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WO2003059264A3 - Methods for the induction of professional and cytokine-producing regulatory cells - Google Patents

Methods for the induction of professional and cytokine-producing regulatory cells Download PDF

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Publication number
WO2003059264A3
WO2003059264A3 PCT/US2002/041288 US0241288W WO03059264A3 WO 2003059264 A3 WO2003059264 A3 WO 2003059264A3 US 0241288 W US0241288 W US 0241288W WO 03059264 A3 WO03059264 A3 WO 03059264A3
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Prior art keywords
methods
cytokine
induction
professional
regulatory cells
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Application number
PCT/US2002/041288
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French (fr)
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WO2003059264A2 (en
WO2003059264A9 (en
Inventor
David A Horwitz
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Univ Southern California
David A Horwitz
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Publication date
Application filed by Univ Southern California, David A Horwitz filed Critical Univ Southern California
Priority to EP02799306A priority Critical patent/EP1463799A4/en
Priority to AU2002364230A priority patent/AU2002364230B2/en
Priority to JP2003559429A priority patent/JP2005514054A/en
Priority to CA002469800A priority patent/CA2469800A1/en
Publication of WO2003059264A2 publication Critical patent/WO2003059264A2/en
Publication of WO2003059264A3 publication Critical patent/WO2003059264A3/en
Publication of WO2003059264A9 publication Critical patent/WO2003059264A9/en

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
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Abstract

The field of the invention is generally related to methods used for the induction of T cells with suppressive activity. More specifically, the methods are sued to generate professional regulatory T cells and cytokine-producing T cells with enhanced suppressive activity.
PCT/US2002/041288 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory cells WO2003059264A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02799306A EP1463799A4 (en) 2001-12-21 2002-12-20 PROCESS FOR INDUCTION OF LEARNED AND CYTOKINE-PRODUCING REGULATORY CELLS
AU2002364230A AU2002364230B2 (en) 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory cells
JP2003559429A JP2005514054A (en) 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory T cells
CA002469800A CA2469800A1 (en) 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34265501P 2001-12-21 2001-12-21
US60/342,655 2001-12-21
US37410202P 2002-04-19 2002-04-19
US60/374,102 2002-04-19

Publications (3)

Publication Number Publication Date
WO2003059264A2 WO2003059264A2 (en) 2003-07-24
WO2003059264A3 true WO2003059264A3 (en) 2004-02-12
WO2003059264A9 WO2003059264A9 (en) 2004-11-11

Family

ID=26993124

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041288 WO2003059264A2 (en) 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory cells

Country Status (5)

Country Link
EP (1) EP1463799A4 (en)
JP (1) JP2005514054A (en)
AU (1) AU2002364230B2 (en)
CA (1) CA2469800A1 (en)
WO (1) WO2003059264A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2558879A1 (en) * 2004-02-12 2005-08-25 Immuno Frontier, Inc. Regulatory cell controlling immunological activity of t cell
US8053235B2 (en) 2004-10-29 2011-11-08 Benaroya Research Institute At Virginia Mason Methods of generating antigen-specific CD4+CD25+regulatory T cells, compositions and methods of use
AU2006285446B2 (en) * 2005-08-31 2013-08-22 Tla Targeted Immunotherapies Ab Treatment of inflammatory bowel disease
ITRM20070437A1 (en) * 2007-08-10 2009-02-11 Istituto Naz Per Le Malattie I METHOD FOR THE GENERATION AND EXPANSION OF CELLS T RANGE / DELTA REGULATORY CELLS SOON OBTAINED AND THEIR APPLICATIONS

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0497275A2 (en) * 1991-01-31 1992-08-05 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Generation of CD4+ helper T cells with interleukin 2 and interleukin 4 from L-phenylalanine methyl ester treated human peripheral blood cells
WO2000042856A1 (en) * 1999-01-22 2000-07-27 The Schepens Eye Research Institute, Inc. Activation of regulatory t cells by alpha-melanocyte stimulating hormone
US6228359B1 (en) * 1997-11-05 2001-05-08 University Of Southern California Use of cytokines and mitogens to inhibit pathological immune responses
US20020034500A1 (en) * 2000-08-15 2002-03-21 Levings Megan K. Regulatory T cells; methods
EP1241249A1 (en) * 2001-03-12 2002-09-18 Gerold Schuler CD4+CD25+regulatory T cells from human blood
FR2824567A1 (en) * 2001-05-11 2002-11-15 Inst Nat Sante Rech Med PROCESS FOR OBTAINING TR1 LYMPHOCYTES SPECIFIC ANTIGEN REGULATORS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077299A2 (en) * 2000-04-11 2001-10-18 University Of Southern California A METHOD TO PREVENT GRAFT REJECTION USING TGF-β TO INDUCE T SUPPRESSOR CELLS

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0497275A2 (en) * 1991-01-31 1992-08-05 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Generation of CD4+ helper T cells with interleukin 2 and interleukin 4 from L-phenylalanine methyl ester treated human peripheral blood cells
US6228359B1 (en) * 1997-11-05 2001-05-08 University Of Southern California Use of cytokines and mitogens to inhibit pathological immune responses
WO2000042856A1 (en) * 1999-01-22 2000-07-27 The Schepens Eye Research Institute, Inc. Activation of regulatory t cells by alpha-melanocyte stimulating hormone
US20020034500A1 (en) * 2000-08-15 2002-03-21 Levings Megan K. Regulatory T cells; methods
EP1241249A1 (en) * 2001-03-12 2002-09-18 Gerold Schuler CD4+CD25+regulatory T cells from human blood
FR2824567A1 (en) * 2001-05-11 2002-11-15 Inst Nat Sante Rech Med PROCESS FOR OBTAINING TR1 LYMPHOCYTES SPECIFIC ANTIGEN REGULATORS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEVINGS M. ET AL.: "Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 193, no. 11, 2001, pages 1295 - 1301, XP002210571 *
YAMAGIWA ET AL.: "The role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood", JOURNAL OF IMMUNOLOGY, vol. 166, no. 12, 2001, pages 7282 - 7289, XP002969113 *

Also Published As

Publication number Publication date
EP1463799A4 (en) 2006-01-18
EP1463799A2 (en) 2004-10-06
AU2002364230A1 (en) 2003-07-30
CA2469800A1 (en) 2003-07-24
WO2003059264A2 (en) 2003-07-24
AU2002364230B2 (en) 2008-05-01
WO2003059264A9 (en) 2004-11-11
JP2005514054A (en) 2005-05-19

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