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WO2003014297A3 - Compositions and methods relating to the daptomycin biosynthetic gene cluster - Google Patents

Compositions and methods relating to the daptomycin biosynthetic gene cluster Download PDF

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Publication number
WO2003014297A3
WO2003014297A3 PCT/US2002/024310 US0224310W WO03014297A3 WO 2003014297 A3 WO2003014297 A3 WO 2003014297A3 US 0224310 W US0224310 W US 0224310W WO 03014297 A3 WO03014297 A3 WO 03014297A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene cluster
biosynthetic gene
compositions
nucleic acid
acid molecules
Prior art date
Application number
PCT/US2002/024310
Other languages
French (fr)
Other versions
WO2003014297A2 (en
Inventor
Vivian Pak Woon Miao
Paul Brian
Richard H Baltz
Marie Francoise Coeffet-Legal
Original Assignee
Cubist Pharm Inc
Vivian Pak Woon Miao
Paul Brian
Richard H Baltz
Marie Francoise Coeffet-Legal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/032354 external-priority patent/WO2002059322A2/en
Application filed by Cubist Pharm Inc, Vivian Pak Woon Miao, Paul Brian, Richard H Baltz, Marie Francoise Coeffet-Legal filed Critical Cubist Pharm Inc
Priority to EP02759231A priority Critical patent/EP1421097A4/en
Priority to CA002456552A priority patent/CA2456552A1/en
Priority to JP2003519229A priority patent/JP2005508622A/en
Priority to IL16016902A priority patent/IL160169A0/en
Priority to AU2002324580A priority patent/AU2002324580A1/en
Priority to KR10-2004-7001843A priority patent/KR20040032891A/en
Publication of WO2003014297A2 publication Critical patent/WO2003014297A2/en
Publication of WO2003014297A3 publication Critical patent/WO2003014297A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides nucleic acid molecules comprising all or a part of a daptomycin biosynthetic gene cluster. The daptomycin biosynthetic gene cluster may be derived from Streptomyces, preferably from S. roseosporus. The invention also provides other nucleic acid molecules from S. roseosporus. The invention further provides polypeptides encoded by the nucleic acid molecules, antibodies that specifically bind to the polypeptides, and methods of using the nucleic acid molecules, polypeptides and antibodies to produce daptomycin and other compounds.
PCT/US2002/024310 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster WO2003014297A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP02759231A EP1421097A4 (en) 2001-08-06 2002-07-31 COMPOSITIONS AND METHODS CONCERNING THE DAPTOMYCIN BIOSYNTHESEGENCLUSTER
CA002456552A CA2456552A1 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
JP2003519229A JP2005508622A (en) 2001-08-06 2002-07-31 Compositions and methods for daptomycin biosynthetic gene clusters
IL16016902A IL160169A0 (en) 2001-08-06 2002-07-31 Nucleic acid molecules that encode a daptomycin non-ribosomal peptide synthetase and methods for the production thereof
AU2002324580A AU2002324580A1 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
KR10-2004-7001843A KR20040032891A (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US31038501P 2001-08-06 2001-08-06
US60/310,385 2001-08-06
PCT/US2001/032354 WO2002059322A2 (en) 2000-10-17 2001-10-17 Compositions and methods relating to the daptomycin biosynthetic gene cluster
USPCT/US01/32354 2001-10-17
US37986602P 2002-05-10 2002-05-10
US60/379,866 2002-05-10

Publications (2)

Publication Number Publication Date
WO2003014297A2 WO2003014297A2 (en) 2003-02-20
WO2003014297A3 true WO2003014297A3 (en) 2003-05-22

Family

ID=27359112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024310 WO2003014297A2 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster

Country Status (3)

Country Link
EP (1) EP1421097A4 (en)
CA (1) CA2456552A1 (en)
WO (1) WO2003014297A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1814588A2 (en) * 2004-11-12 2007-08-08 Cubist Pharmaceuticals, Inc. Antiinfective lipopeptides
CN101830970B (en) * 2009-03-12 2012-06-27 成都雅途生物技术有限公司 Purification and preparation method of high-purity Daptomycin
CN102260700B (en) * 2010-09-24 2014-03-26 天津大学 Construction method and application of streptomyces roseosporus gene engineering bacteria HP-ORF53-55
CN102206694B (en) * 2011-04-06 2013-10-16 山东新时代药业有限公司 Slow-release composition containing capric acid
CN117965408A (en) 2013-03-15 2024-05-03 模块遗传学公司 Production of acyl amino acids
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
CN110408603B (en) * 2019-08-01 2022-09-23 上海交通大学 A54145C1 mutant with altered fatty acyl selectivity and its construction and application
CN113717909B (en) * 2020-05-26 2024-11-05 杭州中美华东制药有限公司 A daptomycin high-yield strain and its application
CN111575251B (en) * 2020-05-29 2022-03-11 上海交通大学 Construction of dptC1 mutant for daptomycin biosynthesis
CN112089823B (en) * 2020-09-25 2024-02-06 珠海中科先进技术研究院有限公司 Composition of aureobasidin A and nystatin and composite ointment, gel and spray thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827689A (en) * 1996-11-13 1998-10-27 Smithkline Beecham Corporation FabD polynucleotides
US6258934B1 (en) * 1997-01-24 2001-07-10 Smithkline Beecham Corporation FabD

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MCHENNEY M.A. ET AL.: "Gene transfer and transposition mutagenesis in streptomyces roseosporus: mapping of insertions that influence daptomycin or pigment production", MICROBIOLOGY, vol. 142, September 1996 (1996-09-01), pages 2363 - 2373, XP000946801 *
MCHENNEY M.A. ET AL.: "Molecular cloning and physical mapping of the daptomycin gene cluster from streptomyces roseosporus", J. BACTERIOL., vol. 180, no. 1, January 1998 (1998-01-01), pages 143 - 151, XP002961809 *
MOOTZ H.D. ET AL.: "Design and application of multimodular peptide synthetases", CURRENT OPINION IN BIOTECHNOLOGY, vol. 10, no. 4, 1999, pages 341 - 348, XP000892842 *
See also references of EP1421097A4 *

Also Published As

Publication number Publication date
EP1421097A2 (en) 2004-05-26
WO2003014297A2 (en) 2003-02-20
EP1421097A4 (en) 2005-07-06
CA2456552A1 (en) 2003-02-20

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