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WO2003070253A1 - Composant oestrogenique pour traiter la diminution de la libido chez les femmes - Google Patents

Composant oestrogenique pour traiter la diminution de la libido chez les femmes Download PDF

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Publication number
WO2003070253A1
WO2003070253A1 PCT/NL2003/000125 NL0300125W WO03070253A1 WO 2003070253 A1 WO2003070253 A1 WO 2003070253A1 NL 0300125 W NL0300125 W NL 0300125W WO 03070253 A1 WO03070253 A1 WO 03070253A1
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WIPO (PCT)
Prior art keywords
component
use according
estrogenic
estrogenic component
administered
Prior art date
Application number
PCT/NL2003/000125
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English (en)
Inventor
Herman Jian Tijmen Coelingh Bennink
Original Assignee
Pantarhei Bioscience B.V.
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Publication date
Application filed by Pantarhei Bioscience B.V. filed Critical Pantarhei Bioscience B.V.
Priority to AU2003206442A priority Critical patent/AU2003206442A1/en
Publication of WO2003070253A1 publication Critical patent/WO2003070253A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Definitions

  • the present invention is concerned with a method of treating decreased libido in pre- menopausal women, said decreased libido being the result of the repeated administration of a progestogenic component, e.g. as part of an oral contraceptive protocol.
  • libido defined as the urge to engage in sexual activity and intercourse
  • This decrease in libido is characterised by a lack of interest in sexual intercourse and/or the lack of ability to achieve orgasm.
  • a decrease in libido may also be accompamed by a decrease in intensity of orgasm. It is important to note that this decrease in libido is often associated with a profound sense of loss of a once normal and active interest in sexual activity.
  • US 5,439,931 (Sales) describes a method of increasing libido in post-menopausal women comprising administering to a female human an effective amount of a benzothiophene substance like raloxifene, a selective estrogen receptor modulator (SERM).
  • a benzothiophene substance like raloxifene
  • SERM selective estrogen receptor modulator
  • WO 00/66084 (Cole et al.) relates to aerosol formulations and devices for increasing libido in women via acute testosterone administration. It is stated in this application that in both men and women the primary naturally occurring hormone responsible for libido is testosterone.
  • the inventors have found that decreased libido in some pre-menopausal women is associated with the repeated administration of a progestogenic component, e.g. as part of a P T/NL03/00125 contraceptive protocol.
  • the inventors have additionally discovered that complaints about decreased libido in women who use a hormonal contraceptive, are strongly correlated with reduced, i.e. sub-physiological serum estrogen levels.
  • the administration of an estrogen component in an effective amount to significantly increase the woman's estrogen activity was found to be a very effective way to improve or restore libido in such women.
  • the present invention is specifically concerned with a method of treating decreased libido in pre-menopausal women, said decreased libido being the result of the repeated administration of a progestogenic component, wherein the method comprises the administration of the estrogenic component to a woman in an effective amount to improve the woman's libido.
  • progestogenic component is used to describe substances that are capable of binding to the one or more progesterone receptors and that can activate said receptors.
  • estrogenic component is used to refer to substances that are capable of binding to one or more estrogen receptors and that can activate one or more of these receptors.
  • the decreased libido as a result of repeated administration of a progestogenic component is believed to be caused by a relative estrogen deficiency.
  • the administration of progestogenic components is known to suppress the pituitary release of luteinising hormone (LH) and follicle stimulating hormone (FSH) which suppression in turn will lead to a reduction of the endogenous production of the estrogen 17 ⁇ -estradiol.
  • LH luteinising hormone
  • FSH follicle stimulating hormone
  • the present method is particularly suited for treating decreased libido in women using hormonal contraceptives that employ combined administration of a progestogenic component and an estrogen, in particular once daily oral administration of the combination of these components.
