WO2003007861A1 - Systeme pour realiser une operation de micro-forage chez un homme ou un animal et son procede d'utilisation - Google Patents
Systeme pour realiser une operation de micro-forage chez un homme ou un animal et son procede d'utilisation Download PDFInfo
- Publication number
- WO2003007861A1 WO2003007861A1 PCT/IL2001/000671 IL0100671W WO03007861A1 WO 2003007861 A1 WO2003007861 A1 WO 2003007861A1 IL 0100671 W IL0100671 W IL 0100671W WO 03007861 A1 WO03007861 A1 WO 03007861A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drill
- micro
- control box
- sleeve
- tube
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 78
- 238000005553 drilling Methods 0.000 title claims abstract description 51
- 241001465754 Metazoa Species 0.000 title abstract description 4
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 60
- 238000003780 insertion Methods 0.000 claims abstract description 15
- 230000037431 insertion Effects 0.000 claims abstract description 15
- 239000002699 waste material Substances 0.000 claims abstract description 11
- 230000008236 biological pathway Effects 0.000 claims abstract description 10
- 239000000835 fiber Substances 0.000 claims description 66
- 230000007246 mechanism Effects 0.000 claims description 56
- 230000037361 pathway Effects 0.000 claims description 47
- 229920001296 polysiloxane Polymers 0.000 claims description 35
- 210000001331 nose Anatomy 0.000 claims description 26
- 210000000845 cartilage Anatomy 0.000 claims description 13
- 238000005286 illumination Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 5
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims description 5
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 5
- 239000003292 glue Substances 0.000 claims description 4
- 210000003928 nasal cavity Anatomy 0.000 claims description 4
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims description 2
- 238000012800 visualization Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000002627 tracheal intubation Methods 0.000 description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 241001631457 Cannula Species 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 201000004356 excessive tearing Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000005236 sound signal Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00345—Micromachines, nanomachines, microsystems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00973—Surgical instruments, devices or methods pedal-operated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/30—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
- A61B2090/306—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure using optical fibres
Definitions
- the present invention relates to a system for performing a micro-drilling
- the present invention relates to a system for performing
- DCR dacryocystorhinostomy
- Obstruction may occur in the lacrimal
- DCR dacryocystorhinostomy
- the procedure can be extremely bloody
- present invention utilizes the natural lacrimal pathway in order to
- the present invention relates to a system for performing micro-drilling of
- control box is adapted
- micro-drill is operable through the control box when said
- micro-drill is inserted through said sleeve and said micro-drill
- waste produced during the drilling of the bone can be aspirated from the surgical site.
- the system of the present invention is especially useful in the
- micro-drilling refers to the drilling of a relatively small hole, on the
- micro-drill refers to a drill that is capable of forming a hole of
- the system further comprises an optic fiber.
- the optic fiber extends through the flexible tube and also extends from
- the distal end of the tube such that the optic fiber may be connected to a
- the connecting member is formed form rubber or
- the optic fiber and the sleeve are affixed to the inner wall of
- the affixment can be accomplished through any combination
- adhesive means such as silicone glue.
- system further comprises a cover for
- micro-drill becomes positioned at the "zero" location
- the micro-drill moves from the
- the resistance to the advance is sensed by the system, which causes the
- micro-drill to rotate in the clockwise direction at a high speed
- the micro-drill has a diameter of approximately 0.5
- the sleeve has an outer diameter of approximately 0.8
- the flexible tube in other preferred embodiments of the present invention, the flexible tube
- control box In other preferred embodiments of the present invention, the control box
- control card containing program control and a display card
- control box In other preferred embodiments of the present invention, the control box
- the release/retract mechanism is coupled to the control
- the empty sleeve can be used to thread a
- control box further includes a mechanism for controlling the directional and rotational
- the drilling mechanism is controlled by the control card
- the drilling mechanism allows for both
- control card which controls the rotation speed of the micro-drill.
- control box In other preferred embodiments of the present invention, the control box
- a laser diode that is connectable to a first end of an optic fiber through a plug on the panel of the control box for providing
- illumination is produced at the proximal end of the tube so
- control box In other preferred embodiments of the present invention, the control box
- the air pump is detachably connected to the air suction tube
- control box In other preferred embodiments of the present invention, the control box
- control box and coupled to the display card such that the particular
- control box In other preferred embodiments of the present invention, the control box
- the micro-drill can be made of NITINOL or any other suitable material.
- Nitinol is formed from nickel and titanium and can exist in two different
- the micro-drill in plastic form and it can be
- micro-drill is raised during disinfection (causing a to change to the
- the micro-drill returns to the original, substantially
- the present invention also relates to a method for performing a
- the micro-drill is located immediately behind a
- the method need not be restricted only to the performance of a DCR.
