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WO2003014745A3 - Method for identifying anti-inflammatory drugs - Google Patents

Method for identifying anti-inflammatory drugs Download PDF

Info

Publication number
WO2003014745A3
WO2003014745A3 PCT/EP2002/007937 EP0207937W WO03014745A3 WO 2003014745 A3 WO2003014745 A3 WO 2003014745A3 EP 0207937 W EP0207937 W EP 0207937W WO 03014745 A3 WO03014745 A3 WO 03014745A3
Authority
WO
WIPO (PCT)
Prior art keywords
inflammatory drugs
identifying anti
nhr
identifying
inflammatory
Prior art date
Application number
PCT/EP2002/007937
Other languages
French (fr)
Other versions
WO2003014745A2 (en
Inventor
Birgit Jung
Norbert Kraut
Stefan Mueller
Original Assignee
Boehringer Ingelheim Pharma
Birgit Jung
Norbert Kraut
Stefan Mueller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Birgit Jung, Norbert Kraut, Stefan Mueller filed Critical Boehringer Ingelheim Pharma
Priority to EP02754896A priority Critical patent/EP1425587A2/en
Priority to JP2003519426A priority patent/JP2005503787A/en
Priority to MXPA04001128A priority patent/MXPA04001128A/en
Priority to CA002453913A priority patent/CA2453913A1/en
Priority to AU2002321229A priority patent/AU2002321229A1/en
Publication of WO2003014745A2 publication Critical patent/WO2003014745A2/en
Publication of WO2003014745A3 publication Critical patent/WO2003014745A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to NHR-proteins involved in inflammatory processes and the modulation of the function of such a NHR-protein in order to positively influence inflammatory diseases.
PCT/EP2002/007937 2001-08-06 2002-07-17 Method for identifying anti-inflammatory drugs WO2003014745A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP02754896A EP1425587A2 (en) 2001-08-06 2002-07-17 Method for identifying anti-inflammatory drugs
JP2003519426A JP2005503787A (en) 2001-08-06 2002-07-17 Methods for identifying substances that positively affect inflammatory symptoms
MXPA04001128A MXPA04001128A (en) 2001-08-06 2002-07-17 Method for identifying substances which positively influence inflammatory conditions.
CA002453913A CA2453913A1 (en) 2001-08-06 2002-07-17 Method for identifying substances which positively influence inflammatory conditions
AU2002321229A AU2002321229A1 (en) 2001-08-06 2002-07-17 Method for identifying anti-inflammatory drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01119003.0 2001-08-06
EP01119003 2001-08-06

Publications (2)

Publication Number Publication Date
WO2003014745A2 WO2003014745A2 (en) 2003-02-20
WO2003014745A3 true WO2003014745A3 (en) 2004-03-25

Family

ID=8178260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007937 WO2003014745A2 (en) 2001-08-06 2002-07-17 Method for identifying anti-inflammatory drugs

Country Status (6)

Country Link
EP (1) EP1425587A2 (en)
JP (1) JP2005503787A (en)
AU (1) AU2002321229A1 (en)
CA (1) CA2453913A1 (en)
MX (1) MXPA04001128A (en)
WO (1) WO2003014745A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005074969A2 (en) * 2004-02-07 2005-08-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human nuclear receptor nr4a1 (nr4a1)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024471A1 (en) * 1997-11-10 1999-05-20 The Research Foundation Of State University Of New York Opiate, cannabinoid, and estrogen receptors
WO2000053563A1 (en) * 1999-03-11 2000-09-14 Nuclear Receptor Research Limited Novel ligands of nuclear receptors ppar's
WO2001022988A1 (en) * 1999-09-30 2001-04-05 Aubin Jane E ESTROGEN RELATED RECEPTOR, ERRα, A REGULATOR OF BONE FORMATION
WO2002052270A2 (en) * 2000-12-22 2002-07-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases
WO2002052036A2 (en) * 2000-12-22 2002-07-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Identification of modulators of dham-kinase and inflammatory diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024471A1 (en) * 1997-11-10 1999-05-20 The Research Foundation Of State University Of New York Opiate, cannabinoid, and estrogen receptors
WO2000053563A1 (en) * 1999-03-11 2000-09-14 Nuclear Receptor Research Limited Novel ligands of nuclear receptors ppar's
WO2001022988A1 (en) * 1999-09-30 2001-04-05 Aubin Jane E ESTROGEN RELATED RECEPTOR, ERRα, A REGULATOR OF BONE FORMATION
WO2002052270A2 (en) * 2000-12-22 2002-07-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases
WO2002052036A2 (en) * 2000-12-22 2002-07-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Identification of modulators of dham-kinase and inflammatory diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NUCLEAR RECEPTORS NOMENCLATURE COMMITTEE, 1999: "A unified nomenclature system for the nuclear receptor superfamily.", CELL, vol. 97, 16 April 1999 (1999-04-16), pages 161 - 163, XP002267664 *

Also Published As

Publication number Publication date
JP2005503787A (en) 2005-02-10
CA2453913A1 (en) 2003-02-20
MXPA04001128A (en) 2004-05-20
AU2002321229A1 (en) 2003-02-24
WO2003014745A2 (en) 2003-02-20
EP1425587A2 (en) 2004-06-09

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