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WO2003065979A3 - Methods of diagnosis, monitoring and treatment of fertility - Google Patents

Methods of diagnosis, monitoring and treatment of fertility Download PDF

Info

Publication number
WO2003065979A3
WO2003065979A3 PCT/US2002/038629 US0238629W WO03065979A3 WO 2003065979 A3 WO2003065979 A3 WO 2003065979A3 US 0238629 W US0238629 W US 0238629W WO 03065979 A3 WO03065979 A3 WO 03065979A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
fertility
diagnosis
treatment
monitoring
Prior art date
Application number
PCT/US2002/038629
Other languages
French (fr)
Other versions
WO2003065979A2 (en
Inventor
Yousef Ai-Abed
Original Assignee
Long Island Jewish Res Inst
Yousef Ai-Abed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Long Island Jewish Res Inst, Yousef Ai-Abed filed Critical Long Island Jewish Res Inst
Priority to AU2002365941A priority Critical patent/AU2002365941A1/en
Publication of WO2003065979A2 publication Critical patent/WO2003065979A2/en
Publication of WO2003065979A3 publication Critical patent/WO2003065979A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention generally relates to methods of using dopachrome tautomerase activity of macrophage migration inhibitory factor (MIF) and related or other proteins present in the seminal fluid (ejaculate) of a male subject to evaluate fertility and other related diseases. Further utilities relate to the diagnosis and treatment of fertility, to new methods of contraception, and to methods of enhancing artificial insemination and in vitro fertilization.
PCT/US2002/038629 2001-12-05 2002-12-05 Methods of diagnosis, monitoring and treatment of fertility WO2003065979A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002365941A AU2002365941A1 (en) 2001-12-05 2002-12-05 Methods of diagnosis, monitoring and treatment of fertility

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35575501P 2001-12-05 2001-12-05
US60/355,755 2001-12-05

Publications (2)

Publication Number Publication Date
WO2003065979A2 WO2003065979A2 (en) 2003-08-14
WO2003065979A3 true WO2003065979A3 (en) 2004-02-12

Family

ID=27734557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038629 WO2003065979A2 (en) 2001-12-05 2002-12-05 Methods of diagnosis, monitoring and treatment of fertility

Country Status (2)

Country Link
AU (1) AU2002365941A1 (en)
WO (1) WO2003065979A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140679A (en) 2001-05-24 2010-01-15 Avanir Pharmaceuticals Inhibitors of macrohage migration inhibitory factor and methods for identifying the same
TW200418829A (en) 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
JP2008534502A (en) 2005-03-24 2008-08-28 アバニール・ファーマシューティカルズ Thienopyridinone derivatives as inhibitors of macrophage migration inhibitory factor
WO2007044622A1 (en) * 2005-10-07 2007-04-19 Yale University Use of mif and mif pathway agonists
WO2010147194A1 (en) * 2009-06-17 2010-12-23 国立大学法人広島大学 Sperm diluent solution and method for artificial insemination using same
US20150359763A1 (en) * 2013-01-30 2015-12-17 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada Use of 3-bromopyruvate as a contraceptive

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420188B1 (en) * 1996-02-16 2002-07-16 The Picower Institute For Medical Research Screening assay for the identification of inhibitors for macrophage migration inhibitory factor
US6492428B1 (en) * 2000-07-26 2002-12-10 The Picower Institute For Medical Research Compounds having MIF antagonist activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420188B1 (en) * 1996-02-16 2002-07-16 The Picower Institute For Medical Research Screening assay for the identification of inhibitors for macrophage migration inhibitory factor
US6492428B1 (en) * 2000-07-26 2002-12-10 The Picower Institute For Medical Research Compounds having MIF antagonist activity

Also Published As

Publication number Publication date
WO2003065979A2 (en) 2003-08-14
AU2002365941A8 (en) 2003-09-02
AU2002365941A1 (en) 2003-09-02

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