+

WO2003059264A3 - Methods for the induction of professional and cytokine-producing regulatory cells - Google Patents

Methods for the induction of professional and cytokine-producing regulatory cells Download PDF

Info

Publication number
WO2003059264A3
WO2003059264A3 PCT/US2002/041288 US0241288W WO03059264A3 WO 2003059264 A3 WO2003059264 A3 WO 2003059264A3 US 0241288 W US0241288 W US 0241288W WO 03059264 A3 WO03059264 A3 WO 03059264A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cytokine
induction
professional
regulatory cells
Prior art date
Application number
PCT/US2002/041288
Other languages
French (fr)
Other versions
WO2003059264A2 (en
WO2003059264A9 (en
Inventor
David A Horwitz
Original Assignee
Univ Southern California
David A Horwitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California, David A Horwitz filed Critical Univ Southern California
Priority to EP02799306A priority Critical patent/EP1463799A4/en
Priority to AU2002364230A priority patent/AU2002364230B2/en
Priority to JP2003559429A priority patent/JP2005514054A/en
Priority to CA002469800A priority patent/CA2469800A1/en
Publication of WO2003059264A2 publication Critical patent/WO2003059264A2/en
Publication of WO2003059264A3 publication Critical patent/WO2003059264A3/en
Publication of WO2003059264A9 publication Critical patent/WO2003059264A9/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)

Abstract

The field of the invention is generally related to methods used for the induction of T cells with suppressive activity. More specifically, the methods are sued to generate professional regulatory T cells and cytokine-producing T cells with enhanced suppressive activity.
PCT/US2002/041288 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory cells WO2003059264A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02799306A EP1463799A4 (en) 2001-12-21 2002-12-20 PROCESS FOR INDUCTION OF LEARNED AND CYTOKINE-PRODUCING REGULATORY CELLS
AU2002364230A AU2002364230B2 (en) 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory cells
JP2003559429A JP2005514054A (en) 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory T cells
CA002469800A CA2469800A1 (en) 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34265501P 2001-12-21 2001-12-21
US60/342,655 2001-12-21
US37410202P 2002-04-19 2002-04-19
US60/374,102 2002-04-19

Publications (3)

Publication Number Publication Date
WO2003059264A2 WO2003059264A2 (en) 2003-07-24
WO2003059264A3 true WO2003059264A3 (en) 2004-02-12
WO2003059264A9 WO2003059264A9 (en) 2004-11-11

Family

ID=26993124

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041288 WO2003059264A2 (en) 2001-12-21 2002-12-20 Methods for the induction of professional and cytokine-producing regulatory cells

Country Status (5)

Country Link
EP (1) EP1463799A4 (en)
JP (1) JP2005514054A (en)
AU (1) AU2002364230B2 (en)
CA (1) CA2469800A1 (en)
WO (1) WO2003059264A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2558879A1 (en) * 2004-02-12 2005-08-25 Immuno Frontier, Inc. Regulatory cell controlling immunological activity of t cell
US8053235B2 (en) 2004-10-29 2011-11-08 Benaroya Research Institute At Virginia Mason Methods of generating antigen-specific CD4+CD25+regulatory T cells, compositions and methods of use
AU2006285446B2 (en) * 2005-08-31 2013-08-22 Tla Targeted Immunotherapies Ab Treatment of inflammatory bowel disease
ITRM20070437A1 (en) * 2007-08-10 2009-02-11 Istituto Naz Per Le Malattie I METHOD FOR THE GENERATION AND EXPANSION OF CELLS T RANGE / DELTA REGULATORY CELLS SOON OBTAINED AND THEIR APPLICATIONS

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0497275A2 (en) * 1991-01-31 1992-08-05 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Generation of CD4+ helper T cells with interleukin 2 and interleukin 4 from L-phenylalanine methyl ester treated human peripheral blood cells
WO2000042856A1 (en) * 1999-01-22 2000-07-27 The Schepens Eye Research Institute, Inc. Activation of regulatory t cells by alpha-melanocyte stimulating hormone
US6228359B1 (en) * 1997-11-05 2001-05-08 University Of Southern California Use of cytokines and mitogens to inhibit pathological immune responses
US20020034500A1 (en) * 2000-08-15 2002-03-21 Levings Megan K. Regulatory T cells; methods
EP1241249A1 (en) * 2001-03-12 2002-09-18 Gerold Schuler CD4+CD25+regulatory T cells from human blood
FR2824567A1 (en) * 2001-05-11 2002-11-15 Inst Nat Sante Rech Med PROCESS FOR OBTAINING TR1 LYMPHOCYTES SPECIFIC ANTIGEN REGULATORS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077299A2 (en) * 2000-04-11 2001-10-18 University Of Southern California A METHOD TO PREVENT GRAFT REJECTION USING TGF-β TO INDUCE T SUPPRESSOR CELLS

