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WO2003010324A3 - Process for the preparation of simvastatin - Google Patents

Process for the preparation of simvastatin Download PDF

Info

Publication number
WO2003010324A3
WO2003010324A3 PCT/IN2002/000157 IN0200157W WO03010324A3 WO 2003010324 A3 WO2003010324 A3 WO 2003010324A3 IN 0200157 W IN0200157 W IN 0200157W WO 03010324 A3 WO03010324 A3 WO 03010324A3
Authority
WO
WIPO (PCT)
Prior art keywords
simvastatin
preparation
analogs
host
derivatives
Prior art date
Application number
PCT/IN2002/000157
Other languages
French (fr)
Other versions
WO2003010324A2 (en
Inventor
Anand Ranganathan
Original Assignee
Icgeb
Anand Ranganathan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icgeb, Anand Ranganathan filed Critical Icgeb
Priority to AU2002337601A priority Critical patent/AU2002337601A1/en
Publication of WO2003010324A2 publication Critical patent/WO2003010324A2/en
Publication of WO2003010324A3 publication Critical patent/WO2003010324A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pyrane Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention discloses a method of preparing simvastatin or analogs or derivatives thereof, by biological expression, wherein said method comprises: a) providing a host having a customised gene encoding for a polyketide synthase; b) fermenting the said host to obtain simvastatin or analogs or derivatives thereof.
PCT/IN2002/000157 2001-07-25 2002-07-25 Process for the preparation of simvastatin WO2003010324A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002337601A AU2002337601A1 (en) 2001-07-25 2002-07-25 Process for the preparation of simvastatin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN796/DEL/01 2001-07-25
IN796DE2001 2001-07-25

Publications (2)

Publication Number Publication Date
WO2003010324A2 WO2003010324A2 (en) 2003-02-06
WO2003010324A3 true WO2003010324A3 (en) 2003-08-21

Family

ID=11097092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2002/000157 WO2003010324A2 (en) 2001-07-25 2002-07-25 Process for the preparation of simvastatin

Country Status (2)

Country Link
AU (1) AU2002337601A1 (en)
WO (1) WO2003010324A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060129196A (en) * 2003-10-21 2006-12-15 다이버사 코포레이션 Method for preparing simvastatin and intermediates
RU2447152C2 (en) 2006-05-24 2012-04-10 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Methods and materials for producing simvastatin and related compounds
EP2029760A1 (en) * 2006-06-20 2009-03-04 DSMIP Assets B.V. Method for the production of simvastatin
WO2009056539A1 (en) * 2007-10-30 2009-05-07 Dsm Ip Assets B.V. Fermentative production of simvastatin
US9499803B2 (en) 2009-10-08 2016-11-22 The Regents Of The University Of California Variant LovD polypeptide
IN2012DN03403A (en) 2009-10-08 2015-10-23 Univ California

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037629A2 (en) * 1998-12-18 2000-06-29 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037629A2 (en) * 1998-12-18 2000-06-29 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KENNEDY J ET AL: "Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.", SCIENCE. UNITED STATES 21 MAY 1999, vol. 284, no. 5418, 21 May 1999 (1999-05-21), pages 1368 - 1372, XP002243924, ISSN: 0036-8075 *
MOLNAR I ET AL: "THE BIOSYNTHETIC GENE CLUSTER FOR THE MICROTUBULE-STABILIZING AGENTS EPOTHILONES A AND B FROM SORANGIUM CELLULOSUM SO CE90", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 7, no. 7, February 2000 (2000-02-01), pages 97 - 109, XP000904734, ISSN: 1074-5521 *
OLIYNYK M ET AL: "A hybrid modular polyketide synthase obtained by domain swapping", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 3, no. 10, 1996, pages 833 - 839, XP002045171, ISSN: 1074-5521 *
RANGANATHAN A ET AL: "KNOWLEDGE-BASED DESIGN OF BIMODULAR AND TRIMODULAR POLYKETIDE SYNTHASES BASED ON DOMAIN AND MODULE SWAPS: A ROUTE TO SIMPLE STATIN ANALOGUES", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 6, no. 10, October 1999 (1999-10-01), pages 731 - 741, XP000879061, ISSN: 1074-5521 *
SUTHERLAND A ET AL: "Recent advances in the biosynthetic studies of lovastatin.", CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT. ENGLAND MAR 2001, vol. 4, no. 2, March 2001 (2001-03-01), pages 229 - 236, XP008018200, ISSN: 1367-6733 *

Also Published As

Publication number Publication date
AU2002337601A1 (en) 2003-02-17
WO2003010324A2 (en) 2003-02-06

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