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WO2003068753A1 - Composes a noyau fusionne contenant n-carbamoyle azote et medicaments contenant ces composes comme ingredients actifs - Google Patents

Composes a noyau fusionne contenant n-carbamoyle azote et medicaments contenant ces composes comme ingredients actifs Download PDF

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Publication number
WO2003068753A1
WO2003068753A1 PCT/JP2003/001481 JP0301481W WO03068753A1 WO 2003068753 A1 WO2003068753 A1 WO 2003068753A1 JP 0301481 W JP0301481 W JP 0301481W WO 03068753 A1 WO03068753 A1 WO 03068753A1
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WO
WIPO (PCT)
Prior art keywords
compounds
active ingredient
fused ring
drugs
carbamoyl nitrogen
Prior art date
Application number
PCT/JP2003/001481
Other languages
English (en)
French (fr)
Inventor
Takuya Seko
Seishi Katsumata
Masashi Kato
Jun-Ichiro Manako
Kazuyuki Ohmoto
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Priority to AU2003211951A priority Critical patent/AU2003211951A1/en
Priority to EP03705105A priority patent/EP1475368A4/en
Priority to JP2003567884A priority patent/JPWO2003068753A1/ja
Priority to US10/504,422 priority patent/US7368444B2/en
Publication of WO2003068753A1 publication Critical patent/WO2003068753A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/JP2003/001481 2002-02-14 2003-02-13 Composes a noyau fusionne contenant n-carbamoyle azote et medicaments contenant ces composes comme ingredients actifs WO2003068753A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003211951A AU2003211951A1 (en) 2002-02-14 2003-02-13 N-carbamoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient
EP03705105A EP1475368A4 (en) 2002-02-14 2003-02-13 FUSED CORE COMPOUNDS CONTAINING N-CARBAMOYL NITROGEN AND MEDICAMENTS CONTAINING SAID COMPOUNDS AS ACTIVE INGREDIENTS
JP2003567884A JPWO2003068753A1 (ja) 2002-02-14 2003-02-13 Ｎ−カルバモイル窒素含有縮合環化合物およびその化合物を有効成分として含有する薬剤
US10/504,422 US7368444B2 (en) 2002-02-14 2003-02-13 N-carbamoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002036340 2002-02-14
JP2002-36340 2002-02-14

Publications (1)

Publication Number Publication Date
WO2003068753A1 true WO2003068753A1 (fr) 2003-08-21

Family

ID=27678082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/001481 WO2003068753A1 (fr) 2002-02-14 2003-02-13 Composes a noyau fusionne contenant n-carbamoyle azote et medicaments contenant ces composes comme ingredients actifs

Country Status (6)

Country Link
US (1) US7368444B2 (ja)
EP (1) EP1475368A4 (ja)
JP (1) JPWO2003068753A1 (ja)
AU (1) AU2003211951A1 (ja)
TW (1) TW200305423A (ja)
WO (1) WO2003068753A1 (ja)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004113300A1 (ja) * 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. 新規三環性複素環化合物
WO2005040135A1 (ja) * 2003-10-24 2005-05-06 Ono Pharmaceutical Co., Ltd. 抗ストレス薬およびその医薬用途
WO2005047286A1 (ja) * 2003-11-13 2005-05-26 Ono Pharmaceutical Co., Ltd. スピロ複素環化合物
WO2005063241A1 (ja) * 2003-12-26 2005-07-14 Ono Pharmaceutical Co., Ltd. ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および／または治療剤
FR2867187A1 (fr) * 2004-03-02 2005-09-09 Centre Nat Rech Scient Procede utile pour la preparation de benzazepines et derives de celles-ci.
WO2006044707A1 (en) * 2004-10-13 2006-04-27 Smithkline Beecham Corporation Chemical compounds
EP2011481A2 (fr) 2007-07-06 2009-01-07 L'Oreal Composition de protection solaire contenant l'association d'un polymère semi-cristallin et de particules de latex creuses
EP2014277A1 (fr) 2007-07-12 2009-01-14 L'Oreal Composition photoprotectrice fluide aqueuse à base d'un polymère polyamide à terminaison amide tertiaire
EP2016932A2 (fr) 2007-07-09 2009-01-21 L'Oréal Utilisation pour la coloration de la peau de l'acide dehydroascorbique ou de ses derives polymeres ; procedes de soin et/ou de maquillage
EP2119429A1 (fr) 2008-05-14 2009-11-18 L'Oréal Composition cosmetique contenant un derive de dibenzoylmethane et un derive de pyrrolidinone ; procede de photostabilisation du derive de dibenzoylmethane
EP2174644A1 (fr) 2008-10-08 2010-04-14 L'oreal Composition cosmétique contenant un dérivé de dibenzoylméthane et un composé dithiolane; procédé de photostabilisation du dérivé de dibenzoylmethane
EP2191869A1 (fr) 2008-12-01 2010-06-02 L'oreal Procédé de coloration artificielle de la peau utilisant un mélange de caroténoide et de colorant vert lipophile ; nouveau mélange de colorants lipophiles ; composition
US7741317B2 (en) * 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7964726B2 (en) 2004-12-22 2011-06-21 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
WO2011073280A2 (fr) 2009-12-18 2011-06-23 L'oreal Procédé de traitement cosmétique impliquant un composé apte à condenser in situ résistant
WO2011151203A2 (en) 2010-06-03 2011-12-08 L'oreal Cosmetic treatment process using a coating based on a copolymer containing polyamide blocks and polyether blocks
CN103804367A (zh) * 2014-02-28 2014-05-21 天津药物研究院 苯并氮杂卓衍生物、其制备方法和用途
JP2014534261A (ja) * 2011-11-21 2014-12-18 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ カルボキシｘローダミン類似体
US9266883B2 (en) 2013-10-25 2016-02-23 Novartis Ag Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
US9802917B2 (en) 2015-03-25 2017-10-31 Novartis Ag Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

