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WO2003014738A2 - Porteur de substances pourvu d'un marqueur - Google Patents

Porteur de substances pourvu d'un marqueur Download PDF

Info

Publication number
WO2003014738A2
WO2003014738A2 PCT/EP2002/008299 EP0208299W WO03014738A2 WO 2003014738 A2 WO2003014738 A2 WO 2003014738A2 EP 0208299 W EP0208299 W EP 0208299W WO 03014738 A2 WO03014738 A2 WO 03014738A2
Authority
WO
WIPO (PCT)
Prior art keywords
carrier
marking
carrier according
substances
markings
Prior art date
Application number
PCT/EP2002/008299
Other languages
German (de)
English (en)
Other versions
WO2003014738A3 (fr
Inventor
Lars Ziegenhagen
Original Assignee
Picorapid Technologie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Picorapid Technologie Gmbh filed Critical Picorapid Technologie Gmbh
Priority to EP02762397A priority Critical patent/EP1415157A2/fr
Publication of WO2003014738A2 publication Critical patent/WO2003014738A2/fr
Publication of WO2003014738A3 publication Critical patent/WO2003014738A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Definitions

  • the invention relates to a carrier for substances, particularly used in chemistry or biology, on which certain substances, e.g. Nucleic acids, antibodies, peptides or proteins can be applied.
  • biochips In chemistry, biochemistry, molecular biology or molecular genetic analysis, so-called “biochips” are increasingly being used for investigation purposes.
  • a “biochip” is a basic substrate on which certain substances, e.g. molecular probes, arranged systematically. For example, tens of thousands of different samples can be applied to the base substrate with a high density and subsequently examined in parallel under identical test and reaction conditions. In order to ensure optimal quality control and effective data management, such biochip substrates must be clearly labeled.
  • Various ner drives are known for marking substrates, among others, which are described, for example, in DE 198 12 072 AI, DE 195 16 863 AI, DE 36 20 233 C2, EP 0 233 146 B1, EP 0 391 848 AI, EP 0 296 312 A2, DE 38 29 025 AI or DE 199 05 490 AI are described.
  • carrier materials or base substrates are available for the production of biochips, on the surface of which two or more work steps are used to mark them, for example by gluing, baking, vapor deposition, sputtering, coloring, clamping or sandblasting.
  • Such surface markings are difficult to apply and can be damaged or destroyed relatively easily by mechanical stress or chemicals.
  • the effectively usable area of a substrate is reduced by markings applied to the surface, since, as a rule, no samples to be examined can be applied to a marking.
  • the carrier according to the invention for substances has at least one marking which is formed in the carrier itself, that is to say below the surface.
  • no marking is provided on a surface of the carrier, but instead, according to the invention, a corresponding marking is arranged inside the carrier.
  • the carrier can be both solid, a chemically or physically modified carrier material or a material that differs from the surrounding carrier material, for example with regard to its optical, magnetic, electrical or other properties, can be used as a marking in the carrier.
  • a marking which is itself formed or produced in a carrier in accordance with the invention is insensitive to mechanical loads, such as rubbing or scratching, or chemical substances which act on the surface of the carrier, in comparison to markings formed on or on the surface. This results in a high level of security against unintentional or deliberate changes to the marking.
  • a carrier according to the invention can, for example, be produced in an environmentally friendly manner without the use of a solvent or adhesive and is permanently marked by the marking according to the invention, since the marking cannot flake off, rub off or rub off. Furthermore, contamination of substances applied to the carrier is prevented by the marking, since the carrier, which is mostly resistant to the chemicals used, protects the marking arranged in it.
  • a mark made in a carrier is advantageous since there are no raised or roughened spots on the carrier due to the marking, which considerably simplifies the storage and handling of the carrier. Essentially the entire surface of the carrier can be used to apply corresponding substances, since no surface of the carrier is required for marking. However, the marking according to the invention can of course also be combined with surface markings.
  • the marking is advantageously arranged approximately in the middle between two opposing surfaces of a carrier and can e.g. be flat, i.e. e.g. extend in parallel along all or part of a surface.
  • the marking can be arranged approximately in the center of the carrier, that is to say approximately at a distance of 0.5 mm from a surface.
  • Markings can preferably be applied in different layers of a carrier, that is to say, for example, 2, 3 to 10 or more markings which are arranged at different distances from a surface and overlap. pen can be arranged or laterally offset from each other.
  • a carrier that is to say, for example, 2, 3 to 10 or more markings which are arranged at different distances from a surface and overlap. pen can be arranged or laterally offset from each other.
  • markings in a carrier which are arranged, for example, parallel to one another, but at different depths of the carrier, that is to say that, for example, one marker is closer to a first surface and another marker is closer to a second surface
  • both can Surfaces of the carrier are used for applying substances, the substances applied to the respective surfaces being able to be identified or labeled independently of one another by the corresponding markings.
  • the carrier can consist at least in part of glass
  • the marking in the glass carrier e.g. can be generated by means of a laser, e.g. described in DE 198 55 623 C1, the disclosure of which is included in this description with regard to the generation of a marking in a vitreous body.
  • the marking created under the surface of the support in the support can e.g. a defect in the glass that scatters or absorbs light and can thus be recognized as a marking point.
