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WO2003008589A1 - Elk1 gene associe a la phosphorylation - Google Patents

Elk1 gene associe a la phosphorylation Download PDF

Info

Publication number
WO2003008589A1
WO2003008589A1 PCT/JP2002/007174 JP0207174W WO03008589A1 WO 2003008589 A1 WO2003008589 A1 WO 2003008589A1 JP 0207174 W JP0207174 W JP 0207174W WO 03008589 A1 WO03008589 A1 WO 03008589A1
Authority
WO
WIPO (PCT)
Prior art keywords
map kinase
kinase cascade
protein
dna
usable
Prior art date
Application number
PCT/JP2002/007174
Other languages
English (en)
Japanese (ja)
Inventor
Osamu Matsuzaki
Akio Matsuda
Yukiko Nagano
Naomi Suzuki
Original Assignee
Asahi Kasei Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Kabushiki Kaisha filed Critical Asahi Kasei Kabushiki Kaisha
Publication of WO2003008589A1 publication Critical patent/WO2003008589A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne une protéine possédant un effet activateur de cascade MAP kinase qu'il est possible d'utiliser, par exemple, dans le diagnostic, le traitement ou la prévention de maladies associées à une activation excessive ou à une inhibition de la cascade MAP kinase. Grâce à l'utilisation de plasmides pFR-Luc et pFA2-Elk1 il est possible de cloner, à partir d'une banque d'ADNc dérivé de fibroblaste de poumon humain, un ADNc codant pour une protéine possédant un effet activateur de la cascade MAP kinase. Les séquences d'ADN et d'acides aminés déduite sont alors déterminées. Cette protéine, l'ADN qui la code, un vecteur recombinant contenant cet ADN et un transformant contenant ce vecteur recombinant sont utilisables dans le criblage d'une substance qui inhibe ou accélère l'activation de la cascade MAP kinase.
PCT/JP2002/007174 2001-07-18 2002-07-15 Elk1 gene associe a la phosphorylation WO2003008589A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001-218204 2001-07-18
JP2001218204 2001-07-18
JP2001-263450 2001-08-31
JP2001263450 2001-08-31
JP2002012176 2002-01-21
JP2002-12176 2002-01-21

Publications (1)

Publication Number Publication Date
WO2003008589A1 true WO2003008589A1 (fr) 2003-01-30

Family

ID=27347180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007174 WO2003008589A1 (fr) 2001-07-18 2002-07-15 Elk1 gene associe a la phosphorylation

Country Status (1)

Country Link
WO (1) WO2003008589A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046281A2 (fr) * 1998-03-10 1999-09-16 Genentech, Inc. Nouveaux polypeptides et acides nucleiques les codant
WO2000053756A2 (fr) * 1999-03-08 2000-09-14 Genentech, Inc. Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides
WO2001012662A2 (fr) * 1999-08-17 2001-02-22 Incyte Genomics, Inc. Proteines associees a la membrane
WO2001016318A2 (fr) * 1999-09-01 2001-03-08 Genentech, Inc. Polypeptides secretes et transmembranaires et acides nucleiques codant pour ceux-ci
WO2001075167A1 (fr) * 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Strategie genetique inverse pour identifier des mutations fonctionnelles dans des genes de sequence connue
WO2001090304A2 (fr) * 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046281A2 (fr) * 1998-03-10 1999-09-16 Genentech, Inc. Nouveaux polypeptides et acides nucleiques les codant
WO2000053756A2 (fr) * 1999-03-08 2000-09-14 Genentech, Inc. Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides
WO2001012662A2 (fr) * 1999-08-17 2001-02-22 Incyte Genomics, Inc. Proteines associees a la membrane
WO2001016318A2 (fr) * 1999-09-01 2001-03-08 Genentech, Inc. Polypeptides secretes et transmembranaires et acides nucleiques codant pour ceux-ci
WO2001075167A1 (fr) * 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Strategie genetique inverse pour identifier des mutations fonctionnelles dans des genes de sequence connue
WO2001090304A2 (fr) * 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps

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