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WO2003066811A3 - Msrebps as modifiers of the srebp pathway and methods of use - Google Patents

Msrebps as modifiers of the srebp pathway and methods of use Download PDF

Info

Publication number
WO2003066811A3
WO2003066811A3 PCT/US2003/003384 US0303384W WO03066811A3 WO 2003066811 A3 WO2003066811 A3 WO 2003066811A3 US 0303384 W US0303384 W US 0303384W WO 03066811 A3 WO03066811 A3 WO 03066811A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
srebp
msrebps
modifiers
srebp pathway
Prior art date
Application number
PCT/US2003/003384
Other languages
French (fr)
Other versions
WO2003066811A2 (en
Inventor
Arthur Brace
Agnes V Eliares
Kimberly Carr Ferguson
Cynthia Seidel-Dugen
Felipa A Mapa
Donald Ruhrmund
Original Assignee
Exelixis Inc
Arthur Brace
Agnes V Eliares
Kimberly Carr Ferguson
Cynthia Seidel-Dugen
Felipa A Mapa
Donald Ruhrmund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Arthur Brace, Agnes V Eliares, Kimberly Carr Ferguson, Cynthia Seidel-Dugen, Felipa A Mapa, Donald Ruhrmund filed Critical Exelixis Inc
Priority to AU2003215004A priority Critical patent/AU2003215004A1/en
Publication of WO2003066811A2 publication Critical patent/WO2003066811A2/en
Publication of WO2003066811A3 publication Critical patent/WO2003066811A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Human MSREBP genes are identified as modulators of the SREBP pathway, and thus are therapeutic targets for disorders associated with defective SREBP function. Methods for identifying modulators of SREBP, comprising screening for agents that modulate the activity of MSREBP are provided.
PCT/US2003/003384 2002-02-06 2003-02-05 Msrebps as modifiers of the srebp pathway and methods of use WO2003066811A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003215004A AU2003215004A1 (en) 2002-02-06 2003-02-05 Msrebps as modifiers of the srebp pathway and methods of use

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US35468902P 2002-02-06 2002-02-06
US60/354,689 2002-02-06
US35812502P 2002-02-20 2002-02-20
US60/358,125 2002-02-20
US35876602P 2002-02-21 2002-02-21
US35878602P 2002-02-21 2002-02-21
US60/358,766 2002-02-21
US60/358,786 2002-02-21
US36030202P 2002-02-25 2002-02-25
US35941002P 2002-02-25 2002-02-25
US35939502P 2002-02-25 2002-02-25
US36045802P 2002-02-25 2002-02-25
US36040402P 2002-02-25 2002-02-25
US60/360,302 2002-02-25
US60/359,395 2002-02-25
US60/360,404 2002-02-25
US60/360,458 2002-02-25
US60/359,410 2002-02-25
US36035902P 2002-02-26 2002-02-26
US60/360,359 2002-02-26

Publications (2)

Publication Number Publication Date
WO2003066811A2 WO2003066811A2 (en) 2003-08-14
WO2003066811A3 true WO2003066811A3 (en) 2005-03-31

Family

ID=27739569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003384 WO2003066811A2 (en) 2002-02-06 2003-02-05 Msrebps as modifiers of the srebp pathway and methods of use

Country Status (2)

Country Link
AU (1) AU2003215004A1 (en)
WO (1) WO2003066811A2 (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LOUVEAU I. ET AL.: "GH and insulin affect fatty acid synthase activity in isolated porcine adipocytes in culture without any modifications of sterol regulatory element binding protein-1 expression", JOURNAL OF ENDOCRINOLOGY, vol. 181, 2004, pages 271 - 280 *

Also Published As

Publication number Publication date
AU2003215004A1 (en) 2003-09-02
WO2003066811A2 (en) 2003-08-14
AU2003215004A8 (en) 2003-09-02

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