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WO2003013565A1 - Materiaux fonctionnels, agonistes sod, hypotensifs et thrombolytiques, leur procede de production et souches microbiennes a utiliser - Google Patents

Materiaux fonctionnels, agonistes sod, hypotensifs et thrombolytiques, leur procede de production et souches microbiennes a utiliser Download PDF

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Publication number
WO2003013565A1
WO2003013565A1 PCT/JP2002/003726 JP0203726W WO03013565A1 WO 2003013565 A1 WO2003013565 A1 WO 2003013565A1 JP 0203726 W JP0203726 W JP 0203726W WO 03013565 A1 WO03013565 A1 WO 03013565A1
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WO
WIPO (PCT)
Prior art keywords
sod
functional materials
microbial strains
hypotensives
thrombolytics
Prior art date
Application number
PCT/JP2002/003726
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English (en)
Japanese (ja)
Inventor
Akihiko Kimura
Yuji Harada
Atsushi Takada
Asao Shioda
Toshio Izawa
Toshitaka Okada
Kaoru Yamashita
Original Assignee
Toyo Hakko Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2001241363A external-priority patent/JP2002121141A/ja
Application filed by Toyo Hakko Co., Ltd. filed Critical Toyo Hakko Co., Ltd.
Publication of WO2003013565A1 publication Critical patent/WO2003013565A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Beans For Foods Or Fodder (AREA)

Abstract

On obtient des matériaux fonctionnels ayant un excellent effet thrombolytique, une fonction SOD et une fonction ACE en mettant en culture un bouillon de graines de haricots. On inocule ensuite le bouillon stérilisé é l'une des souches microbiennes TOYO-11 à 13 (Dépôt Nos FERM Bp-8011 à 8013) et on procède à une culture par agitation. Après centrifugation de la culture, le surnageant ainsi obtenu est utilisé comme matériau fonctionnel. Ces matériaux fonctionnels sont excellents dans l'activité de SOD (32, 7 à 37, 2 %), l'activité inhibitrice d'ACE (92,0 à 97, 2 %) et l'activité thrombolytique (25,0 FU/g ou plus) et présentent un goût et des propriétés (notamment la stringence) dans l'évaluation sensorielle comme le natto (total : 4 à 5).
PCT/JP2002/003726 2001-08-08 2002-04-15 Materiaux fonctionnels, agonistes sod, hypotensifs et thrombolytiques, leur procede de production et souches microbiennes a utiliser WO2003013565A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-241363 2001-08-08
JP2001241363A JP2002121141A (ja) 2000-08-10 2001-08-08 機能性素材、ｓｏｄ作用剤、血圧降下剤、血栓溶解剤及びその製造方法並びにその製造方法に用いる菌株

Publications (1)

Publication Number Publication Date
WO2003013565A1 true WO2003013565A1 (fr) 2003-02-20

Family

ID=19071820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003726 WO2003013565A1 (fr) 2001-08-08 2002-04-15 Materiaux fonctionnels, agonistes sod, hypotensifs et thrombolytiques, leur procede de production et souches microbiennes a utiliser

Country Status (1)

Country Link
WO (1) WO2003013565A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104274615A (zh) * 2014-09-16 2015-01-14 田清峰 一种治疗高血压的中药组合物及其制备方法
CN104490999A (zh) * 2014-12-08 2015-04-08 黄平县兴且民族民间中草医药科学发展有限责任公司 治疗高血压的中药
CN104606421A (zh) * 2015-02-06 2015-05-13 苏州市天灵中药饮片有限公司 一种治疗高血压的中药组合物及其制备方法