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GB0421525D0 (en) 2004-09-28 2004-10-27 Novartis Ag Inhibitors of protein kineses
EP1830796A2 (fr) * 2004-12-20 2007-09-12 L'Oréal Utilisation de ligands du recepteur des benzodiazepines pour lutter contre les signes du vieillissement
WO2006067327A2 (fr) * 2004-12-20 2006-06-29 L'oreal Antagonistes des recepteurs peripheriques des benzodiazepines pour le traitement des peaux seches
KR100651849B1 (ko) * 2005-02-01 2006-12-01 엘지전자 주식회사 세탁기
EP2295432A1 (en) * 2006-02-10 2011-03-16 TransTech Pharma Inc. Process for the preparation of aminobenzimidazole derivatives
WO2007103719A2 (en) * 2006-03-03 2007-09-13 Incyte Corporation MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
KR20100017767A (ko) * 2007-05-10 2010-02-16 에이엠알 테크놀로지, 인크. 아릴옥시- 및 헤테로 아릴옥시-치환된 테트라히드로벤즈아제핀 및 도파민 및 세로토닌의 재흡수를 차단하기 위한 이의 용도
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ES2565826T3 (es) 2012-01-13 2016-04-07 Novartis Ag Pirroles fusionados como agonistas del receptor IP para el tratamiento de hipertensión arterial pulmonar (PAH) y trastornos relacionados
EP2956455B1 (en) 2013-02-13 2017-05-17 Novartis AG Ip receptor agonist heterocyclic compounds
US20180185341A1 (en) 2014-10-03 2018-07-05 Novartis Ag Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
CN109843379B (zh) * 2016-09-01 2022-12-30 梅比斯发现公司 取代脲及其制备和使用方法
EP3570838B1 (en) 2017-01-17 2024-06-05 Mebias Discovery, Inc. Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
JP2025506410A (ja) * 2022-02-03 2025-03-11 シーフォーエックス・ディスカバリー・リミテッド Ｍａｌｔ１阻害剤としてのヘテロ環誘導体
CN115246842B (zh) * 2022-06-15 2024-05-24 深圳湾实验室 一类靶向去泛素化酶usp25和usp28的小分子抑制剂

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US3346565A (en) * 1963-05-22 1967-10-10 Lepetit Spa 1, 2, 3, 5-tetrahydro-4, 1-benzoxazepines and 3, 5-dehydro-4, 1-benzoxazepin-2-(1h)-ones
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US3458498A (en) * 1966-04-25 1969-07-29 American Home Prod Certain 1-acyl derivatives of 7-alkoxy-2,3,4,5-tetrahydro-1h-1-benzazepine
GB1193534A (en) * 1968-02-12 1970-06-03 Ucb Sa Novel Benzazocine Derivatives, the Preparation thereof and Compositions Containing the same
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US4029667A (en) * 1974-03-05 1977-06-14 John Wyeth & Brother Limited Certain 1-carbothioamides of 1,8-naphthyridines, pyrrolo(2,3-b)pyridines and pyrido(2,3-b)azepines
WO2001032610A1 (fr) * 1999-10-29 2001-05-10 Kaken Pharmaceutical Co., Ltd. Derive d'uree, son procede de production, et produit pharmaceutique contenant ce derive d'uree
WO2003030937A1 (fr) * 2001-10-05 2003-04-17 Ono Pharmaceutical Co., Ltd. Remedes contre des maladies liees au stress comprenant des antagonistes de recepteurs mithochondriaux de la benzodiazepine

