+

WO2003059305A1 - Procede et dispositif pour la prevention de la carie dentaire - Google Patents

Procede et dispositif pour la prevention de la carie dentaire Download PDF

Info

Publication number
WO2003059305A1
WO2003059305A1 PCT/US2002/000084 US0200084W WO03059305A1 WO 2003059305 A1 WO2003059305 A1 WO 2003059305A1 US 0200084 W US0200084 W US 0200084W WO 03059305 A1 WO03059305 A1 WO 03059305A1
Authority
WO
WIPO (PCT)
Prior art keywords
tooth
fluoride
laser
treatment
enamel
Prior art date
Application number
PCT/US2002/000084
Other languages
English (en)
Inventor
Colette Cozean
Lynn Powell
Samir Nammour
Original Assignee
Colette Cozean
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colette Cozean filed Critical Colette Cozean
Priority to AU2002248294A priority Critical patent/AU2002248294A1/en
Priority to PCT/US2002/000084 priority patent/WO2003059305A1/fr
Publication of WO2003059305A1 publication Critical patent/WO2003059305A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C1/00—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design
    • A61C1/0046—Dental lasers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0606—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes

Definitions

  • This invention relates to a method and an apparatus for preventing tooth decay.
  • the invention relates to using a visible light beam or electromagnetic radiation treatment and subsequent low concentration fluoride treatment to prevent tooth decay.
  • Tooth decay is caused by demineralization of the tooth structure at either the enamel or root surface.
  • the enamel is a thin layer (1-2 mm) composed of a crystal-type structure of hydroxyapatite or calcium phosphate hydroxide, containing large amounts of calcium and phosphorus.
  • Dental enamel is a porous material and although it contains about 96% by weight of mineral, this is equivalent to approximately 85 percent by volume. The remaining 15 percent by volume is made up of water, protein and lipid, which form the diffusion channels though which acids and minerals can travel in or out of the tooth.
  • the dentin, the major part of the core of the tooth is composed of CaCO 3 , a chalk-like material. Although it is 70% by weight of mineral, it also contains 20% by weight organic and 10% by weight water. This corresponds to 47% by volume mineral.
  • Tooth decay, or dental caries results from the growth of bacteria on the tooth.
  • the bacteria metabolize sugars to acid and this dissolves the tooth.
  • the bacteria grow as a plaque on the tooth and treatment involves periodic removal of the plaque and strengthening of the tooth to make it more resistant to the acid produced by the bacteria.
  • Other professional methods to prevent tooth decay have included fluoride, pit and fissure sealants, and varnishes. However, none of these methods individually protect all of the tooth surfaces nor are they permanent, usually lasting less than 5 years.
  • heat treatment has been explored as an alternative method. By treating the tooth with a very high heat, from 250-1000°C, the structure of the tooth is changed, making it more resistant to acid. This method has never been used clinically because of safety concerns.
  • the action of the laser, as well as other types of tooth treatments, to produce resistance of the tooth to acid can be envisioned as follows: it has been hypothesized that tooth enamel crystals ("hydroxyapatite") possess two types of sites from which dissolution can occur.
  • the first type of site (the "thermal” site) is less resistant to dissolution by acids under conditions typically found in the oral environment than is the second type of site (the “thermal” site).
  • the invention provides a composition for preventing tooth decay in a tooth treated with electromagnetic radiation having fluoride at a concentration of less than 45 ppm fluoride to (0.01%) to 0.002 ppm fluoride.
  • the composition may be a mouthwash, a patch, or a toothpaste.
  • the invention provides a method of treating a tooth by irradiating the tooth with a light beam, having wavelengths in the range of between from about 400nm to about 810nm, and irradiating by exposing the tooth to an energy and an energy density sufficient to vaporize organic material without damaging the tooth structure.
  • a further embodiment involves bonding a chemical agent to the crystalline structures of the tooth after removal of the organic compound.
  • the chemical agent is fluoride.
  • the effective concentration of fluoride is less than or equal to 200 ppm of stannous fluoride (0.08%) or 1000 ppm of sodium fluoride (0.275%).
  • the fluoride acts by binding to hydroxide groups within the hydroxyapatite crystal.
  • the fluoride penetrates to the subsurface more than 0.1 microns.
  • the light beam may be a coherent or incoherent light source.
  • it is a laser, more preferably an argon laser.
  • the wavelength of the laser is selected from the group consisting of: red, green, blue, and yellow lasers.
  • a incoherent light source may be an LED, preferably having a wavelength from the IR spectra selected from the group consisting of green, blue, yellow, and red light.
  • the argon laser beam is applied at 250mJ for 10 seconds for each treated surface.
  • the tooth is treated for a period of time of more than 1 sec for each treated surface.
  • the light beam has an energy density below about 65 J/cm , even more preferably, 30 J/cm and even more preferably, 12 J/cm .
  • the treatment heats the tooth structure to a temperature less than about
