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WO2003009708A1 - Produit laitier comprenant un sterol non esterifie - Google Patents

Produit laitier comprenant un sterol non esterifie Download PDF

Info

Publication number
WO2003009708A1
WO2003009708A1 PCT/EP2002/007952 EP0207952W WO03009708A1 WO 2003009708 A1 WO2003009708 A1 WO 2003009708A1 EP 0207952 W EP0207952 W EP 0207952W WO 03009708 A1 WO03009708 A1 WO 03009708A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition according
sterol
sts
sterols
composition
Prior art date
Application number
PCT/EP2002/007952
Other languages
English (en)
Inventor
Michel John Arthur Groux
Martin Leser
Alvin Berger
Original Assignee
Societe Des Produits Nestle S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe Des Produits Nestle S.A. filed Critical Societe Des Produits Nestle S.A.
Priority to MXPA04000816A priority Critical patent/MXPA04000816A/es
Publication of WO2003009708A1 publication Critical patent/WO2003009708A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C11/00—Milk substitutes, e.g. coffee whitener compositions
    • A23C11/02—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins
    • A23C11/04—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins containing non-milk fats but no non-milk proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a composition
  • a composition comprising an unesterified sterol and a
  • composition a liquid crystal modifier and a method for production of the composition.
  • cholesterpl concentration which comprises adrninistration or consumption of the
  • a diet low in cholesterol is generally recommended which typically includes fruits, vegetables, and grains, and a
  • flavours associated with these foods In contrast, diets rich in fruits, vegetables, and
  • Sterols which include phytosterols, stanols, esters of stanols, esters of phytosterols,
  • Plant sterols have structures that are similar to cholesterol, but differ by
  • matrices - sterols are able to decrease cholesterol absorption only when solubilized in
  • sterols in the form of crystals are not readily absorbed by the
  • GI gastrointestinal
  • sterols must be in a solubilized form in order
  • composition comprising one or more sterols is described in US patent no. 6190720.
  • the composition has one or more sterols, one or more fats and one or more
  • compositions comprising sterols are not stable and therefore they do not have a long
  • the present invention addresses the problems set out above.
  • sorbitan tristearate STS
  • composition wherein sterols are kept in molecular form for a shelf-life of at least
  • the present invention provides a composition which
  • sorbitan tristearate STS
  • sorbitan monostearate SMS
  • monoglycerides one or more diglycerides
  • PGMS propyleneglycohnonosterate
  • composition therefore has a long shelf life.
  • the composition provides a product having a long shelf life at room
  • the monoglycerides are provided in the form of saturated distilled
  • sterol in the composition More preferably it is about the same amount of sterol by
  • the amount of sterol is about the same amount of sterol by weight.
  • the amount of sterol is about the same amount of sterol by weight.
  • the amount of sterol is about the same amount of sterol by weight.
  • SMS in the mixture is from about 15% to about 35% by weight the total amount of the
  • the amount of SMS in the mixture is
  • amount of PGMS in the mixture is from about 15% to about 35% by weight the total
  • the amount of the mixture of STS and PGMS More preferably, the amount of PGMS in
  • the mixture is about 25% by weight the total amount of the mixture of STS and
  • composition according to the present invention is a composition according to the present invention.
  • the amount of sterol in the composition More preferably it is about the same
  • monoglyceride in the mixture is from about 15% to about 35% by weight the total
  • the amount of saturated distilled monoglyceride in the mixture is about 25% by weight
  • sterol selected from the group consisting of unesterified sterols. More
  • the sterol is selected from the group consisting of unhydrogenated sterols.
  • the sterol is predominantly from soy origin and non-
  • composition according to the present invention is a composition according to the present invention
  • sterol in an amount of about 400mg to about 1200mg per serving, more
  • the milk comprises milk.
  • the milk comprises about 0.8% to about 2.2% by weight
  • fat more preferably 1.58% by weight fat (including emulsifier).
  • fat preferably 1.58% by weight fat (including emulsifier).
  • emulsifier preferably 1.58% by weight fat (including emulsifier).
  • weight milk most preferably about 98.16% by weight milk.
  • the milk is cows milk or milk from another source including soy milk.
  • the milk can be a fat free or low fat aqueous extract including for
  • the oil is a vegetable oil having applicable amounts of mono-
  • the oil comprises rapeseed oil
