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WO2003002593A3 - Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv - Google Patents

Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv Download PDF

Info

Publication number
WO2003002593A3
WO2003002593A3 PCT/EP2002/007128 EP0207128W WO03002593A3 WO 2003002593 A3 WO2003002593 A3 WO 2003002593A3 EP 0207128 W EP0207128 W EP 0207128W WO 03002593 A3 WO03002593 A3 WO 03002593A3
Authority
WO
WIPO (PCT)
Prior art keywords
dipeptidyl peptidase
catalysis
peptide structures
structures useful
modulation
Prior art date
Application number
PCT/EP2002/007128
Other languages
English (en)
Other versions
WO2003002593A2 (fr
Inventor
Hans Ulrich Demuth
Torsten Hoffmann
Susanne Manhart
Matthias Hoffmann
Jochen Heins
Original Assignee
Probiodrug Ag
Hans Ulrich Demuth
Torsten Hoffmann
Susanne Manhart
Matthias Hoffmann
Jochen Heins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiodrug Ag, Hans Ulrich Demuth, Torsten Hoffmann, Susanne Manhart, Matthias Hoffmann, Jochen Heins filed Critical Probiodrug Ag
Priority to JP2003508973A priority Critical patent/JP2004530729A/ja
Priority to EP02762308A priority patent/EP1399469A2/fr
Priority to CA002419888A priority patent/CA2419888A1/fr
Publication of WO2003002593A2 publication Critical patent/WO2003002593A2/fr
Priority to NO20030900A priority patent/NO20030900L/no
Publication of WO2003002593A3 publication Critical patent/WO2003002593A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un composé représenté par la formule (I), et ses sels acceptables sur le plan pharmaceutique. On peut utiliser ces composés afin de préparer un médicament prophylactique ou thérapeutique pour un état dans lequel la modulation de l'activité de dipeptidyle peptidase IV joue un rôle intermédiaire, cet état étant, de préférence, sélectionné dans la diminution de la tolérance au glucose, le diabète sucré, la glycosurie ou l'acidose métabolique.
PCT/EP2002/007128 2001-06-27 2002-06-27 Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv WO2003002593A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003508973A JP2004530729A (ja) 2001-06-27 2002-06-27 ジペプチジルペプチダーゼｉｖ触媒作用の拮抗調節に有用なペプチド構造
EP02762308A EP1399469A2 (fr) 2001-06-27 2002-06-27 Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv
CA002419888A CA2419888A1 (fr) 2001-06-27 2002-06-27 Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv
NO20030900A NO20030900L (no) 2001-06-27 2003-02-26 Peptidstrukturer nyttige for kompetitiv modulering av dipeptidyl peptidaseIV-katalyse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01114796 2001-06-27
EP01114796.4 2001-06-27

Publications (2)

Publication Number Publication Date
WO2003002593A2 WO2003002593A2 (fr) 2003-01-09
WO2003002593A3 true WO2003002593A3 (fr) 2003-09-04

Family

ID=8177756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007128 WO2003002593A2 (fr) 2001-06-27 2002-06-27 Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv

Country Status (8)

Country Link
EP (1) EP1399469A2 (fr)
JP (1) JP2004530729A (fr)
CN (2) CN1688599A (fr)
CA (1) CA2419888A1 (fr)
NO (1) NO20030900L (fr)
RU (2) RU2003105463A (fr)
WO (1) WO2003002593A2 (fr)
ZA (3) ZA200301312B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638638B2 (en) 2003-05-14 2009-12-29 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US7897633B2 (en) 2004-02-05 2011-03-01 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8883714B2 (en) 2008-04-07 2014-11-11 Arena Pharmaceuticals, Inc. Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues
US9468598B2 (en) 2002-02-20 2016-10-18 Astrazeneca Ab Oral dosage form containing a PDE 4 inhibitor as an active ingredient and polyvinylpyrrolidon as excipient

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DE10211555A1 (de) * 2002-03-15 2003-10-02 Imtm Inst Fuer Medizintechnolo Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit sebozytärer Hyperproliferation und veränderten Differenzierungszuständen
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CN1894234A (zh) 2003-03-25 2007-01-10 武田药品工业株式会社 二肽基肽酶抑制剂
DE202004021723U1 (de) 2003-05-05 2010-07-15 Probiodrug Ag Medizinische Verwendung von Hemmern von Glutaminyl- und Glutamatcyclasen
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US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
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EP1699777B1 (fr) 2003-09-08 2012-12-12 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidylpeptidase
KR101121882B1 (ko) 2003-10-15 2012-04-12 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도
NZ546887A (en) 2003-11-03 2009-04-30 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
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EP3738585B1 (fr) 2004-01-20 2022-12-14 Novartis Ag Formulation de compression directe et procédé
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EA013427B1 (ru) 2004-03-15 2010-04-30 Такеда Фармасьютикал Компани Лимитед Ингибиторы дипептидилпептидазы
AU2005230864A1 (en) 2004-03-29 2005-10-20 Merck Sharp & Dohme Corp. Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
EP2305352A1 (fr) 2004-04-02 2011-04-06 Merck Sharp & Dohme Corp. Inhibiteurs de la 5-alpha-reductase pour le traitement d'hommes aux troubles métaboliques et anthropométriques
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EP1399469A2 (fr) 2004-03-24
CN1688599A (zh) 2005-10-26
NO20030900L (no) 2003-04-24
WO2003002593A2 (fr) 2003-01-09
CA2419888A1 (fr) 2003-01-09
RU2299066C2 (ru) 2007-05-20
ZA200300833B (en) 2004-02-10
ZA200300595B (en) 2004-02-13
NO20030900D0 (no) 2003-02-26
JP2004530729A (ja) 2004-10-07
RU2003105463A (ru) 2004-11-27

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