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WO2003083059A3 - Proteines de mutants de mcp-1, anticorps, compositions, procedes et utilisations - Google Patents

Proteines de mutants de mcp-1, anticorps, compositions, procedes et utilisations Download PDF

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Publication number
WO2003083059A3
WO2003083059A3 PCT/US2003/009056 US0309056W WO03083059A3 WO 2003083059 A3 WO2003083059 A3 WO 2003083059A3 US 0309056 W US0309056 W US 0309056W WO 03083059 A3 WO03083059 A3 WO 03083059A3
Authority
WO
WIPO (PCT)
Prior art keywords
mcp
methods
antibodies
compositions
mutant proteins
Prior art date
Application number
PCT/US2003/009056
Other languages
English (en)
Other versions
WO2003083059A2 (fr
Inventor
George A Heavner
Anuk Das
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Priority to EP03721448A priority Critical patent/EP1497423A4/fr
Priority to AU2003224761A priority patent/AU2003224761A1/en
Publication of WO2003083059A2 publication Critical patent/WO2003083059A2/fr
Publication of WO2003083059A3 publication Critical patent/WO2003083059A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention a trait à au moins une nouvelle protéine de mutants de MCP-1, des anticorps, des acides nucléiques isolés codant pour au moins une protéine ou un anticorps de mutant de MCP-1, des vecteurs de mutants de MCP-1, des animaux ou plantes transgéniques, et leurs procédés de fabrication et d'utilisation, y compris des compositions, procédés et dispositifs thérapeutiques.
PCT/US2003/009056 2002-03-26 2003-03-24 Proteines de mutants de mcp-1, anticorps, compositions, procedes et utilisations WO2003083059A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03721448A EP1497423A4 (fr) 2002-03-26 2003-03-24 Proteines de mutants de mcp-1, anticorps, compositions, procedes et utilisations
AU2003224761A AU2003224761A1 (en) 2002-03-26 2003-03-24 Mcp-1 mutant proteins, antibodies, compositions, methods and uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36793202P 2002-03-26 2002-03-26
US60/367,932 2002-03-26

Publications (2)

Publication Number Publication Date
WO2003083059A2 WO2003083059A2 (fr) 2003-10-09
WO2003083059A3 true WO2003083059A3 (fr) 2004-10-07

Family

ID=28675424

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/009056 WO2003083059A2 (fr) 2002-03-26 2003-03-24 Proteines de mutants de mcp-1, anticorps, compositions, procedes et utilisations

Country Status (3)

Country Link
EP (1) EP1497423A4 (fr)
AU (1) AU2003224761A1 (fr)
WO (1) WO2003083059A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR046594A1 (es) * 2003-10-16 2005-12-14 Applied Research Systems Usos terapeuticos de variantes de quemoquina
CN101443357A (zh) 2005-08-12 2009-05-27 先灵公司 Mcp1融合物
US8524217B2 (en) 2010-05-11 2013-09-03 Merck Sharp & Dohme Corp. MCP1-Ig fusion variants

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413778A (en) * 1992-10-05 1995-05-09 The Regents Of The University Of Michigan Labelled monocyte chemoattractant protein material and medical uses thereof
US5688927A (en) * 1995-06-07 1997-11-18 Icos Corporation Macrophage derived chemokine
WO1999005279A1 (fr) * 1997-07-25 1999-02-04 Zeneca Limited Analogues de mcp-1
US6174995B1 (en) * 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413778A (en) * 1992-10-05 1995-05-09 The Regents Of The University Of Michigan Labelled monocyte chemoattractant protein material and medical uses thereof
US6174995B1 (en) * 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US5688927A (en) * 1995-06-07 1997-11-18 Icos Corporation Macrophage derived chemokine
WO1999005279A1 (fr) * 1997-07-25 1999-02-04 Zeneca Limited Analogues de mcp-1
US6383782B1 (en) * 1997-07-25 2002-05-07 Zeneca Limited MCP-1 analogs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HEMMERICH S. ET AL: "Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2", BIOCHEMISTRY, vol. 38, August 1999 (1999-08-01), pages 13013 - 13025, XP002198634 *
See also references of EP1497423A4 *
ZHANG Y.J. ET AL: "Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis.", J. BIOL. CHEM., vol. 269, no. 22, 3 June 1994 (1994-06-03), pages 15918 - 15924, XP002025858 *

Also Published As

Publication number Publication date
WO2003083059A2 (fr) 2003-10-09
EP1497423A4 (fr) 2006-05-24
AU2003224761A1 (en) 2003-10-13
AU2003224761A8 (en) 2003-10-13
EP1497423A2 (fr) 2005-01-19

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