  • the treatment heats the tooth structure to a temperature less than about 100°C.
  • the tooth structure which is being heated may specifically be localized sites containing concentrations of water and/or organic materials.
  • the method includes treating with fluoridated mouthwash, toothpaste, or a patch after treatment.
  • the mouthwash contains 45 ppm fluoride to (0.01%)) to 0.002 ppm fluoride.
  • the fluoride is applied for 1 day to 80 years.
  • a further embodiment is a method which reduces the a axis of a crystal of hydroxyapatite in a tooth from 9.45A to 9.43A by irradiating the tooth with a visible or near visible light beam, preferably having wavelengths in the range of between from about 400nm to about 810nm. Preferably at an energy density below about 65 J/cm 2 , even more
  • the a axis is reduced at a temperature less than 250°C.
  • a further embodiment is a method of treating a tooth by changing the phosphate/calcium ratio in a portion of a tooth by more than 10% using electromagnetic radiation, preferably having a wavelength between about 400nm to about 810nm.
  • the electromagnetic radiation is of a wavelength which is substantially transmissible through water.
  • the calcium phosphate ratio is changed at a temperature less than about 250°C.
  • a further embodiment of the invention is a home treatment kit for the treatment of a tooth containing a fluoride mixture for application to the tooth, a light source which produces wavelengths in the range of between about 400nm to about 750 nm adapted to illuminate the fluoride mixture, and at least one of a fluoride mouthwash, and a fluoride patch.
  • a further embodiment of the invention is a method of treating a tooth by irradiating the organic molecules within the tooth structure to reduce the solubility of the tooth to acid.
  • the method is applied to the tooth enamel, dentin, or cementum.
  • the treatment heats the tooth structure to a temperature less than about 250°C.
  • the method results in a permanent or semi-permanent change to the solubility of the tooth.
  • a further embodiment of the invention is a method of treating a tooth, by changing the structure and composition of a tooth to include P 2 O 7 as measured by x-ray diffraction by irradiating said tooth with a visible or near visible light beam, preferably at a heat less than
  • a further embodiment is a method of treating a tooth by changing the structure and composition of the tooth to decrease the amount of carbonate in said tooth by irradiating said tooth with a visible or near visible light beam.
  • the structure is changed at a heat less than 250°C.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention describes a method which changes the solubility of a tooth without significant production of heat, in fact the present invention produces changes in the tooth at temperatures less than 250°C.
  • the present invention also allows for a deeper treatment of the tooth, as well as the use of a lower concentration of fluoride, and has the potential to allow one to keep teeth completely free of caries for the lifetime of the patient.
  • the method uses a visible light beam (or electromagnetic radiation) alone or in combination with a chemical agent to prevent dental caries.
  • a visible light beam or electromagnetic radiation
  • a chemical agent to prevent dental caries.
  • the application of the visible light beam of the correct wavelength, (i.e. an argon laser beam) at low powers to the tooth acts on the "thermal sites" at a much reduced temperature (usually around 100°C) and produces considerably less heat then CO or comparable lasers.
  • the visible light beam reduces the carbonated phase of the hydroxyapatite, making the tooth more resistant to attack.
  • the removal or vaporization of carbonate lowers the solubility and changes the water content of the hydroxyapatite. It also changes the phase of the hydroxyapatite and makes it more pure.
  • the treatment may heat local sites in proximity to the surface, which have a high concentration of organic material and/or water.
  • the ratio of phosphate to calcium changes. All of these changes result in the increased capability of the tooth to resist demineralization, a precursor to tooth decay.
  • Fluoridation, or other chemical agents act on the "chemical sites" by binding to hydroxide radicals and sterically or chemically preventing the action of acid on those sites.
  • fluoride can accumulate in the body and too much fluoride can result in fluorosis, a syndrome whereby teeth are discolored, resulting in white splotchy areas on the enamel during development.
  • Children are particularly susceptible to fluorosis and can obtain the necessary concentration of fluoride simply from tap water and toothpaste which is accidentally swallowed during brushing, hi addition, more serious diseases have been linked to too much fluoride including iodine deficiency disorders, confusion, drowsiness, and listlessness.
  • the laser treatment results in a situation in which less fluoride is necessary to provide the same result.
  • the visible and near visible light beams can be coherent or incoherent light sources.
  • Lasers, coherent sources of light beams, useful in the present invention are those which generate sufficient power to increase the acid resistivity of tooth enamel at low power (producing less heat) which preferably fall within the visible part of the infrared.
  • the lasers possess one or more wavelengths which are not absorbed by water, but are absorbed by organic compounds.
