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WO2003010184A3 - A conserved xiap-interaction motif in caspase-9 and smac/diablo for mediating apoptosis - Google Patents

A conserved xiap-interaction motif in caspase-9 and smac/diablo for mediating apoptosis Download PDF

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Publication number
WO2003010184A3
WO2003010184A3 PCT/US2002/003553 US0203553W WO03010184A3 WO 2003010184 A3 WO2003010184 A3 WO 2003010184A3 US 0203553 W US0203553 W US 0203553W WO 03010184 A3 WO03010184 A3 WO 03010184A3
Authority
WO
WIPO (PCT)
Prior art keywords
caspase
diablo
xiap
smac
conserved
Prior art date
Application number
PCT/US2002/003553
Other languages
French (fr)
Other versions
WO2003010184A2 (en
Inventor
Emad S Alnemri
Original Assignee
Univ Jefferson
Emad S Alnemri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson, Emad S Alnemri filed Critical Univ Jefferson
Priority to AU2002253908A priority Critical patent/AU2002253908A1/en
Priority to IL15716802A priority patent/IL157168A0/en
Publication of WO2003010184A2 publication Critical patent/WO2003010184A2/en
Publication of WO2003010184A3 publication Critical patent/WO2003010184A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides caspase-9-related peptides and polypeptides capable of binding to an Inhibitor of Apoptosis Protein (IAP), as well as caspase-9 mutant that fail to undergo normal processing and fail to bind to an IAP. Nucleic acid molecules, including expression vectors, encoding such peptides and polypeptides are also provided. Such peptides and polypeptides, are useful for inducing apoptosis and identifying inhibitors and enhancer of apoptosis.
PCT/US2002/003553 2001-02-08 2002-02-06 A conserved xiap-interaction motif in caspase-9 and smac/diablo for mediating apoptosis WO2003010184A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002253908A AU2002253908A1 (en) 2001-02-08 2002-02-06 A conserved xiap-interaction motif in caspase-9 and smac/diablo for mediating apoptosis
IL15716802A IL157168A0 (en) 2001-04-12 2002-03-28 Method and apparatus for measuring the position, shape, size and intensity distribution of the effective focal spot of an x-ray tube

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26796601P 2001-02-08 2001-02-08
US60/267,966 2001-02-08

Publications (2)

Publication Number Publication Date
WO2003010184A2 WO2003010184A2 (en) 2003-02-06
WO2003010184A3 true WO2003010184A3 (en) 2003-08-14

Family

ID=23020873

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003553 WO2003010184A2 (en) 2001-02-08 2002-02-06 A conserved xiap-interaction motif in caspase-9 and smac/diablo for mediating apoptosis

Country Status (2)

Country Link
AU (1) AU2002253908A1 (en)
WO (1) WO2003010184A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005218555B2 (en) 2004-03-01 2008-01-03 Board Of Regents, The University Of Texas System Dimeric small molecule potentiators of apoptosis
JP5122275B2 (en) 2004-03-23 2013-01-16 ジェネンテック， インコーポレイテッド Azabicyclo-octane inhibitors of IAP
BRPI0511350A (en) 2004-07-02 2007-12-04 Genentech Inc compound, methods for inducing apoptosis in a cell, sensitizing a cell to an apoptotic signal, inhibiting the binding of an iap protein, and treating a disease and cancer, and using a compound.
AU2005319305B2 (en) 2004-12-20 2012-08-23 Genentech, Inc. Pyrrolidine inhibitors of IAP
CN101374829A (en) 2005-12-19 2009-02-25 健泰科生物技术公司 Inhibitors of IAP
KR20090094461A (en) 2006-12-19 2009-09-07 제넨테크, 인크. Imidazopyridine inhibitors of iap
RU2491276C2 (en) 2007-04-30 2013-08-27 Дженентек, Инк. Iap inhibitors
CN102171209A (en) 2008-08-02 2011-08-31 健泰科生物技术公司 Inhibitors of IAP

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE PIR [online] 16 July 1999 (1999-07-16), AHRENS C.A. ET AL., XP002962285, Database accession no. (T10375) *
KIPP R.A. ET AL.: "Molecular targeting of inhibitor of apoptosis based on small molecule mimics of natural binding partners", BIOCHEM., vol. 41, 2002, pages 7344 - 7349, XP002962287 *
LIU Z. ET AL.: "Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain", NATURE, vol. 408, no. 21, 28 December 2000 (2000-12-28), pages 1004 - 1008, XP002909550 *
SRINIVASULA S.M. ET AL.: "A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis", NATURE, vol. 410, 1 March 2001 (2001-03-01), pages 112 - 116, XP002962286 *
VIROLOGY, vol. 229, 1997, pages 381 - 399 *
WRIGHT C.W. ET AL.: "Sequence requirements of Hid binding and apoptosis regulation in the Baculovirus inhibitor of apoptosis OP-IAP", J. BIOL. CHEM., vol. 277, no. 4, 25 January 2002 (2002-01-25), pages 2454 - 2462, XP002962288 *

Also Published As

Publication number Publication date
WO2003010184A2 (en) 2003-02-06
AU2002253908A1 (en) 2003-02-17

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