+

WO2003008379A1 - Composes azasucre - Google Patents

Composes azasucre Download PDF

Info

Publication number
WO2003008379A1
WO2003008379A1 PCT/JP2002/005672 JP0205672W WO03008379A1 WO 2003008379 A1 WO2003008379 A1 WO 2003008379A1 JP 0205672 W JP0205672 W JP 0205672W WO 03008379 A1 WO03008379 A1 WO 03008379A1
Authority
WO
WIPO (PCT)
Prior art keywords
optionally substituted
alkyl
hydrogen
compounds
sugar chain
Prior art date
Application number
PCT/JP2002/005672
Other languages
English (en)
French (fr)
Inventor
Osamu Kanie
Chikako Saotome
Original Assignee
Mitsubishi Chemical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corporation filed Critical Mitsubishi Chemical Corporation
Priority to JP2003513939A priority Critical patent/JP4363183B2/ja
Publication of WO2003008379A1 publication Critical patent/WO2003008379A1/ja
Priority to US10/726,550 priority patent/US7288565B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PCT/JP2002/005672 2001-06-08 2002-06-07 Composes azasucre WO2003008379A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2003513939A JP4363183B2 (ja) 2001-06-08 2002-06-07 アザ糖化合物
US10/726,550 US7288565B2 (en) 2001-06-08 2003-12-04 Azasugar compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001173855 2001-06-08
JP2001-173855 2001-06-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/726,550 Continuation-In-Part US7288565B2 (en) 2001-06-08 2003-12-04 Azasugar compound

Publications (1)

Publication Number Publication Date
WO2003008379A1 true WO2003008379A1 (fr) 2003-01-30

Family

ID=19015240

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/005672 WO2003008379A1 (fr) 2001-06-08 2002-06-07 Composes azasucre

Country Status (3)

Country Link
US (1) US7288565B2 (ja)
JP (1) JP4363183B2 (ja)
WO (1) WO2003008379A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288565B2 (en) 2001-06-08 2007-10-30 Mitsubishi Chemical Corporation Azasugar compound
JP2012502884A (ja) * 2008-09-16 2012-02-02 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
JP2013544841A (ja) * 2010-12-01 2013-12-19 ヤンセン ファーマシューティカ エヌ．ベー． Ｃｃｒ２の４−置換シクロヘキシルアミノ−４−ピペリジニル−アセトアミドアンタゴニスト

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7652039B2 (en) * 2002-05-17 2010-01-26 Sequella, Inc. Methods of use and compositions for the diagnosis and treatment of infectious disease
US20040033986A1 (en) * 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
US7456222B2 (en) * 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
US7884097B2 (en) * 2003-09-05 2011-02-08 Sequella, Inc. Methods and compositions comprising diamines as new anti-tubercular therapeutics
US20050256168A1 (en) * 2004-04-28 2005-11-17 Block Timothy M Compositions for oral administration for the treatment of interferon-responsive disorders
BRPI0517828A (pt) 2004-11-16 2008-10-21 Thomson Licensing inserção de mensagens sei de grão de filme para uma simulação exata em bits em um sistema de vìdeo
US20070088164A1 (en) * 2005-09-02 2007-04-19 Moriarity Robert M Combinatorial library approach to iminocyclitols with biological activity
FR2902097A1 (fr) * 2006-06-13 2007-12-14 Univ Joseph Fourier Etablissem Nouveau procede de preparation de nitrones et de n-hydroxylamines comportant au moins un groupe hydroxyle, et produits tels qu'obtenus
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
EP2146709A2 (en) * 2007-04-24 2010-01-27 University of Oxford Iminosugar for treatment of tumors
US20090281054A1 (en) * 2008-05-06 2009-11-12 Venkata Reddy Compositions and methods comprising capuramycin analogues
AU2009271325A1 (en) * 2008-06-24 2010-01-21 Merck Sharp & Dohme Corp. Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
RU2609210C2 (ru) 2010-12-23 2017-01-31 Алектос Терапьютикс Инк. Селективные ингибиторы гликозидазы и их применение
US9718854B2 (en) 2011-03-31 2017-08-01 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US9701693B2 (en) 2011-06-27 2017-07-11 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2014032185A1 (en) 2012-08-31 2014-03-06 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2890675A4 (en) 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
CA2890115A1 (en) 2012-10-31 2014-05-08 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04502619A (ja) * 1989-01-13 1992-05-14 ニユコメド・アクシエセルカペト 複素環式キレート化剤
WO1995024392A1 (en) * 1994-03-08 1995-09-14 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
WO2000068194A1 (en) * 1999-05-11 2000-11-16 The Scripps Research Institute Iminocyclitol inhibitors of hexoaminidase and glycosidase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008379A1 (fr) 2001-06-08 2003-01-30 Mitsubishi Chemical Corporation Composes azasucre