  • the wavelengths are between about 400 and 810 nm, more preferably between about 457 and 514 nm.
  • the wavelengths correspond visibly to blue, green, yellow or red light. Examples of such lasers include argon lasers and diode lasers.
  • the visible light beams can be incoherent sources which generate sufficient power to increase the acid resistivity of tooth enamel at low power (producing less heat), such as a light emitting diodes (LEDs).
  • LEDs light emitting diodes
  • the wavelengths are between about 400 and 810 nm, more preferably between about 457 and 514 nm.
  • the wavelengths correspond visibly to blue, green, yellow or red.
  • the lasers need only be used at low power to produce the desired effect.
  • the light beam has an energy density below about 65 J/cm 2 , preferably about 30 J/cm 2 , preferably an energy density below about 12 J/cm 2 .
  • the chemical agents may have very different mechanisms of action, but include: ethane- l-hydroxy-l,l-di- ⁇ hosphonic acid, fluoride, dodecylamine HC1, and most preferably fluoride.
  • fluoride treatments can be used alone or in combination.
  • the fluoride can be applied as a paste before treatment with the laser or after treatment with the laser.
  • the fluoride can be applied as a mouthwash or as part of a toothpaste.
  • the fluoride may also be applied as a patch, providing a low concentration of fluoride in a timed-release manner.
  • mucoadhesive fluoride tablets consisting of a bioerodible matrix which dissolves completely after depletion can be used such as those described in Bottenberg et al. J Dent. Res. 77(1): 68-72.
  • Fluoride (F1-) interacts at several stages of the caries process to inhibit progression or enhance reversal.
  • the following three mechanisms of action are now considered to be the most important way in which fluoride works.
  • fluoride has antibacterial properties at lower pH in the plaque when it enters the bacterial cell as HF1.
  • fluoride enters the bacteria it interferes with the enzymes inside the bacteria, slowing down or inhibiting acid production.
  • fluoride when fluoride is present in the aqueous phase on and within the tooth at the same time as an acid challenge, it dramatically inhibits dissolution of calcium and phosphate at the crystal surfaces in the subsurface regions of enamel.
  • fluoride is present in the tooth crystals where it is incorporated systematically during tooth development, it will dissolve out during the demineralization process and help to inhibit subsequent demineralization. Lastly, fluoride present in the aqueous phase at the crystal surfaces within the tooth speeds up the recrystallization by helping to bring calcium and phosphate ions together. This provides a much more acid-resistant "new" crystal surface. During subsequent acid challenges following ingestion of fermentable carbohydrates the acid bypasses this resistant mineral, and is forced to go deeper into the tooth before mineral can be dissolved making decay less and less likely to progress. Remineralization following demineralization in this way makes the tooth more and more resistant as time progresses with these natural pH-cycles.
  • Example 1 shows for the first time in the literature that the a axis of hydroxyapatite can be changed by treatment with a laser at low heat.
  • Enamel from 47 human teeth were subjected to treatment with an argon laser at various energy densities ranging from 65 to 283 J/cm 2 for 0.2 sec at 1 Hz.
  • the enamel was then subjected to x-ray diffraction.
  • Results from this treatment showed that there was a mechanical change in the a axis of the human enamel (HE) from 9.45 A to 9.43 A (see Table 1). Such a reduction was statistically significant. It is known in the literature that the hydroxyapatite of human enamel is more soluble than stoichiometric hydroxyapatite, which has an a axis of 9.418 A approaching that of lased enamel.
  • This axis reduction is caused by a loss of structural water and a corresponding increase in structural hydroxide groups (OH-) along the a axis.
  • Another causative factor is the vaporization of organic compounds such as carbonate which results in a prism structure with reduced voids where acids would preferentially attack when the tooth is exposed to acids in the saliva.
  • enamel from 7 human teeth was subjected to treatment with an argon laser at various energy densities ranging from 65 to 283 J/cm 2 for 0.2 sec at 1 Hz.
  • Laser treatment in combination with fluoride treatment results in the removal of organic compounds and a hardening of the hydroxyapatite crystal at a deeper level
  • Enamel from human teeth is treated with a fluoride paste at a concentration of 200 ppm (0.08%) Fl of stannous fluoride.
  • the treated enamel is then subjected to treatment with an argon laser at 12-30 J/cm 2 for 10 seconds for each treated surface.
  • Treatment efficacy is compared to enamel treated with fluoride alone or argon laser alone.
  • the argon laser is safer and still penetrates more deeply due to its lower absorption, vaporization of the organic molecules including carbonate and hydrolyzation of the HPO 4 molecule.
  • the removal of H+ at the surface as well as below the surface and the removal of water within the tooth structure allows for the bonding of fluoride at deeper levels of the hydroxyapatite.
  • the present method provides for the bonding of fluoride to the hydroxide molecule in decreasing concentrations as one descends from the surface of the enamel towards the pulp, providing a much deeper effect on the tooth (to at least 1 mm).
