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WO2003009750A3 - System and method for determining brain oxygenation - Google Patents

System and method for determining brain oxygenation Download PDF

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Publication number
WO2003009750A3
WO2003009750A3 PCT/US2002/023592 US0223592W WO03009750A3 WO 2003009750 A3 WO2003009750 A3 WO 2003009750A3 US 0223592 W US0223592 W US 0223592W WO 03009750 A3 WO03009750 A3 WO 03009750A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood vessel
oxygenation
retinal blood
reflectance
subject
Prior art date
Application number
PCT/US2002/023592
Other languages
French (fr)
Other versions
WO2003009750A2 (en
Inventor
Michael Henry Brill
Christopher C Gregory
Original Assignee
Sarnoff Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarnoff Corp filed Critical Sarnoff Corp
Publication of WO2003009750A2 publication Critical patent/WO2003009750A2/en
Publication of WO2003009750A3 publication Critical patent/WO2003009750A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/489—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Vascular Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

A method for determining a blood oxygenation associated with a brain of a subject, the method includes scanning a retina of the subject to identify at least one retinal blood vessel using at least a first optical energy source. In response to the identifying, identified retinal blood vessel is selectively flashed using at least a second optical energy source. At least one reflectance is detected from the flashed retinal blood vessel, and a ratio being indicative of the oxygenation using the detected at least one reflectance is determined.
PCT/US2002/023592 2001-07-25 2002-07-25 System and method for determining brain oxygenation WO2003009750A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30776101P 2001-07-25 2001-07-25
US60/307,761 2001-07-25

Publications (2)

Publication Number Publication Date
WO2003009750A2 WO2003009750A2 (en) 2003-02-06
WO2003009750A3 true WO2003009750A3 (en) 2003-10-16

Family

ID=23191073

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023592 WO2003009750A2 (en) 2001-07-25 2002-07-25 System and method for determining brain oxygenation

Country Status (1)

Country Link
WO (1) WO2003009750A2 (en)

Cited By (22)

* Cited by examiner, † Cited by third party
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US7477924B2 (en) 2006-05-02 2009-01-13 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7483731B2 (en) 2005-09-30 2009-01-27 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7486979B2 (en) 2005-09-30 2009-02-03 Nellcor Puritan Bennett Llc Optically aligned pulse oximetry sensor and technique for using the same
US7499740B2 (en) 2004-02-25 2009-03-03 Nellcor Puritan Bennett Llc Techniques for detecting heart pulses and reducing power consumption in sensors
US7522948B2 (en) 2006-05-02 2009-04-21 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7555327B2 (en) 2005-09-30 2009-06-30 Nellcor Puritan Bennett Llc Folding medical sensor and technique for using the same
US7574245B2 (en) 2006-09-27 2009-08-11 Nellcor Puritan Bennett Llc Flexible medical sensor enclosure
US7574244B2 (en) 2005-08-08 2009-08-11 Nellcor Puritan Bennett Llc Compliant diaphragm medical sensor and technique for using the same
US7590439B2 (en) 2005-08-08 2009-09-15 Nellcor Puritan Bennett Llc Bi-stable medical sensor and technique for using the same
US7684842B2 (en) 2006-09-29 2010-03-23 Nellcor Puritan Bennett Llc System and method for preventing sensor misuse
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8265724B2 (en) 2007-03-09 2012-09-11 Nellcor Puritan Bennett Llc Cancellation of light shunting
US8280469B2 (en) 2007-03-09 2012-10-02 Nellcor Puritan Bennett Llc Method for detection of aberrant tissue spectra
US8600469B2 (en) 2005-09-29 2013-12-03 Covidien Lp Medical sensor and technique for using the same
US8838210B2 (en) 2006-06-29 2014-09-16 AccuView, Inc. Scanned laser vein contrast enhancer using a single laser
US8965473B2 (en) 2005-09-29 2015-02-24 Covidien Lp Medical sensor for reducing motion artifacts and technique for using the same
US9042966B2 (en) 2006-01-10 2015-05-26 Accuvein, Inc. Three dimensional imaging of veins
US9061109B2 (en) 2009-07-22 2015-06-23 Accuvein, Inc. Vein scanner with user interface
US9345427B2 (en) 2006-06-29 2016-05-24 Accuvein, Inc. Method of using a combination vein contrast enhancer and bar code scanning device
US9430819B2 (en) 2007-06-28 2016-08-30 Accuvein, Inc. Automatic alignment of a contrast enhancement system
US9492117B2 (en) 2006-01-10 2016-11-15 Accuvein, Inc. Practitioner-mounted micro vein enhancer
US12295744B2 (en) 2023-04-18 2025-05-13 Accuvein, Inc. Micro vein enhancer with two lasers and two optical detectors configured for removing surface topology

