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WO2003004608A3 - Enzymes de metabolisation de medicaments - Google Patents

Enzymes de metabolisation de medicaments Download PDF

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Publication number
WO2003004608A3
WO2003004608A3 PCT/US2002/021105 US0221105W WO03004608A3 WO 2003004608 A3 WO2003004608 A3 WO 2003004608A3 US 0221105 W US0221105 W US 0221105W WO 03004608 A3 WO03004608 A3 WO 03004608A3
Authority
WO
WIPO (PCT)
Prior art keywords
dme
metabolizing enzymes
drug metabolizing
polynucleotides
agonists
Prior art date
Application number
PCT/US2002/021105
Other languages
English (en)
Other versions
WO2003004608A2 (fr
Inventor
Jennifer A Griffin
Jayalaxmi Ramkumar
Brooke M Emerling
Thomas W Richardson
Joana X Li
Bridget A Warren
Cynthia D Honchell
Mariah R Baughn
Y Tom Tang
Ernestine A Lee
Vicki S Elliott
Henry Yue
Sally Lee
Anita Swarnakar
Ian J Forsythe
Madhusudan M Sanjanwala
Monique G Yao
Yeganeh Zebarjadian
Ann E Gorvad
Shanya D Becha
Neil Burford
Original Assignee
Incyte Genomics Inc
Jennifer A Griffin
Jayalaxmi Ramkumar
Brooke M Emerling
Thomas W Richardson
Joana X Li
Bridget A Warren
Cynthia D Honchell
Mariah R Baughn
Y Tom Tang
Ernestine A Lee
Vicki S Elliott
Henry Yue
Sally Lee
Anita Swarnakar
Ian J Forsythe
Madhusudan M Sanjanwala
Monique G Yao
Yeganeh Zebarjadian
Ann E Gorvad
Shanya D Becha
Neil Burford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Jennifer A Griffin, Jayalaxmi Ramkumar, Brooke M Emerling, Thomas W Richardson, Joana X Li, Bridget A Warren, Cynthia D Honchell, Mariah R Baughn, Y Tom Tang, Ernestine A Lee, Vicki S Elliott, Henry Yue, Sally Lee, Anita Swarnakar, Ian J Forsythe, Madhusudan M Sanjanwala, Monique G Yao, Yeganeh Zebarjadian, Ann E Gorvad, Shanya D Becha, Neil Burford filed Critical Incyte Genomics Inc
Priority to CA002453075A priority Critical patent/CA2453075A1/fr
Priority to EP02740014A priority patent/EP1572877A3/fr
Priority to AU2002312624A priority patent/AU2002312624A1/en
Priority to JP2003510767A priority patent/JP2005508614A/ja
Publication of WO2003004608A2 publication Critical patent/WO2003004608A2/fr
Publication of WO2003004608A3 publication Critical patent/WO2003004608A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
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    • A61P37/08—Antiallergic agents
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Wood Science & Technology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)

Abstract

Divers modes de réalisation de cette invention concernent des enzymes humaines de métabolisation de médicaments et des polynucléotides qui identifient et codent lesdites enzymes. Certains modes de réalisation de l'invention ont trait à des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes, et des antagonistes. D'autres modes de réalisation portent sur des méthodes de diagnostic, de traitement ou de prévention de troubles liés à l'expression aberrante des enzymes de métabolisation de médicaments.
PCT/US2002/021105 2001-07-06 2002-07-05 Enzymes de metabolisation de medicaments WO2003004608A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002453075A CA2453075A1 (fr) 2001-07-06 2002-07-05 Enzymes de metabolisation de medicaments
EP02740014A EP1572877A3 (fr) 2001-07-06 2002-07-05 Enzymes de metabolisation de medicaments
AU2002312624A AU2002312624A1 (en) 2001-07-06 2002-07-05 Drug metabolizing enzymes
JP2003510767A JP2005508614A (ja) 2001-07-06 2002-07-05 薬物代謝酵素

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US30374501P 2001-07-06 2001-07-06
US60/303,745 2001-07-06
US30540201P 2001-07-13 2001-07-13
US60/305,402 2001-07-13
US30815801P 2001-07-27 2001-07-27
US60/308,158 2001-07-27
US32212701P 2001-09-14 2001-09-14
US60/322,127 2001-09-14

Publications (2)

Publication Number Publication Date
WO2003004608A2 WO2003004608A2 (fr) 2003-01-16
WO2003004608A3 true WO2003004608A3 (fr) 2005-08-18

Family

ID=27501837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021105 WO2003004608A2 (fr) 2001-07-06 2002-07-05 Enzymes de metabolisation de medicaments

Country Status (5)

Country Link
EP (1) EP1572877A3 (fr)
JP (1) JP2005508614A (fr)
AU (1) AU2002312624A1 (fr)
CA (1) CA2453075A1 (fr)
WO (1) WO2003004608A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2570478B1 (fr) * 2010-05-12 2018-06-27 Amano Enzyme Inc. Réducteur dérivé de micro-organisme appartenant au genre bacillus, et application de celui-ci
CN102727752A (zh) * 2012-06-19 2012-10-17 卞毓平 五虎丹胶囊在制备治疗痛风药物中的应用
EP4100519A2 (fr) 2020-02-05 2022-12-14 The Broad Institute, Inc. Éditeurs de base d'adénine et leurs utilisations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
WO2002040651A2 (fr) * 2000-11-17 2002-05-23 Bayer Aktiengesellschaft Regulation de l'adenosine desaminase humaine specifique a arnt

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
WO2002040651A2 (fr) * 2000-11-17 2002-05-23 Bayer Aktiengesellschaft Regulation de l'adenosine desaminase humaine specifique a arnt

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ADAMS M.D. ET AL.: "The genome sequence of drosophila melanogaster.", SCIENCE., vol. 287, 24 March 2000 (2000-03-24), pages 2185 - 2195, XP002144875 *

Also Published As

Publication number Publication date
EP1572877A3 (fr) 2005-10-05
AU2002312624A8 (en) 2005-11-17
EP1572877A2 (fr) 2005-09-14
JP2005508614A (ja) 2005-04-07
WO2003004608A2 (fr) 2003-01-16
CA2453075A1 (fr) 2003-01-16
AU2002312624A1 (en) 2003-01-21

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