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WO2003006687A3 - Novel target genes for diseases of the heart - Google Patents

Novel target genes for diseases of the heart Download PDF

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Publication number
WO2003006687A3
WO2003006687A3 PCT/EP2002/007704 EP0207704W WO03006687A3 WO 2003006687 A3 WO2003006687 A3 WO 2003006687A3 EP 0207704 W EP0207704 W EP 0207704W WO 03006687 A3 WO03006687 A3 WO 03006687A3
Authority
WO
WIPO (PCT)
Prior art keywords
genes
heart
diseases
cardiomyopathy
relates
Prior art date
Application number
PCT/EP2002/007704
Other languages
French (fr)
Other versions
WO2003006687A2 (en
Inventor
Birgit Reuner
Daniela Bunk
Thomas Henkel
Original Assignee
Medigene Ag
Birgit Reuner
Daniela Bunk
Thomas Henkel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medigene Ag, Birgit Reuner, Daniela Bunk, Thomas Henkel filed Critical Medigene Ag
Publication of WO2003006687A2 publication Critical patent/WO2003006687A2/en
Publication of WO2003006687A3 publication Critical patent/WO2003006687A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a variety of genes abnormally expressed in heart tissue as well as to fragments of such genes. Assessment of the expression level of these genes may be used for testing the predisposition of mammals and preferably humans of a heart disease or for an acute state of such a disease. Preferred diseases in accordance with the invention are congestive heart failure, dilative cardiomyopathy, hypertrophic cardiomyopathy and ischemic cardiomyopathy. The present invention further relates to methods of identifying compounds capable of normalizing the expression level of the aforementioned genes and of further genes affected by the abnormal expression. The identified compounds may be used for formulating compositions, preferably pharmaceutical compositions for preventing or treating diseases. They may be used as lead compounds for the development of medicament having an inproved efficiency, a longer half-life, a decreased toxicity etc. and to be employed in the treatment of heart diseases. Included in the invention are also somatic gene therapy methods comparing the introduction of at least one functional copy of any of the above-mentioned genes into a suitable cell. Finally, the invention relates to non-human transgenic animals comprising at least one of the aformentioned genes in their germ line. The transgenic animals of the invention may be used for the development of medicaments for the treatment of heart diseases.
PCT/EP2002/007704 2001-07-10 2002-07-10 Novel target genes for diseases of the heart WO2003006687A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30438501P 2001-07-10 2001-07-10
US60/304,385 2001-07-10

Publications (2)

Publication Number Publication Date
WO2003006687A2 WO2003006687A2 (en) 2003-01-23
WO2003006687A3 true WO2003006687A3 (en) 2003-08-28

Family

ID=23176292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007704 WO2003006687A2 (en) 2001-07-10 2002-07-10 Novel target genes for diseases of the heart

Country Status (1)

Country Link
WO (1) WO2003006687A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005078452A1 (en) 2004-02-05 2005-08-25 Medtronic, Inc. Methods and apparatus for identifying patients at risk for life threatening arrhythmias
US7608458B2 (en) 2004-02-05 2009-10-27 Medtronic, Inc. Identifying patients at risk for life threatening arrhythmias
US8027791B2 (en) 2004-06-23 2011-09-27 Medtronic, Inc. Self-improving classification system
US8335652B2 (en) 2004-06-23 2012-12-18 Yougene Corp. Self-improving identification method
WO2008053358A2 (en) * 2006-07-25 2008-05-08 Deutsches Krebsforschungszentrum A common gene expression signature in dilated cardiomyopathy

