+

WO2003004080A1 - Seringue pour injecter un medicament - Google Patents

Seringue pour injecter un medicament Download PDF

Info

Publication number
WO2003004080A1
WO2003004080A1 PCT/EP2002/007634 EP0207634W WO03004080A1 WO 2003004080 A1 WO2003004080 A1 WO 2003004080A1 EP 0207634 W EP0207634 W EP 0207634W WO 03004080 A1 WO03004080 A1 WO 03004080A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
cylinder
plunger rod
plunger
block
Prior art date
Application number
PCT/EP2002/007634
Other languages
English (en)
Inventor
Johannes Mathias Gerardus Rikken
Victor Johannes Nickolson
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of WO2003004080A1 publication Critical patent/WO2003004080A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button

Definitions

  • the invention pertains to a syringe for the injection of a medicament comprising a cylinder, a plunger sealing one end of the cylinder, and a plunger rod with which the plunger can be moved relative to the cylinder.
  • the invention further pertains to a block suitable for attachment to the end of the plunger rod as well as to a kit comprising a plurality of such blocks.
  • Syringes are in common use for injecting a medicament, typically a pharmaceutical fluid, e.g. a solution, suspension, or emulsion containing a pharmaceutical substance, into the human or animal body.
  • a medicament typically a pharmaceutical fluid, e.g. a solution, suspension, or emulsion containing a pharmaceutical substance
  • the syringe comprises a medicine injection cartridge (numeral 10 in figure 2) which has been provided with a converter (80) .
  • the cartridge (10) comprises an ampule (12), i.e. a glass or plastic vial that contains a measured amount of fluid medication (18) . It further includes a fluid-tight plunger (14) for forcing the fluid medication through a hollow needle (24) attached to the nosepiece of the cartridge (10) .
  • the converter (80) which is mounted on the end of the ampule (12) remote from the needle (24) , comprises a plunger shaft (120) surrounded by two collars (206, 208) .
  • One of the collars (208) is attached to the head (205) of the plunger shaft (120) by means of a breakable connection (209) .
  • the length of the plunger shaft and of the collars (206, 208) are calibrated so that motion-impeding contact between a stop (210) , located on the ampule (12) , and lower collar (206) occurs after a predetermined displacement sufficient to assure displacement of all gas and initial wastage of medicine.
  • the collars (206, 208) are removed one by one so as to dispense two predetermined doses . Removal of the collars is difficult and may lead to a shifting of the plunger thus altering the predetermined dose or drawing air into the needle.
  • US 5,975,355 discloses a syringe, particularly useful to visually impaired individuals suffering from diabetes or other conditions.
  • a "unit measurer” comprises a plurality of blocks of different length. The length of each of the blocks is precisely selected so the amount of depression of the end of the plunger rod is limited and a selected volume can be delivered after removal of the block. Again, removal of the block may interfere with the position of the plunger. Further, the movement of the plunger is stopped by the bottom of the cylinder (barrel 22 in figure 1) and is likely to deform, thus altering the dosage further still.
  • the said end of the cylinder and/or the end of the plunger rod is provided with at least a first stop, which allows a movement of the plunger sufficient for priming the syringe, and preferably at least a second stop, which allows sufficient movement of the plunger for ejecting a selected quantity of the medicament.
  • the end of the said cylinder respectively of the plunger rod is more accessible thus improving ease of handling and reducing the risk of interfering with the axial position of the plunger.
  • the stop(s) is (are) located on the end of the plunger rod
  • the stop co-operates with a counterpart on the cylinder and that the stops are rotatable with respect to the cylinder. If the plunger rod is connected to the plunger by means of a threaded connection, it is preferred that the stops are rotatable with respect to the plunger rod. Thus, unscrewing of a plunger rod, as a result of rotating the stops, is substantially avoided.
  • stop(s) is (are) part of a detachable block.
  • several interchangeable blocks e.g. wherein the distance between the first and second stops varies, can be employed with a single, preferably pre-filled, syringe.
