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WO2003063950A2 - Utilisation de la stimulation electrique pour traiter la chute de cheveux - Google Patents

Utilisation de la stimulation electrique pour traiter la chute de cheveux Download PDF

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Publication number
WO2003063950A2
WO2003063950A2 PCT/US2003/003210 US0303210W WO03063950A2 WO 2003063950 A2 WO2003063950 A2 WO 2003063950A2 US 0303210 W US0303210 W US 0303210W WO 03063950 A2 WO03063950 A2 WO 03063950A2
Authority
WO
WIPO (PCT)
Prior art keywords
electrical
electrode
set forth
electrical signal
area
Prior art date
Application number
PCT/US2003/003210
Other languages
English (en)
Other versions
WO2003063950A3 (fr
Inventor
Ali Rezai
Original Assignee
The Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Cleveland Clinic Foundation filed Critical The Cleveland Clinic Foundation
Priority to US10/503,029 priority Critical patent/US7493168B2/en
Publication of WO2003063950A2 publication Critical patent/WO2003063950A2/fr
Publication of WO2003063950A3 publication Critical patent/WO2003063950A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells

Definitions

  • the present invention relates generally to the electrical arts. It finds particular application in the medical arts where electrical or chemical stimulation is provided for therapeutic purpose. It will be appreciated however, that the present invention is also amenable to other fields of endeavor where controlled, localized electrical stimulation is desired.
  • DHT "strangles" hair follicles. While this process is the primary cause there are several other factors that contribute to further deterioration of the hair follicle such as: poor- circulation of the scalp, clogged or harshly treated hair follicles, over active sebaceous glands, and nutrient deficient hair follicles.
  • an electrical apparatus for treating hair loss includes a power supply capable of selectively generating an electrical signal and a controller in operative connection with the power supply.
  • An electrode mechanism is also provided disposed adjacent to an area of hair loss. The electrode mechanism is in electrical communication with the power supply and is formable by a user to correspond to an area of hair loss.
  • a hair restoration apparatus includes an electrical generator configured to generate an electrical signal having selected characteristics.
  • a controller in operative connection with the generator controls the operation of the electrical generator and characteristics of the generated electrical signal selected to effect a therapeutically effective application of electrical signal to a hair restoration site.
  • An electrode in electrical communication with the electrical generator is disposed in an area where application of the electrical signal is desired.
  • An electrical connection between the electrical generator and the electrode is sealed for at least partial implantation under the skin of a patient.
  • the invention may take form in various components and arrangements of components and in various steps and arrangements of steps.
  • the drawings are only for purposes of illustrating the preferred embodiments and are not to be constmed as limiting the invention. Moreover, the drawings are not to scale and certain elements may be illustrated in exaggerated form for clarity or to illustrate particular features.
  • Figure 1 illustrates a system suitable to practice the present invention
  • Figure 2 is a cross sectional view of the electrode taken along lines II-H in Figure
  • Figure 3 is a perspective view of an alternative embodiment suitable to practice the present invention.
  • Figure 4 is a side view of a subcutaneous implant
  • Figure 5 is a side view of a subgaleal implant
  • Figure 6 illustrates a dome infusion reservoir
  • Figure 7 illustrates an alternate dome infusion reservoir
  • Figure 8 illustrates a catheter tip with capability for perineural insertion
  • Figure 9 is a cross-sectional view of a stimulator device suitable to practice an aspect of the present invention.
  • Figure 10 is a view of a stimulator device
  • Figure 11 is a view of a burr hole ring with three groves.
  • a hair restoration apparatus 10 includes a power supply 12, a controller 14, and an electrode 16.
  • the controller 14 is operatively connected to the power supply and controls the electrical signal output from the power supply 12.
  • the electrical signal generated preferably includes a voltage between .1 ⁇ V and 20 V, a pulse within the range of 10 microseconds to 1000 microseconds, a frequency in the range of 2 Hz to 2500 Hz, and combinations thereof.
  • the controller 14 is illustrated as a separate component from the power supply 12, those skilled in the art will appreciate that alternate embodiments are possible without departing from the scope of the present invention. These include a controller packaged with a power supply or being an integral part of the power supply and the like.
  • an implanted controller is controlled via telemetry, magnetic, radio frequency, and the like control mechanisms.
  • Systems for communicating with implantable medical devices are disclosed for example in United States Patent Application No. 20020082665 entitled System And Method Of Communicating Between An Implantable Medical Device And A Remote Computer System Or Health Care Provider and United States Patent Application No. 20010012955 entitled Method And Apparatus For Communicating With An Implantable Medical Device, and United States Patent No. 6,201,993 entitled Medical Device Telemetry Receiver Having Improved Noise Discrimination, and are incorporated by reference here for their teachings.
  • power supply 12 is electrically connected with the electrode 16 by an insulated coupling or electrical lead 20.
