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WO2003046944A8 - Methods and apparatus for improved laser desorption ionization tandem mass spectrometry - Google Patents

Methods and apparatus for improved laser desorption ionization tandem mass spectrometry

Info

Publication number
WO2003046944A8
WO2003046944A8 PCT/US2002/033719 US0233719W WO03046944A8 WO 2003046944 A8 WO2003046944 A8 WO 2003046944A8 US 0233719 W US0233719 W US 0233719W WO 03046944 A8 WO03046944 A8 WO 03046944A8
Authority
WO
WIPO (PCT)
Prior art keywords
laser desorption
methods
mass spectrometry
tandem mass
ionization tandem
Prior art date
Application number
PCT/US2002/033719
Other languages
French (fr)
Other versions
WO2003046944A1 (en
Inventor
Scot R Weinberger
Pete Tornatore
Original Assignee
Ciphergen Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciphergen Biosystems Inc filed Critical Ciphergen Biosystems Inc
Priority to CA002467504A priority Critical patent/CA2467504A1/en
Priority to JP2003548272A priority patent/JP2005510842A/en
Priority to AU2002360294A priority patent/AU2002360294A1/en
Priority to EP02795542A priority patent/EP1451851A1/en
Publication of WO2003046944A1 publication Critical patent/WO2003046944A1/en
Publication of WO2003046944A8 publication Critical patent/WO2003046944A8/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/0481—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for collisional cooling
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

Laser desorption/ionization tandem mass spectrometer instruments that include source, probe (16), bulk head (42), proble holder (40), and chambers (44, 20) are presented, as are analytical methods that employ such instruments to achieve increased sensitivity and ion yield. Also presented are laser desorption/ionization mass spectrometry methods that improve sensitivity and relative ion yield by combining affinity capture probes with matrices having low melting point energy absorbing molecules combined with alkali metal scavengers.
PCT/US2002/033719 2001-11-27 2002-10-21 Methods and apparatus for improved laser desorption ionization tandem mass spectrometry WO2003046944A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002467504A CA2467504A1 (en) 2001-11-27 2002-10-21 Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
JP2003548272A JP2005510842A (en) 2001-11-27 2002-10-21 Method and apparatus for improved laser desorption ionization tandem mass spectrometry
AU2002360294A AU2002360294A1 (en) 2001-11-27 2002-10-21 Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
EP02795542A EP1451851A1 (en) 2001-11-27 2002-10-21 Methods and apparatus for improved laser desorption ionization tandem mass spectrometry

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33390901P 2001-11-27 2001-11-27
US60/333,909 2001-11-27
US10/184,450 US6946653B2 (en) 2001-11-27 2002-06-26 Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
US10/184,450 2002-06-26

Publications (2)

Publication Number Publication Date
WO2003046944A1 WO2003046944A1 (en) 2003-06-05
WO2003046944A8 true WO2003046944A8 (en) 2003-10-09

Family

ID=26880138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033719 WO2003046944A1 (en) 2001-11-27 2002-10-21 Methods and apparatus for improved laser desorption ionization tandem mass spectrometry

Country Status (7)

Country Link
US (1) US6946653B2 (en)
EP (1) EP1451851A1 (en)
JP (1) JP2005510842A (en)
AU (1) AU2002360294A1 (en)
CA (1) CA2467504A1 (en)
TW (1) TW587167B (en)
WO (1) WO2003046944A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7388194B2 (en) * 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
US6963066B2 (en) * 2003-06-05 2005-11-08 Thermo Finnigan Llc Rod assembly in ion source
JP4690641B2 (en) * 2003-07-28 2011-06-01 株式会社日立ハイテクノロジーズ Mass spectrometer
WO2005081944A2 (en) * 2004-02-23 2005-09-09 Ciphergen Biosystems, Inc. Ion source with controlled superposition of electrostatic and gas flow fields
US8003934B2 (en) * 2004-02-23 2011-08-23 Andreas Hieke Methods and apparatus for ion sources, ion control and ion measurement for macromolecules
WO2005104307A2 (en) * 2004-03-24 2005-11-03 Imago Scientific Instruments Corporation Laser atom probes
DE102005044307B4 (en) * 2005-09-16 2008-04-17 Bruker Daltonik Gmbh Ionization of desorbed molecules
GB0526245D0 (en) * 2005-12-22 2006-02-01 Shimadzu Res Lab Europe Ltd A mass spectrometer using a dynamic pressure ion source
US7476849B2 (en) * 2006-03-10 2009-01-13 Varian Semiconductor Equipment Associates, Inc. Technique for monitoring and controlling a plasma process
US7453059B2 (en) * 2006-03-10 2008-11-18 Varian Semiconductor Equipment Associates, Inc. Technique for monitoring and controlling a plasma process
JP2009146913A (en) * 2009-03-30 2009-07-02 Hitachi High-Technologies Corp Mass spectrometer
CN101963596B (en) * 2010-09-01 2012-09-05 中国科学院广州地球化学研究所 Rare gas determination system based on quadrupole mass spectrometer
GB201815676D0 (en) 2018-09-26 2018-11-07 Micromass Ltd MALDI nozzle
CN112117173B (en) * 2020-09-07 2021-06-25 华东师范大学 High-efficient cryogenic multipole cold-trap system

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020208A (en) 1994-05-27 2000-02-01 Baylor College Of Medicine Systems for surface-enhanced affinity capture for desorption and detection of analytes
ES2201077T3 (en) 1993-05-28 2004-03-16 Baylor College Of Medicine METHOD AND SPECTROMETER OF MASSES FOR DESORTION AND IONIZATION OF ANALYTS.
US6017693A (en) 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6512226B1 (en) 1997-12-04 2003-01-28 University Of Manitoba Method of and apparatus for selective collision-induced dissociation of ions in a quadrupole ion guide
US6331702B1 (en) 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
DE19911801C1 (en) 1999-03-17 2001-01-11 Bruker Daltonik Gmbh Method and device for matrix-assisted laser desorption ionization of substances
WO2000077822A2 (en) 1999-06-11 2000-12-21 Perseptive Biosystems, Inc. Method and apparatus for determining molecular weight of labile molecules
WO2002031484A2 (en) * 2000-10-11 2002-04-18 Ciphergen Biosystems, Inc. Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry
US20020195555A1 (en) 2000-10-11 2002-12-26 Weinberger Scot R. Apparatus and methods for affinity capture tandem mass spectrometry
JP2005504263A (en) * 2001-02-01 2005-02-10 シファーゲン バイオシステムズ， インコーポレイテッド Improved method for protein identification, characterization and sequencing by tandem mass spectrometry
US6707037B2 (en) 2001-05-25 2004-03-16 Analytica Of Branford, Inc. Atmospheric and vacuum pressure MALDI ion source

Also Published As

Publication number Publication date
CA2467504A1 (en) 2003-06-05
TW587167B (en) 2004-05-11
AU2002360294A1 (en) 2003-06-10
US20030098413A1 (en) 2003-05-29
WO2003046944A1 (en) 2003-06-05
EP1451851A1 (en) 2004-09-01
US6946653B2 (en) 2005-09-20
JP2005510842A (en) 2005-04-21

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