  • invention comprises from about 0.4% to about 0.8% by weight rapeseed oil, more preferably about 0.5% to about 0.7% by weight rapeseed oil, most preferably about
  • to the present invention comprises from about 0.2% to about 0.5% by weight corn oil,
  • corn oil more preferably about 0.3% to about 0.4% by weight corn oil, most preferably about
  • invention comprises from about 1.5% to about 3.0% by weight water, more preferably
  • weight of milk is increased by a corresponding amount.
  • composition which is, for example, beneficial to bone formation and/ or inhibits
  • composition is optionally flavoured. This provides the
  • the composition includes a sweetener.
  • a sweetener Preferably the
  • sweetener is sugar- although other known sweeteners can be included.
  • one or more oligosaccharides and/or polysaccharides are
  • the polysaccharide(s) provide the advantage that they are capable of
  • suspending insoluble minerals which may also be included, for example calcium
  • prebiotics including promotion of gut health.
  • the invention provides a method for production of the composition
  • an embodiment of a method according to the invention comprises the steps
  • sterol is added to the oily matrix consisting of or comprising
  • STS and the oily matrix is maintained at 80°C.
  • a water phase comprising milk is prewarmed to about 80°C and the oily
  • the oil in water emulsion is kept at 80°C and is not cooled below 80°C until
  • the further processing comprises UHT treatment, preferably followed by
  • composition is cooled and filled following the further processing.
  • Figure 1 shows micro-photographs illustrating the emulsion obtained according to the
  • Figure 2 shows micro-photographs illustrating an emulsion obtained according to the
  • Figure 3 shows a schematic showing an embodiment of a method of the invention
  • Figure 4 shows electronically generated images of microscope slides showing
  • an embodiment of a process according to the invention comprises
  • skimmed milk at a temperature of at least 80°C.
  • the two solution are mixed to form a
  • Non-esterified plant sterols are hydrophobic and remain in crystalline form in low-fat
  • liquid milk and low-fat vegetable oil partly filled liquid milks.
  • emulsifiers and mixing, heating, homogenization, and UHT treatment steps are necessary in order for the emulsifier to stay bound to the plant sterol and keep it in a
  • pelletable material is nevertheless proportional to the amount of
  • non-hydrogenated, non-esterified plant sterols predominately of soybean origin in
  • emulsifiers are 80% pelletable (SWM+O above). Adding STS dramatically decreased
  • Plant sterols in the soluble state are known to effectively inhibit the absorption
  • plant sterols were used as a marker to quantify the amount of material in the pellet.
  • the plant sterols must remain solubilised and
  • solubilised plant sterols in the presence of bile acid, lysophospholipids, and fatty acids
  • sterol crystals have a better chance of being re-solubilised in the gut matrix.
  • Bile Acid Preparation A bile acid solution contained 150 mM sodium chloride and
  • BA bile acid solution
  • concentrations of bile salts were 1.5 times less than the starting concentration in BA.
  • the milk BA solution was incubated at 37°C and agitated at 30 rpm for 1 hour.
  • sterol/STS complex inhibits the absorption of dietary and bilary cholesterol
  • Intestinal cells in culture behave similarly to intestinal cells in the hving organism.
  • Radioactive cholesterol is incubated with intestinal cells, and added plant sterols
  • Emulsifyer and plant sterols were first heated at
  • DMEM fetal calf serum
  • micellar solutions were counted in 2 mL scintillation fluid), and the remainder of the micellar solutions were
  • sterols predominately of soybean origin (plus or minus emulsifier) were added in
  • HBSS 0.5 mL of the plant sterol/bile salt/ lysophosphatidylcholine/ fatty acid/
  • radiolabeled cholesterol mixture was added to the cells for 2 hours at 37 °C in a 10%
  • inhibiting uptake of cholesterol is in fact solubilised plant sterols.
  • Vehicle Subjects consumed 2 x 250 mL per day of a low fat milk containing an
  • This milk contained 0.63% butter oil, 0.56% rapeseed
  • Control milks contained no
  • the sterol-containing milk is referred to as OMS.
  • the sterol-containing milk is referred to as OMS.
  • Table 1 shows the cholesterol absorption in 16 subjects who consumed both control
  • absorption inhibition are expected to be correlated with reductions in LDL cholesterol.
  • Example 1 An example of an embodiment of a composition according to the invention comprises
  • rapeseed oil 0.56%
  • Sterol composition 0.40%
  • milk fat in the composition is 0.63% by weight.
  • water is replaced by an corresponding increased
  • this embodiment provides a stable emulsion
  • compositions having a long shelf life.
  • the known compositions have been found to suffer from not being able to form a stable emulsion during mixing; formation of an emulsion which