  • the invention also pertains to a kit comprising a plurality of blocks of which the distance between the first and second stop(s) is different for each block and preferably at least one syringe.
  • the blocks are preferably coded, e.g. by means of different colours and/or patterns of raised and/or recessed features such as dots (Braille) .
  • Such a kit can be used for the administration of medicaments of which the quantity to be administered varies with e.g. age, gender or weight, and can be used at home e.g. by the patient or family and friends who assist the patient.
  • the blocks enable the use of a single size syringe in clinical studies. I.e., instead of having to provide, store, and use several different syringes containing different quantities of a medicament, and having to carry out extensive stability tests to establish the stability of each particular quantity in each syringe of a particular size, it its thus possible to employ a single type (size) of syringe.
  • Figure 1 shows a perspective rear view of a preferred syringe and clip according to the present invention.
  • Figures 2A to 2D show a procedure for using the syringe according to figure 1.
  • Figures 3A and 3B show a second clip according to the present invention.
  • Figure 4A to 4C show a third clip according to the present invention.
  • Figures 1 to 2D show a syringe 1 in accordance with the present invention comprising a cylinder 2 of a transparent material, which is open on one end 3 and comprises a nosepiece 4 and/or needle 5 on the other.
  • the open end 3 of the cylinder 2 is sealed by means of a fluid- tight plunger 6, which is made of a resilient material, such as synthetic or natural rubber, and can slide inside the cylinder 2 to draw in or eject a fluid.
  • Markers (not shown) can be provided on the outer surface of the cylinder 2.
  • plunger rod 8 is connected to the plunger 6 by means of a threaded connection.
  • the end of plunger rod 8 remote from the plunger 6 comprises a rotationally symmetrical, e.g. circular, pusher 9 on which a block e.g. a clip 10 has been attached by means of a snap fit connection.
  • the clip 10 comprises a slot 11 extending through one of its side walls and in a plane at least substantially perpendicular to the central axis 12 of the plunger rod 8.
  • the inner diameter of the slot 11 is equal to or slightly larger than the outer diameter of the circular pusher 9.
  • the clip 10 comprises, e.g. two, first stops 13 which, in the radial direction (i.e. in a direction at least substantially perpendicular to the central axis 12) , extend beyond the outer surface of the cylinder 2, i.e. are not in line with the rim 3 of the cylinder 2, whilst remaining within the radial limits of the finger grips 7. It also comprises, again e.g. two, second stops 14 which, in the axial direction, are further removed form the rim 3 of the cylinder 2 than the first stops 13 and, in the radial direction, overlap at least partly with the rim 3 of the cylinder 2.
  • the position of the second stops is selected such that the plunger 6 cannot reach the bottom of the cylinder 2. Further, by carefully selecting the axial positions of the stops 13, 14, the amount of medicament that, after administration, remains inside the syringe 1 and thus does not cause unnecessary contamination or health risks, can be kept small.
  • a kit in accordance with the present invention preferably comprises one or more pre- illed syringes 1 and several, e.g. five clips 10 of different colour and with gradually increasing distances between the first and second stops (s) 13, 14.
  • the clips 10 are, for instance, blue, green, yellow, orange, and red whereas the said distances increase with steps in a range from e.g. 1 to 5 mm, depending on the dimensions of the syringe (s) 1 and corresponding to the required quantities of the medicament.
  • a user can select a clip 10 in accordance with a particular parameter, e.g. bodyweight .
  • a particular parameter e.g. bodyweight
  • the blue clip could be intended for a person with a body weight in a range from e.g. 50 to 60 kilos, the green clip for a range from 61-70 kilos, the yellow clip for a range form 71-80, and so on.
  • the syringe 1 in accordance with the present invention can be used as follows : 1) screw the threaded end of the plunger rod 8 into the plunger 6, place the clip 10 on the pusher 9 of the rod 8, and position the first stops 13 of the clip 10 in line with the finger grips 7 (figure 2A) ; 2) remove protection cap 15 and prime the syringe 1 by pressing on the clip 10 until the first stops 13 abut finger grips 7 (figure 2B) ;
