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WO2003013499A3 - Drugs for vasculopaties - Google Patents

Drugs for vasculopaties Download PDF

Info

Publication number
WO2003013499A3
WO2003013499A3 PCT/EP2002/008374 EP0208374W WO03013499A3 WO 2003013499 A3 WO2003013499 A3 WO 2003013499A3 EP 0208374 W EP0208374 W EP 0208374W WO 03013499 A3 WO03013499 A3 WO 03013499A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
vasculopaties
drugs
aii
vasculopathy
Prior art date
Application number
PCT/EP2002/008374
Other languages
French (fr)
Other versions
WO2003013499A2 (en
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Soldato Piero Del
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa, Soldato Piero Del filed Critical Nicox Sa
Priority to AU2002333276A priority Critical patent/AU2002333276A1/en
Publication of WO2003013499A2 publication Critical patent/WO2003013499A2/en
Publication of WO2003013499A3 publication Critical patent/WO2003013499A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Use for the vasculopathy treatment of compounds or salts thereof, having the following general formula (I): wherein R is the radical of formula (AII), the radicals RAI, R1, and R6 of formula (AII), and the bivalent linking groups B and C of the general (I) being as defined in the invention.
PCT/EP2002/008374 2001-08-09 2002-07-26 Drugs for vasculopaties WO2003013499A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002333276A AU2002333276A1 (en) 2001-08-09 2002-07-26 Drugs for vasculopaties

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI01A001744 2001-08-09
IT2001MI001744A ITMI20011744A1 (en) 2001-08-09 2001-08-09 DRUGS FOR VASCULOPATHIES

Publications (2)

Publication Number Publication Date
WO2003013499A2 WO2003013499A2 (en) 2003-02-20
WO2003013499A3 true WO2003013499A3 (en) 2003-12-31

Family

ID=11448261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008374 WO2003013499A2 (en) 2001-08-09 2002-07-26 Drugs for vasculopaties

Country Status (3)

Country Link
AU (1) AU2002333276A1 (en)
IT (1) ITMI20011744A1 (en)
WO (1) WO2003013499A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432285B2 (en) 1999-12-23 2008-10-07 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103602A2 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
CN100496490C (en) * 2003-07-31 2009-06-10 尼科克斯公司 Nitrooxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-II receptor blockers for the treatment of cardiovascular diseases
WO2005065361A2 (en) 2003-12-31 2005-07-21 Khosrow Kashfi Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
MX2007002210A (en) 2004-08-26 2007-05-07 Nicholas Piramal India Ltd Prodrugs containing novel bio-cleavable linkers.
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
WO2007088123A2 (en) * 2006-02-03 2007-08-09 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
ES2618482T3 (en) 2007-08-10 2017-06-21 Basil Rigas Anti-inflammatory compounds and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004484A1 (en) * 1992-08-20 1994-03-03 Corlay S.L. Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1996032946A1 (en) * 1995-04-19 1996-10-24 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
WO2000025776A1 (en) * 1998-10-30 2000-05-11 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
WO2000051988A1 (en) * 1999-03-02 2000-09-08 Nicox S.A. Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity
WO2000061537A2 (en) * 1999-04-13 2000-10-19 Nicox S.A. Pharmaceutical compounds
WO2001012584A2 (en) * 1999-08-12 2001-02-22 Nicox S.A. Pharmaceutical compounds

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004484A1 (en) * 1992-08-20 1994-03-03 Corlay S.L. Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1996032946A1 (en) * 1995-04-19 1996-10-24 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
WO2000025776A1 (en) * 1998-10-30 2000-05-11 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
WO2000051988A1 (en) * 1999-03-02 2000-09-08 Nicox S.A. Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity
WO2000061537A2 (en) * 1999-04-13 2000-10-19 Nicox S.A. Pharmaceutical compounds
WO2001012584A2 (en) * 1999-08-12 2001-02-22 Nicox S.A. Pharmaceutical compounds

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADAMI A ET AL: "Vasodilating properties of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on rat aortic rings.", PHARMACOLOGICAL RESEARCH: THE OFFICIAL JOURNAL OF THE ITALIAN PHARMACOLOGICAL SOCIETY. ENGLAND 1996 APR-MAY, vol. 33, no. 4-5, April 1996 (1996-04-01), pages 239 - 244, XP001159734, ISSN: 1043-6618 *
FIORUCCI S ET AL: "Nitric oxide-releasing NSAIDs inhibit interleukin-1beta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha.", ALIMENTARY PHARMACOLOGY & THERAPEUTICS, vol. 13, no. 3, March 1999 (1999-03-01), pages 421 - 435, XP002933651, ISSN: 0269-2813 *
JANERO D R: "Nitric oxide (NO)-related pharmaceuticals: Contemporary approaches to therapeutic no modulation", FREE RADICAL BIOLOGY AND MEDICINE 15 MAY 2000 UNITED STATES, vol. 28, no. 10, 15 May 2000 (2000-05-15), pages 1495 - 1506, XP001159735, ISSN: 0891-5849 *
MAFFIA PASQUALE ET AL: "Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis.", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 22, no. 2, February 2002 (2002-02-01), February, 2002, pages 263 - 267, XP001159163, ISSN: 1079-5642 *
MUSCARA MARCELO N ET AL: "Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 279, no. 2 Part 2, August 2000 (2000-08-01), pages H528 - H535, XP008018686, ISSN: 0002-9513 *
NAPOLI CLAUDIO ET AL: "Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 98, no. 5, 27 February 2001 (2001-02-27), February 27, 2001, pages 2860 - 2864, XP001159738, ISSN: 0027-8424 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432285B2 (en) 1999-12-23 2008-10-07 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use

Also Published As

Publication number Publication date
WO2003013499A2 (en) 2003-02-20
AU2002333276A1 (en) 2003-02-24
ITMI20011744A0 (en) 2001-08-09
ITMI20011744A1 (en) 2003-02-09

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