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WO2003010561A3 - Optical coupler for measuring tissue fluorescence - Google Patents

Optical coupler for measuring tissue fluorescence Download PDF

Info

Publication number
WO2003010561A3
WO2003010561A3 PCT/US2002/023412 US0223412W WO03010561A3 WO 2003010561 A3 WO2003010561 A3 WO 2003010561A3 US 0223412 W US0223412 W US 0223412W WO 03010561 A3 WO03010561 A3 WO 03010561A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
coupler
optical coupler
spectroscope
light
Prior art date
Application number
PCT/US2002/023412
Other languages
French (fr)
Other versions
WO2003010561A2 (en
Inventor
Robert G Messerschmidt
Jim Childs
Pierre Trepagnier
James Mansfield
Jenny E Freeman
Sean Toy
Britton Chance
Original Assignee
Argose Inc
Robert G Messerschmidt
Jim Childs
Pierre Trepagnier
James Mansfield
Jenny E Freeman
Sean Toy
Britton Chance
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argose Inc, Robert G Messerschmidt, Jim Childs, Pierre Trepagnier, James Mansfield, Jenny E Freeman, Sean Toy, Britton Chance filed Critical Argose Inc
Priority to AU2002322606A priority Critical patent/AU2002322606A1/en
Publication of WO2003010561A2 publication Critical patent/WO2003010561A2/en
Publication of WO2003010561A3 publication Critical patent/WO2003010561A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6834—Means for maintaining contact with the body using vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
    • A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The present invention is directed to a device for efficiently optically coupling an area of tissue to a spectroscope. The optical coupler preferably comprises a rigid partial enclosure having an inside wall that reflects electromagnetic radiation, an opening on the enclosure for the passage of light and one or more mirrors and light detector pairs. The coupler may be a component of a tissue spectroscopic system comprising one or more of the coupler, a spectroscope, and interface medium, a detector and a light source. The method involves detecting optical properties of a tissue and preferably the skin.
PCT/US2002/023412 2001-07-25 2002-07-24 Optical coupler for measuring tissue fluorescence WO2003010561A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002322606A AU2002322606A1 (en) 2001-07-25 2002-07-24 Optical coupler for measuring tissue fluorescence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30736801P 2001-07-25 2001-07-25
US60/307,368 2001-07-25

Publications (2)

Publication Number Publication Date
WO2003010561A2 WO2003010561A2 (en) 2003-02-06
WO2003010561A3 true WO2003010561A3 (en) 2003-06-19

Family

ID=23189445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023412 WO2003010561A2 (en) 2001-07-25 2002-07-24 Optical coupler for measuring tissue fluorescence

Country Status (2)

Country Link
AU (1) AU2002322606A1 (en)
WO (1) WO2003010561A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011150919A2 (en) * 2010-06-01 2011-12-08 Mfd Diagnostics Gmbh Optical probe having a probe head and probe ferrule
FI123363B (en) 2011-01-31 2013-03-15 Clothing Plus Holding Oy Substrate of textile for measuring a physical quantity
EP3028587B1 (en) 2014-12-03 2020-03-11 Clothing Plus MBU Oy Device for determining effects of aging of a wearable device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622974A (en) * 1984-03-07 1986-11-18 University Of Tennessee Research Corporation Apparatus and method for in-vivo measurements of chemical concentrations
US4681442A (en) * 1984-05-14 1987-07-21 International Business Machines Corporation Method for surface testing
US5741213A (en) * 1995-10-25 1998-04-21 Toa Medical Electronics Co., Ltd. Apparatus for analyzing blood
US5846513A (en) * 1997-07-08 1998-12-08 Carewise Medical Products Corporation Tumor localization and removal system using penetratable detection probe and removal instrument
US6167290A (en) * 1999-02-03 2000-12-26 Bayspec, Inc. Method and apparatus of non-invasive measurement of human/animal blood glucose and other metabolites

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622974A (en) * 1984-03-07 1986-11-18 University Of Tennessee Research Corporation Apparatus and method for in-vivo measurements of chemical concentrations
US4681442A (en) * 1984-05-14 1987-07-21 International Business Machines Corporation Method for surface testing
US5741213A (en) * 1995-10-25 1998-04-21 Toa Medical Electronics Co., Ltd. Apparatus for analyzing blood
US5846513A (en) * 1997-07-08 1998-12-08 Carewise Medical Products Corporation Tumor localization and removal system using penetratable detection probe and removal instrument
US5846513B1 (en) * 1997-07-08 2000-11-28 Carewise Medical Products Corp Tumor localization and removal system using penetratable detection probe and removal instrument
US6167290A (en) * 1999-02-03 2000-12-26 Bayspec, Inc. Method and apparatus of non-invasive measurement of human/animal blood glucose and other metabolites

Also Published As

Publication number Publication date
WO2003010561A2 (en) 2003-02-06
AU2002322606A1 (en) 2003-02-17

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