  • FIGS. 3A and 3B show a second clip 10 in accordance with the present invention, the upper part 15 of which is curved.
  • a slot 11 provides access to a cavity 16, which runs the length of the upper part 15 and which thus provides a curved path for a pusher of a syringe.
  • One or more, in this case two, relatively long first stops 13, having a curved cross-section so as to improve bending stiffness, are provided on either side of the upper part 15 near the slot 11 and a corresponding number of shorter second stops 14 are provided on either side near the other end of the upper part 15.
  • the bottom wall of the cavity 16 comprises a slide (not shown) for accommodating a plunger rod.
  • the upper wall of the cavity 16 comprises two substantially flat portions, located over first and second stops 13, 14 and indicated by the words "prime" and "inject".
  • the stops 13, 14 are shaped to cooperate with the rim of the cylinder of a syringe or with a safety device surrounding at least part of the syringe.
  • a safety device surrounding at least part of the syringe.
  • Such safety devices are commonly known and are typically intended for protection against accidental needle stick hazard and surround at least part of the cylinder of the syringe.
  • FIG. 4A to 4C show a third clip 10 according to the present invention.
  • a slot 11 provides access to a cavity 16, which comprises a slide 17 in its top wall for accommodating a plunger rod 8 and a slide 18 in its bottom wall for accommodating the cylinder of a syringe.
  • the width of the slide 18 is slightly smaller than the width of the cylinder, except for two portions 19, 20, where the width of the slide is similar to that of the cylinder and where the clip 10, once positioned on the cylinder, will automatically halt.
  • the positions 19, 20 are located between first and second stops 13 , 14 and marked by the words "prime” and "inject”. To improve the resilience of the clip 10, the slides 17 and 18 extend into a notch 21.
  • This third embodiment of the clip 10 can be placed over a rim or, if present, finger grips at or near the end of the cylinder 2 of a syringe and can be operated in a way similar to that of the second embodiment, i.e. be pushed rather than rotated from the "prime" to the "inject” position.
  • the invention enables the administration of a selected quantity of a medicament, substantially without risking an axial shift of the plunger in between the priming of the syringe 1 and the administering of the medicament .
  • a kit comprising two or more blocks (e.g. clips)
  • controlled administration can be carried out by patients at home.
  • a single type syringe can be used in clinical tests requiring only a single stability test for that particular syringe and simplifying the logistics and storage considerably.
  • the block can comprise three of more stops separated by two or more (optionally mutually different) axial distances.
  • two or more selected quantities can be administered using a single syringe.
  • the syringe can be provided with peripheral parts such as the above-mentioned safety device.
  • at least one of the stops can co-operate with one or more features of the safety device, such as its upper rim or protrusions or recesses on, in or near the upper rim.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne une seringue (1) pour injecter un médicament. Cette seringue comprend un cylindre (2), un piston (6), qui rend étanche une extrémité du cylindre, ainsi qu'une tige de piston (8), qui permet de déplacer le piston (6) par rapport au cylindre (2). Ladite extrémité du cylindre (2) et l'extrémité de la tige (8) du piston présentent au moins une première butée (13), qui permet de déplacer suffisamment le piston (6) pour amorcer la seringue (1), ainsi que de préférence au moins une seconde butée (14), qui permet de déplacer suffisamment le piston (6) pour éjecter une quantité choisie du médicament. La présente invention concerne également un bloc (10), qui est conçu pour être fixé à ladite extrémité d'un cylindre (2), respectivement d'une tige de piston (8) d'une seringue (1), ainsi qu'une trousse comprenant plusieurs desdits blocs (10).
PCT/EP2002/007634 2001-07-05 2002-07-04 Seringue pour injecter un medicament WO2003004080A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01202592 2001-07-05
EP01202592.0 2001-07-05
EP02075151.7 2002-01-04
EP02075151 2002-01-04

