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WO2003081234A3 - Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 8 (gpr8) - Google Patents

Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 8 (gpr8) Download PDF

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Publication number
WO2003081234A3
WO2003081234A3 PCT/EP2003/002687 EP0302687W WO03081234A3 WO 2003081234 A3 WO2003081234 A3 WO 2003081234A3 EP 0302687 W EP0302687 W EP 0302687W WO 03081234 A3 WO03081234 A3 WO 03081234A3
Authority
WO
WIPO (PCT)
Prior art keywords
gpr8
therapeutics
diagnostics
protein
homo sapiens
Prior art date
Application number
PCT/EP2003/002687
Other languages
French (fr)
Other versions
WO2003081234A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to AU2003212356A priority Critical patent/AU2003212356A1/en
Publication of WO2003081234A2 publication Critical patent/WO2003081234A2/en
Publication of WO2003081234A3 publication Critical patent/WO2003081234A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a human GPR8 which is associated with the cardiovascular, haemaotological, peripheral and central nervous system diseases, asthma and COPD, inflammation, gastro-intestinal diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular, haemaotological, peripheral and central nervous system diseases, asthma and COPD, inflammation, gastro-intestinal diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR8 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2003/002687 2002-03-26 2003-03-14 Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 8 (gpr8) WO2003081234A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003212356A AU2003212356A1 (en) 2002-03-26 2003-03-14 Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 8 (gpr8)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02006650 2002-03-26
EP02006650.2 2002-03-26

Publications (2)

Publication Number Publication Date
WO2003081234A2 WO2003081234A2 (en) 2003-10-02
WO2003081234A3 true WO2003081234A3 (en) 2004-02-05

Family

ID=28051730

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/002687 WO2003081234A2 (en) 2002-03-26 2003-03-14 Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 8 (gpr8)

Country Status (2)

Country Link
AU (1) AU2003212356A1 (en)
WO (1) WO2003081234A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1602380A4 (en) * 2003-03-13 2009-09-02 Takeda Chemical Industries Ltd Preventive/remedy for diseases in upper digestive tract

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070971A2 (en) * 2000-03-24 2001-09-27 Bayer Aktiengesellschaft Regulation of human mas oncogene-related g protein-coupled receptor
WO2001098494A1 (en) * 2000-06-21 2001-12-27 Takeda Chemical Industries, Ltd Ligand to gpr8 and dna thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070971A2 (en) * 2000-03-24 2001-09-27 Bayer Aktiengesellschaft Regulation of human mas oncogene-related g protein-coupled receptor
WO2001098494A1 (en) * 2000-06-21 2001-12-27 Takeda Chemical Industries, Ltd Ligand to gpr8 and dna thereof
EP1293567A1 (en) * 2000-06-21 2003-03-19 Takeda Chemical Industries, Ltd. Ligand to gpr8 and dna thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KEITOKU MITSUMASA ET AL: "FMLP actions and its binding sites in isolated human coronary arteries.", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 29, no. 3, 1997, pages 881 - 894, XP002249990, ISSN: 0022-2828 *
PADIGARU MURALIDHARA ET AL: "Novel G-protein-coupled receptors: Structure and tissue expression analysis.", INTERNATIONAL GENOME SEQUENCING AND ANALYSIS CONFERENCE, vol. 12, 2000, 12th International Genome Sequencing and Analysis Conference;Miami Beach, Florida, USA; September 12-15, 2000, pages 82, XP001162842 *

Also Published As

Publication number Publication date
WO2003081234A2 (en) 2003-10-02
AU2003212356A1 (en) 2003-10-08
AU2003212356A8 (en) 2003-10-08

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