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01180834A (ja) * 1988-01-13 1989-07-18 Nippon Chem Res Kk 血栓溶解剤
JPH04117330A (ja) * 1990-09-07 1992-04-17 Yakult Honsha Co Ltd 血圧降下作用を有する菌体水抽出物を有効成分とする血圧降下剤
JPH05246865A (ja) * 1992-03-04 1993-09-24 Kikkoman Corp ニコチアナミンの製造法及びそれを含有する健康食品
JPH06284872A (ja) * 1991-10-31 1994-10-11 Toyo Hakko:Kk Ｓｏｄ作用を有する健康・美容増進剤、血圧抑制剤及び便秘改良剤
JPH07289281A (ja) * 1994-04-28 1995-11-07 Nichimo Co Ltd アンギオテンシン変換酵素活性阻害物質を含有する生成物およびその製造方法
JPH0853364A (ja) * 1994-08-10 1996-02-27 Nippon Chem Res Kk 注射用血栓溶解剤
JPH0881381A (ja) * 1994-09-09 1996-03-26 Toyo Hakko:Kk Ｓｏｄ作用を有する健康・美容増進剤、血圧抑制剤及び便秘改良剤
JPH08208512A (ja) * 1995-02-03 1996-08-13 Nippon Chem Res Kk 血栓形成阻害剤
JPH09182583A (ja) * 1995-12-29 1997-07-15 Chieko Yatagai プロ−ウロキナーゼ活性化酵素及びその取得法
JPH09309839A (ja) * 1996-05-21 1997-12-02 Hiroyuki Sumi 血小板凝集阻害物質
JP2000229996A (ja) * 1999-02-08 2000-08-22 Toyo Hakko:Kk オクタペプチド、アンギオテンシンｉ変換酵素阻害ペプチド及びその製造方法
JP2001299277A (ja) * 2000-04-21 2001-10-30 Nippon Seibutsu Kagaku Kenkyusho:Kk 納豆菌培養エキス
JP2002065294A (ja) * 2000-09-01 2002-03-05 Hiroyuki Sumi 線溶賦活物質、およびその取得法

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01180834A (ja) * 1988-01-13 1989-07-18 Nippon Chem Res Kk 血栓溶解剤
JPH04117330A (ja) * 1990-09-07 1992-04-17 Yakult Honsha Co Ltd 血圧降下作用を有する菌体水抽出物を有効成分とする血圧降下剤
JPH06284872A (ja) * 1991-10-31 1994-10-11 Toyo Hakko:Kk Ｓｏｄ作用を有する健康・美容増進剤、血圧抑制剤及び便秘改良剤
JPH05246865A (ja) * 1992-03-04 1993-09-24 Kikkoman Corp ニコチアナミンの製造法及びそれを含有する健康食品
JPH07289281A (ja) * 1994-04-28 1995-11-07 Nichimo Co Ltd アンギオテンシン変換酵素活性阻害物質を含有する生成物およびその製造方法
JPH0853364A (ja) * 1994-08-10 1996-02-27 Nippon Chem Res Kk 注射用血栓溶解剤
JPH0881381A (ja) * 1994-09-09 1996-03-26 Toyo Hakko:Kk Ｓｏｄ作用を有する健康・美容増進剤、血圧抑制剤及び便秘改良剤
JPH08208512A (ja) * 1995-02-03 1996-08-13 Nippon Chem Res Kk 血栓形成阻害剤
JPH09182583A (ja) * 1995-12-29 1997-07-15 Chieko Yatagai プロ−ウロキナーゼ活性化酵素及びその取得法
JPH09309839A (ja) * 1996-05-21 1997-12-02 Hiroyuki Sumi 血小板凝集阻害物質
JP2000229996A (ja) * 1999-02-08 2000-08-22 Toyo Hakko:Kk オクタペプチド、アンギオテンシンｉ変換酵素阻害ペプチド及びその製造方法
JP2001299277A (ja) * 2000-04-21 2001-10-30 Nippon Seibutsu Kagaku Kenkyusho:Kk 納豆菌培養エキス
JP2002065294A (ja) * 2000-09-01 2002-03-05 Hiroyuki Sumi 線溶賦活物質、およびその取得法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AKIKO OKAMOTO ET AL.: "Angiotensin I converting enzyme inhibitory activities of various fermented foods", BIOSCI. BIOTECH. BIOCHEM., vol. 59, no. 3, 1995, pages 1147 - 1149, XP002955071 *
HIROYUKI SUMI ET AL.: "Hakko daizu no kassei sanso shokyokei, tokuni SOD-zai to shiteno natto", THE FOOD INDUSTRY, vol. 41, no. 14, 1998, pages 49 - 55, XP002955073 *
YOKO MIYAMOTO ET AL.: "SOD-like activities of rice bran extracts fermentation", NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, vol. 47, no. 3, 2000, pages 214 - 219, XP002955072 *
YOUKOU SUMI ET AL.: "The method of determination of thrombolytic enzyme nattokinese", J. BREW. SOC. JAPAN, vol. 88, no. 6, 1993, pages 482 - 486, XP002955074 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104274615A (zh) * 2014-09-16 2015-01-14 田清峰 一种治疗高血压的中药组合物及其制备方法
CN104490999A (zh) * 2014-12-08 2015-04-08 黄平县兴且民族民间中草医药科学发展有限责任公司 治疗高血压的中药
CN104606421A (zh) * 2015-02-06 2015-05-13 苏州市天灵中药饮片有限公司 一种治疗高血压的中药组合物及其制备方法

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