- the present invention also relates to a control box for use in the system
- opening of a blocked biological pathway comprising:
- control box and said mechanism is directly controlled by the
- alpha-numeric display on said panel of the control box
- the air-pump is connectable to an exterior air suction tube and said air-pump is
- control card directly controlled by the control card.
- the control box is adapted for connection to an external electrical power
- control box further comprises a laser
- the laser diode is connectable to the optic fiber for enabling
- the present invention also relates to a system for performing
- control box is adapted
- micro-drill and flexible sleeve extend from the proximal end of
- sleeve is detachably connected to the proximal end of the handle.
- the drill cable is positioned inside a sleeve, and the sleeve
- micro-drill is disposable.
- said micro-drill is comprised of
- NITINOL extends between 0.6-0.8mm from the end of the sleeve.
- the present invention also relates to a method for performing a DCR
- the cannula remains in the lacrimal pathway
- steps a-h are repeated by advancing
- the method preferably comprises drawing the two ends of
- a stent may be inserted into the hole in
- the cannula has a slit extending on one
- cannula has two longitudinal slits positioned 180 from one another for
- Figure 1 is a side-view of a flexible tube and the components extending
- Figure 2 is a cross-sectional view of the flexible tube of Figure 1.
- Figure 3 is a schematic view of a control box and central components
- FIG. 4 is an isometric view of the control box of Figure 3, showing the
- Figure 5 is an isometric view of a mechanism for controlling the
- Figure 6 is an isometric view of a mechanism for releasing a drill cable
- Figure 7 is a schematic side view of a handle for facilitating performance
- Figures 8A and 8B are side views of two preferred embodiments of cannulas, according to preferred embodiments of the present invention.
- the system of the present invention includes a
- silicone tube (alternatively, the flexible tube can be adapted in shape and
- (9) has a proximal end (52) and a distal end (51). Extending from the
- distal end (51) of the flexible tube (9) is a hollow sleeve (6) adapted for insertion therethrough of the micro-drill and a drill cable that is attached
- a filament or optic fiber bundle used as a guide can be inserted
- suction tube (2) that connects with the distal end (51) of the tube (9) to
- optic fiber (18) also extends from the distal end (51) of the tube (9) for
- system further includes a removable cover (53) that can fit onto the
- the optic fiber (18) is connectable to a laser
- the air suction tube (referred to in Figure 1) communicates
- the hollow inner portion (11) is essentially comprised of the longitudinal
- the flexible tube (9) is approximately 1.2 millimeters in inner
- the flexible tube may be dimensioned differently according to the
- the sleeve (6) has a diameter of approximately 0.25 millimeters.
- the flexible tube (9) allows for incorporation of various materials
- the flexible tube could be adapted for insertion therethrough of other
- control box (31) of the system includes a
- control card (16) that contains information and instructions for directing
- the system is powered by an external electric power
- central components of the control box (31) include a mechanism (4) for
- control box also referred to as the "release/retract mechanism"
- the drill cable is connected to the drilling
- the control box (31) further includes an air pump (5) that is connectable, by a plug on
- control box (31) for adjusting
- the optic fiber referred to in Figure 1 may be plugged into the laser diode
- any other optic fiber or optic fiber bundle may be any other optic fiber or optic fiber bundle.
- control box (31) is also equipped with
- the panel (71) of the control box (31) includes
- alpha-numeric display (8) and an alpha-numeric display selector (23).
- the panel (71) furthermore includes a series of indicator lamps, for indicating activities or providing warnings for the surgeon during a DCR
- Indicator light 26 is for indicating the ON/OFF status of the
- Indicator light 30 is for indicating READY status of the system.
- Indicator light 29 is for indicating retraction and/or releasing of the drill
- 57 is for indicating the air-pump status (ACTIVE/INACTIVE) of the
- Indicator light 58 is for indicating the drill status (drilling
- Warning light 17 is to
- Warning light 15 is to alert the surgeon when the micro-drill reaches the
- the panel (71) further includes a series of plugs, for providing connection
- control box (31) controls the control box (31) and the other components of the system.
- Plug 27 provides for connection between the drill cable and the
- release/retract mechanism also referred to as the "retract/release plug”
- Plug 19 provides for connection between the air suction tube and the
- Plug 21 provides for connection between the drill cable and the
- the control box (31) is also connected to a foot pedal (1) through a foot pedal cable (7) that
- directional and rotational movement of the micro-drill includes a motor
- micro-drill hereinafter referred to as the "directional motor" and a motor
- the rotational motor (63) rests on a platform (62) and is
- the directional motor (60) is coupled to a gear (39) that is movable
- the release/retract mechanism includes a
- the release/retract mechanism further includes a connective
- the retracting motor (50) is connected to the release/retract plug.