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US11278240B2 (en) 2006-01-10 2022-03-22 Accuvein, Inc. Trigger-actuated laser vein contrast enhancer
US9854977B2 (en) 2006-01-10 2018-01-02 Accuvein, Inc. Scanned laser vein contrast enhancer using a single laser, and modulation circuitry
US8255040B2 (en) 2006-06-29 2012-08-28 Accuvein, Llc Micro vein enhancer
US10813588B2 (en) 2006-01-10 2020-10-27 Accuvein, Inc. Micro vein enhancer
US10238294B2 (en) 2006-06-29 2019-03-26 Accuvein, Inc. Scanned laser vein contrast enhancer using one laser
US11253198B2 (en) 2006-01-10 2022-02-22 Accuvein, Inc. Stand-mounted scanned laser vein contrast enhancer
US12089951B2 (en) 2006-01-10 2024-09-17 AccuVeiw, Inc. Scanned laser vein contrast enhancer with scanning correlated to target distance
US8244333B2 (en) 2006-06-29 2012-08-14 Accuvein, Llc Scanned laser vein contrast enhancer
US8594770B2 (en) 2006-06-29 2013-11-26 Accuvein, Inc. Multispectral detection and presentation of an object's characteristics
US8463364B2 (en) 2009-07-22 2013-06-11 Accuvein Inc. Vein scanner
US9895068B2 (en) 2008-06-30 2018-02-20 Covidien Lp Pulse oximeter with wait-time indication
US9072426B2 (en) 2012-08-02 2015-07-07 AccuVein, Inc Device for detecting and illuminating vasculature using an FPGA
US10376147B2 (en) 2012-12-05 2019-08-13 AccuVeiw, Inc. System and method for multi-color laser imaging and ablation of cancer cells using fluorescence
JP7230052B2 (en) * 2017-12-06 2023-02-28 ジリア，インコーポレイテッド Spectral reflectance interferometry system and method with pointer mode for combined imaging and spectroscopic analysis
CN117322876A (en) * 2023-10-27 2024-01-02 广东省人民医院 Cerebral oxygen supply and demand monitoring system, method and medium based on artery and vein parameters of neck

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308919A (en) * 1992-04-27 1994-05-03 Minnich Thomas E Method and apparatus for monitoring the arteriovenous oxygen difference from the ocular fundus
DE4433827A1 (en) * 1994-09-22 1996-03-28 Univ Schiller Jena Measuring substance parameters in material layer, esp. in vivo oxygen saturation in optically accessible blood containing structure
US5935076A (en) * 1997-02-10 1999-08-10 University Of Alabama In Huntsville Method and apparatus for accurately measuring the transmittance of blood within a retinal vessel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808091A (en) 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308919A (en) * 1992-04-27 1994-05-03 Minnich Thomas E Method and apparatus for monitoring the arteriovenous oxygen difference from the ocular fundus
DE4433827A1 (en) * 1994-09-22 1996-03-28 Univ Schiller Jena Measuring substance parameters in material layer, esp. in vivo oxygen saturation in optically accessible blood containing structure
US5935076A (en) * 1997-02-10 1999-08-10 University Of Alabama In Huntsville Method and apparatus for accurately measuring the transmittance of blood within a retinal vessel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHUTATAPE O ET AL: "Retinal blood vessel detection and tracking by matched Gaussian and Kalman filters", ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, 1998. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE HONG KONG, CHINA 29 OCT.-1 NOV. 1998, PISCATAWAY, NJ, USA,IEEE, US, 29 October 1998 (1998-10-29), pages 3144 - 3149, XP010320817, ISBN: 0-7803-5164-9 *