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024571A2 (en) * 1997-11-10 1999-05-20 Curagen Corporation Differentially expressed genes in cardiac hypertrophy and their uses in treatment and diagnosis
WO1999036522A1 (en) * 1998-01-19 1999-07-22 Shanghai Second Medical University A gene having low similarity to tropomyosin (cbcadb07)
WO2000000506A2 (en) * 1998-06-26 2000-01-06 Sagami Chemical Research Center Human proteins having hydrophobic domains and dnas encoding these proteins
WO2000011942A1 (en) * 1998-09-01 2000-03-09 Gene Logic, Inc. IDENTIFICATION OF A cDNA ASSOCIATED WITH ISCHEMIA IN HUMAN HEART TISSUE
WO2000032221A2 (en) * 1998-12-01 2000-06-08 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
WO2000053753A2 (en) * 1999-03-08 2000-09-14 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024571A2 (en) * 1997-11-10 1999-05-20 Curagen Corporation Differentially expressed genes in cardiac hypertrophy and their uses in treatment and diagnosis
WO1999036522A1 (en) * 1998-01-19 1999-07-22 Shanghai Second Medical University A gene having low similarity to tropomyosin (cbcadb07)
WO2000000506A2 (en) * 1998-06-26 2000-01-06 Sagami Chemical Research Center Human proteins having hydrophobic domains and dnas encoding these proteins
WO2000011942A1 (en) * 1998-09-01 2000-03-09 Gene Logic, Inc. IDENTIFICATION OF A cDNA ASSOCIATED WITH ISCHEMIA IN HUMAN HEART TISSUE
WO2000032221A2 (en) * 1998-12-01 2000-06-08 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
WO2000053753A2 (en) * 1999-03-08 2000-09-14 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
DATABASE EBI [online] EMBL; 20 September 1999 (1999-09-20), HE, K. ET AL.: "Human CBCADB07 polypeptide encoding cDNA", XP002231546, retrieved from EMBL accession no. AAX82075 Database accession no. AAX82075 *
DATABASE EBI [online] EMBL; 20 September 1999 (1999-09-20), HE, K.: "CBCADB07", XP002220905, retrieved from EMBL accession no. AAY17299 Database accession no. AAY17299 *
DATABASE EBI [online] EMBL; 22 July 1998 (1998-07-22), MAO, M. ET AL.: "Homo sapiens unknown mRNA, complete cds.", XP002231547, retrieved from EBI accession no. AF047439 Database accession no. AF047439 *
DATABASE EBI [online] EMBL; 28 February 2001 (2001-02-28), ASHKENAZI, A.J. ET AL.: "Human angiogenesis-associated protein PRO195 cDNA, SEQ ID NO:45", XP002231545, retrieved from EBI accession no. AAC97400 Database accession no. AAC97400 *
DATABASE EBI [online] EMBL; 28 February 2001 (2001-02-28), ASHKENAZI, A.J. ET AL.: "Human angiogenesis-associated protein PRO195, SEQ. ID. NO: 46.", XP002220904, retrieved from EMBL accession no. AAB53073 Database accession no. AAB53073 *
DATABASE EBI [online] EMBL; 7 November 2000 (2000-11-07), ASHKENAZI, A.J. ET AL.: "Human PRO195 protein sequence SEQ. ID. NO. 31", XP002220906, retrieved from EMBL accession no. AAB24394 Database accession no. AAB24394 *
DATABASE EBI [online] EMBL; 8 February 2001 (2001-02-08), ASHKENAZI, A.J. ET AL.: "Human PRO195 (UNQ169) protein sequence SEQ. ID. NO. 330", XP002220907, retrieved from EMBL accession no. AAB44289 Database accession no. AAB44289 *
DATABASE EBI [online] EMBL; 9 May 2000 (2000-05-09), KATO, S., KIMURA, T.: "Hydrophobic domain containing protein clone HP10349", XP002220908, retrieved from EMBL accession no. AAY78804 Database accession no. AAY78804 *
KNOELL R ET AL: "CHARACTERIZATION OF DIFFERENTIALLY EXPRESSED GENES FOLLOWING BRIEF CARDIAC ISCHEMIA", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 221, 16 April 1996 (1996-04-16), pages 402 - 407, XP002051684, ISSN: 0006-291X *
LATIF N ET AL: "Frequency and specificity of antiheart antibodies in patients with dilated cardiomyopathy detected using SDS-PAGE and western blotting.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. UNITED STATES 1 NOV 1993, vol. 22, no. 5, 1 November 1993 (1993-11-01), pages 1378 - 1384, XP008010596, ISSN: 0735-1097 *
MAO, MAO ET AL.: "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 95, no. 14, 7 July 1998 (1998-07-07), pages 8175 - 8180, XP002997332, DOI: doi:10.1073/pnas.95.14.8175 *
REDWOOD C S ET AL: "Functional effects of hypertrophic cardiomyopathy mutations in alpha-tropomyosin on Ca2+ regulation of thin filaments.", BIOPHYSICAL JOURNAL, vol. 74, no. 2 PART 2, February 1998 (1998-02-01), Forty-second Annual Meeting of the Biophysical Society;Kansas City, Missouri, USA; February 22-26, 1998, pages A354, XP008010594, ISSN: 0006-3495 *

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