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Dairy Products (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne une composition comprenant un stérol non estérifié et un modificateur cristallin qui renferme un tristéarate de sorbitane (STS). Des modes de réalisations préférés comprennent un composé supplémentaire sélectionné dans le groupe constitué par un monostéarate de sorbitane (SMS), au moins un monoglycéride, au moins un diglycéride, des propylèneglycolmonostérates (PGMS) ou une combinaison d'au moins deux des composés précités. La composition est stable, possède une longue durée de conservation et les stérols de ladite composition ne se recristallisent pas. On peut utiliser cette composition pour abaisser les niveaux de cholestérol LDL.
PCT/EP2002/007952 2001-07-26 2002-07-16 Produit laitier comprenant un sterol non esterifie WO2003009708A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MXPA04000816A MXPA04000816A (es) 2001-07-26 2002-07-16 Producto lacteo que comprende esterol no esterificado.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0118225.2A GB0118225D0 (en) 2001-07-26 2001-07-26 Milk product comprising unesterfied sterol
GB0118225.2 2001-07-26

Publications (1)

Publication Number Publication Date
WO2003009708A1 true WO2003009708A1 (fr) 2003-02-06

Family

ID=9919228

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007952 WO2003009708A1 (fr) 2001-07-26 2002-07-16 Produit laitier comprenant un sterol non esterifie

Country Status (4)

Country Link
CN (1) CN100334958C (fr)
GB (1) GB0118225D0 (fr)
MX (1) MXPA04000816A (fr)
WO (1) WO2003009708A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056188A1 (fr) * 2002-12-20 2004-07-08 Angel Technology Limited Produit de fromage de substitution et procede de preparation d'un tel produit
WO2004066753A1 (fr) * 2003-01-29 2004-08-12 Nestec S.A. Produit laitier sous forme de poudre comprenant un sterol non esterifie
US11576397B2 (en) 2016-02-05 2023-02-14 Conopco, Inc. Frozen confection

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1025276A (fr) * 1973-08-15 1978-01-31 Canada Packers Limited Matieres grasses molles stabilisees derivees d'huile de canbra hydrogenee
WO1999043218A1 (fr) * 1998-02-27 1999-09-02 Spice Sciences Oy Procede de production d'un melange gras
WO2000033669A1 (fr) * 1998-12-08 2000-06-15 Arla Fou Preparation de produits alimentaires reduisant le cholesterol par melangeage de sterols/stanols d'origine vegetale dans un emulsifiant alimentaire fondu
WO2001032029A2 (fr) * 1999-11-03 2001-05-10 Forbes Medi-Tech Inc. Compositions contenant des huiles ou des graisses comestibles ainsi que des phytostérols et/ou des phytostanols sensiblement dissous, procédé de production de ces compositions et leurs applications dans le traitement ou la prévention de maladies cardio-vasculaires et de leurs atteintes sous-jacentes
EP1142494A1 (fr) * 2000-04-06 2001-10-10 Kraft Foods, Inc. Microbroyage de stéroles de plantes et d'émulsifiants
US20020064548A1 (en) * 2000-09-30 2002-05-30 Won-Tae Yoon Method for dispersing plant sterol in aqueous phase and plant sterol-dispersed beverages

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2325336C (fr) * 1999-11-12 2004-10-05 Kraft Foods, Inc. Micromalaxage de sterols vegetaux et d'emulsifiants

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1025276A (fr) * 1973-08-15 1978-01-31 Canada Packers Limited Matieres grasses molles stabilisees derivees d'huile de canbra hydrogenee
WO1999043218A1 (fr) * 1998-02-27 1999-09-02 Spice Sciences Oy Procede de production d'un melange gras
WO2000033669A1 (fr) * 1998-12-08 2000-06-15 Arla Fou Preparation de produits alimentaires reduisant le cholesterol par melangeage de sterols/stanols d'origine vegetale dans un emulsifiant alimentaire fondu
WO2001032029A2 (fr) * 1999-11-03 2001-05-10 Forbes Medi-Tech Inc. Compositions contenant des huiles ou des graisses comestibles ainsi que des phytostérols et/ou des phytostanols sensiblement dissous, procédé de production de ces compositions et leurs applications dans le traitement ou la prévention de maladies cardio-vasculaires et de leurs atteintes sous-jacentes
EP1142494A1 (fr) * 2000-04-06 2001-10-10 Kraft Foods, Inc. Microbroyage de stéroles de plantes et d'émulsifiants
US20020064548A1 (en) * 2000-09-30 2002-05-30 Won-Tae Yoon Method for dispersing plant sterol in aqueous phase and plant sterol-dispersed beverages

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE FSTA [online] INTERNATIONAL FOOD INFORMATION SERVICE (IFIS), FRANFURT/MAIN, DE; MAGEE E L JR: "Microencapsulation of cheese ripening systems in milkfat.", XP002218910, Database accession no. 81-3-03-p0537 *
DATABASE WPI Section Ch Week 197807, Derwent World Patents Index; Class D13, AN 1978-12382A, XP002218912 *
DATABASE WPI Section Ch Week 199246, Derwent World Patents Index; Class D13, AN 1992-379500, XP002218911, GRINDSTED PROD AS: "Anti-crystallisers for cooking oil - comprises blend of sorbitan tri:stearate and lecithin" *
DISSERTATION ABSTRACTS INTERNATIONAL, B 2103: ORDER NO. 79-18157, 175PP. 1979 UNIV. OF WISCONSIN, MADISON, WISCONSIN 53706, USA, vol. 40, no. 5 *
RESEARCH DISCLOSURE, vol. 342, no. 077, 10 October 1992 (1992-10-10), Emsworth, GB *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056188A1 (fr) * 2002-12-20 2004-07-08 Angel Technology Limited Produit de fromage de substitution et procede de preparation d'un tel produit
WO2004066753A1 (fr) * 2003-01-29 2004-08-12 Nestec S.A. Produit laitier sous forme de poudre comprenant un sterol non esterifie
US11576397B2 (en) 2016-02-05 2023-02-14 Conopco, Inc. Frozen confection

Also Published As

Publication number Publication date
GB0118225D0 (en) 2001-09-19
CN1713826A (zh) 2005-12-28
MXPA04000816A (es) 2004-05-21
CN100334958C (zh) 2007-09-05

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