- the retracting motor (50) is connected to the release/retract plug.
- the releasing motor (42) is coupled to a lower roller (45b)
- cord (69) and drill cable (32) can move such that when the releasing
- the system first is switched ON (switch 24). The system then switches ON (switch 24).
- the micro-drill is
- micro-drill reaches the bone of the nose, the sharp change in the
- control card sensed by the control card and causes the following events to occur
- indicator light 17 turns ON, to indicate reaching of the
- an audio warning is sounded, also indicating that the bone of the
- indicator light 17 turns OFF and indicator light 15
- indicator light 29 is ON.
- micro-drill (and drill cable) empty empty (said components having been
- the sleeve can be used in order to thread a
- numeric display (8) may convey other information as well, as one skilled
- a handle (80) is adapted for facilitating performance of the
- the handle has a generally cylindrical shape
- Said handle has a distal end (87) and a proximal end (89).
- a circular opening (81) is
- the drill cable (32) is connected to the micro-drill (82) via a mechanical
- micro-drill (82) rotates and is advanced within the handle (80) (and
- the flexible sleeve (85) is of a flexible metal
- Said sleeve (85) is attached to the proximal end (89) of the
- the drill cable (32) is positioned inside a second flexible sleeve (91)
- sleeve (91) is also connected to the handle via a ring (93) clamped to the
- the bone is drilled in the same manner as described above.
- the micro-drill (82) is
- the ring (86) remain inside the lacrimal pathway.
- a cannula is then inserted through the ring and the flexible sleeve into the
- the cannula is then retracted and disengaged from around the tube or
- the cannula comprises a flexible tubular member having either
- the slit (98) is sized to allow for removing the tube or fiber from within the cannula (96).
- silicone tube or optic fiber is inserted through the cannula.
- micro-drill, cannula, optic for the next operation. It is appreciated that the micro-drill, cannula, optic
- a stent Prior to insertion of the cannula inside the flexible sleeve (85), a stent is
- stent is preferably 6- 15mm in length and is comprised of nitinol (conventionally used for blood vessel stents).
- the diameter of the stent is
- the stent is
- a second stent is
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IL2001/000671 WO2003007861A1 (fr) | 2001-07-20 | 2001-07-20 | Systeme pour realiser une operation de micro-forage chez un homme ou un animal et son procede d'utilisation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IL2001/000671 WO2003007861A1 (fr) | 2001-07-20 | 2001-07-20 | Systeme pour realiser une operation de micro-forage chez un homme ou un animal et son procede d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003007861A1 true WO2003007861A1 (fr) | 2003-01-30 |
Family
ID=11043072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IL2001/000671 WO2003007861A1 (fr) | 2001-07-20 | 2001-07-20 | Systeme pour realiser une operation de micro-forage chez un homme ou un animal et son procede d'utilisation |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2003007861A1 (fr) |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7560612B2 (en) | 2002-03-13 | 2009-07-14 | Pioneer Hi-Bred International, Inc. | Early-inflorescence-preferred regulatory elements and uses thereof |
| US8058508B2 (en) | 2002-03-19 | 2011-11-15 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| US8193415B2 (en) | 1999-10-26 | 2012-06-05 | Stichting Dienst Landbouwkundig Onderzock | Plant expressing mammalian β1,4-galactosyltransferase and β1,3-glucuronyltransferase |
| US8439947B2 (en) | 2009-07-16 | 2013-05-14 | Howmedica Osteonics Corp. | Suture anchor implantation instrumentation system |
| US8492613B2 (en) | 2002-03-19 | 2013-07-23 | Stichting Dienst Landbouwkundig Onderzoek | GNTIII expression in plants |
| US8821494B2 (en) | 2012-08-03 | 2014-09-02 | Howmedica Osteonics Corp. | Surgical instruments and methods of use |
| US8829276B2 (en) | 2007-04-17 | 2014-09-09 | Stichting Dienst Landbouwkundig Onderzoek | Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases |
| US9078740B2 (en) | 2013-01-21 | 2015-07-14 | Howmedica Osteonics Corp. | Instrumentation and method for positioning and securing a graft |
