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WO2003068975A1 - ss-LACTAMASE/ANMINOGLYCOSIDES MODIFYING ENZYME GENES, THEIR FUSION GENE AND THE EXPRESSION PRODUCTS, THE COMPOSITION THEREOF, AND THEIR USES IN MEDICINE AND ENVIRONMENTAL PROTECTION - Google Patents

ss-LACTAMASE/ANMINOGLYCOSIDES MODIFYING ENZYME GENES, THEIR FUSION GENE AND THE EXPRESSION PRODUCTS, THE COMPOSITION THEREOF, AND THEIR USES IN MEDICINE AND ENVIRONMENTAL PROTECTION Download PDF

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Publication number
WO2003068975A1
WO2003068975A1 PCT/CN2003/000119 CN0300119W WO03068975A1 WO 2003068975 A1 WO2003068975 A1 WO 2003068975A1 CN 0300119 W CN0300119 W CN 0300119W WO 03068975 A1 WO03068975 A1 WO 03068975A1
Authority
WO
WIPO (PCT)
Prior art keywords
anminoglycosides
lactamase
medicine
composition
fusion gene
Prior art date
Application number
PCT/CN2003/000119
Other languages
French (fr)
Chinese (zh)
Inventor
Xiushu Chen
Original Assignee
Xiushu Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xiushu Chen filed Critical Xiushu Chen
Priority to AU2003211845A priority Critical patent/AU2003211845A1/en
Priority to CNB038036932A priority patent/CN1296483C/en
Publication of WO2003068975A1 publication Critical patent/WO2003068975A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to the isolation of antibiotics resistance enzyme genes, the preparation of their fusion gene, and the isolation of the expression products of the resistance enzyme genes and the fusion gene, the composition comprising the resistance enzyme proteins and fusion protein, as well as their uses in medicine and environmental protection. In particularly, the invention relates to the isolation of the genes coding for ß-lactamase, anminoglycosides modifying enzyme, the preparation of the ß-lactamase/anminoglycosides modifying enzyme fusion gene, and the isolation of their expression products, the composition comprising the fusion protein of the resistance enzyme proteins, as well as their uses in medicine and environmental protection.
PCT/CN2003/000119 2002-02-11 2003-02-08 ss-LACTAMASE/ANMINOGLYCOSIDES MODIFYING ENZYME GENES, THEIR FUSION GENE AND THE EXPRESSION PRODUCTS, THE COMPOSITION THEREOF, AND THEIR USES IN MEDICINE AND ENVIRONMENTAL PROTECTION WO2003068975A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003211845A AU2003211845A1 (en) 2002-02-11 2003-02-08 ss-LACTAMASE/ANMINOGLYCOSIDES MODIFYING ENZYME GENES, THEIR FUSION GENE AND THE EXPRESSION PRODUCTS, THE COMPOSITION THEREOF, AND THEIR USES IN MEDICINE AND ENVIRONMENTAL PROTECTION
CNB038036932A CN1296483C (en) 2002-02-11 2003-02-08 Beta-lactamase/anminoglycosides modifying enzyme genes, their fusion gene and the expression products, the composition thereof, and their uses in medicine and environmental protection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB021050384A CN1191363C (en) 2002-02-11 2002-02-11 Beta-lactamase/amino-glucosidic passive zyme interfused gene, its expressed products and composition thereof and use
CN02105038.4 2002-02-11

Publications (1)

Publication Number Publication Date
WO2003068975A1 true WO2003068975A1 (en) 2003-08-21

Family

ID=27672139

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2003/000119 WO2003068975A1 (en) 2002-02-11 2003-02-08 ss-LACTAMASE/ANMINOGLYCOSIDES MODIFYING ENZYME GENES, THEIR FUSION GENE AND THE EXPRESSION PRODUCTS, THE COMPOSITION THEREOF, AND THEIR USES IN MEDICINE AND ENVIRONMENTAL PROTECTION