  • coupling 20 passes through the skin 22 of a patient to establish electrical conductivity with the implanted electrode 16.
  • the electrode 16 is formable by cutting, tearing, or separating perforations to substantially conform with the area where treatment is desired. It is to be appreciated that various sizes of electrodes are provided to minimize waste in matching an appropriately sized electrode with the area to be treated such as a hair restoration site.
  • the electrode is generally flat and includes an identifiable first side 30 placed or implanted such that it lies close or adjacent to the treatment area.
  • electrode 16 further includes a second side 32 comprising an electrically insulating material to minimize electric field away from the area of interest.
  • the electric field is substantially directed away from the electrode toward the treatment area (indicated by arrows in Figure 2) while the electrical field is minimized on the opposite side.
  • the electrode is externally applied in a pad form, as part of a cap or hair net, or in a grid configuration.
  • an electrode 16' is configured with electrically conductive needles or extensions 40 that are gently pressed into the treatment area.
  • the electrical field generated radiates generally in circular or hemispherical patterns around the needles.
  • the electrode inserted beneath the treatment area as further explained below.
  • the electrode is surgically placed in an area of the hypothalmus using, for example, deep brain surgical techniques as know by neuro surgeons and skilled artisans.
  • an implant is programmed to disrupt the production of testosterone or derivatives thereof.
  • the electrode 16 is placed subcutaneously. It is now apparent that such a placement can be achieved through a small incision and subsequent insertion of a folded electrode. The procedure is completed by unfolding or forming the electrode beneath the skin with only the electrical lead 20 protruding. As discussed above, alternate embodiments include an entirely implanted system where the insulated coupling extends from the electrode subcutaneously to an implanted power supply.
  • an electrode array 16" is effective as a subgaleal implant. Such an implant is most preferably achieved by inserting a folded electrode array and subsequently forming or spreading the array in place.
  • FIG. 6 another embodiment of the present invention provides a microinfusion system 50 including a domed-type chamber or reservoir 52 which in the illustrated embodiment can contain a single medication. Multiple dose chambers are also within the skill of an artisan.
  • the system further includes a base 54 having a radius larger than the base of the reservoir 52. Incorporated into the base 54 are outlets 56 at opposing sides of the reservoir 52. Those skilled in the art can appreciate that in alternative embodiment, many outlets may be spaced about the periphery of the base 54.
  • the system also includes a dose control 60 which regulates the rate of medication to outlets 56.
  • the exterior shell 62 of the reservoir 56 includes a penitratable surface such that a hypodermic needle, for example, may be used to replenish a medication supply without removing the entire system.
  • the system illustrated in Figure 6 is a single use, preloaded system which remains in place until the supply of medication is exhausted.
  • Those of ordinary skill in the art can recognize that the size of such a system permits subcutaneous implantation, both for cosmetic reasons and to place the medication closer to the area where needed.
  • an alternate embodiment of the system includes an extended catheter tip 70 for depositing medication to a deep or remote location such as in deep brain infusion. Also illustrated is a sensing embodiment. A fiber optic or other sensor 72 is included for sensing the medication at the point of interest. A feedback loop 74 permits the dose controller 60 to adjust the rate of medication delivery depending on the sensed data. As is now evident from continued reference to Figure 2, medication can alternately flow from both the extended catheter 70 as well as outlets 56.
  • FIG. 8 the system is shown with a catheter 80 connected to outlets 56.
  • the catheter may be inserted into an area of interest, such as a peripheral nerve 82 as illustrated.
  • the device consists of a domed type chamber which may have septations to allow the introduction of one, two, or multiple drugs into an area of interest including the central or peripheral nervous system with a microcatheter, or an area directly on the scalp.
  • the device in one embodiment can also have a fixed or electronically adjustable valve system to allow a particular dosing of the drug.
  • there are sensors at the output end of the chamber providing feedback to automatically adjust the dosing. Additionally, this system can be attached to currently existing deep brain stimulation burr hole devices.
  • the device comprises the actual burr hole ring.
  • the circle of the ring will include a chamber or reservoir with a port for injection and a tab or notch for insertion of a cannula and a notch for insertion of an electrode.
  • the system in its one form would be a disposable system for fixed dosing a single medication which could be implanted in a patient as a tool for trial chemical modulation. Prior to the present invention, this was accomplished through the implantation of a large and bulky drag delivery system having a diameter of about 7.5 cm.
  • system is semi-permanent and reusable but still more compact than present drug delivery systems.
