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WO2003076668A3 - Procede d'identification d'inhibiteurs d'arn specifiques - Google Patents

Procede d'identification d'inhibiteurs d'arn specifiques Download PDF

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Publication number
WO2003076668A3
WO2003076668A3 PCT/EP2003/002350 EP0302350W WO03076668A3 WO 2003076668 A3 WO2003076668 A3 WO 2003076668A3 EP 0302350 W EP0302350 W EP 0302350W WO 03076668 A3 WO03076668 A3 WO 03076668A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
specific rna
identifying specific
nucleic acid
relates
Prior art date
Application number
PCT/EP2003/002350
Other languages
German (de)
English (en)
Other versions
WO2003076668A2 (fr
Inventor
Martin Rohrbach
Martin Funk
Original Assignee
Medigene Ag
Martin Rohrbach
Martin Funk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medigene Ag, Martin Rohrbach, Martin Funk filed Critical Medigene Ag
Priority to AU2003214103A priority Critical patent/AU2003214103A1/en
Publication of WO2003076668A2 publication Critical patent/WO2003076668A2/fr
Publication of WO2003076668A3 publication Critical patent/WO2003076668A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un procédé permettant d'identifier des substances, adaptées pour inhiber spécifiquement l'expression d'une protéine ou l'action d'un acide nucléique. L'invention concerne en outre un ARN codant une toxine et une protéine cible ou un acide nucléique cible, ainsi que son utilisation pour identifier des inhibiteurs d'ARN spécifiques.
PCT/EP2003/002350 2002-03-08 2003-03-07 Procede d'identification d'inhibiteurs d'arn specifiques WO2003076668A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003214103A AU2003214103A1 (en) 2002-03-08 2003-03-07 Method for identifying specific rna-inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10210284.8 2002-03-08
DE2002110284 DE10210284A1 (de) 2002-03-08 2002-03-08 Verfahren zum Identifizieren von spezifischen RNA-Inhibitoren

Publications (2)

Publication Number Publication Date
WO2003076668A2 WO2003076668A2 (fr) 2003-09-18
WO2003076668A3 true WO2003076668A3 (fr) 2004-04-08

Family

ID=27797609

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/002350 WO2003076668A2 (fr) 2002-03-08 2003-03-07 Procede d'identification d'inhibiteurs d'arn specifiques

Country Status (3)

Country Link
AU (1) AU2003214103A1 (fr)
DE (1) DE10210284A1 (fr)
WO (1) WO2003076668A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021107508B4 (de) * 2021-03-25 2023-06-15 Martin-Luther-Universität Halle-Wittenberg, Körperschaft des öffentlichen Rechts Zuverlässige Identifikation von Bereichen (,a-Sites') in komlexen RNA-Molekülen, die zugänglich sind für Nukleinsäuren oder Komplexe von Nukleinsäuren mit Endonukleasen

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0825262A2 (fr) * 1989-12-29 1998-02-25 Novartis AG Expression de toxine dans des plantes à spécificité tissulaire
US5733726A (en) * 1995-06-07 1998-03-31 Emory University Cytotoxicity-based genetic selection system (TOXSEL)
US5932435A (en) * 1994-04-20 1999-08-03 Gene Shears Pty. Ltd. Screening antisense and ribozyme nucleic acids in schizosaccharomyces pombe
US20010031485A1 (en) * 2000-03-22 2001-10-18 Sibtech, Inc. Recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor fragments
US20020002278A1 (en) * 1999-11-05 2002-01-03 Timothy W. Nilsen Random intracellular method for obtaining optimally active nucleic acid molecules

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19905501B4 (de) * 1999-02-10 2005-05-19 MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0825262A2 (fr) * 1989-12-29 1998-02-25 Novartis AG Expression de toxine dans des plantes à spécificité tissulaire
US5932435A (en) * 1994-04-20 1999-08-03 Gene Shears Pty. Ltd. Screening antisense and ribozyme nucleic acids in schizosaccharomyces pombe
US5733726A (en) * 1995-06-07 1998-03-31 Emory University Cytotoxicity-based genetic selection system (TOXSEL)
US20020002278A1 (en) * 1999-11-05 2002-01-03 Timothy W. Nilsen Random intracellular method for obtaining optimally active nucleic acid molecules
US20010031485A1 (en) * 2000-03-22 2001-10-18 Sibtech, Inc. Recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor fragments

Also Published As

Publication number Publication date
AU2003214103A8 (en) 2003-09-22
AU2003214103A1 (en) 2003-09-22
DE10210284A1 (de) 2003-10-02
WO2003076668A2 (fr) 2003-09-18

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