Country Status (3)

Country Link
CN (2) CN1191363C (en)
AU (1) AU2003211845A1 (en)
WO (1) WO2003068975A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010072892A1 (en) * 2008-12-22 2010-07-01 Tuula Heinonen Method and product for degrading antibiotic residues in aqueous waste material
EP3207141B1 (en) * 2014-10-16 2019-07-31 Azurrx SAS Hybrid protein molecule being able to inhiit at least one antibiotic and pharmaceutical composition containing it

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1191363C (en) * 2002-02-11 2005-03-02 陈秀枢 Beta-lactamase/amino-glucosidic passive zyme interfused gene, its expressed products and composition thereof and use
CN101003798B (en) * 2006-01-17 2010-05-12 温州医学院 Purified expression of recombined beta lactamase in superspectrum, and fermentation process in high density
CN108355141B (en) * 2018-01-11 2019-06-18 广西壮族自治区人民医院 A kind of medicine for treating allergic diseases based on TIM-4-Fc fusion protein and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0467049A1 (en) * 1990-07-16 1992-01-22 American Cyanamid Company DNA sequences and amino acid sequences of class b beta-lactamase enzymes from bacteroides fragilis
SU1707078A1 (en) * 1989-11-21 1992-01-23 Институт биоорганической химии им.М.М.Шемякина Recombinant plasmid dna pthy314, encoding polypeptide with properties of human @@@-thymosine, recombinant plasmid dna pthy12 - an intermediate product for its construction, and the strain of bacteria escherichia coli - a producer of polypeptide with properties of human @@@-thymosine
WO1993017113A1 (en) * 1992-02-14 1993-09-02 Institut Pasteur RECOMBINANT β-LACTAMASE USABLE AS CARRIER MOLECULE FOR THE PREPARATION OF IMMUNOGENIC COMPOSITIONS
WO1994026913A2 (en) * 1993-05-13 1994-11-24 Plant Genetic Systems, N.V. Marker gene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1191363C (en) * 2002-02-11 2005-03-02 陈秀枢 Beta-lactamase/amino-glucosidic passive zyme interfused gene, its expressed products and composition thereof and use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1707078A1 (en) * 1989-11-21 1992-01-23 Институт биоорганической химии им.М.М.Шемякина Recombinant plasmid dna pthy314, encoding polypeptide with properties of human @@@-thymosine, recombinant plasmid dna pthy12 - an intermediate product for its construction, and the strain of bacteria escherichia coli - a producer of polypeptide with properties of human @@@-thymosine
EP0467049A1 (en) * 1990-07-16 1992-01-22 American Cyanamid Company DNA sequences and amino acid sequences of class b beta-lactamase enzymes from bacteroides fragilis
WO1993017113A1 (en) * 1992-02-14 1993-09-02 Institut Pasteur RECOMBINANT β-LACTAMASE USABLE AS CARRIER MOLECULE FOR THE PREPARATION OF IMMUNOGENIC COMPOSITIONS
WO1994026913A2 (en) * 1993-05-13 1994-11-24 Plant Genetic Systems, N.V. Marker gene

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010072892A1 (en) * 2008-12-22 2010-07-01 Tuula Heinonen Method and product for degrading antibiotic residues in aqueous waste material
EP3207141B1 (en) * 2014-10-16 2019-07-31 Azurrx SAS Hybrid protein molecule being able to inhiit at least one antibiotic and pharmaceutical composition containing it
EP3584321A1 (en) * 2014-10-16 2019-12-25 Azurrx SAS Hybrid protein molecule capable of inhibiting at least one antibiotic and pharmaceutical composition comprising same

Also Published As

Publication number Publication date
CN1438315A (en) 2003-08-27
CN1296483C (en) 2007-01-24
CN1191363C (en) 2005-03-02
AU2003211845A1 (en) 2003-09-04
CN1630726A (en) 2005-06-22

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