WO2003066652A8 - Jlp cytoplasmic scaffolding protein and nucleic acids encoding it - Google Patents
Jlp cytoplasmic scaffolding protein and nucleic acids encoding itInfo
- Publication number
- WO2003066652A8 WO2003066652A8 PCT/US2003/003355 US0303355W WO03066652A8 WO 2003066652 A8 WO2003066652 A8 WO 2003066652A8 US 0303355 W US0303355 W US 0303355W WO 03066652 A8 WO03066652 A8 WO 03066652A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- jlp
- nucleic acids
- scaffolding protein
- acids encoding
- cytoplasmic scaffolding
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 101710184528 Scaffolding protein Proteins 0.000 title abstract 2
- 230000001086 cytosolic effect Effects 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 230000005735 apoptotic response Effects 0.000 abstract 2
- 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 abstract 1
- 101001115395 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Proteins 0.000 abstract 1
- 101001018145 Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Proteins 0.000 abstract 1
- 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 abstract 1
- 102000019145 JUN kinase activity proteins Human genes 0.000 abstract 1
- 102100033059 Mitogen-activated protein kinase kinase kinase 3 Human genes 0.000 abstract 1
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A cytoplasmic scaffolding protein named JLP has been isolated, which tethers MEKK3, MKK4, JNK,p38 MAPK, C-Myc and MAX into a sign aling module that controls the apoptotic response. Nucleic acid sequences which encode JLP, and methods of using the JLP nucleic acids and proteins, and mutants thereof, to modulate the apoptotic response in cells are provided.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003216170A AU2003216170A1 (en) | 2002-02-05 | 2003-02-04 | Jlp cytoplasmic scaffolding protein and nucleic acids encoding it |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35437702P | 2002-02-05 | 2002-02-05 | |
| US60/354,377 | 2002-02-05 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2003066652A2 WO2003066652A2 (en) | 2003-08-14 |
| WO2003066652A3 WO2003066652A3 (en) | 2003-10-30 |
| WO2003066652A8 true WO2003066652A8 (en) | 2004-02-19 |
Family
ID=27734363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2003/003355 WO2003066652A2 (en) | 2002-02-05 | 2003-02-04 | Jlp cytoplasmic scaffolding protein and nucleic acids encoding it |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003216170A1 (en) |
| WO (1) | WO2003066652A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1817328A2 (en) * | 2004-11-24 | 2007-08-15 | Theraptosis S.A. | New peptides useful as dual caspase-2/-6 inhibitors and their biological applications |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976838A (en) * | 1996-12-18 | 1999-11-02 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| WO2001057188A2 (en) * | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
-
2003
- 2003-02-04 WO PCT/US2003/003355 patent/WO2003066652A2/en not_active Application Discontinuation
- 2003-02-04 AU AU2003216170A patent/AU2003216170A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003216170A8 (en) | 2003-09-02 |
| WO2003066652A2 (en) | 2003-08-14 |
| AU2003216170A1 (en) | 2003-09-02 |
| WO2003066652A3 (en) | 2003-10-30 |
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