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04502619A (ja) * 1989-01-13 1992-05-14 ニユコメド・アクシエセルカペト 複素環式キレート化剤
WO1995024392A1 (en) * 1994-03-08 1995-09-14 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
WO2000068194A1 (en) * 1999-05-11 2000-11-16 The Scripps Research Institute Iminocyclitol inhibitors of hexoaminidase and glycosidase

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
CAMPANINI, LAURENCE ET AL.: "Concise synthesis of new homoaza sugars. Fully substituted, functionally diverse pyrrolidines", TETRAHEDRON LETT., vol. 36, no. 44, 1995, pages 8015 - 8018, XP002955067 *
CAMPANINI, LAURENCE ET AL.: "One step synthesis of sulfur and nitrogen linked aza-disaccharide precursors from D-mannitol derived bis-aziridines", TETRAHEDRON LETT., vol. 37, no. 29, 1996, pages 5095 - 5098, XP004029598 *
FITREMANN, JULIETTE ET AL.: "2,5-Disubstituted pyrrolidines from D-mannitol-derived bis-aziridines", TETRAHEDRON LETT., vol. 35, no. 8, 1994, pages 1201 - 1204, XP002955070 *
FITREMANN, JULIETTE ET AL.: "Regioselective cyanide ring opening of C2 symmetric bis-aziridines by cyanide", SYNLETT, no. 3, 1995, pages 235 - 237, XP002955068 *
HERMETTER, ALBIN ET AL.: "Powerful probes for glycosidases novel, fluorescently tagged glycosidase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 10, 2001, pages 1339 - 1342, XP002955060 *
JANDA, KIM D. ET AL.: "Chemical selection for catalysis in combinatorial antibody libraries", SCIENCE, vol. 275, no. 5302, 1997, WASHINGTON, D.C., pages 945 - 948, XP001084162 *
KANG, SUNG HO ET AL.: "Intramolecular cyclization of C2 symmetric and meso-iodo amino alcohols: a synthetic approach to azasugars", TETRAHEDRON LETTERS, vol. 38, no. 4, 1997, pages 607 - 610, XP002955065 *
MCCORT, ISABELLE ET AL.: "Practical route to D-gluco aza sugars from C2 symmetric bis-aziridines", TETRAHEDRON LETTERS, vol. 37, no. 43, 1996, pages 7717 - 7720, XP002955066 *
MCCORT, ISABELLE ET AL.: "Synthesis and evaluation as glycosidase inhibitors of 2,5-imino-D-glucitol and 1,5-imino-D-mannitol related derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, no. 1, 2000, pages 135 - 143, XP002955062 *
MCCORT, ISABELLE ET AL.: "Synthesis of ester- and amide-linked pseudo-azadisaccharides via coupling of D-glucose with 6-amino-6-deoxy-2,5-imino-D-glucitol", TETRAHEDRON LETTERS, vol. 39, no. 25, 1998, pages 4463 - 4466, XP002955064 *
REYNOLDS, ROBERT C. ET AL.: "Ethambutol-sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis", CARBOHYDRATE RESEARCH, vol. 317, no. 1-4, 1999, pages 164 - 179, XP004180003 *
SCHUMACHER-WANDERSLEB, MICHAEL H.M.G. ET AL.: "Preparation of the N-acetylglucosaminidase inhibitor 1-acetamido-1,2,5-trideoxy-2,5-imino-D-glucitol from methyl .alpha.-D-mannopyranoside", LIEBIGS ANN. CHEM., no. 6, 1994, pages 555 - 561, XP002955069 *
WONG, CHI-HUEY ET AL.: "Synthesis and evaluation of homoaza sugars as glycosidase inhibitors", J. ORG. CHEM., vol. 60, no. 6, 1995, pages 1492 - 1501, XP002955063 *
WRODNIGG, T.M. ET AL.: "Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful .beta.-glucosidase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 8, 2001, pages 1063 - 1064, XP002955059 *
WRODNIGG, TANJA M. ET AL.: "Biologically active 1-aminodeoxy and 1-0-alkyl derivatives of the powerful D-glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol", JOURNAL OF CARBOHYDRATE CHEMISTRY, vol. 19, no. 8, 2000, pages 975 - 990, XP002955061 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288565B2 (en) 2001-06-08 2007-10-30 Mitsubishi Chemical Corporation Azasugar compound
JP2012502884A (ja) * 2008-09-16 2012-02-02 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
JP2013544841A (ja) * 2010-12-01 2013-12-19 ヤンセン ファーマシューティカ エヌ．ベー． Ｃｃｒ２の４−置換シクロヘキシルアミノ−４−ピペリジニル−アセトアミドアンタゴニスト

