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WO2003008986A2 - Radiotherapie irm et verification de la position - Google Patents

Radiotherapie irm et verification de la position Download PDF

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Publication number
WO2003008986A2
WO2003008986A2 PCT/GB2002/003339 GB0203339W WO03008986A2 WO 2003008986 A2 WO2003008986 A2 WO 2003008986A2 GB 0203339 W GB0203339 W GB 0203339W WO 03008986 A2 WO03008986 A2 WO 03008986A2
Authority
WO
WIPO (PCT)
Prior art keywords
radiation therapy
mri
linear accelerator
therapy apparatus
position verification
Prior art date
Application number
PCT/GB2002/003339
Other languages
English (en)
Other versions
WO2003008986A3 (fr
Inventor
Jan Jacob Wouter Lagendijk
Original Assignee
Elekta Ab (Publ)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elekta Ab (Publ) filed Critical Elekta Ab (Publ)
Priority to AU2002319457A priority Critical patent/AU2002319457A1/en
Publication of WO2003008986A2 publication Critical patent/WO2003008986A2/fr
Publication of WO2003008986A3 publication Critical patent/WO2003008986A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1055—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using magnetic resonance imaging [MRI]

Definitions

  • This invention relates to improvements in radiotherapy techniques and position verification in radiotherapy.
  • the invention relates to the use of Magnetic Resonance Imaging (MRI) in radiotherapy and position verification.
  • MRI Magnetic Resonance Imaging
  • Existing radiotherapy treatments are commonly carried out be means of a linear accelerator which bombards cancerous tissues with high energy X-rays or electron beams to inhibit growth and spreading of the malignant tissues.
  • An essential parameter monitored in existing radiotherapy treatments is the exact daily position and extension of the target volume of tissue, including variations in position and size both during the treatment session and throughout the whole treatment course. Tumour control probability analyses indicate that dose escalation, which can be performed in case of an exactly known tumour position, may greatly enhance tumour control.
  • the positioning problems can be solved with invasive radio opaque markers inside the tumour, which are visible on amorphous silicon flat panel megavoltage imaging.
  • invasive radio opaque markers inside the tumour, which are visible on amorphous silicon flat panel megavoltage imaging.
  • markers gold seeds of 1.0 mm diameter and 5 mm length used for prostate position verification as reported by Nederveen et al in Phys. Med. Biol. 46(4), 2001, 1219-30.
  • CT computed to position verification
  • Major disadvantages of the use of integrated CT for daily radiotherapy position verification are the inherent slow data acquisition (gantry rotation), the inferior soft-tissue visibility and the 2D, transversal slide, imaging.
  • MRI is commonly used in the 3 dimensional imaging of soft tissues such as the brain and spinal cord to detect abnormalities without the need to expose the subject to harmful radiation such as X-rays.
  • the present invention aims to alleviate at least some of the problems identified for the prior art radiotherapy apparatus and methods in this technical field.
  • a radiation therapy apparatus comprising a magnetic resonance imaging device integrated with a linear accelerator.
  • the apparatus is configured such that magnetic imaging device and linear accelerator may be operated both independently and simultaneously.
  • the magnetic imaging device and linear accelerator are so integrated such that they share an isocentre.
  • the linear accelerator as a 6-10mV accelerator, though other accelerator systems may be used and may be preferable depending on the application.
  • MRI is ideal for on-line position verification during radiotherapy.
  • MRI is able to make fast 2D images of soft tissues with orientation along and perpendicular to the field axis, allowing imaging at critical locations which are predefined during the treatment planning procedure.
  • One solution includes MRI system integrated with a 6-10MV accelerator, both using the same isocentre.
  • the MRI could be of an open ring configuration or a drum configuration.
  • Open system may require more sophisticated engineering but may provide benefits to the subject in providing for less intimidating, more comfortable treatment.
  • an open ring MRI system is integrated with a rotating linear accelerator mounted on an additional ring.
  • the additional ring may also support a beam stopper and a megavoltage imaging system.
  • a preferred and probably more economical design solution may use a closed drum design based on the conventional drum MRI design.
  • the beam must pass through the wall of the cryostat. This will produce beam attenuation and some scatter radiation, however, the inventors calculations indicate that such attenuation and scatter are within acceptable limits for a total wall thickness of up to about 6 cm aluminium.
  • the cryostat wall is suitably designed such that the total radiation thickness of the wall is uniform
  • Active magnetic shielding in the integrated system may provide a minimal field strength at the midplane around the MRI magnet. This active shielding can prevent magnetic distortion of the accelerator tube and will also assist in minimising disturbance of the other accelerator systems in the close proximity of the MRI system. Inclusion of the active shielding results in a system necessarily of wider diameter than a conventional system and thus in a larger distance between isocentre and focus.
  • the accelerator tube is positioned in the midplane of the magnet touching the magnet surface.
  • Figure 1 illustrates an open ring type embodiment of the invention
  • Figure 2 illustrates a closed drum type embodiment of the invention
  • Figure 3 shows a sketch of an embodiment similar to that of Figure 2.
  • an open ring arrangement comprises 3 rings 1, 2 and 3 arranged linearly along a common centre and slightly spaced apart.
  • a table 4 is arranged slightly below the centre line of the rings and in parallel therewith.
  • a subject 5 lies on the table 4, encircled by the rings 1 ,2 and 3 for treatment.
  • Rings 1 and 3 represent to MRI system, whilst ring 2 incorporates the linear accelerator.
  • the table 4 is moveable linearly through the rings 1 , 2 and 3 so that the subject tissue may be located, imaged and treated.
  • the MRI rings 1 and 3 create an imaging volume which encompasses the accelerator isocentre of ring 2.
  • FIG. 2 illustrates a closed drum arrangement of the invention.
  • the drum comprises two main portions, an outer portion 22 which incorporates the linear accelerator and an inner portion 21 incorporating the MR imaging system.
  • a common bore 20 extends concentrically through the centre of the two cylindrical portions 23, 21.
  • a table 24 is positioned within the bore, slightly below the centre, and is slideable into and out of the bore 20.
  • Figure 3 shows a more detailed outline sketch of an embodiment of the form shown in Figure 2.
  • the arrangement comprises outer portion 32 which incorporates the linear accelerator having a head including an X-ray gun 39, tube 38 magnet 36 and focus 37.
  • the inner portion 31 of the drum consists of the MR imaging system and surrounds a central bore 30, common to both the MRI and accelerator which share a common isocentre 41.
  • the line 40 indicates the typical floor level relative to the apparatus.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Radiation-Therapy Devices (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

