+

WO2003012102A3 - Nucleic acids coding for novel hect domain proteins, their diagnostic and therapeutic uses - Google Patents

Nucleic acids coding for novel hect domain proteins, their diagnostic and therapeutic uses Download PDF

Info

Publication number
WO2003012102A3
WO2003012102A3 PCT/FR2002/002782 FR0202782W WO03012102A3 WO 2003012102 A3 WO2003012102 A3 WO 2003012102A3 FR 0202782 W FR0202782 W FR 0202782W WO 03012102 A3 WO03012102 A3 WO 03012102A3
Authority
WO
WIPO (PCT)
Prior art keywords
domain proteins
hect domain
diagnostic
nucleic acids
novel
Prior art date
Application number
PCT/FR2002/002782
Other languages
French (fr)
Other versions
WO2003012102A2 (en
Inventor
Dominique Thomas
Bruno Sargueil
Frederic Scaerou
Original Assignee
Cytomics Systems
Dominique Thomas
Bruno Sargueil
Frederic Scaerou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytomics Systems, Dominique Thomas, Bruno Sargueil, Frederic Scaerou filed Critical Cytomics Systems
Publication of WO2003012102A2 publication Critical patent/WO2003012102A2/en
Publication of WO2003012102A3 publication Critical patent/WO2003012102A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention concerns novel HECT domain proteins and novel HECT domain protein substrates. The invention provides screening methods for identifying novel HECT protein substrates and for identifying small molecules and drugs which modulate the interaction and/or activity of HECT domain proteins and of their substrates.
PCT/FR2002/002782 2001-08-01 2002-08-01 Nucleic acids coding for novel hect domain proteins, their diagnostic and therapeutic uses WO2003012102A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR01/10364 2001-08-01
FR0110364A FR2828209A1 (en) 2001-08-01 2001-08-01 New nucleic acid encoding HECT-domain polypeptides, useful e.g. for treatment of cancer or inflammation, also new proteins, antibodies and modulators

Publications (2)

Publication Number Publication Date
WO2003012102A2 WO2003012102A2 (en) 2003-02-13
WO2003012102A3 true WO2003012102A3 (en) 2004-04-08

Family

ID=8866216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/002782 WO2003012102A2 (en) 2001-08-01 2002-08-01 Nucleic acids coding for novel hect domain proteins, their diagnostic and therapeutic uses

Country Status (2)

Country Link
FR (1) FR2828209A1 (en)
WO (1) WO2003012102A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1595945A1 (en) * 2004-05-14 2005-11-16 Boehringer Ingelheim International GmbH Screening method for identifying compounds that have the ability to inhibit the activity of Myc
JP4651481B2 (en) * 2005-08-11 2011-03-16 久光製薬株式会社 Method for screening pro-apoptotic compound or anti-apoptotic compound and method for determining malignancy of neurodegenerative disease
WO2007070907A2 (en) * 2005-12-21 2007-06-28 St. Anna Kinderkrebsforschung Therapeutic compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001075067A2 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001075067A2 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 8 September 2000 (2000-09-08), NAKAGAWARA A ET AL: "Homo sapiens NEDL1 mRNA for NEDD4-like ubiquitin ligase 1, complete cds", XP002202670, Database accession no. AB048365 *
HUIBREGTSE J M ET AL: "A FAMILY OF PROTEINS STRUCTURALLY AND FUNCTIONALLY RELATED TO THE E6-AP UBIQUITIN-PROTEIN LIGASE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, 28 March 1995 (1995-03-28), pages 2563 - 2567, XP000611567, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
FR2828209A1 (en) 2003-02-07
WO2003012102A2 (en) 2003-02-13

Similar Documents

Publication Publication Date Title
WO1999053061A3 (en) Tumor associated nucleic acids and uses therefor
WO2002099055A3 (en) Cips as modifiers of the p53 pathway and method of use
WO2003016475A3 (en) Nucleic acid and amino acid sequences involved in pain
AU7494701A (en) Nrg-2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
WO2004092210A3 (en) Molecules having immunomodulatory activity
DE69839444D1 (en) SMAD 6 AND ITS APPLICATIONS
WO2002065134A3 (en) Modulators of p53-p300 interactions and screening methods therefor
WO2004113500A3 (en) B7s1: an immune modulator
WO2003016551A3 (en) Novel salicylic acid-binding protein encoding nucleic acid, sabp2, and methods of use thereof
WO2003027251A3 (en) Novel molecules of the pyrin domain protein family and uses thereof
WO2003012103A3 (en) Nucleic acids coding for novel fbox proteins, their diagnostic and therapeutic uses
WO2003012102A3 (en) Nucleic acids coding for novel hect domain proteins, their diagnostic and therapeutic uses
WO2003070965A8 (en) The eaat2 promoter and uses thereof
WO2002031115A3 (en) Nucleic acid molecules and polypeptides for immune modulation
WO2004089982A3 (en) April variants and methods thereof
WO2002059149A3 (en) Pro-apoptotic proteins and dna molecules encoding them
AU2002258617A1 (en) Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
AP9901510A0 (en) Polypeptides comprising gax protein domains, involved in repressing transcription and or interacting with other proteins corresponding nucleic acids andtheir use.
DE60120187D1 (en) SHORTEN BARD1 PROTEIN AND ITS DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
AU2002323612A1 (en) Novel clark protein and nucleic acid molecules and uses therefor
WO2002074930A3 (en) Trans inteins for protein domain shuffling and biopolymerization
WO2005019446A3 (en) Novel form of protein tyrosine phosphatases and methods for identifying molecules binding thereto
WO2003099209A3 (en) Compositions and methods for screening and identifying anti-hcv agents
AU2002254438A1 (en) Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
AU2002356494A1 (en) Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VN YU ZA ZM

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG US

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载