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US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
FR1473839A (fr) * 1965-04-02 1967-03-24 Alphachimie Nouveaux dérivés de la 2, 3, 4, 5-tétrahydro-(1h)-1-benzazépine et leurs procédés de fabrication
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US3542760A (en) * 1966-04-25 1970-11-24 American Home Prod 7-alkoxy-2,3,4,5-tetrahydro-1h-1-benzazepine and derivatives thereof
GB1193534A (en) * 1968-02-12 1970-06-03 Ucb Sa Novel Benzazocine Derivatives, the Preparation thereof and Compositions Containing the same
US3960876A (en) * 1974-03-05 1976-06-01 John Wyeth & Brother, Ltd. Certain 1-carbothioamides of 1,8-naphthyridines, pyrrolo(2,3-b)pyridines and pyrido(2,3-b)azepines
US4029667A (en) * 1974-03-05 1977-06-14 John Wyeth & Brother Limited Certain 1-carbothioamides of 1,8-naphthyridines, pyrrolo(2,3-b)pyridines and pyrido(2,3-b)azepines
WO2001032610A1 (fr) * 1999-10-29 2001-05-10 Kaken Pharmaceutical Co., Ltd. Derive d'uree, son procede de production, et produit pharmaceutique contenant ce derive d'uree
WO2003030937A1 (fr) * 2001-10-05 2003-04-17 Ono Pharmaceutical Co., Ltd. Remedes contre des maladies liees au stress comprenant des antagonistes de recepteurs mithochondriaux de la benzodiazepine

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DODD ROBERT H. ET AL.: "Modification of mitochondrial benzodiazepine receptor numbers in stressful situations", PERIPHER. BENZODIAZEPINE RECEPT, 1993, pages 187 - 207, XP002969403 *
ISHIHARA YUJI ET AL.: "Regioselective Friedel-Crafts acylation of 1,2,3,4-tetrahydroquinoline and related nitrogen heterocycles: effects of NH protective groups and ring size", J. CHEM. SOC. PERKIN TRANS. 1, vol. 24, 1992, pages 3401 - 3406, XP002968898 *
KHANNA J.M. ET AL.: "Agents acting on the central nervous system. X. 1-Substituted 3-phenyl-2,3,4,5-tetrahydro-1H-1benzazepines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 395, no. 10, 1967, pages 944 - 945, XP002968897 *
TESTA E. ET AL.: "Substances active on the nervous system. XXXVIII. Synthesis of 5-phenyl-3,5-dihydro-4,1-benzoazepin-2(1H)-ones and 5-phenyl.2.3.5-tetrahydro-4,1-benzoxazepines", FARMACO(PAVIA), ED. SCI., vol. 18, no. 11, 1963, pages 815 - 827, XP002969402 *
YANAGIDA A. JOSSANG ET AL.: "Derivatives of 2,3,4,5-tetrahydro-1H-pyrido(3,2-b)azepine, of 2,3,4,5-tetrahydro-1H-pyrido(2,3-b)azepine and their corresponding lactams. II. Synthesis and pharmacological study on their psychotropic activity", FARMACO, EDIZIONE SCIENTIFICA, vol. 34, no. 1, 1979, pages 26 - 35 *
YANAGIDA A. JOSSANG ET AL.: "Derivatives of tetrahydropyrido azepines and tetrahydropyridoazepinones. I. Derivatives of 2,3,4,5-tetrahydro-1H-pyrido(3,2-b)azepine and the corresponding lactam", FARMACO, EDIZIONE SCIENTIFICA, vol. 33, no. 12, 1978, pages 984 - 991, XP002968899 *

Cited By (27)

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US9533988B2 (en) 2013-10-25 2017-01-03 Novartis Ag Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
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CN103804367A (zh) * 2014-02-28 2014-05-21 天津药物研究院 苯并氮杂卓衍生物、其制备方法和用途
CN103804367B (zh) * 2014-02-28 2016-09-14 天津药物研究院 苯并氮杂卓衍生物、其制备方法和用途
US9802917B2 (en) 2015-03-25 2017-10-31 Novartis Ag Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

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EP1475368A1 (en) 2004-11-10
AU2003211951A1 (en) 2003-09-04
EP1475368A4 (en) 2006-03-29
JPWO2003068753A1 (ja) 2005-06-02

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