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7499740B2 (en) 2004-02-25 2009-03-03 Nellcor Puritan Bennett Llc Techniques for detecting heart pulses and reducing power consumption in sensors
US7590439B2 (en) 2005-08-08 2009-09-15 Nellcor Puritan Bennett Llc Bi-stable medical sensor and technique for using the same
US7574244B2 (en) 2005-08-08 2009-08-11 Nellcor Puritan Bennett Llc Compliant diaphragm medical sensor and technique for using the same
US8600469B2 (en) 2005-09-29 2013-12-03 Covidien Lp Medical sensor and technique for using the same
US8965473B2 (en) 2005-09-29 2015-02-24 Covidien Lp Medical sensor for reducing motion artifacts and technique for using the same
US7555327B2 (en) 2005-09-30 2009-06-30 Nellcor Puritan Bennett Llc Folding medical sensor and technique for using the same
US7486979B2 (en) 2005-09-30 2009-02-03 Nellcor Puritan Bennett Llc Optically aligned pulse oximetry sensor and technique for using the same
US7483731B2 (en) 2005-09-30 2009-01-27 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US9492117B2 (en) 2006-01-10 2016-11-15 Accuvein, Inc. Practitioner-mounted micro vein enhancer
US9125629B2 (en) 2006-01-10 2015-09-08 Accuvein, Inc. Vial-mounted micro vein enhancer
US9044207B2 (en) 2006-01-10 2015-06-02 Accuvein, Inc. Micro vein enhancer for use with a vial holder
US9042966B2 (en) 2006-01-10 2015-05-26 Accuvein, Inc. Three dimensional imaging of veins
US7477924B2 (en) 2006-05-02 2009-01-13 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7522948B2 (en) 2006-05-02 2009-04-21 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US9226664B2 (en) 2006-06-29 2016-01-05 Accuvein, Inc. Scanned laser vein contrast enhancer using a single laser
US8838210B2 (en) 2006-06-29 2014-09-16 AccuView, Inc. Scanned laser vein contrast enhancer using a single laser
US9345427B2 (en) 2006-06-29 2016-05-24 Accuvein, Inc. Method of using a combination vein contrast enhancer and bar code scanning device
US9186063B2 (en) 2006-06-29 2015-11-17 Accu Vein, Inc. Scanned laser vein contrast enhancer using one laser for a detection mode and a display mode
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8315685B2 (en) 2006-09-27 2012-11-20 Nellcor Puritan Bennett Llc Flexible medical sensor enclosure
US7574245B2 (en) 2006-09-27 2009-08-11 Nellcor Puritan Bennett Llc Flexible medical sensor enclosure
US7684842B2 (en) 2006-09-29 2010-03-23 Nellcor Puritan Bennett Llc System and method for preventing sensor misuse
US8265724B2 (en) 2007-03-09 2012-09-11 Nellcor Puritan Bennett Llc Cancellation of light shunting
US8280469B2 (en) 2007-03-09 2012-10-02 Nellcor Puritan Bennett Llc Method for detection of aberrant tissue spectra
US9430819B2 (en) 2007-06-28 2016-08-30 Accuvein, Inc. Automatic alignment of a contrast enhancement system
US11847768B2 (en) 2007-06-28 2023-12-19 Accuvein Inc. Automatic alignment of a contrast enhancement system
US9061109B2 (en) 2009-07-22 2015-06-23 Accuvein, Inc. Vein scanner with user interface
US12295744B2 (en) 2023-04-18 2025-05-13 Accuvein, Inc. Micro vein enhancer with two lasers and two optical detectors configured for removing surface topology

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