  • Decreased libido occurs most frequently in females using a contraceptive that employs a progestogenic component per se, or alternatively a progestogenic component in combination with a relatively low amount of an estrogen.
  • a relatively low amount of an estrogen is meant an amount which is equivalent to a daily oral dosage of at most 35 ⁇ g ethinyl estradiol.
  • the present method is particularly advantageous in case the estrogen in the contraceptive is administered in an amount which is equivalent to a daily oral dosage of at most 25 ⁇ g ethinyl estradiol, preferably of at most 20 ⁇ g ethinyl estradiol.
  • the present method is used to treat decreased libido resulting from daily oral administration of a progestogenic component in combination with an estrogen in a daily amount which is equivalent to between 5 and 25 ⁇ g ethinyl estradiol.
  • the administration of the estrogenic component is particularly effective if the period during which the estrogenic component is administered coincides with the period during which a progestogenic component is administered.
  • the administration of the progestogenic component occurs at regular intervals, the present method does not require the admimstration of the estrogenic component to follow a predefined pattern.
  • estrogenic components examples include ethinyl estradiol, mestranol, quinestranol, estradiol, estrone, estran, estriol, conjugated equine estrogens, precursors capable of liberating such an estrogenic component when used in the present method and mixtures thereof.
  • the estrogenic component is selected from the group consisting of ethinyl estradiol, estradiol, precursors capable of liberating such an estrogenic component when used in the present method and mixtures thereof. More preferably the estrogenic component is selected from the group consisting of ethinyl estradiol, 17/3-estradiol and mixtures thereof.
  • the estrogenic component is ethinyl estradiol.
  • the estrogenic component is administered in a dosage which is equivalent to an oral dosage of between 5 and 40 ⁇ g ethinyl estradiol, preferably of between 10 and 30 ⁇ g ethinyl estradiol.
  • an oral dosage of between 0.5 and 4 mg is equivalent to an oral dosage of between 5 and 40 ⁇ g ethinyl estradiol.
  • dosage refers to the amount that is administered within a relatively short time interval, e.g. of less than 10 minutes, preferably of less than 5 minutes.
  • dosage also encompasses the action of applying a dosage unit which, following said application, will effectively introduce the estrogenic component into the body over a prolonged period of time, as is the case for e.g. transdermal or intravaginal admimstration. If the actual release of the estrogenic component from such a sustained release dosage unit continuous for more than 24 hours, the aforementioned dosage amounts are to be calculated on a daily basis.
  • a dosage may be administered in the form of a single dosage unit, or alternatively in the form of 2 or more dosage units, provided these 2 or more dosage units are administered within the aforementioned short interval.
  • the estrogenic component will be administered at intervals that exceed 12 hours. Preferably the interval between subsequent administrations of the estrogenic component exceeds 20 hours.
  • the estrogenic component is a selective estrogen receptor modulator (SERM).
  • SERM selective estrogen receptor modulator
  • SERMS that may suitably be employed in the present method include tamoxifen, Z-tamoxifen, raloxifene, toremifene, idoxifene, droloxifene, nafoxidine, trioxifene, MER-25, EM-652, clomiphene, cyclophenil, lasofoxifene, arzoxifene, levormeloxifene, zindoxifene, miproxifene, fulvestrant, LY-117018, LY-326315ZK119010 LY-357489, GW-5638, GW 7603, GW-7604, TSE-424, FC1271a, Sch-57050, CDRI-85-287, NNC-45-0095, SG-292, RU-51625, RU-58668, ZK-164015, BE- 143
  • the present method is particularly suited for treating decreased libido in women using a hormonal contraceptive, in particular females who are repeatedly (self) administering a progestogenic component, optionally in combination with an estrogen, in accordance with a contraceptive protocol.
  • the present method employs the co-administration of the estrogenic component with an androgenic component. It was found that in some cases the combined administration of an estrogenic and an androgenic component is more effective than the administration of the estrogenic component per se in achieving improved libido.