  • the carrier can be made of plastic, preferably of transparent plastic, the marking being e.g. can in turn be generated with a laser.
  • the marking being e.g. can in turn be generated with a laser.
  • transparent plastic in a desired area, a defect or blackening can be created as a marker.
  • the carrier can be made of metal, the marking in the carrier being generated, for example, by a specific magnetization, so that, for example, as in known magnetic recording and reading methods, a marking can be written into the carrier and read out from the carrier ,
  • a marking can be written into the carrier and read out from the carrier
  • techniques can be used as are known for the storage of data in magnetic tape or hard disk technology.
  • any marking can be used according to the invention, which can be attached to a carrier and read out again from the outside.
  • a glass, plastic or metal carrier can additionally have regions made of another material, so that, for example, a combined glass and plastic carrier or a glass and metal carrier is created , in which suitable markings can be made in a desired area of the carrier.
  • marking it is also possible, for example, to use holographic methods or holograms, methods based on electromagnetic interaction, such as, for example, a coupling via an oscillating circuit arranged in the carrier, or generally an inductance, methods for determining specific material properties, such as, for example, a specific dielectric constant, or others Procedures are used.
  • the marking is advantageously designed such that it can be read without the aid of technical aids, e.g. a sequence of digits can be formed in a transparent substrate.
  • the coding can preferably also be designed such that it is machine-readable, in particular the marking can advantageously be designed as a code, e.g. as a bar code, data matrix or as a grid point.
  • the marking in particular with a machine-readable code, can be used to mark a large number of substances applied to the carrier.
  • At least one marking is preferably designed in such a way that it can be used to position at least one substance on the carrier, such as a grid pattern, preferably with coordinates. It is particularly preferred to provide several areas, each marked, to which several substances can be applied. It is also advantageous to provide a marking with which the position of the carrier can be determined, for example the correct position of the Carrier in a device which, for example, examines the samples applied to the carrier or subjects them to a special process. ,
  • the present invention relates to the use of a carrier as described above in chemical, biochemical or molecular biological methods or methods for molecular genetic analysis.
  • a method for marking a carrier is proposed according to the invention, wherein a marking as described above is generated in the carrier, that is to say essentially without influencing or changing the surface of the carrier.
  • An inventive device for performing the method has an input device, such as a keyboard, a mouse, a touch screen, a scanner or the like, with which e.g. With the aid of a known input mask, a desired marking to be formed in the carrier can be entered, a control device, such as e.g. a microprocessor, based on the input, controls a marking device in such a way that the desired markings are generated.
  • the marking device can e.g. a laser controlled by a robot or a magnetic writing head.
  • Fig. La shows a first embodiment of a carrier with the invention
  • Fig. Lb is a side view of the carrier shown in Fig la;
  • FIG. 2 shows a second embodiment of a carrier according to the invention.
  • Fig. 3 shows a third embodiment of the carrier according to the invention.
  • Fig. La shows a carrier which can be used as a biochip, as described above.
  • a commercially available transparent glass or plastic carrier can be used.
  • the marking 3-10 shown can be formed in the carrier 1 itself, for example by laser radiation, as shown in the side view of FIG. 1b.
  • the marking elements described in detail below, designated by the reference numbers 3 to 9 are arranged approximately in the center of the carrier, as shown in the side view of FIG. 1b and represented there by the reference number 10.
  • the samples or substances applied to the carriers before or after the marking remain unaffected by the marking, since the marking is arranged in the carrier 1 itself without direct contact with the surface and thus with the substances applied.
  • a company logo 3 As a mark, for example, as shown in FIG. 1 a, a company logo 3, a machine-readable bar code 4, a machine-readable data matrix code 5 and a digit code 6 can be generated, so that the carrier 1 can be clearly identified by a user and / or a suitable device .
  • the sample field is identified by a marking 8, which can also be used, for example, for suitable positioning of the carrier in a device.
  • the sample area can be subdivided by means of a grid pattern with coordinate information 7, so that individual samples or substances can be applied to areas specified by the coordinates. A simple assignment of a sample to a specific area of the carrier 1 is thus possible. A specific substance applied can easily be located on the carrier 1 using the coordinates or the grid 7.
  • a title block 9 can be provided in the carrier 1 for special instructions or information.
  • 2 shows a second embodiment of the present invention, each individual sample field being identified separately by means of a machine-readable identification in the form of a data matrix code 11.
  • a machine-readable identification in the form of a data matrix code 11.
  • Fig. 3 shows a third embodiment of the present invention, wherein a data matrix code is provided in a carrier for applying a single sample. This means that individual samples can also be easily examined with simultaneous unambiguous identification of the applied sample by the data matrix. This is e.g. advantageous if a smaller number of samples is to be examined, since not a large carrier, e.g. shown in Figs. 1 and 2 must be used.
  • any suitable type of marking of a single sample from a plurality of samples or also of a single sample present can be carried out by means of a marking made in the carrier.