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0497275A2 (en) * 1991-01-31 1992-08-05 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Generation of CD4+ helper T cells with interleukin 2 and interleukin 4 from L-phenylalanine methyl ester treated human peripheral blood cells
US6228359B1 (en) * 1997-11-05 2001-05-08 University Of Southern California Use of cytokines and mitogens to inhibit pathological immune responses
WO2000042856A1 (en) * 1999-01-22 2000-07-27 The Schepens Eye Research Institute, Inc. Activation of regulatory t cells by alpha-melanocyte stimulating hormone
US20020034500A1 (en) * 2000-08-15 2002-03-21 Levings Megan K. Regulatory T cells; methods
EP1241249A1 (en) * 2001-03-12 2002-09-18 Gerold Schuler CD4+CD25+regulatory T cells from human blood
FR2824567A1 (en) * 2001-05-11 2002-11-15 Inst Nat Sante Rech Med PROCESS FOR OBTAINING TR1 LYMPHOCYTES SPECIFIC ANTIGEN REGULATORS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEVINGS M. ET AL.: "Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 193, no. 11, 2001, pages 1295 - 1301, XP002210571 *
YAMAGIWA ET AL.: "The role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood", JOURNAL OF IMMUNOLOGY, vol. 166, no. 12, 2001, pages 7282 - 7289, XP002969113 *

Also Published As

Publication number Publication date
EP1463799A4 (en) 2006-01-18
EP1463799A2 (en) 2004-10-06
AU2002364230A1 (en) 2003-07-30
CA2469800A1 (en) 2003-07-24
WO2003059264A2 (en) 2003-07-24
AU2002364230B2 (en) 2008-05-01
WO2003059264A9 (en) 2004-11-11
JP2005514054A (en) 2005-05-19

Similar Documents

Publication Publication Date Title
AU2561799A (en) Radiotelephone adapted to the identity of its user
AU2003248331A1 (en) Hybrid membrane, method for producing the same and use of said membrane
AU144678S (en) Bottle
AU153659S (en) Container
AU2002224927A1 (en) Use of substituted imidazoazines, novel imidazoazines, methods for the production thereof, and agents containing these compounds
ID23374A (en) HALOGENOPIRIMIDIN
WO2003059356A3 (en) Novel anti-infectives
MY133969A (en) Indoloquinazolinones
AU2002321292A1 (en) Hybrid membrane, method for the production thereof and use of said membrane
AU2003219100A1 (en) Pyrazolopyridazine derivatives, process for preparation and use for the inhibition of gsk-3
WO2000063247A3 (en) Osteopontin-derived chemotactic and inhibitory agents and uses therefor
EP1261623A4 (en) New retinol derivatives, the method of preparations and the uses thereof
WO2003059264A3 (en) Methods for the induction of professional and cytokine-producing regulatory cells
AU9569998A (en) Photo-spectrometers, methods of use and manufacture
AU2001287218A1 (en) The use of melatonin for induction of general anesthesia
AU2002309646A1 (en) Novel human proteins, polynucleotides encoding them and methods of using the same
AU2002320079A1 (en) Vaccines, immunotherapeutics and methods of using the same
EP1517879A4 (en) Aminoalkylphenols, methods of using and making the same
MXPA04004526A (en) N-methyl-homocystines, use thereof and method for the production thereof.
DE60018253D1 (en) The use of 5-carboxanilido-2,4-bis-trifluoromethylthiazole against rice tanning
AU2001233588A1 (en) New toralactone and its derivation and the use of decreasing blood-fat and losing weight
AU2003246485A1 (en) Interactions of the epstein-barr virus protein ebna1, and uses thereof
WO2001098512A3 (en) Control of metabolism with compositions of the human 2-oxoglutarate carrier
AU7478098A (en) Methods of treatment using nbs-1, antibodies and proteins thereto, and uses of the antibodies
AU2002303232A1 (en) Novel human proteins, polynucleotides encoding them and methods of using the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2002364230

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2469800

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003559429

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002799306

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002799306

Country of ref document: EP

COP Corrected version of pamphlet

Free format text: PAGES 1/19-19/19, DRAWINGS, REPLACED BY NEW PAGES 1/16-16/16; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载