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WO2003051909A3 - Procede - Google Patents

Procede Download PDF

Info

Publication number
WO2003051909A3
WO2003051909A3 PCT/GB2002/005740 GB0205740W WO03051909A3 WO 2003051909 A3 WO2003051909 A3 WO 2003051909A3 GB 0205740 W GB0205740 W GB 0205740W WO 03051909 A3 WO03051909 A3 WO 03051909A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
manufacture
pharmaceutically acceptable
acceptable salts
salt
Prior art date
Application number
PCT/GB2002/005740
Other languages
English (en)
Other versions
WO2003051909A2 (fr
Inventor
Alan Charles Barker
Nigel Philip Taylor
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Alan Charles Barker
Nigel Philip Taylor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Alan Charles Barker, Nigel Philip Taylor filed Critical Astrazeneca Ab
Priority to AU2002352423A priority Critical patent/AU2002352423A1/en
Publication of WO2003051909A2 publication Critical patent/WO2003051909A2/fr
Publication of WO2003051909A3 publication Critical patent/WO2003051909A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un procédé de préparation d'un composé de formule (II) un de ses sels. Dans cette formule, R2 et R3 sont sélectionné indépendamment des groupes protecteurs arginine ; et R1 représente hydrogène ou un groupe protecteur pour un groupe amino d'une fraction d'acétamide. Ledit procédé comprend l'accouplement d'un acide carboxylique de formule (V) ou un de ses sels, dans laquelle R2 est tel que défini ci-dessus, avec une amine de formule (VI), telle que définie dans l'application, ou un de ses sels. L'invention concerne également des intermédiaires utilisés dans le procédé ainsi que les procédés de préparation desdits intermédiaires.
PCT/GB2002/005740 2001-12-19 2002-12-18 Procede WO2003051909A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002352423A AU2002352423A1 (en) 2001-12-19 2002-12-18 Process for the manufacture of pharmaceutically acceptable salts of a compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0130286.8 2001-12-19
GBGB0130286.8A GB0130286D0 (en) 2001-12-19 2001-12-19 Chemical process

Publications (2)

Publication Number Publication Date
WO2003051909A2 WO2003051909A2 (fr) 2003-06-26
WO2003051909A3 true WO2003051909A3 (fr) 2003-12-31

Family

ID=9927876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/005740 WO2003051909A2 (fr) 2001-12-19 2002-12-18 Procede

Country Status (3)

Country Link
AU (1) AU2002352423A1 (fr)
GB (1) GB0130286D0 (fr)
WO (1) WO2003051909A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923577B2 (en) 2009-04-27 2011-04-12 International Flavors & Fragrances Inc. Menthylcarboxamides and their use as cooling agents
CN111848433B (zh) * 2020-07-14 2023-04-28 安徽中草香料股份有限公司 4-氨基苯基乙酰胺的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1155925A (en) * 1967-02-16 1969-06-25 Miles Lab Synthesis Of Octapeptides
US4152322A (en) * 1978-04-28 1979-05-01 Merck & Co., Inc. Process for selective reduction of nitroarginyl peptides with titanium (iii)
DE3712050A1 (de) * 1986-04-09 1987-10-15 Ellem Ind Farmaceutica Tripeptid mit immunostimulierender aktivitaet
WO1997031023A1 (fr) * 1996-02-23 1997-08-28 Zeneca Limited Derives peptidiques
WO2002008247A2 (fr) * 2000-07-22 2002-01-31 Astrazeneca Ab Procede chimique
WO2003051918A1 (fr) * 2001-12-19 2003-06-26 Astrazeneca Ab Procede en solution de phase pour la production d'un decapeptide

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1155925A (en) * 1967-02-16 1969-06-25 Miles Lab Synthesis Of Octapeptides
US4152322A (en) * 1978-04-28 1979-05-01 Merck & Co., Inc. Process for selective reduction of nitroarginyl peptides with titanium (iii)
DE3712050A1 (de) * 1986-04-09 1987-10-15 Ellem Ind Farmaceutica Tripeptid mit immunostimulierender aktivitaet
WO1997031023A1 (fr) * 1996-02-23 1997-08-28 Zeneca Limited Derives peptidiques
US6087336A (en) * 1996-02-23 2000-07-11 Zeneca Limited Peptide derivatives useful in treating autoimmune diseases
WO2002008247A2 (fr) * 2000-07-22 2002-01-31 Astrazeneca Ab Procede chimique
WO2003051918A1 (fr) * 2001-12-19 2003-06-26 Astrazeneca Ab Procede en solution de phase pour la production d'un decapeptide

Also Published As

Publication number Publication date
WO2003051909A2 (fr) 2003-06-26
GB0130286D0 (en) 2002-02-06
AU2002352423A1 (en) 2003-06-30
AU2002352423A8 (en) 2003-06-30

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