  • Enamel from a human tooth is treated with a fluoride paste at a concentration of 200 ppm (0.08%) Fl of stannous fluoride or 1000 ppm (0.22%) Fl of sodium fluoride.
  • the treated enamel is then subjected to treatment with an argon laser at 12-65 J/cm for 0.2 to 10 seconds for each treated surface.
  • the treatment effectiveness is compared to a comparable treatment using much higher (5-fold) concentrations of fluoride.
  • Previous results using a CO 2 laser have shown that the amount of fluoride applied to the tooth after laser treatment can be reduced by about five-fold for an effective treatment. Therefore, the effective concentration of fluoride applied before or after laser treatment is reduced approximately five fold in the present method.
  • Example 1 When the laser treatment as presented in Example 1 is used in combination with the fluoride treatment a synergistic effect occurred and this was partly responsible for the need for less fluoride. This is shown by the fact that the results in Examples 3 and 4 with both fluoride and argon laser treatment are more then additive when compared to those with fluoride alone or laser treatment alone.
  • Enamel from 4 human teeth is treated with a fluoride paste at a concentration of 200 ppm (0.08%) Fl of stannous fluoride or 1000 ppm (0.22%) Fl of sodium fluoride.
  • the treated enamel is then subjected to treatment with an argon laser at 250 MW, 10 Hz for 0.2 to 10 seconds for each treated surface. Three measurements were per tooth and the mean value is shown below.
  • the two-tailed p value is 0,0320; Significant
  • Mean A unlased enamel
  • Mean C Enamel + fluoride + lased
  • the two tailed p value is 0.0408; Significant
  • the Argon laser is applied to the tooth at 250 mW (or 12 to 65 J/cm 2 ) for 0.2 to 10 sec at a 5 mm diameter spot size on the tooth surfaces.
  • the teeth Prior to lasing, the teeth were prophied (cleaned) and a low concentration of fluoride gel was applied.
  • the fluoride gel may be applied after laser treatment.
  • Maintenance treatment includes using a fluoride mouthwash containing low concentrations of fluoride once a day, and fluoride patches containing low concentrations of fluoride applied weekly.
  • the teeth are laser treated every 2 to 5 years.
  • EXAMPLE 8 Method of treating a tooth using a visible LED
  • the tooth is treated as in Example 6, however an LED is used in place of the argon laser.
  • the LED is used at a wavelength from the IR spectra of green, blue, yellow, or red.
  • the tooth is treated with fluoride at a concentration of about 200 ppm (0.08%) Fl of stannous fluoride or 1000 ppm (0.22%) Fl of sodium fluoride.
  • the Argon laser is applied to the tooth at 250 to 300 mW for 10 sec (or longer) at an 8 mm diameter spot size on each of the surfaces.
  • the teeth Prior to lasing, the teeth were prophied (cleaned) and a low concentration of fluoride gel was applied.
  • Maintenance treatment includes using a fluoride mouthwash containing low concentrations of fluoride once a day, and fluoride patches containing low concentrations of fluoride applied weekly.
  • the teeth are laser treated every 2 to 5 years.
  • EXAMPLE 10 Kit for at-home use The kit includes a hand-held light source, LED with a shield which protects the patient from laser reflections which may damage their eyes, while still allowing viewing of the process, a fluoride treatment for application to the tooth before laser treatment, a mouthwash with a low fluoride concentration, and patches with a low fluoride concentration for follow-up use.
  • the patient applies the fluoride, treats the tooth with the laser, uses the mouthwash daily, and attaches the patch once a week or once a month. This allows the patient to keep the teeth caries-free as long as treatment is continued. However, treatment may still be effective without the addition of the mouthwash or the patch.
  • EXAMPLE 11 Kit for professional use The kit includes a hand-held light source, LED with a shield which protects the patient from laser reflections which may damage their eyes, while still allowing viewing of the process, a fluoride treatment for application to the tooth before laser treatment, a mouthwash with a low fluoride concentration, and patches with
  • the kit includes a fluoride treatment containing a low concentration of fluoride, a means for applying the fluoride to the tooth, sample mouthwash and sample patches for the patient to take home.
  • a fluoride treatment containing a low concentration of fluoride
  • a means for applying the fluoride to the tooth sample mouthwash and sample patches for the patient to take home.
  • Various types of light sources can be used by the professional.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un procédé relatif à la prévention de la carie dentaire, qui consiste à traiter initialement la surface des dents au laser à source lumineuse cohérente ou incohérente. On renforce ainsi la résistance des dents à l'acidité et leur capacité de fixation du fluorure, moyennant quoi le processus de fixation considéré nécessite une concentration de fluorure moins élevée. Le procédé décrit assure une pénétration dentaire plus profonde que les autres procédés.
PCT/US2002/000084 2002-01-04 2002-01-04 Procede et dispositif pour la prevention de la carie dentaire WO2003059305A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002248294A AU2002248294A1 (en) 2002-01-04 2002-01-04 Method and apparatus for preventing tooth decay
PCT/US2002/000084 WO2003059305A1 (fr) 2002-01-04 2002-01-04 Procede et dispositif pour la prevention de la carie dentaire