| US9232954B2 (en) | 2009-08-20 | 2016-01-12 | Howmedica Osteonics Corp. | Flexible ACL instrumentation, kit and method |
| US9402620B2 (en) | 2013-03-04 | 2016-08-02 | Howmedica Osteonics Corp. | Knotless filamentary fixation devices, assemblies and systems and methods of assembly and use |
| US9463013B2 (en) | 2013-03-13 | 2016-10-11 | Stryker Corporation | Adjustable continuous filament structure and method of manufacture and use |
| US9788826B2 (en) | 2013-03-11 | 2017-10-17 | Howmedica Osteonics Corp. | Filamentary fixation device and assembly and method of assembly, manufacture and use |
| US9795398B2 (en) | 2011-04-13 | 2017-10-24 | Howmedica Osteonics Corp. | Flexible ACL instrumentation, kit and method |
| US9986992B2 (en) | 2014-10-28 | 2018-06-05 | Stryker Corporation | Suture anchor and associated methods of use |
| WO2019064292A1 (fr) * | 2017-09-27 | 2019-04-04 | Prof. Arie Nemet Sherutei Refuah | Outils et procédés de dacryocystorhinostomie |
| US10448944B2 (en) | 2011-11-23 | 2019-10-22 | Howmedica Osteonics Corp. | Filamentary fixation device |
| US10568616B2 (en) | 2014-12-17 | 2020-02-25 | Howmedica Osteonics Corp. | Instruments and methods of soft tissue fixation |
| US10610211B2 (en) | 2013-12-12 | 2020-04-07 | Howmedica Osteonics Corp. | Filament engagement system and methods of use |
| WO2020202156A1 (fr) * | 2019-04-03 | 2020-10-08 | Tearflow Care Ltd. | Outils et procédés de dacryocystorhinostomie |
| USD902405S1 (en) | 2018-02-22 | 2020-11-17 | Stryker Corporation | Self-punching bone anchor inserter |
| US11331094B2 (en) | 2013-04-22 | 2022-05-17 | Stryker Corporation | Method and apparatus for attaching tissue to bone |
| CN115708704A (zh) * | 2022-10-26 | 2023-02-24 | 南京市第一医院 | 一种泪囊鼻腔钻孔器 |
| US11759271B2 (en) | 2017-04-28 | 2023-09-19 | Stryker Corporation | System and method for indicating mapping of console-based surgical systems |
| CN111200974B (zh) * | 2017-06-05 | 2023-10-20 | 康曼德公司 | 多筒钻孔导向器及其系统 |
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|---|---|---|---|---|
| FR2344267A1 (fr) * | 1976-03-16 | 1977-10-14 | Ulrich Max | Appareil de perforation pour chirurgie osseuse |
| SU941010A1 (ru) * | 1980-11-26 | 1982-07-07 | Липецкий политехнический институт | Способ получени заклепочного соединени |
| US5269785A (en) * | 1990-06-28 | 1993-12-14 | Bonutti Peter M | Apparatus and method for tissue removal |
| US5312427A (en) * | 1992-10-16 | 1994-05-17 | Shturman Cardiology Systems, Inc. | Device and method for directional rotational atherectomy |
| DE19542955A1 (de) * | 1995-11-17 | 1997-05-22 | Schwind Gmbh & Co Kg Herbert | Endoskop |
| US6018094A (en) * | 1995-02-06 | 2000-01-25 | Biomedical Enterprises, Inc. | Implant and insert assembly for bone and uses thereof |
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| FR2344267A1 (fr) * | 1976-03-16 | 1977-10-14 | Ulrich Max | Appareil de perforation pour chirurgie osseuse |
| SU941010A1 (ru) * | 1980-11-26 | 1982-07-07 | Липецкий политехнический институт | Способ получени заклепочного соединени |
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| EP1010404A2 (fr) * | 1998-12-14 | 2000-06-21 | Christof Ellerbrock | Dispositif intelligent de traitement médical |
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| DATABASE WPI 7 July 1982 Derwent World Patents Index; AN 1983-G4034K, XP002193592 * |
Cited By (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193415B2 (en) | 1999-10-26 | 2012-06-05 | Stichting Dienst Landbouwkundig Onderzock | Plant expressing mammalian β1,4-galactosyltransferase and β1,3-glucuronyltransferase |
| US7560612B2 (en) | 2002-03-13 | 2009-07-14 | Pioneer Hi-Bred International, Inc. | Early-inflorescence-preferred regulatory elements and uses thereof |
| US8058508B2 (en) | 2002-03-19 | 2011-11-15 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| US8492613B2 (en) | 2002-03-19 | 2013-07-23 | Stichting Dienst Landbouwkundig Onderzoek | GNTIII expression in plants |
| US8829276B2 (en) | 2007-04-17 | 2014-09-09 | Stichting Dienst Landbouwkundig Onderzoek | Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases |
| US10159478B2 (en) | 2009-07-16 | 2018-12-25 | Howmedica Osteonics Corp. | Suture anchor implantation instrumentation system |
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