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)

Abstract

L'invention se rapporte à un porteur de substances, auquel un marqueur est ajouté. Cette invention concerne également l'utilisation dudit porteur ainsi qu'un procédé et un dispositif de marquage de ce porteur.
PCT/EP2002/008299 2001-08-02 2002-07-25 Porteur de substances pourvu d'un marqueur WO2003014738A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02762397A EP1415157A2 (fr) 2001-08-02 2002-07-25 Porteur de substances pourvu d'un marqueur

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10137864.5 2001-08-02
DE10137864A DE10137864B4 (de) 2001-08-02 2001-08-02 Substanzträger mit Markierung

Publications (2)

Publication Number Publication Date
WO2003014738A2 true WO2003014738A2 (fr) 2003-02-20
WO2003014738A3 WO2003014738A3 (fr) 2003-11-13

Family

ID=7694107

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008299 WO2003014738A2 (fr) 2001-08-02 2002-07-25 Porteur de substances pourvu d'un marqueur

Country Status (3)

Country Link
EP (1) EP1415157A2 (fr)
DE (1) DE10137864B4 (fr)
WO (1) WO2003014738A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105916583A (zh) * 2014-01-16 2016-08-31 欧蒙医学诊断技术有限公司 具有标记的透明显微镜载玻片

Families Citing this family (7)

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DE102004018404B4 (de) * 2004-04-16 2015-06-25 Leuze Electronic Gmbh & Co. Kg Optoelektronische Vorrichtung
DE102006019422A1 (de) * 2006-04-26 2007-10-31 Siemens Ag Cartridge zur Durchführung einer Analyse, Analysegerät und Verfahren zur Durchführung einer Analyse mittels einer Cartridge
DE102009005307B4 (de) * 2009-01-16 2011-06-01 Waldemar Knittel Glasbearbeitungs Gmbh Objektträger
DE102014202860B4 (de) * 2014-02-17 2016-12-29 Leica Microsystems Cms Gmbh Bereitstellen von Probeninformationen mit einem Lasermikrodissektionssystem
EP3095517B1 (fr) * 2015-05-22 2020-01-08 ibidi GmbH Porte-échantillons ayant une structure de référence et procédé de production d'un porte-échantillons doté d'une structure de référence
DE102015113557B4 (de) 2015-08-17 2019-05-02 Gerresheimer Regensburg Gmbh Probenvorrichtung mit Referenzmarkierung
EP3904112A1 (fr) * 2020-04-29 2021-11-03 Fa-Tech Diagnostics Italia S.R.L. Procédé d'inscription de lames de microscope en verre et lames de microscope en verre ainsi obtenues

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DE3133826A1 (de) * 1981-08-27 1983-03-10 Boehringer Mannheim Gmbh, 6800 Mannheim Analyseteststreifen und verfahren zu seiner herstellung
US5439826A (en) * 1988-12-02 1995-08-08 Bio-Tek Instruments, Inc. Method of distinguishing among strips for different assays in an automated instrument
DE4041905A1 (de) * 1990-12-27 1992-07-02 Boehringer Mannheim Gmbh Testtraeger-analysesystem
JP3164403B2 (ja) * 1992-03-27 2001-05-08 オリンパス光学工業株式会社 自動分析装置
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DE4406969A1 (de) * 1993-03-15 1994-09-22 Volkswagen Ag Fälschungssichere Kennzeichnung eines mit einer Glasscheibe ausgerüsteten Gegenstands, insbesondere eines Kraftfahrzeugs
EP0633207A1 (fr) * 1993-07-07 1995-01-11 Siemens Aktiengesellschaft Système de transport pour transporter des échantillons sur des dispositifs de traitement différents
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
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GB2334347B (en) * 1998-02-13 2001-02-28 Univ Hertfordshire An improved method of fabricating coded particles
DE29906382U1 (de) * 1998-04-14 1999-09-30 BioTul/Bio Instruments GmbH, 80339 München Probenträger mit Kennzeichnung
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DE19855623C1 (de) * 1998-12-02 2000-02-24 Lpkf Laser & Electronics Ag Verfahren zur Erzeugung einer Markierung in einem Glaskörper
NZ515214A (en) * 1999-04-16 2003-06-30 Tibotec Nv Encoding of microcarriers on or beneath the surface with multiple intensities for higher encoding rate
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105916583A (zh) * 2014-01-16 2016-08-31 欧蒙医学诊断技术有限公司 具有标记的透明显微镜载玻片
US10082660B2 (en) 2014-01-16 2018-09-25 Euroimmun Medizinische Labordiagnostika Ag Transparent microscope slide having a marking

Also Published As

Publication number Publication date
WO2003014738A3 (fr) 2003-11-13
EP1415157A2 (fr) 2004-05-06
DE10137864B4 (de) 2005-05-19
DE10137864A1 (de) 2003-02-27

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