  • the system is smaller than that which is presently available which is advantageous when delivering drug/chemical within the substrate of the entral or peripheral nervous system. Also, dosing concentrations for direct nervous system injection are in order of magnitude smaller than either oral, intravenous, or intrathecal dosages. [0037] In yet other forms, the system allows the delivery of multiple types of drugs, chemicals, medication and the like. The system allows controlled medication delivery such that a microinfusion device adds drugs, neurotransmitters, Rogaine, or other such material to the local environment at a determined rate. Moreover, other embodiments include combinations of electrical and chemical neuromodulation.
  • the chemical agent may be a neurotransmitter mimic; neuropeptide; hormone; pro-hormone; antagonist, agonist, reuptake inhibitor, or degrading enzyme thereof; peptide; protein; therapeutic agent; nucleic acid; or stem cell and may be delivered by a slow release matrix or drug pump.
  • Such chemical agents are generally administered orally in traditional pharmacotherapies, by directly stimulating the target sites that synthesize or release such products, low and precise doses of the chemical agents can be administered so as to minimize or avoid the side effects and delayed onset of relief common to traditional pharmacotherapy.
  • the system is subcutaneously implantable.
  • the system can be utilized for delivery of drugs/chemicals/gene therapy vectors/viral vectors into the central or peripheral nervous system.
  • the applications of the invention includes drug delivery for Parkinson's Disease
  • Essential tremor MS, Dystonia, cerebral palsy, psychiatric disorders, obsessive compulsive disorder, depression, Mucimol, Dystonia, ALS, Gene therapy vectors to allow delivery of substance retrograde through the peripheral nerves. Controlled antibiotic therapy for meningitis bacterial or chemical. Chemotherapy for carcinomatous meningitis, or central nervous system lymphoma or other metastatic disease.
  • Another embodiment of the present invention includes set of compact RF compatible receiving coils or a smaller temporary impulse generator which is coupled to an already implanted deep brain stimulator electrodes, other neurostimulation electrodes such as those used for motor cortex or spinal cord stimulation, or generally to implanted electrodes anywhere.
  • This compact receiving RF coil or smaller temporary impulse generator can be implanted in the subgaleal space and can be externally stimulated with an accessory external antenna (outside of the skin) connected to a battery powered transmitter (in the case of an RF system).
  • Such coil systems permit externally applied signals to be communicated to electrodes without dedicated pulse generators in each instance or otherwise when dedicated generators are undesirable.
  • a neurostimulator includes a cap 90 which rests snugly in a burr hole ring 92 overlaying a region of interest. Disposed within cap 90 are antenna windings 100 which are suitable for receiving RF radiation from a transmitter 102. A lead 106 from winding 100 connects with windings 108 associated with burr ring 92.
  • burr ring 92 includes a plurality of channels C in which the windings reside. At an end of channel C towards central opening 110 the implanted electrode is electrically connected to the winding 108. As those skilled in the art can appreciate, this completes the electrical connection between the coil or winding 100 and the electrode tip disposed in the treatment site (not shown). It can now be appreciated that other electrode locations are possible without departing from the scope of the invention.
  • cap 90 is illustrated partially cut away to reveal windings 100 disposed therein.
  • the cap is preferably made from a material which will readily pass the received RF energy to the coil or windings 100 disposed within.
  • the ring has a gap G permitting, among others, custom and secure fit within the burr hole.
  • G permitting, among others, custom and secure fit within the burr hole.
  • its smaller size would allow for its implantation into the head or via a small incision after the insertion of a percutaneous spinal cord stimulator system. Additionally, It would be cheaper and smaller than the currently available totally implantable pulse generators.
  • the stimulation controller is activated thereby applying to the target site an oscillating electrical signal having specified pulsing parameters.
  • the oscillating electrical signal may be applied continuously or intermittently and the pulsing parameters, such as the pulse width, amplitude, frequency, voltage, current, intensity, and/or waveform may be adjusted to affect a desired result.
  • the oscillating electrical signal is operated at a voltage between about O.l ⁇ V to about 20 V. More preferably, the oscillating electrical signal is operated at a voltage between about 1 V to about 15 V.
  • the electric signal is operated at a frequency range between about 2 Hz to about 2500 Hz.
  • the electric signal is operated at a frequency range between about 2 Hz to about 200 Hz.
  • the pulse width of the oscillating electrical signal is between about 10 microseconds to about 1,000 microseconds. More preferably, the pulse width of the oscillating electrical signal is between about 50 microseconds to about 500 microseconds.
  • the application of the oscillating electrical signal is: monopolar when the electrode is monopolar, bipolar when the electrode is bipolar, and multipolar when the electrode is multipolar.
  • we can generate various waveforms such as sine wave and others in addition to the square wave forms of stimulation.
  • disorders treatable by the present invention include hyperandrogenic Alopecia — occurring for example in premenopausal females, Alopecia Aerata, Androgenetic Alopecia, Drug indued Alopecia, Alopecial Aerata, and the like. Accordingly, the scope of the invention should be determined solely by the appended claims and the equivalents thereof.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

