age group 20 - 50 years

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  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Pediatric Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medical Informatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cereal-Derived Products (AREA)
  • Seeds, Soups, And Other Foods (AREA)

Abstract

L'invention se rapporte à une composition nutraceutique à base d'herbes, protégeant et favorisant la santé des femmes/femmes enceintes, ainsi qu'à son procédé de préparation. Cette composition comprend 80 à 90 % en poids de graines/produits de graines sélectionné(e)s dans le groupe comprenant des légumes, des céréales et des pseudocéréales ; 10 à 20 % en poids d'extraits d'herbes essentielles/plantes médicinales du genre Centella, Chlorophytum, Boerhaavia et Sida, et éventuellement des herbes/plantes médicinales choisies parmi Withania somnifera, Pueraria tuberosa, Asparagus racemosus et Saraca indica.
PCT/IN2001/000151 2001-08-30 2001-08-30 Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation WO2003017784A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CNB018236812A CN100521969C (zh) 2001-08-30 2001-08-30 用于妇女/孕妇的草药营养药制剂及其制备方法
EP01963364A EP1420657A1 (fr) 2001-08-30 2001-08-30 Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation
JP2003522317A JP2005500074A (ja) 2001-08-30 2001-08-30 女性／妊婦用の薬草由来の栄養補助製剤およびその調製方法
KR1020047003064A KR100855376B1 (ko) 2001-08-30 2001-08-30 여성 및 임산부를 위한 허브 기능식품 제제 및 이의 제조방법
PCT/IN2001/000151 WO2003017784A1 (fr) 2001-08-30 2001-08-30 Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2001/000151 WO2003017784A1 (fr) 2001-08-30 2001-08-30 Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation

Publications (1)

Publication Number Publication Date
WO2003017784A1 true WO2003017784A1 (fr) 2003-03-06

Family

ID=11076374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2001/000151 WO2003017784A1 (fr) 2001-08-30 2001-08-30 Composition nutraceutique a base d'herbes destinee aux femmes/femmes enceintes et son procede de preparation

Country Status (5)

Country Link
EP (1) EP1420657A1 (fr)
JP (1) JP2005500074A (fr)
KR (1) KR100855376B1 (fr)
CN (1) CN100521969C (fr)
WO (1) WO2003017784A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056382A1 (fr) * 2002-12-20 2004-07-08 Council Of Scientific And Industrial Research Boisson sans alcool a base d'herbes ayurvediques
GB2412834A (en) * 2004-04-07 2005-10-12 International Ltd Valid A ready-to-use nutritional supplement
WO2005074958A3 (fr) * 2004-01-09 2006-04-06 Council Scient Ind Res Procede pour augmenter la phosphorylation et la translocation de glut4 afin d'augmenter le signal de l'insuline
WO2006053379A1 (fr) * 2004-11-16 2006-05-26 Universal Food Solutions Pty Ltd Formule améliorée de produit nutraceutique
WO2006061849A1 (fr) * 2004-12-10 2006-06-15 Council Of Scientific And Industrial Research Nouveaux aliments fonctionnels favorables a la sante renforces en herbes medicinales
WO2009023918A1 (fr) * 2007-08-20 2009-02-26 Quinn Pharmaceuticals Procédé de production de formulations d'extraits de plantes
US8142800B1 (en) * 2001-12-18 2012-03-27 Tamea Rae Sisco Oral high potency clinical anti-craving treatment and method of use
WO2020031209A1 (fr) * 2018-08-09 2020-02-13 Sushil Kumar Procédé de préparation d'un complément alimentaire et formulation associée
JP2021119754A (ja) * 2020-01-30 2021-08-19 フジッコ株式会社 Ｌ−ドーパを含有する豆類の加工方法

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* Cited by examiner, † Cited by third party
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JP5159568B2 (ja) * 2008-11-07 2013-03-06 小林製薬株式会社 ヒハツ抽出物を含有する飲食品組成物及びヒハツ抽出物含有飲食品組成物の味改善方法
FR2948537B1 (fr) * 2009-07-29 2011-09-09 France Bebe Nutrition Lab Composition nutritive pour femmes allaitant
KR101505576B1 (ko) * 2014-08-08 2015-03-25 주식회사 코씨드바이오팜 아스파라거스 추출물을 함유하는 팽창선조 예방 또는 개선용 조성물
JP7043708B2 (ja) * 2017-11-29 2022-03-30 株式会社デザインサプリ サプリメント推奨システム
CN108851079A (zh) * 2018-08-27 2018-11-23 陕西鹤鸣健康科技有限公司 一种促进生长发育的复方制剂及其制备方法

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GB2304050A (en) * 1992-11-26 1997-03-12 Eladevi Shah Herbal compositions
AU7190496A (en) * 1995-11-21 1997-05-29 New Chapter IP Pty Ltd Therapeutic compositions
EP0890360A1 (fr) * 1997-04-21 1999-01-13 Dabur Research Foundation Compositions pharmaceutiques à base de plantes utiles pour le traitement de conditions associés avec les infections virales de l'hépatite E et l'hépatite B

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AU7190496A (en) * 1995-11-21 1997-05-29 New Chapter IP Pty Ltd Therapeutic compositions
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8142800B1 (en) * 2001-12-18 2012-03-27 Tamea Rae Sisco Oral high potency clinical anti-craving treatment and method of use
WO2004056382A1 (fr) * 2002-12-20 2004-07-08 Council Of Scientific And Industrial Research Boisson sans alcool a base d'herbes ayurvediques
US7550163B2 (en) 2002-12-20 2009-06-23 Council Of Scientific And Industrial Research Herbal soft drink
WO2005074958A3 (fr) * 2004-01-09 2006-04-06 Council Scient Ind Res Procede pour augmenter la phosphorylation et la translocation de glut4 afin d'augmenter le signal de l'insuline
GB2412834A (en) * 2004-04-07 2005-10-12 International Ltd Valid A ready-to-use nutritional supplement
WO2006053379A1 (fr) * 2004-11-16 2006-05-26 Universal Food Solutions Pty Ltd Formule améliorée de produit nutraceutique
WO2006061849A1 (fr) * 2004-12-10 2006-06-15 Council Of Scientific And Industrial Research Nouveaux aliments fonctionnels favorables a la sante renforces en herbes medicinales
WO2009023918A1 (fr) * 2007-08-20 2009-02-26 Quinn Pharmaceuticals Procédé de production de formulations d'extraits de plantes
WO2020031209A1 (fr) * 2018-08-09 2020-02-13 Sushil Kumar Procédé de préparation d'un complément alimentaire et formulation associée
JP2021119754A (ja) * 2020-01-30 2021-08-19 フジッコ株式会社 Ｌ−ドーパを含有する豆類の加工方法
JP7282047B2 (ja) 2020-01-30 2023-05-26 フジッコ株式会社 Ｌ－ドーパを含有する豆類の加工方法

Also Published As

Publication number Publication date
EP1420657A1 (fr) 2004-05-26
JP2005500074A (ja) 2005-01-06
KR20040111326A (ko) 2004-12-31
KR100855376B1 (ko) 2008-09-04
CN1558724A (zh) 2004-12-29
CN100521969C (zh) 2009-08-05

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