Publications (1)

Publication Number Publication Date
WO2003004080A1 true WO2003004080A1 (fr) 2003-01-16

Family

ID=26076952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007634 WO2003004080A1 (fr) 2001-07-05 2002-07-04 Seringue pour injecter un medicament

Country Status (1)

Country Link
WO (1) WO2003004080A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10351597A1 (de) * 2003-11-05 2005-06-16 Tecpharma Licensing Ag Vorrichtung für die Verabreichung eines injizierbaren Produkts
WO2011061313A1 (fr) 2009-11-20 2011-05-26 Novartis Ag Seringue
WO2011073176A1 (fr) 2009-12-15 2011-06-23 Novartis Ag Seringue
WO2011073174A1 (fr) 2009-12-15 2011-06-23 Novartis Ag Seringue
WO2015085215A1 (fr) 2013-12-06 2015-06-11 Teleflex Medical Incorporated Seringue à séparateur de dose
US20160243313A1 (en) * 2015-02-24 2016-08-25 Teleflex Medical Incorporated Dose divider syringe
EP3254717A1 (fr) 2016-06-09 2017-12-13 Novartis Ag Seringue et procédé de distribution d'un liquide
JP2019537469A (ja) * 2016-11-04 2019-12-26 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 小単位投薬量プランジャロッド止め具
EP2701778B1 (fr) 2011-04-28 2020-07-08 Biogen MA Inc. Limiteur pour dispositif distributeur
WO2020232503A1 (fr) * 2019-05-20 2020-11-26 The University Of Sydney Adaptateur destiné à un dispositif d'administration de médicament et procédé associé
US11433186B2 (en) 2017-12-13 2022-09-06 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
US11439758B2 (en) 2019-06-05 2022-09-13 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
JP7483243B2 (ja) 2020-03-16 2024-05-15 株式会社トクヤマデンタル シリンジのプランジャー操作補助具

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3052239A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3337095A (en) * 1966-08-29 1967-08-22 Jacob P Marbach Syringe for automatic proportioning
GB1133714A (en) * 1965-12-10 1968-11-13 Edward Philip Marbach A liquid proportioning syringe
US3770026A (en) * 1971-09-17 1973-11-06 J Isenberg Apparatus and method for accurately loading syringes
US4563178A (en) * 1985-02-06 1986-01-07 Santeramo Joseph J Syringe dosage limiter
US4874385A (en) * 1987-12-16 1989-10-17 Sherwood Medical Company Plunger lock device
US4915692A (en) * 1987-12-30 1990-04-10 Jacques Verlier Non-reusable syringe
WO1997001362A2 (fr) * 1995-06-28 1997-01-16 Sergei Popov Seringue doseuse
US5833669A (en) * 1993-05-27 1998-11-10 Washington Biotech Corp. Medicine injection syringe constructions
US5975355A (en) * 1997-06-25 1999-11-02 Cecala; Ann Dosage unit measurer for syringe
WO2001062319A2 (fr) * 2000-02-23 2001-08-30 Abbott Laboratories Seringues et dispositifs de seringues pour administrer de maniere selective des doses controlees d'une substance therapeutique

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3052239A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
GB1133714A (en) * 1965-12-10 1968-11-13 Edward Philip Marbach A liquid proportioning syringe
US3337095A (en) * 1966-08-29 1967-08-22 Jacob P Marbach Syringe for automatic proportioning
US3770026A (en) * 1971-09-17 1973-11-06 J Isenberg Apparatus and method for accurately loading syringes
US4563178A (en) * 1985-02-06 1986-01-07 Santeramo Joseph J Syringe dosage limiter
US4874385A (en) * 1987-12-16 1989-10-17 Sherwood Medical Company Plunger lock device
US4915692A (en) * 1987-12-30 1990-04-10 Jacques Verlier Non-reusable syringe
US5833669A (en) * 1993-05-27 1998-11-10 Washington Biotech Corp. Medicine injection syringe constructions
WO1997001362A2 (fr) * 1995-06-28 1997-01-16 Sergei Popov Seringue doseuse
US5975355A (en) * 1997-06-25 1999-11-02 Cecala; Ann Dosage unit measurer for syringe
WO2001062319A2 (fr) * 2000-02-23 2001-08-30 Abbott Laboratories Seringues et dispositifs de seringues pour administrer de maniere selective des doses controlees d'une substance therapeutique