  • the androgenic component may suitably be selected from the group consisting of dehydroepiandrosterone (DHEA); DHEA-sulphate; testosterone; testosterone esters such as testosterone undecanoate , testosterone propionate, testosterone phenylpropionate, testosterone isohexanoate, testosterone enantate, testosterone bucanate, testosterone decanoate, testosterone buciclate; danazol; gestrinone; methyltestosterone; mesterolon; stanozolol; androstenedione; dihydrotestosterone; androstanediol; metenolon; fluoxymesterone; oxymesterone; methandrostenolol; MENT; precursors capable of liberating these androgens when used in the present method and mixtures thereof.
  • DHEA dehydroepiandrosterone
  • DHEA-sulphate testosterone
  • testosterone esters such as testosterone undecanoate , testosterone propionate, testosterone phenylpropionate
  • the androgenic component is selected from the group consisting of DHEA, testosterone esters, androstenedione, precursors capable of liberating these androgens when used in the present method and mixtures thereof.
  • the androgenic component is selected from the group consisting of dehydroepiandrosterone, esters of testosterone and mixtures thereof.
  • the testosterone esters employed in the present method comprise an acyl group which comprises at least 6, more preferably from 8-20 and preferably 9-13 carbon atoms.
  • the androgens used in the present method are DHEA and/or testosterone undecanoate. These androgens offer the advantage that they can effectively be used in oral dosage units.
  • DHEA testosterone undecanoate and androstenedione are precursors of testosterone and that said precursors j ⁇ er se exhibit virtually no affinity for androgen receptors in the female body.
  • the effectiveness of the androgens within the method of the invention is determined by their functionally active form, which may well be different from the form in which they are administered.
  • the androgen is preferably provided in an amount equivalent to an oral dosage of at least 5 mg DHEA, which is equivalent to an oral dosage of at least 1 mg testosterone undecanoate. More preferably the androgen is provided in an amount which is equivalent to an oral dosage of a least 10 mg DHEA, most preferably of at least 20 mg DHEA. Usually the androgen dosage employed will not exceed the equivalent of an oral dosage of 250 mg DHEA, which is equivalent to an oral dosage of 50 mg testosterone undecanoate. Preferably the androgen is administered in a dosage which does not exceed the equivalent of an oral dosage of 120 mg DHEA, more preferably it does not exceed the equivalent of an oral dosage 60 mg DHEA.
  • the estrogenic component, and the optional androgenic component may suitably be administered orally, pulmonary, parenterally, sublingually, transdermally, intravaginally, intranasally or buccally.
  • the estrogenic component, and the optional androgenic component are administered orally, pulmonary or intranasally.
  • the estrogenic component is administered orally, h case the present method employs a combination of an estrogenic and an androgenic component, both components are advantageously delivered by means of the same mode of administration.
  • both components are administered orally, preferably in the form of a single oral dosage unit that contains both the estrogenic and the androgenic component.
  • DHEA may have a beneficial effect on libido in females who suffer from adrenal sufficiency, i a preferred embodiment the present method does not encompass the treatment of a woman suffering from adrenal sufficiency.
  • a clinical study is conducted in 40 healthy young women who have been using a low dose oral contraceptive (20 ⁇ g ethinyl estradiol in combination with a progestogen) for at least 3 years. In a baseline cycle, coitus frequency and sexual function are recorded.
  • Each participant receives blinded medication in 2 differently labeled bottles, filled with tablets.
  • One bottle comprises tablets that contain 20 ⁇ g ethinyl estradiol, whilst the other bottle contains identical placebo tablets.
  • the participants are allowed to choose from which bottle to take a tablet, but are instructed not to use more than 1 tablet per 24 hours and not more than 4 tablets a week.
  • the total duration of the study is 4 months, during which period the participants continue with their usual low dose oral contraceptive regimen.
  • Example 1 is repeated except that instead of tablets containing 20 ⁇ g ethinyl estradiol, tablets containing 2 mg 17/3-estradiol are used.
  • the findings show that oral administration of 2 mg 17/3-estradiol to users of a low dose oral contraceptive leads to an improvement of libido and sexual enjoyment in some of these users. Again no undesirable side-effects are reported.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Reproductive Health (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