L'invention porte sur un système d'imagerie par résonance magnétique (IRM) intégré avec un accélérateur linéaire afin de vérifier la position en ligne. Cette intégration d'un système IRM avec un accélérateur linéaire permet d'administrer des traitements améliorés en radiothérapie par le biais d'une exposition réduite à un rayonnement nocif du patient, une imagerie 3-D meilleure des tumeurs et une acquisition plus rapide des données en vue de la vérification de la position quotidienne en radiothérapie.
PCT/GB2002/003339 2001-07-20 2002-07-22 Radiotherapie irm et verification de la position WO2003008986A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002319457A AU2002319457A1 (en) 2001-07-20 2002-07-22 Mri in guided radiotherapy and position verification

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0117730A GB2382512A (en) 2001-07-20 2001-07-20 MRI in guided radiotherapy and position verification
GB0117730.2 2001-07-20

Publications (2)

Publication Number Publication Date
WO2003008986A2 true WO2003008986A2 (fr) 2003-01-30
WO2003008986A3 WO2003008986A3 (fr) 2003-04-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/003339 WO2003008986A2 (fr) 2001-07-20 2002-07-22 Radiotherapie irm et verification de la position

Country Status (3)

Country Link
AU (1) AU2002319457A1 (fr)
GB (1) GB2382512A (fr)
WO (1) WO2003008986A2 (fr)

Cited By (45)

