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WO2003070969A3 - Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) - Google Patents

Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) Download PDF

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Publication number
WO2003070969A3
WO2003070969A3 PCT/US2003/004908 US0304908W WO03070969A3 WO 2003070969 A3 WO2003070969 A3 WO 2003070969A3 US 0304908 W US0304908 W US 0304908W WO 03070969 A3 WO03070969 A3 WO 03070969A3
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WIPO (PCT)
Prior art keywords
bcl2
nucleic acid
gene expression
rna
bcl
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PCT/US2003/004908
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English (en)
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WO2003070969A2 (fr
Inventor
James Mcswiggen
Leonid Beigelman
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Sirna Therapeutics Inc
James Mcswiggen
Leonid Beigelman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirna Therapeutics Inc, James Mcswiggen, Leonid Beigelman filed Critical Sirna Therapeutics Inc
Priority to EP03709164A priority Critical patent/EP1442143A4/fr
Priority to JP2003569860A priority patent/JP2005517452A/ja
Priority to CA002463595A priority patent/CA2463595A1/fr
Priority to AU2003213119A priority patent/AU2003213119A1/en
Publication of WO2003070969A2 publication Critical patent/WO2003070969A2/fr
Publication of WO2003070969A3 publication Critical patent/WO2003070969A3/fr
Priority to US10/923,516 priority patent/US20050176025A1/en
Priority to US12/192,878 priority patent/US20090247613A1/en

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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Abstract

La présente invention concerne des techniques et des réactifs qui conviennent pour moduler l'expression du gène BCL2 dans diverses applications comprenant l'utilisation de ces techniques et de ces réactifs dans une validation de cible thérapeutique et diagnostique et dans des applications de recherche génomique. Cette invention concerne spécifiquement de petites molécules d'acide nucléique telles que de petites molécules d'acide nucléique interférent (siNA), de petites molécules d'ARN interférent (siRNA), des molécules d'ARN double brin (dsRNA), des micro-ARN (miRNA),et de petites molécules d'ARN en épingle à cheveux (shRNA) capables d'induire une interférence ARN (RNAi) contre l'expression des gènes BCL2, BCL-XL, MCL-1, BCL2-Ll, CED-9, BAG-1, ElB-194 et/ou BCL-A. Ces petites molécules conviennent pour le traitement du cancer et d'autres pathologies qui répondent à la modulation de l'expression de BCL2, BCL-XL, MCL-1, BCL2-Ll, CED-9, BAG-1, E1B-194 et/ou BCL-A1.
PCT/US2003/004908 2001-05-18 2003-02-18 Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) WO2003070969A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP03709164A EP1442143A4 (fr) 2002-02-20 2003-02-18 Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina)
JP2003569860A JP2005517452A (ja) 2002-02-20 2003-02-18 短干渉核酸（ｓｉＮＡ）を用いるＢＣＬ２遺伝子発現のＲＮＡ干渉媒介性阻害
CA002463595A CA2463595A1 (fr) 2002-02-20 2003-02-18 Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina)
AU2003213119A AU2003213119A1 (en) 2002-02-20 2003-02-18 RNA INTERFERENCE MEDIATED INHIBITION OF BCL2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US10/923,516 US20050176025A1 (en) 2001-05-18 2004-08-20 RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
US12/192,878 US20090247613A1 (en) 2002-02-20 2008-08-15 RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US35858002P 2002-02-20 2002-02-20
US60/358,580 2002-02-20
US36312402P 2002-03-11 2002-03-11
US60/363,124 2002-03-11
US38678202P 2002-06-06 2002-06-06
US60/386,782 2002-06-06
US39690502P 2002-07-18 2002-07-18
US60/396,905 2002-07-18
US40678402P 2002-08-29 2002-08-29
US60/406,784 2002-08-29
US40837802P 2002-09-05 2002-09-05
US60/408,378 2002-09-05
US40929302P 2002-09-09 2002-09-09
US60/409,293 2002-09-09
US44012903P 2003-01-15 2003-01-15
US60/440,129 2003-01-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/923,516 Continuation-In-Part US20050176025A1 (en) 2001-05-18 2004-08-20 RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)

Publications (2)

Publication Number Publication Date
WO2003070969A2 WO2003070969A2 (fr) 2003-08-28
WO2003070969A3 true WO2003070969A3 (fr) 2004-01-08

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Application Number Title Priority Date Filing Date
PCT/US2003/004908 WO2003070969A2 (fr) 2001-05-18 2003-02-18 Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina)

Country Status (5)

Country Link
EP (1) EP1442143A4 (fr)
JP (1) JP2005517452A (fr)
AU (1) AU2003213119A1 (fr)
CA (1) CA2463595A1 (fr)
WO (1) WO2003070969A2 (fr)

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US9228186B2 (en) 2002-11-14 2016-01-05 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US9399774B2 (en) 2010-04-29 2016-07-26 Ionis Pharmaceuticals, Inc. Modulation of transthyretin expression

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US7423142B2 (en) 2001-01-09 2008-09-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7767802B2 (en) 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US8546143B2 (en) 2001-01-09 2013-10-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
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US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9719094B2 (en) 2002-11-14 2017-08-01 Thermo Fisher Scientific Inc. RNAi targeting SEC61G
US7951935B2 (en) 2002-11-14 2011-05-31 Dharmacon, Inc. siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC)
US9879266B2 (en) 2002-11-14 2018-01-30 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
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US9719092B2 (en) 2002-11-14 2017-08-01 Thermo Fisher Scientific Inc. RNAi targeting CNTD2
US10011836B2 (en) 2002-11-14 2018-07-03 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
WO2006006948A2 (fr) 2002-11-14 2006-01-19 Dharmacon, Inc. Methodes et compositions permettant de selectionner des arnsi presentant une fonctionnalite amelioree
ATE517992T1 (de) 2002-11-14 2011-08-15 Dharmacon Inc Funktionelle und hyperfunktionelle sirna
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US7612196B2 (en) 2002-11-14 2009-11-03 Dharmacon, Inc. siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
US8198427B1 (en) 2002-11-14 2012-06-12 Dharmacon, Inc. SiRNA targeting catenin, beta-1 (CTNNB1)
US9839649B2 (en) 2002-11-14 2017-12-12 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
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JP2005517452A (ja) 2005-06-16
AU2003213119A1 (en) 2003-09-09
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EP1442143A4 (fr) 2005-02-16
EP1442143A2 (fr) 2004-08-04

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