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WO2003051305A3 - Vaccins agissant sur le systeme immunitaire inne - Google Patents

Vaccins agissant sur le systeme immunitaire inne Download PDF

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Publication number
WO2003051305A3
WO2003051305A3 PCT/US2002/040046 US0240046W WO03051305A3 WO 2003051305 A3 WO2003051305 A3 WO 2003051305A3 US 0240046 W US0240046 W US 0240046W WO 03051305 A3 WO03051305 A3 WO 03051305A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccines
immune system
innate immune
directed vaccines
methods
Prior art date
Application number
PCT/US2002/040046
Other languages
English (en)
Other versions
WO2003051305A2 (fr
Inventor
Ruslan Medzhitov
Elizabeth Kopp
Original Assignee
Univ Yale
Ruslan Medzhitov
Elizabeth Kopp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Ruslan Medzhitov, Elizabeth Kopp filed Critical Univ Yale
Priority to AU2002361682A priority Critical patent/AU2002361682A1/en
Publication of WO2003051305A2 publication Critical patent/WO2003051305A2/fr
Publication of WO2003051305A3 publication Critical patent/WO2003051305A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6043—Heat shock proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouveaux vaccins, ainsi que des procédés de production et d'utilisation desdits vaccins. Les nouveaux vaccins selon l'invention associent les deux signaux nécessaires à l'activation des lymphocytes T natifs, à savoir un antigène spécifique et le signal co-stimulant, ce qui provoque une réponse immunitaire spécifique et vigoureuse des lymphocytes T.
PCT/US2002/040046 2001-12-14 2002-12-13 Vaccins agissant sur le systeme immunitaire inne WO2003051305A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002361682A AU2002361682A1 (en) 2001-12-14 2002-12-13 Innate immune system-directed vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34017401P 2001-12-14 2001-12-14
US60/340,174 2001-12-14

Publications (2)

Publication Number Publication Date
WO2003051305A2 WO2003051305A2 (fr) 2003-06-26
WO2003051305A3 true WO2003051305A3 (fr) 2004-04-29

Family

ID=23332201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/040046 WO2003051305A2 (fr) 2001-12-14 2002-12-13 Vaccins agissant sur le systeme immunitaire inne

Country Status (2)

Country Link
AU (1) AU2002361682A1 (fr)
WO (1) WO2003051305A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9200042B2 (en) 2006-03-07 2015-12-01 Vaxinnate Corporation Flagellin fusion proteins
US9205138B2 (en) 2008-04-18 2015-12-08 Vaxinnate Corporation Deletion mutants of flagellin and methods of use

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2555253A1 (fr) * 2004-02-06 2005-08-25 Yale University Compositions de modele moleculaire associe a un pathogene (pamp) et monocytogenes listeria et leurs procedes d'utilisation
KR101415864B1 (ko) * 2005-01-28 2014-07-09 갈렌바이오 인코포레이티드 면역학적 활성 조성물
ES2368624T3 (es) * 2007-04-20 2011-11-18 F. Hoffmann-La Roche Ag Detección de infecciones primarias por patógenos.
WO2009082440A2 (fr) * 2007-12-18 2009-07-02 Vaxinnate Corporation Compositions d'agonistes de recepteurs de type toll et d'antigènes de la malaria et procédés d'utilisation correspondants
SI22883A (sl) * 2008-10-28 2010-04-30 Kemijski inštitut Vakcine, ki združujejo antigen in Tollu-podobne receptorje
US8932598B2 (en) 2012-08-28 2015-01-13 Vaxinnate Corporation Fusion proteins and methods of use
EP2921178A1 (fr) * 2014-03-19 2015-09-23 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin Agonistes du récepteur 2 de type toll, vaccins et leurs utilisations
CN109414461A (zh) 2016-04-26 2019-03-01 曲生物制品公司 治疗性地触发靶组织中的先天性免疫应答

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060069A1 (fr) * 1999-04-01 2000-10-12 The Governing Council Of The University Of Toronto Proteine membranaire associee a la preseniline et ses utilisations
US20020058276A1 (en) * 2000-09-01 2002-05-16 The Governing Council Of The University Of Toronto Proteins related to schizophrenia and uses thereof
US20020061312A1 (en) * 2000-07-31 2002-05-23 Ruslan Medzhitov Innate immune system-directed vaccines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060069A1 (fr) * 1999-04-01 2000-10-12 The Governing Council Of The University Of Toronto Proteine membranaire associee a la preseniline et ses utilisations
US20020061312A1 (en) * 2000-07-31 2002-05-23 Ruslan Medzhitov Innate immune system-directed vaccines
US20020058276A1 (en) * 2000-09-01 2002-05-16 The Governing Council Of The University Of Toronto Proteins related to schizophrenia and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AHMAD-NEJAD ET AL.: "Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 32, no. 7, July 2002 (2002-07-01), pages 1958 - 1968, XP002971121 *
HAYASHI ET AL.: "The innate immune response to bacterial flagellin is mediated by Toll-like receptor", NATURE, vol. 4, no. 10, 2001, pages 1099 - 1103, XP002971120 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9200042B2 (en) 2006-03-07 2015-12-01 Vaxinnate Corporation Flagellin fusion proteins
US9205138B2 (en) 2008-04-18 2015-12-08 Vaxinnate Corporation Deletion mutants of flagellin and methods of use
US9211320B2 (en) 2008-04-18 2015-12-15 Vaxinnate Corporation Deletion mutants of flagellin and methods of use

Also Published As

Publication number Publication date
WO2003051305A2 (fr) 2003-06-26
AU2002361682A8 (en) 2003-06-30
AU2002361682A1 (en) 2003-06-30

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