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WO2003063765A3 - Approche pluridisciplinaire de validation ou d'identification de cibles au moyen d'un systeme in vivo - Google Patents

Approche pluridisciplinaire de validation ou d'identification de cibles au moyen d'un systeme in vivo Download PDF

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Publication number
WO2003063765A3
WO2003063765A3 PCT/US2002/031554 US0231554W WO03063765A3 WO 2003063765 A3 WO2003063765 A3 WO 2003063765A3 US 0231554 W US0231554 W US 0231554W WO 03063765 A3 WO03063765 A3 WO 03063765A3
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WO
WIPO (PCT)
Prior art keywords
pathway
targets
vivo system
approach
biological process
Prior art date
Application number
PCT/US2002/031554
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English (en)
Other versions
WO2003063765A2 (fr
Inventor
Patrick Y Lu
Robert W Malone
Puthupparampil Scaria
Martin C Woodle
Original Assignee
Intradigm Corp
Patrick Y Lu
Robert W Malone
Puthupparampil Scaria
Martin C Woodle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intradigm Corp, Patrick Y Lu, Robert W Malone, Puthupparampil Scaria, Martin C Woodle filed Critical Intradigm Corp
Priority to AU2002365217A priority Critical patent/AU2002365217A1/en
Priority to EP02804816A priority patent/EP1451572A4/fr
Publication of WO2003063765A2 publication Critical patent/WO2003063765A2/fr
Publication of WO2003063765A3 publication Critical patent/WO2003063765A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne une approche pluridisciplinaire en vue de valider ou d'identifier des cibles impliquées dans tout processus ou cheminement biologique donné, par exemple une réponse immune, ou progression ou régression d'une maladie. En soumettant au moins une cible avec, par exemple, au moins un vecteur d'apport génique ou d'autres matières étrangères, à un système in vivo, et en intégrant, par exemple, des données pathologiques, pharmacologiques, d'essais biologiques, de microréseaux et bioinformatiques dans ledit système, il est possible (1) d'identifier au moins une cible, par exemple des gènes, impliquée dans un cheminement biologique d'intérêt, (2) de mettre en oeuvre ces cibles identifiées en vue d'une nouvelle analyse du processus ou cheminement biologique et (3) de produire une approche évolutive in vivo pour de grandes quantités potentielles de découvertes et validations cibles. Ce processus peut servir quel que soit le nombre d'applications, y compris l'identification d'agonistes et d'antagonistes, à un processus ou cheminement biologique, susceptibles de conduire à la découverte de médicaments et de vaccins.
PCT/US2002/031554 2001-10-03 2002-10-03 Approche pluridisciplinaire de validation ou d'identification de cibles au moyen d'un systeme in vivo WO2003063765A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002365217A AU2002365217A1 (en) 2001-10-03 2002-10-03 Multi-disciplinary approach to validating or identifying targets using an in vivo system
EP02804816A EP1451572A4 (fr) 2001-10-03 2002-10-03 Approche pluridisciplinaire de validation ou d'identification de cibles au moyen d'un systeme in vivo

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32642201P 2001-10-03 2001-10-03
US60/326,422 2001-10-03

Publications (2)

Publication Number Publication Date
WO2003063765A2 WO2003063765A2 (fr) 2003-08-07
WO2003063765A3 true WO2003063765A3 (fr) 2004-02-26

Family

ID=27662906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/031554 WO2003063765A2 (fr) 2001-10-03 2002-10-03 Approche pluridisciplinaire de validation ou d'identification de cibles au moyen d'un systeme in vivo

Country Status (4)

Country Link
EP (1) EP1451572A4 (fr)
CN (1) CN1599866A (fr)
AU (1) AU2002365217A1 (fr)
WO (1) WO2003063765A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
WO2018102397A1 (fr) 2016-11-29 2018-06-07 PureTech Health LLC Exosomes destinés à l'administration d'agents thérapeutiques
EP3583528A2 (fr) * 2017-02-15 2019-12-25 Zymergen, Inc. Outil de prédictions bio-atteignables

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5917124A (en) * 1997-09-12 1999-06-29 Washington University Transgenic mouse model of prostate cancer
US5919997A (en) * 1993-11-18 1999-07-06 Cold Spring Habor Labortary Transgenic mice having modified cell-cycle regulation
US20010011073A1 (en) * 1998-10-08 2001-08-02 Cheah Kathryn S.E. Uses of transgenic animals containing a type X collagen mutant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919997A (en) * 1993-11-18 1999-07-06 Cold Spring Habor Labortary Transgenic mice having modified cell-cycle regulation
US5917124A (en) * 1997-09-12 1999-06-29 Washington University Transgenic mouse model of prostate cancer
US20010011073A1 (en) * 1998-10-08 2001-08-02 Cheah Kathryn S.E. Uses of transgenic animals containing a type X collagen mutant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATEL I.R.: "TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by dofferential display, expression of the active enzyme and regulation of TNF-alpha", JOUR. OF IMMUNOL., vol. 160, 1995, pages 4570 - 4579, XP002243657 *
See also references of EP1451572A4 *
YAMADA E.: "Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA encoding murine ATPase inhibitor", IMMUNOLOGY, vol. 92, 1997, pages 571 - 576, XP001016129 *

Also Published As

Publication number Publication date
WO2003063765A2 (fr) 2003-08-07
EP1451572A2 (fr) 2004-09-01
AU2002365217A1 (en) 2003-09-02
EP1451572A4 (fr) 2007-04-04
CN1599866A (zh) 2005-03-23

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