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WO2003010308A3 - Control of gene expression - Google Patents

Control of gene expression Download PDF

Info

Publication number
WO2003010308A3
WO2003010308A3 PCT/GB2002/003336 GB0203336W WO03010308A3 WO 2003010308 A3 WO2003010308 A3 WO 2003010308A3 GB 0203336 W GB0203336 W GB 0203336W WO 03010308 A3 WO03010308 A3 WO 03010308A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
polypeptide
binding portion
molecule
control
Prior art date
Application number
PCT/GB2002/003336
Other languages
French (fr)
Other versions
WO2003010308A2 (en
Inventor
Lakjaya Buluwela
David Holmes
Tahereh Kamalati
Jonathan Waxman
Simak Ali
Original Assignee
Gene Expression Technologies L
Lakjaya Buluwela
David Holmes
Tahereh Kamalati
Jonathan Waxman
Simak Ali
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Expression Technologies L, Lakjaya Buluwela, David Holmes, Tahereh Kamalati, Jonathan Waxman, Simak Ali filed Critical Gene Expression Technologies L
Priority to AU2002317373A priority Critical patent/AU2002317373A1/en
Publication of WO2003010308A2 publication Critical patent/WO2003010308A2/en
Publication of WO2003010308A3 publication Critical patent/WO2003010308A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of suppressing the expression of a selected endogenous gene in a eukaryotic cell the method comprising introducing into the cell (a) a polypeptide comprising a nucleic acid binding portion which binds to a site at or associated with the selected gene and a modifying portion which comprises a polypeptide or peptidomimetic which is capable of modulating covalent modification of nucleic acid or chromatin, for example a chromatin inactivation portion, or (b) a polynucleotide encoding said polypeptide. The binding of the molecule to nucleic acid may be modulated by a ligand and the molecule may comprise a ligand binding portion. The nucleic acid binding portion may be a nucleic acid binding portion of a nuclear receptor DNA binding protein.
PCT/GB2002/003336 2001-07-24 2002-07-19 Control of gene expression WO2003010308A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002317373A AU2002317373A1 (en) 2001-07-24 2002-07-19 Control of gene expression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0117964.7 2001-07-24
GBGB0117964.7A GB0117964D0 (en) 2001-07-24 2001-07-24 Control of gene expression

Publications (2)

Publication Number Publication Date
WO2003010308A2 WO2003010308A2 (en) 2003-02-06
WO2003010308A3 true WO2003010308A3 (en) 2003-05-08

Family

ID=9919042

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/003336 WO2003010308A2 (en) 2001-07-24 2002-07-19 Control of gene expression

Country Status (3)

Country Link
AU (1) AU2002317373A1 (en)
GB (2) GB0117964D0 (en)
WO (1) WO2003010308A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060247192A1 (en) * 2002-12-05 2006-11-02 Jenkinson John D Control of apoptosis
NL1027479C2 (en) * 2004-10-21 2006-05-01 Synvolux Ip B V Protection of biologically active molecules with the help of amphiphiles.
WO2014134567A1 (en) 2013-03-01 2014-09-04 The Regents Of The University Of California Methods and compositions for targeting rna polymerases and non-coding rna biogenesis to specific loci

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002019A2 (en) * 1999-06-30 2001-01-11 Imperial College Innovations Limited Control of gene expression

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2034220A1 (en) * 1990-01-16 1991-07-17 Donald P. Mcdonnell Expression vectors that produce steroid receptors, steroid receptor chimera, screening assays for steroid receptors and clinical assays using synthesized receptors and receptor vector
WO1997011972A1 (en) * 1995-09-28 1997-04-03 The Trustees Of Columbia University In The City Of New York Chimeric dna-binding/dna methyltransferase nucleic acid and polypeptide and uses thereof
CA2316036A1 (en) * 1999-08-27 2001-02-27 Keqiang Wu Repressing gene expression in plants
AU5391401A (en) * 2000-04-28 2001-11-12 Sangamo Biosciences Inc Targeted modification of chromatin structure

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002019A2 (en) * 1999-06-30 2001-01-11 Imperial College Innovations Limited Control of gene expression

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHIEN P-Y ET AL: "A FUSION PROTEIN OF THE ESTROGEN RECEPTOR (ER) AND NUCLEAR RECEPTORCOREPRESSOR (NCOR) STRONGLY INHIBITS ESTROGEN-DEPENDENT RESPONSES IN BREAST CANCER CELLS", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 13, no. 12, December 1999 (1999-12-01), pages 2122 - 2136, XP000978743, ISSN: 0888-8809 *
MANTEUFFEL-CYMBOROWSKA MALGORZATA: "Nuclear receptors, their coactivators and modulation of transcription.", ACTA BIOCHIMICA POLONICA, vol. 46, no. 1, 1999, pages 77 - 89, XP009005858, ISSN: 0001-527X *
RAZIN AHARON: "CpG methylation, chromatin structure and gene silencing - a three-way connection.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 17, no. 17, pages 4905 - 4908, XP002233552, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
AU2002317373A1 (en) 2003-02-17
WO2003010308A2 (en) 2003-02-06
GB2380195A (en) 2003-04-02
GB0216776D0 (en) 2002-08-28
GB0117964D0 (en) 2001-09-19

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