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GB2393373A (en) * 2002-09-13 2004-03-24 Elekta Ab MRI in guided radiotherapy and position verification
DE102007060189A1 (de) 2007-12-14 2009-02-19 Siemens Ag Strahlentherapievorrichtung und Verfahren zur Steuerung einer Strahlentherapievorrichtung
DE102007054324A1 (de) 2007-11-14 2009-06-04 Siemens Ag Einrichtung zur Strahlentherapie unter Bildüberwachung
US7907987B2 (en) 2004-02-20 2011-03-15 University Of Florida Research Foundation, Inc. System for delivering conformal radiation therapy while simultaneously imaging soft tissue
EP2353647A1 (fr) 2010-02-10 2011-08-10 Siemens Aktiengesellschaft Dispositif doté d'une combinaison à partir d'un dispositif à résonance magnétique et d'un dispositif de thérapie par rayonnement
EP2359905A1 (fr) * 2010-02-12 2011-08-24 Elekta AB (PUBL) Radiothérapie et appareil d'imagerie
EP2359906A1 (fr) * 2010-02-12 2011-08-24 Elekta AB (PUBL) Radiothérapie et appareil d'imagerie
DE102010001746A1 (de) 2010-02-10 2011-09-22 Siemens Aktiengesellschaft Vorrichtung mit einer Kombination aus einer Magnetresonanzvorrichtung und einer Strahlentherapievorrichtung
GB2491363A (en) * 2011-05-31 2012-12-05 Elekta Ab Radiotherapeutic apparatus with MRI and slip rings
EP2535086A1 (fr) 2011-06-15 2012-12-19 Imris Inc. Intégration d'IRM dans un traitement de radiothérapie
CN103800009A (zh) * 2012-11-12 2014-05-21 英国西门子公司 组合的磁共振成像和放射治疗系统
EP2774537A1 (fr) 2013-03-08 2014-09-10 Imris Inc. Alignement de patient dans une radiothérapie guidée par IRM
DE102013205211A1 (de) 2013-03-25 2014-10-09 Siemens Aktiengesellschaft Strahlentherapiebehandlungseinrichtung mit Bildaufnahmeeinrichtung und Bestrahlungseinrichtung sowie Verfahren zur Strahlentherapie
US9333375B2 (en) 2013-10-28 2016-05-10 Elekta Ab (Publ) Image guided radiation therapy apparatus
US9423477B2 (en) 2010-02-24 2016-08-23 Viewray Technologies, Inc. Split magnetic resonance imaging system
US9472000B2 (en) 2009-06-19 2016-10-18 Viewray Technologies, Inc. System and method for performing tomographic image acquisition and reconstruction
US9599687B2 (en) 2011-12-13 2017-03-21 Viewray Technologies, Inc. Active resistive shimming for MRI devices
US9630025B2 (en) 2005-07-25 2017-04-25 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9669238B2 (en) 2010-12-08 2017-06-06 Elekta Ab (Publ) Radiotherapeutic apparatus
US9675271B2 (en) 2013-03-13 2017-06-13 Viewray Technologies, Inc. Systems and methods for radiotherapy with magnetic resonance imaging
US9700741B2 (en) 2013-10-28 2017-07-11 Elekta Ab (Publ) Image guided radiation therapy apparatus
US9889318B2 (en) 2012-10-26 2018-02-13 Viewray Technologies, Inc. Assessment and improvement of treatment using imaging of physiological responses to radiation therapy
US9901750B2 (en) 2002-12-18 2018-02-27 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
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USRE46953E1 (en) 2007-04-20 2018-07-17 University Of Maryland, Baltimore Single-arc dose painting for precision radiation therapy
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US10433729B2 (en) 2013-06-06 2019-10-08 Koninklijke Philips N.V. RF shielded exam room of a magnetic resonance imaging system
US10463884B2 (en) 2013-03-15 2019-11-05 Viewray Technologies, Inc. Systems and methods for linear accelerator radiotherapy with magnetic resonance imaging
US10463883B2 (en) 2009-07-15 2019-11-05 Viewray Technologies, Inc. Method and apparatus for shielding a linear accelerator and a magnetic resonance imaging device from each other
US10561861B2 (en) 2012-05-02 2020-02-18 Viewray Technologies, Inc. Videographic display of real-time medical treatment
EP3610922A2 (fr) 2018-08-15 2020-02-19 Elekta Limited Support ajustable
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GB2393373A (en) * 2002-09-13 2004-03-24 Elekta Ab MRI in guided radiotherapy and position verification
US9901750B2 (en) 2002-12-18 2018-02-27 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US11344748B2 (en) 2002-12-18 2022-05-31 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US11497937B2 (en) 2004-02-20 2022-11-15 University Of Florida Research Foundation, Inc. System for delivering conformal radiation therapy while simultaneously imaging soft tissue
US7907987B2 (en) 2004-02-20 2011-03-15 University Of Florida Research Foundation, Inc. System for delivering conformal radiation therapy while simultaneously imaging soft tissue
US10688319B2 (en) 2004-02-20 2020-06-23 University Of Florida Research Foundation, Inc. System for delivering conformal radiation therapy while simultaneously imaging soft tissue
US9687674B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US11642027B2 (en) 2005-07-25 2023-05-09 Siemens Healthineers International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687677B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687673B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687678B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9788783B2 (en) 2005-07-25 2017-10-17 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9764159B2 (en) 2005-07-25 2017-09-19 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9630025B2 (en) 2005-07-25 2017-04-25 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687675B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US10595774B2 (en) 2005-07-25 2020-03-24 Varian Medical Systems International Methods and apparatus for the planning and delivery of radiation treatments