L'invention a trait à un appareil de restauration capillaire, qui comprend un générateur électrique configuré de manière à générer un signal électrique possédant des caractéristiques définies. Un contrôleur se trouvant en communication fonctionnelle avec le générateur commande le fonctionnement du générateur et les caractéristiques du signal électrique généré, sélectionnées pour une application thérapeutiquement efficace de signaux électriques sur un site de restauration capillaire. Une électrode se trouvant en communication électrique avec le générateur électrique est disposée dans la zone où l'on souhaite appliquer le signal électrique. Certains modes de réalisation comprennent une liaison électrique entre le générateur électrique et l'électrode, qui est étanchéifiée pour être implantée au moins partiellement sous la peau d'un patient.
PCT/US2003/003210 2002-02-01 2003-02-03 Utilisation de la stimulation electrique pour traiter la chute de cheveux WO2003063950A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/503,029 US7493168B2 (en) 2002-02-01 2003-02-03 Electrical stimulation to treat hair loss

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US35369402P 2002-02-01 2002-02-01
US35370602P 2002-02-01 2002-02-01
US60/353,694 2002-02-01
US60/353,706 2002-02-01
US35817602P 2002-02-20 2002-02-20
US60/358,176 2002-02-20

Publications (2)

Publication Number Publication Date
WO2003063950A2 true WO2003063950A2 (fr) 2003-08-07
WO2003063950A3 WO2003063950A3 (fr) 2003-11-27

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101216653B1 (ko) 2011-12-23 2012-12-28 주식회사 웨이전스 미세전류의 흐름을 유도하는 탈모 예방을 위한 모자

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101216653B1 (ko) 2011-12-23 2012-12-28 주식회사 웨이전스 미세전류의 흐름을 유도하는 탈모 예방을 위한 모자
WO2013094907A1 (fr) * 2011-12-23 2013-06-27 주식회사 웨이전스 Chapeau destiné à prévenir une alopécie utilisant un débit de micro courant

Also Published As

Publication number Publication date
WO2003063950A3 (fr) 2003-11-27

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