L'invention concerne une méthode de traitement pour la diminution de la libido chez les femmes en préménopause, cette diminution étant le résultat de l'administration répétée d'un composant progestogénique. Ladite méthode comprend l'administration d'un composant oestrogénique à une femme dans une quantité suffisante pour améliorer sa libido. La méthode de l'invention est adaptée, en particulier, au traitement de la diminution de la libido chez les femmes utilisant des contraceptifs hormonaux, ces derniers nécessitant l'administration d'un composant progestogénique.
PCT/NL2003/000125 2002-02-21 2003-02-19 Composant oestrogenique pour traiter la diminution de la libido chez les femmes WO2003070253A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003206442A AU2003206442A1 (en) 2002-02-21 2003-02-19 Estrogenic component for treating decreased libido in women

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02075696 2002-02-21
EP02075696.1 2002-02-21

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WO2003070253A1 true WO2003070253A1 (fr) 2003-08-28

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2351358C2 (ru) * 2003-10-13 2009-04-10 Михель ЕМЕК Применение lh для лечения отсутствия либидо и достижения оргазма у женщин
US8703810B2 (en) 2010-06-10 2014-04-22 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
US9187460B2 (en) 2011-12-14 2015-11-17 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof

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Publication number Priority date Publication date Assignee Title
US5661141A (en) * 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
WO1998033499A1 (fr) * 1997-01-29 1998-08-06 Novo Nordisk A/S Utilisation de chromanes de 3,4-diphenyle pour la fabrication d'une composition pharmaceutique destinee a augmenter la libido chez les femmes en phase de post-menopause
US5854229A (en) * 1993-01-19 1998-12-29 Endorecherche, Inc. Therapeutic methods and delivery systems utilizing sex steroid precursors
WO1999000019A1 (fr) * 1997-06-27 1999-01-07 Smithkline Beecham Corporation Procedes de traitement des symptomes de la vaginite atrophique et du comportement sexuel modifie chez des femmes postmenopausees
WO1999063973A2 (fr) * 1998-06-11 1999-12-16 Endorecherche, Inc. COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS POUR L'ANDROST-5-ENE-3β,17β-DIOL
EP0659411B1 (fr) * 1993-12-21 2001-07-25 Eli Lilly And Company Méthode pour augmenter la libido chez les femmes en post-ménopause

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US5854229A (en) * 1993-01-19 1998-12-29 Endorecherche, Inc. Therapeutic methods and delivery systems utilizing sex steroid precursors
US5872114A (en) * 1993-01-19 1999-02-16 Endorecherche, Inc. Therapeutic methods and delivery systems utilizing sex steroid precursors
EP0659411B1 (fr) * 1993-12-21 2001-07-25 Eli Lilly And Company Méthode pour augmenter la libido chez les femmes en post-ménopause
US5661141A (en) * 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
WO1998033499A1 (fr) * 1997-01-29 1998-08-06 Novo Nordisk A/S Utilisation de chromanes de 3,4-diphenyle pour la fabrication d'une composition pharmaceutique destinee a augmenter la libido chez les femmes en phase de post-menopause
WO1999000019A1 (fr) * 1997-06-27 1999-01-07 Smithkline Beecham Corporation Procedes de traitement des symptomes de la vaginite atrophique et du comportement sexuel modifie chez des femmes postmenopausees
WO1999063973A2 (fr) * 1998-06-11 1999-12-16 Endorecherche, Inc. COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS POUR L'ANDROST-5-ENE-3β,17β-DIOL

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E-E BAULIEU ET AL: "Dehydroepiandrosterone (DHEA), DHEA sulfate and aging: Contribution of the DHEAge study to a sociobiomedical issue", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 8, 11 April 2000 (2000-04-11), pages 4279 - 4284, XP002141516, ISSN: 0027-8424 *
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2351358C2 (ru) * 2003-10-13 2009-04-10 Михель ЕМЕК Применение lh для лечения отсутствия либидо и достижения оргазма у женщин
US8703810B2 (en) 2010-06-10 2014-04-22 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
US9078871B2 (en) 2010-06-10 2015-07-14 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
US9187460B2 (en) 2011-12-14 2015-11-17 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
US9193714B2 (en) 2011-12-14 2015-11-24 Seragon Pharmaceuticals, Inc. Fluorinated estrogen receptor modulators and uses thereof

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