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/000084 WO2003059305A1 (fr) 2002-01-04 2002-01-04 Procede et dispositif pour la prevention de la carie dentaire

Publications (1)

Publication Number Publication Date
WO2003059305A1 true WO2003059305A1 (fr) 2003-07-24

Family

ID=21743189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000084 WO2003059305A1 (fr) 2002-01-04 2002-01-04 Procede et dispositif pour la prevention de la carie dentaire

Country Status (2)

Country Link
AU (1) AU2002248294A1 (fr)
WO (1) WO2003059305A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7845039B2 (en) 2003-09-09 2010-12-07 The Procter & Gamble Company Toothbrush with severable electrical connections
EP2873388A1 (fr) * 2013-11-19 2015-05-20 Sirona Dental Systems GmbH Chirurgie laser de tissus mous
US11529214B2 (en) 2017-05-12 2022-12-20 Convergent Dental, Inc. System and methods for preventative dental hard tissue treatment with a laser
US11918824B2 (en) 2020-01-03 2024-03-05 Convergent Dental, Inc. Laser system for enhancing remineralization and strength of hard tissue

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732617A (en) * 1982-08-24 1988-03-22 National Research Development Corporation Fluoride-containing compositions
US4877401A (en) * 1988-03-09 1989-10-31 University Of Utah Method of preventing tooth decay by laser beam irradiation and chemical treatment
US5145667A (en) * 1990-03-29 1992-09-08 Beecham Inc. Compositions
US5616141A (en) * 1993-04-09 1997-04-01 Ion Laser Technology Laser system for use in dental procedures
WO2000067048A2 (fr) * 1999-05-03 2000-11-09 Premier Laser Systems, Inc. Source optique et procede