Also Published As

Publication number Publication date
US20040147591A1 (en) 2004-07-29
JP4363183B2 (ja) 2009-11-11
US7288565B2 (en) 2007-10-30
JPWO2003008379A1 (ja) 2004-11-04

Similar Documents

Publication Publication Date Title
WO2003008379A1 (fr) Composes azasucre
WO2003097656A3 (en) Novel substituted sulfamate anticonvulsant derivatives
WO2005116002A3 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL128666A (en) Substituted cyclic amine metalloprotease inhibitors
NZ536734A (en) Spiroindolinepiperidine derivatives
WO2005061458A3 (en) Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
NO923533L (no) Nye 5-amino-4-hydroksyheksansyrederivater som terapeutika
EP2374464A3 (en) HCV N3S-NS4A protease inhibition
CA2367017A1 (en) Inhibitors of impdh enzyme
CA2318349A1 (en) Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
TW200420542A (en) A compound having TGF β inhibition activity and a medicinal composition containing the same
AU2003258621A1 (en) Novel purine derivatives, production and use thereof as medicaments
IL148014A0 (en) Cell adhesion inhibitors
MXPA02003977A (es) Inhibidores de adhesion de celula mediada por al°2.
HU9401571D0 (en) Saccharin derivative proteolytic enzyme inhibitors
SG52659A1 (en) Saccharin derivative proteolytic enzyme inhibitors
WO2003068795A1 (fr) Analogues de nucleoside et derive d'oligonucleotide comprenant un analogue nucleotidique de ces composes
TWI265929B (en) Triazinyl derivatives for inhibiting the production of IL-12
WO2004094386A8 (en) Isoquinoline-5-sulfonic acid amides as inhibitors of akt (protein kinase b)
WO2004048352A3 (en) 2-cyanopyrrolidines and their analogues as dpp-iv inhibitors
NO984470L (no) Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase
WO2003030886A3 (en) Allylamides useful in the treatment of alzheimer's disease
AU2003293746A1 (en) Crystalline cefdinir salts
MXPA05012274A (es) Derivado de cianofluoropirrolidina.
AU2002356991A1 (en) Amino acid derivatives useful for the treatment of alzheimer's disease

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2003513939

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 10726550

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载