US9687676B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
USRE46953E1 (en) 2007-04-20 2018-07-17 University Of Maryland, Baltimore Single-arc dose painting for precision radiation therapy
DE102007054324A1 (de) 2007-11-14 2009-06-04 Siemens Ag Einrichtung zur Strahlentherapie unter Bildüberwachung
US8788016B2 (en) 2007-11-14 2014-07-22 Siemens Aktiengesellschaft Device for radiation therapy under image monitoring
DE102007060189A1 (de) 2007-12-14 2009-02-19 Siemens Ag Strahlentherapievorrichtung und Verfahren zur Steuerung einer Strahlentherapievorrichtung
US10183176B2 (en) 2008-12-12 2019-01-22 Koninklijke Philips N.V. Therapeutic apparatus
US9472000B2 (en) 2009-06-19 2016-10-18 Viewray Technologies, Inc. System and method for performing tomographic image acquisition and reconstruction
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US10918887B2 (en) 2009-07-15 2021-02-16 Viewray Technologies, Inc. Method and apparatus for shielding a linear accelerator and a magnetic resonance imaging device from each other
US11452463B2 (en) 2009-07-15 2022-09-27 Viewray Technologies, Inc. Method and apparatus for shielding a linear accelerator and a magnetic resonance imaging device from each other
US10132888B2 (en) 2009-11-20 2018-11-20 Viewray Technologies, Inc. Self-shielded split gradient coil
EP2353647A1 (fr) 2010-02-10 2011-08-10 Siemens Aktiengesellschaft Dispositif doté d'une combinaison à partir d'un dispositif à résonance magnétique et d'un dispositif de thérapie par rayonnement
DE102010001743A1 (de) 2010-02-10 2011-08-11 Siemens Aktiengesellschaft, 80333 Vorrichtung mit einer Kombination aus einer Magnetresonanzvorrichtung und einer Strahlentherapievorrichtung
DE102010001746A1 (de) 2010-02-10 2011-09-22 Siemens Aktiengesellschaft Vorrichtung mit einer Kombination aus einer Magnetresonanzvorrichtung und einer Strahlentherapievorrichtung
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US11986671B2 (en) 2010-06-22 2024-05-21 Siemens Healthineers International Ag System and method for estimating and manipulating estimated radiation dose
US9669238B2 (en) 2010-12-08 2017-06-06 Elekta Ab (Publ) Radiotherapeutic apparatus
GB2491363A (en) * 2011-05-31 2012-12-05 Elekta Ab Radiotherapeutic apparatus with MRI and slip rings
GB2491363B (en) * 2011-05-31 2016-12-14 Elekta Ab Radiotherapeutic apparatus
US9138145B2 (en) 2011-06-15 2015-09-22 Imris Inc. Integration of MRI into radiation therapy treatment
EP2535086A1 (fr) 2011-06-15 2012-12-19 Imris Inc. Intégration d'IRM dans un traitement de radiothérapie
US10393836B2 (en) 2011-12-13 2019-08-27 Viewray Technologies, Inc. Active resistive shimming for MRI devices
US9599687B2 (en) 2011-12-13 2017-03-21 Viewray Technologies, Inc. Active resistive shimming for MRI devices
US10561861B2 (en) 2012-05-02 2020-02-18 Viewray Technologies, Inc. Videographic display of real-time medical treatment
US10835763B2 (en) 2012-10-26 2020-11-17 Viewray Technologies, Inc. Assessment and improvement of treatment using imaging of physiological responses to radiation therapy
US10821303B2 (en) 2012-10-26 2020-11-03 Viewray Technologies, Inc. Assessment and improvement of treatment using imaging of physiological responses to radiation therapy
US11040222B2 (en) 2012-10-26 2021-06-22 Viewray Technologies, Inc. Assessment and improvement of treatment using imaging of physiological responses to radiation therapy
US9889318B2 (en) 2012-10-26 2018-02-13 Viewray Technologies, Inc. Assessment and improvement of treatment using imaging of physiological responses to radiation therapy
US9526918B2 (en) 2012-11-12 2016-12-27 Siemens Plc Combined MRI and radiation therapy system
CN103800009A (zh) * 2012-11-12 2014-05-21 英国西门子公司 组合的磁共振成像和放射治疗系统
EP2774537A1 (fr) 2013-03-08 2014-09-10 Imris Inc. Alignement de patient dans une radiothérapie guidée par IRM
US9675271B2 (en) 2013-03-13 2017-06-13 Viewray Technologies, Inc. Systems and methods for radiotherapy with magnetic resonance imaging
US11612764B2 (en) 2013-03-15 2023-03-28 Viewray Technologies, Inc. Systems and methods for linear accelerator radiotherapy with magnetic resonance imaging
US11083912B2 (en) 2013-03-15 2021-08-10 Viewray Technologies, Inc. Systems and methods for linear accelerator radiotherapy with magnetic resonance imaging
US10463884B2 (en) 2013-03-15 2019-11-05 Viewray Technologies, Inc. Systems and methods for linear accelerator radiotherapy with magnetic resonance imaging
US9211423B2 (en) 2013-03-25 2015-12-15 Siemens Aktiengesellschaft Radiotherapy treatment device comprising image acquisition device and irradiation device, and radiotherapy method
DE102013205211A1 (de) 2013-03-25 2014-10-09 Siemens Aktiengesellschaft Strahlentherapiebehandlungseinrichtung mit Bildaufnahmeeinrichtung und Bestrahlungseinrichtung sowie Verfahren zur Strahlentherapie
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GB0117730D0 (en) 2001-09-12

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