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732617A (en) * 1982-08-24 1988-03-22 National Research Development Corporation Fluoride-containing compositions
US4877401A (en) * 1988-03-09 1989-10-31 University Of Utah Method of preventing tooth decay by laser beam irradiation and chemical treatment
US5145667A (en) * 1990-03-29 1992-09-08 Beecham Inc. Compositions
US5616141A (en) * 1993-04-09 1997-04-01 Ion Laser Technology Laser system for use in dental procedures
WO2000067048A2 (fr) * 1999-05-03 2000-11-09 Premier Laser Systems, Inc. Source optique et procede

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7845039B2 (en) 2003-09-09 2010-12-07 The Procter & Gamble Company Toothbrush with severable electrical connections
EP2873388A1 (fr) * 2013-11-19 2015-05-20 Sirona Dental Systems GmbH Chirurgie laser de tissus mous
US11529214B2 (en) 2017-05-12 2022-12-20 Convergent Dental, Inc. System and methods for preventative dental hard tissue treatment with a laser
US11744671B2 (en) 2017-05-12 2023-09-05 Convergent Dental, Inc. System and methods for preventative dental hard tissue treatment with a laser
US11918824B2 (en) 2020-01-03 2024-03-05 Convergent Dental, Inc. Laser system for enhancing remineralization and strength of hard tissue
US12233278B2 (en) 2020-01-03 2025-02-25 Convergent Dental, Inc. Laser system for enhancing remineralization and strength of hard tissue

Also Published As

Publication number Publication date
AU2002248294A1 (en) 2003-07-30

Similar Documents

Publication Publication Date Title
US7163400B2 (en) Method and laser apparatus for preventing tooth decay
Hsu et al. Laser-matrix-fluoride effects on enamel demineralization
Zezell et al. Nd: YAG laser in caries prevention: a clinical trial
EP1951184B1 (fr) Procédés et compositions pour le blanchiment des dents
EP0814756B1 (fr) Procede d'elaboration d'une preparation de blanchiment des dents ou de traitement de symptomes cutanes et de troubles des muqueuses
US20070237728A1 (en) Method and Composition for Dental Bleaching
Steiner-Oliveira et al. Effect of the CO2 laser combined with fluoridated products on the inhibition of enamel demineralization
Huang et al. Synergistic effect of Nd: YAG laser combined with fluoride varnish on inhibition of caries formation in dental pits and fissures in vitro.
AU2000272625A1 (en) Method and composition for dental bleaching
Araujo et al. Effect of pH values of two bleaching gels on enamel microhardness
US6939535B2 (en) Method and apparatus for preventing tooth decay
Sanavia et al. Remineralization strategies in oral hygiene: a position paper of Italian society of oral hygiene sciences-SISIO Working group
WO2003059305A1 (fr) Procede et dispositif pour la prevention de la carie dentaire
WO2009133525A2 (fr) Composition pour blanchiment des dents
Malik et al. Effect of laser and fluoride application for prevention of dental caries: A polarized microscope analysis
KR20080050590A (ko) 치아 표백재 및 치아 표백 방법
Zanin et al. Dental bleaching with LEDs and lasers
Baid et al. Comparison of effectiveness of diode laser with er: YAG laser on fluoride uptake of enamel surface using acidic and neutral topical fluorides: an in-vitro study
dos Santos et al. Effect of a new carbon dioxide laser and fluoride on occlusal caries progression in dental enamel
Sharma Biomodification of tooth discolouration
Walsh Strategies for remineralization
Hashim et al. Alterations In Enamel Minerals Occur On Remineralizing Artificially Created White Spot Lesions Subjected To Either Chemical Or Laser-Assisted Bleaching.
WO2023159244A3 (fr) Traitement et prévention de la déminéralisation dentaire
Almarsomy et al. Differnts Effectiveness of 10,600 nm Carbon Dioxide Laser on Enamel Surface
Fekrazad et al. The role of laser in caries prevention

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载