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10351597A1 (de) * 2003-11-05 2005-06-16 Tecpharma Licensing Ag Vorrichtung für die Verabreichung eines injizierbaren Produkts
WO2011061313A1 (fr) 2009-11-20 2011-05-26 Novartis Ag Seringue
US20120226240A1 (en) * 2009-11-20 2012-09-06 Novartis Ag Syringe
AU2010320885B2 (en) * 2009-11-20 2013-03-14 Novartis Ag Syringe
JP2013511309A (ja) * 2009-11-20 2013-04-04 ノバルティス アーゲー シリンジ
WO2011073176A1 (fr) 2009-12-15 2011-06-23 Novartis Ag Seringue
WO2011073174A1 (fr) 2009-12-15 2011-06-23 Novartis Ag Seringue
EP2701778B1 (fr) 2011-04-28 2020-07-08 Biogen MA Inc. Limiteur pour dispositif distributeur
WO2015085215A1 (fr) 2013-12-06 2015-06-11 Teleflex Medical Incorporated Seringue à séparateur de dose
US10391259B2 (en) 2013-12-06 2019-08-27 Teleflex Medical Incorporated Dose divider syringe
CN105979988A (zh) * 2013-12-06 2016-09-28 泰利福医疗公司 剂量分配注射器
JP2016538960A (ja) * 2013-12-06 2016-12-15 テレフレックス メディカル インコーポレイテッド 投与量分割器付きシリンジ
EP3077026A4 (fr) * 2013-12-06 2017-08-23 Teleflex Medical Incorporated Seringue à séparateur de dose
EP3261695A4 (fr) * 2015-02-24 2018-08-29 Teleflex Medical Incorporated Seringue à séparateur de dose
US20160243313A1 (en) * 2015-02-24 2016-08-25 Teleflex Medical Incorporated Dose divider syringe
JP2018506374A (ja) * 2015-02-24 2018-03-08 テレフレックス メディカル インコーポレイテッド 投与量分割器付きシリンジ
WO2016137764A1 (fr) 2015-02-24 2016-09-01 Teleflex Medical Incorporated Seringue à séparateur de dose
CN107249672A (zh) * 2015-02-24 2017-10-13 泰利福医疗公司 剂量分配注射器
US10420894B2 (en) * 2015-02-24 2019-09-24 Teleflex Medical Incorporated Dose divider syringe
WO2017212033A1 (fr) 2016-06-09 2017-12-14 Novartis Ag Seringue et procédé de distribution de liquide
EP3254717A1 (fr) 2016-06-09 2017-12-13 Novartis Ag Seringue et procédé de distribution d'un liquide
JP2019537469A (ja) * 2016-11-04 2019-12-26 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 小単位投薬量プランジャロッド止め具
US20210275751A1 (en) * 2016-11-04 2021-09-09 Shire Human Genetic Therapies, Inc. Small unit dosage plunger rod stops
US11806513B2 (en) 2016-11-04 2023-11-07 Takeda Pharmaceutical Company Limited Small unit dosage plunger rod stops
US11433186B2 (en) 2017-12-13 2022-09-06 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
WO2020232503A1 (fr) * 2019-05-20 2020-11-26 The University Of Sydney Adaptateur destiné à un dispositif d'administration de médicament et procédé associé
US11439758B2 (en) 2019-06-05 2022-09-13 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
JP7483243B2 (ja) 2020-03-16 2024-05-15 株式会社トクヤマデンタル シリンジのプランジャー操作補助具

Similar Documents

Publication Publication Date Title
EP3723828B1 (fr) Dispositifs et procédés d'administration de doses de précision
JP2540026B2 (ja) バイアル及びアンプルのための薬液アクセス組立体
CA2990666C (fr) Capuchon exterieur d'aiguille de stylo injecteur pour stylo d'administration de medicament
EP1094857B1 (fr) Dispositif medical d'administration et ensemble cartouche destine a etre utilise avec celui-ci
US5496284A (en) Dual-chamber syringe & method
EP0378305B1 (fr) Seringue à multidose
US5374256A (en) Fluid container for use with a fluid delivery apparatus
US20240189557A1 (en) Applicator and system for administering and dispensing flowable pharmaceutical preparations
CN113966240A (zh) 用于精确剂量递送的装置及方法
JP6902035B2 (ja) 医薬送達装置
JPH05345024A (ja) 再使用可能なペン型薬剤投与装置
JP2012000470A (ja) 調整可能なプランジャーの用量停止部材
WO2003004080A1 (fr) Seringue pour injecter un medicament
US9802002B2 (en) Training cartridge for a drug delivery device
US2453591A (en) Hypodermic syringe
US9833572B2 (en) Modular dual chamber syringe system
US20240374824A1 (en) Medical delivery device
US20210205528A1 (en) Pen needle magazine
WO2022069571A1 (fr) Ensemble de réglage de dose pour dispositif d'injection médicale
EA041108B1 (ru) Устройство и способ для доставки прецизионной дозы
EA044677B1 (ru) Устройство для введения, предназначенное для интравитреального введения жидкости

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2004113557

Country of ref document: RU

Kind code of ref document: A

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载