+

WO2003058233A1 - Technique de criblage d'un compose dote d'une activite inhibitrice de la synthese de la paroi cellulaire fongique - Google Patents

Technique de criblage d'un compose dote d'une activite inhibitrice de la synthese de la paroi cellulaire fongique Download PDF

Info

Publication number
WO2003058233A1
WO2003058233A1 PCT/JP2002/013807 JP0213807W WO03058233A1 WO 2003058233 A1 WO2003058233 A1 WO 2003058233A1 JP 0213807 W JP0213807 W JP 0213807W WO 03058233 A1 WO03058233 A1 WO 03058233A1
Authority
WO
WIPO (PCT)
Prior art keywords
cell wall
fungal cell
inhibitory activity
wall synthesis
screening compound
Prior art date
Application number
PCT/JP2002/013807
Other languages
English (en)
Japanese (ja)
Inventor
Kappei Tsukahara
Toshitaka Sato
Kazutaka Nakamoto
Mamiko Tsuchiya
Koji Sagane
Original Assignee
Eisai Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co., Ltd. filed Critical Eisai Co., Ltd.
Priority to AU2002357533A priority Critical patent/AU2002357533A1/en
Publication of WO2003058233A1 publication Critical patent/WO2003058233A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A l'aide d'un simple essai de liaison avec utilisation d'une fraction de membrane dans laquelle s'exprime la protéine GWT1, Il est possible de cribler un composé inhibant le transport de la protéine d'ancrage GPI vers une paroi cellulaire fongique.
PCT/JP2002/013807 2001-12-28 2002-12-27 Technique de criblage d'un compose dote d'une activite inhibitrice de la synthese de la paroi cellulaire fongique WO2003058233A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002357533A AU2002357533A1 (en) 2001-12-28 2002-12-27 Method of screening compound having fungal cell wall synthesis inhibitory activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-401947 2001-12-28
JP2001401947A JP2005168301A (ja) 2001-12-28 2001-12-28 真菌細胞壁合成阻害活性を有する化合物をスクリーニングする方法

Publications (1)

Publication Number Publication Date
WO2003058233A1 true WO2003058233A1 (fr) 2003-07-17

Family

ID=19189897

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/013807 WO2003058233A1 (fr) 2001-12-28 2002-12-27 Technique de criblage d'un compose dote d'une activite inhibitrice de la synthese de la paroi cellulaire fongique

Country Status (3)

Country Link
JP (1) JP2005168301A (fr)
AU (1) AU2002357533A1 (fr)
WO (1) WO2003058233A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048604A1 (fr) * 2002-11-22 2004-06-10 Eisai Co., Ltd. Procede de depistage d'un compose inhibant l'activite enzymatique d'un produit genique gwt1
CN1313828C (zh) * 2004-07-20 2007-05-02 中国人民解放军第二军医大学 一种抗真菌剂筛选试剂盒

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013666A (en) * 1976-03-15 1977-03-22 G. D. Searle & Co. (8α,13Aβ)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quinolizines and intermediates thereto
WO2000001387A1 (fr) * 1998-07-01 2000-01-13 Celgro, A Division Of Celgene Corporation Inhibiteurs de croissance fongique
WO2002004626A1 (fr) * 2000-07-07 2002-01-17 Eisai Co., Ltd. Gene de synthese de la paroi des cellules fongiques

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013666A (en) * 1976-03-15 1977-03-22 G. D. Searle & Co. (8α,13Aβ)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quinolizines and intermediates thereto
WO2000001387A1 (fr) * 1998-07-01 2000-01-13 Celgro, A Division Of Celgene Corporation Inhibiteurs de croissance fongique
WO2002004626A1 (fr) * 2000-07-07 2002-01-17 Eisai Co., Ltd. Gene de synthese de la paroi des cellules fongiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KAWARABAYASHI ET AL.: "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, aeropyrum pernix K1", DNA RES., vol. 6, 1999, pages 83 - 101, XP002966854 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048604A1 (fr) * 2002-11-22 2004-06-10 Eisai Co., Ltd. Procede de depistage d'un compose inhibant l'activite enzymatique d'un produit genique gwt1
US8323917B2 (en) 2002-11-22 2012-12-04 National Institute Of Advanced Industrial Science And Technology Method of screening for compounds that inhibit the enzymatic activity of GWT1 gene product
CN1313828C (zh) * 2004-07-20 2007-05-02 中国人民解放军第二军医大学 一种抗真菌剂筛选试剂盒

Also Published As

Publication number Publication date
JP2005168301A (ja) 2005-06-30
AU2002357533A1 (en) 2003-07-24

Similar Documents

Publication Publication Date Title
USD550578S1 (en) Watch dial
AU2003222664A1 (en) Production of functional antibodies in filamentous fungi
ZA200307453B (en) Uses of benzylideneamino guanidines as ligands to the melanocortin receptors.
WO2005084305A3 (fr) Flavonoides
EP1363125A3 (fr) Determination de profils des facteurs de transcription sur une surface solide
EP1300464A4 (fr) Gene de synthese de la paroi des cellules fongiques
AU2003269339A1 (en) Very large vessel construction
WO2004001384A3 (fr) Procede pour inhiber l'angiogenese, la migration cellulaire, l'adherence cellulaire et la survie cellulaire
AU2003217026A1 (en) Electrochemical multi-well plate
WO2003058233A1 (fr) Technique de criblage d'un compose dote d'une activite inhibitrice de la synthese de la paroi cellulaire fongique
WO2003067212A3 (fr) Procedes et reactifs permettant de realiser des dosages biologiques multiplexes de plusieurs melanges a analyser
AU2003261353A1 (en) High density reagent array preparation methods
WO2005001416A3 (fr) Essai pour déterminer avec un grand rendement l'activité de la lp-pla2
WO2005084369A3 (fr) Reseaux de cristaux colloidaux
WO2004085618A3 (fr) Methode criblage de ligands cibles
AU2003221356A1 (en) Cdc7-ASK KINASE COMPLEX, SUBSTRATE OF THE KINASE COMPLEX, ANTIBODY SPECIFIC TO THE SUBSTRATE, AND METHOD OF SCREENING COMPOUND CAPABLE OF INHIBITING Cdc7-ASK KINASE USING THE SAME
AU2003220812A1 (en) Boat mooring system.
WO2004104191A8 (fr) Vap-1 cristalline et ses utilisations
AU2003267527A1 (en) Sandwich structure
AU2003276725A1 (en) Construction method of shear wall type structure using for plural direction deck plate.
AU2003277688A1 (en) Plural direction deck plate.
WO2001071342A3 (fr) Composes organiques
USD502888S1 (en) Gemstone design
WO2003038096A1 (fr) Recepteur pour inhibiteur de l'angiogenese et procede de criblage dudit inhibiteur
WO2007110702A3 (fr) Titrages

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载